Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2
Identifieur interne : 001039 ( Ncbi/Checkpoint ); précédent : 001038; suivant : 001040Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2
Auteurs : Yadi Zhou [États-Unis] ; Yuan Hou [États-Unis] ; Jiayu Shen [États-Unis] ; Yin Huang [États-Unis] ; William Martin [États-Unis] ; Feixiong Cheng [États-Unis]Source :
- Cell Discovery [ 2056-5968 ] ; 2020.
Abstract
Human coronaviruses (HCoVs), including severe acute respiratory syndrome coronavirus (SARS-CoV) and 2019 novel coronavirus (2019-nCoV, also known as SARS-CoV-2), lead global epidemics with high morbidity and mortality. However, there are currently no effective drugs targeting 2019-nCoV/SARS-CoV-2. Drug repurposing, representing as an effective drug discovery strategy from existing drugs, could shorten the time and reduce the cost compared to de novo drug discovery. In this study, we present an integrative, antiviral drug repurposing methodology implementing a systems pharmacology-based network medicine platform, quantifying the interplay between the HCoV–host interactome and drug targets in the human protein–protein interaction network. Phylogenetic analyses of 15 HCoV whole genomes reveal that 2019-nCoV/SARS-CoV-2 shares the highest nucleotide sequence identity with SARS-CoV (79.7%). Specifically, the envelope and nucleocapsid proteins of 2019-nCoV/SARS-CoV-2 are two evolutionarily conserved regions, having the sequence identities of 96% and 89.6%, respectively, compared to SARS-CoV. Using network proximity analyses of drug targets and HCoV–host interactions in the human interactome, we prioritize 16 potential anti-HCoV repurposable drugs (e.g., melatonin, mercaptopurine, and sirolimus) that are further validated by enrichment analyses of drug-gene signatures and HCoV-induced transcriptomics data in human cell lines. We further identify three potential drug combinations (e.g., sirolimus plus dactinomycin, mercaptopurine plus melatonin, and toremifene plus emodin) captured by the “
Url:
DOI: 10.1038/s41421-020-0153-3
PubMed: 32194980
PubMed Central: 7073332
Affiliations:
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<front><div type="abstract" xml:lang="en"><p id="Par1">Human coronaviruses (HCoVs), including severe acute respiratory syndrome coronavirus (SARS-CoV) and 2019 novel coronavirus (2019-nCoV, also known as SARS-CoV-2), lead global epidemics with high morbidity and mortality. However, there are currently no effective drugs targeting 2019-nCoV/SARS-CoV-2. Drug repurposing, representing as an effective drug discovery strategy from existing drugs, could shorten the time and reduce the cost compared to de novo drug discovery. In this study, we present an integrative, antiviral drug repurposing methodology implementing a systems pharmacology-based network medicine platform, quantifying the interplay between the HCoV–host interactome and drug targets in the human protein–protein interaction network. Phylogenetic analyses of 15 HCoV whole genomes reveal that 2019-nCoV/SARS-CoV-2 shares the highest nucleotide sequence identity with SARS-CoV (79.7%). Specifically, the envelope and nucleocapsid proteins of 2019-nCoV/SARS-CoV-2 are two evolutionarily conserved regions, having the sequence identities of 96% and 89.6%, respectively, compared to SARS-CoV. Using network proximity analyses of drug targets and HCoV–host interactions in the human interactome, we prioritize 16 potential anti-HCoV repurposable drugs (e.g., melatonin, mercaptopurine, and sirolimus) that are further validated by enrichment analyses of drug-gene signatures and HCoV-induced transcriptomics data in human cell lines. We further identify three potential drug combinations (e.g., sirolimus plus dactinomycin, mercaptopurine plus melatonin, and toremifene plus emodin) captured by the “<italic>Complementary Exposure</italic>
” pattern: the targets of the drugs both hit the HCoV–host subnetwork, but target separate neighborhoods in the human interactome network. In summary, this study offers powerful network-based methodologies for rapid identification of candidate repurposable drugs and potential drug combinations targeting 2019-nCoV/SARS-CoV-2.</p>
</div>
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<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zumla, A" uniqKey="Zumla A">A Zumla</name>
</author>
<author><name sortKey="Chan, Jf" uniqKey="Chan J">JF Chan</name>
</author>
<author><name sortKey="Azhar, Ei" uniqKey="Azhar E">EI Azhar</name>
</author>
<author><name sortKey="Hui, Ds" uniqKey="Hui D">DS Hui</name>
</author>
<author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Paules, Ci" uniqKey="Paules C">CI Paules</name>
</author>
<author><name sortKey="Marston, Hd" uniqKey="Marston H">HD Marston</name>
</author>
<author><name sortKey="Fauci, As" uniqKey="Fauci A">AS Fauci</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name>
</author>
<author><name sortKey="Van Doremalen, N" uniqKey="Van Doremalen N">N van Doremalen</name>
</author>
<author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D Falzarano</name>
</author>
<author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Wilde, Ah" uniqKey="De Wilde A">AH de Wilde</name>
</author>
<author><name sortKey="Snijder, Ej" uniqKey="Snijder E">EJ Snijder</name>
</author>
<author><name sortKey="Kikkert, M" uniqKey="Kikkert M">M Kikkert</name>
</author>
<author><name sortKey="Van Hemert, Mj" uniqKey="Van Hemert M">MJ van Hemert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, N" uniqKey="Chen N">N Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Greene, Ja" uniqKey="Greene J">JA Greene</name>
</author>
<author><name sortKey="Loscalzo, J" uniqKey="Loscalzo J">J Loscalzo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Avorn, J" uniqKey="Avorn J">J Avorn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cheng, F" uniqKey="Cheng F">F Cheng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cheng, F" uniqKey="Cheng F">F Cheng</name>
</author>
<author><name sortKey="Hong, H" uniqKey="Hong H">H Hong</name>
</author>
<author><name sortKey="Yang, S" uniqKey="Yang S">S Yang</name>
</author>
<author><name sortKey="Wei, Y" uniqKey="Wei Y">Y Wei</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cheng, F" uniqKey="Cheng F">F Cheng</name>
</author>
<author><name sortKey="Murray, Jl" uniqKey="Murray J">JL Murray</name>
</author>
<author><name sortKey="Rubin, Dh" uniqKey="Rubin D">DH Rubin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Santos, R" uniqKey="Santos R">R Santos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cheng, F" uniqKey="Cheng F">F Cheng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cheng, F" uniqKey="Cheng F">F Cheng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, S" uniqKey="Yang S">S Yang</name>
</author>
<author><name sortKey="Fu, C" uniqKey="Fu C">C Fu</name>
</author>
<author><name sortKey="Lian, X" uniqKey="Lian X">X Lian</name>
</author>
<author><name sortKey="Dong, X" uniqKey="Dong X">X Dong</name>
</author>
<author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, Chuang" uniqKey="Liu C">Chuang Liu</name>
</author>
<author><name sortKey="Ma, Yifang" uniqKey="Ma Y">Yifang Ma</name>
</author>
<author><name sortKey="Zhao, Jing" uniqKey="Zhao J">Jing Zhao</name>
</author>
<author><name sortKey="Nussinov, Ruth" uniqKey="Nussinov R">Ruth Nussinov</name>
</author>
<author><name sortKey="Zhang, Yi Cheng" uniqKey="Zhang Y">Yi-Cheng Zhang</name>
</author>
<author><name sortKey="Cheng, Feixiong" uniqKey="Cheng F">Feixiong Cheng</name>
</author>
<author><name sortKey="Zhang, Zi Ke" uniqKey="Zhang Z">Zi-Ke Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dyall, J" uniqKey="Dyall J">J Dyall</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Johansen, Lm" uniqKey="Johansen L">LM Johansen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="He, S" uniqKey="He S">S He</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Barrows, Nj" uniqKey="Barrows N">NJ Barrows</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xu, M" uniqKey="Xu M">M Xu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cheng, F" uniqKey="Cheng F">F Cheng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cheng, F" uniqKey="Cheng F">F Cheng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zeng, X" uniqKey="Zeng X">X Zeng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zeng, X" uniqKey="Zeng X">X Zeng</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Cheng, F" uniqKey="Cheng F">F Cheng</name>
</author>
<author><name sortKey="Kovacs, Ia" uniqKey="Kovacs I">IA Kovacs</name>
</author>
<author><name sortKey="Barabasi, Al" uniqKey="Barabasi A">AL Barabasi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Forni, D" uniqKey="Forni D">D Forni</name>
</author>
<author><name sortKey="Cagliani, R" uniqKey="Cagliani R">R Cagliani</name>
</author>
<author><name sortKey="Clerici, M" uniqKey="Clerici M">M Clerici</name>
</author>
<author><name sortKey="Sironi, M" uniqKey="Sironi M">M Sironi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kirchdoerfer, Rn" uniqKey="Kirchdoerfer R">RN Kirchdoerfer</name>
</author>
<author><name sortKey="Ward, Ab" uniqKey="Ward A">AB Ward</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, F" uniqKey="Li F">F Li</name>
</author>
<author><name sortKey="Li, W" uniqKey="Li W">W Li</name>
</author>
<author><name sortKey="Farzan, M" uniqKey="Farzan M">M Farzan</name>
</author>
<author><name sortKey="Harrison, Sc" uniqKey="Harrison S">SC Harrison</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lu, R" uniqKey="Lu R">R Lu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhou, Peng" uniqKey="Zhou P">Peng Zhou</name>
</author>
<author><name sortKey="Yang, Xing Lou" uniqKey="Yang X">Xing-Lou Yang</name>
</author>
<author><name sortKey="Wang, Xian Guang" uniqKey="Wang X">Xian-Guang Wang</name>
</author>
<author><name sortKey="Hu, Ben" uniqKey="Hu B">Ben Hu</name>
</author>
<author><name sortKey="Zhang, Lei" uniqKey="Zhang L">Lei Zhang</name>
</author>
<author><name sortKey="Zhang, Wei" uniqKey="Zhang W">Wei Zhang</name>
</author>
<author><name sortKey="Si, Hao Rui" uniqKey="Si H">Hao-Rui Si</name>
</author>
<author><name sortKey="Zhu, Yan" uniqKey="Zhu Y">Yan Zhu</name>
</author>
<author><name sortKey="Li, Bei" uniqKey="Li B">Bei Li</name>
</author>
<author><name sortKey="Huang, Chao Lin" uniqKey="Huang C">Chao-Lin Huang</name>
</author>
<author><name sortKey="Chen, Hui Dong" uniqKey="Chen H">Hui-Dong Chen</name>
</author>
<author><name sortKey="Chen, Jing" uniqKey="Chen J">Jing Chen</name>
</author>
<author><name sortKey="Luo, Yun" uniqKey="Luo Y">Yun Luo</name>
</author>
<author><name sortKey="Guo, Hua" uniqKey="Guo H">Hua Guo</name>
</author>
<author><name sortKey="Jiang, Ren Di" uniqKey="Jiang R">Ren-Di Jiang</name>
</author>
<author><name sortKey="Liu, Mei Qin" uniqKey="Liu M">Mei-Qin Liu</name>
</author>
<author><name sortKey="Chen, Ying" uniqKey="Chen Y">Ying Chen</name>
</author>
<author><name sortKey="Shen, Xu Rui" uniqKey="Shen X">Xu-Rui Shen</name>
</author>
<author><name sortKey="Wang, Xi" uniqKey="Wang X">Xi Wang</name>
</author>
<author><name sortKey="Zheng, Xiao Shuang" uniqKey="Zheng X">Xiao-Shuang Zheng</name>
</author>
<author><name sortKey="Zhao, Kai" uniqKey="Zhao K">Kai Zhao</name>
</author>
<author><name sortKey="Chen, Quan Jiao" uniqKey="Chen Q">Quan-Jiao Chen</name>
</author>
<author><name sortKey="Deng, Fei" uniqKey="Deng F">Fei Deng</name>
</author>
<author><name sortKey="Liu, Lin Lin" uniqKey="Liu L">Lin-Lin Liu</name>
</author>
<author><name sortKey="Yan, Bing" uniqKey="Yan B">Bing Yan</name>
</author>
<author><name sortKey="Zhan, Fa Xian" uniqKey="Zhan F">Fa-Xian Zhan</name>
</author>
<author><name sortKey="Wang, Yan Yi" uniqKey="Wang Y">Yan-Yi Wang</name>
</author>
<author><name sortKey="Xiao, Geng Fu" uniqKey="Xiao G">Geng-Fu Xiao</name>
</author>
<author><name sortKey="Shi, Zheng Li" uniqKey="Shi Z">Zheng-Li Shi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wrapp, Daniel" uniqKey="Wrapp D">Daniel Wrapp</name>
</author>
<author><name sortKey="Wang, Nianshuang" uniqKey="Wang N">Nianshuang Wang</name>
</author>
<author><name sortKey="Corbett, Kizzmekia S" uniqKey="Corbett K">Kizzmekia S. Corbett</name>
</author>
<author><name sortKey="Goldsmith, Jory A" uniqKey="Goldsmith J">Jory A. Goldsmith</name>
</author>
<author><name sortKey="Hsieh, Ching Lin" uniqKey="Hsieh C">Ching-Lin Hsieh</name>
</author>
<author><name sortKey="Abiona, Olubukola" uniqKey="Abiona O">Olubukola Abiona</name>
</author>
<author><name sortKey="Graham, Barney S" uniqKey="Graham B">Barney S. Graham</name>
</author>
<author><name sortKey="Mclellan, Jason S" uniqKey="Mclellan J">Jason S. McLellan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chang, Ck" uniqKey="Chang C">CK Chang</name>
</author>
<author><name sortKey="Chen, Cm" uniqKey="Chen C">CM Chen</name>
</author>
<author><name sortKey="Chiang, Mh" uniqKey="Chiang M">MH Chiang</name>
</author>
<author><name sortKey="Hsu, Yl" uniqKey="Hsu Y">YL Hsu</name>
</author>
<author><name sortKey="Huang, Th" uniqKey="Huang T">TH Huang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lamb, J" uniqKey="Lamb J">J Lamb</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lasso, G" uniqKey="Lasso G">G Lasso</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Wilde, Ah" uniqKey="De Wilde A">AH de Wilde</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y Zhao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Emmott, E" uniqKey="Emmott E">E Emmott</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="V Ovski, P" uniqKey="V Ovski P">P V’Kovski</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Moskowitz, Dw" uniqKey="Moskowitz D">DW Moskowitz</name>
</author>
<author><name sortKey="Johnson, Fe" uniqKey="Johnson F">FE Johnson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seko, Y" uniqKey="Seko Y">Y Seko</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Erlandson, Km" uniqKey="Erlandson K">KM Erlandson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Xj" uniqKey="Wang X">XJ Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ko, C" uniqKey="Ko C">C Ko</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hong, M" uniqKey="Hong M">M Hong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mcnulty, S" uniqKey="Mcnulty S">S McNulty</name>
</author>
<author><name sortKey="Flint, M" uniqKey="Flint M">M Flint</name>
</author>
<author><name sortKey="Nichol, St" uniqKey="Nichol S">ST Nichol</name>
</author>
<author><name sortKey="Spiropoulou, Cf" uniqKey="Spiropoulou C">CF Spiropoulou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stohr, S" uniqKey="Stohr S">S Stohr</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Ch" uniqKey="Wang C">CH Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dyall, J" uniqKey="Dyall J">J Dyall</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Karran, P" uniqKey="Karran P">P Karran</name>
</author>
<author><name sortKey="Attard, N" uniqKey="Attard N">N Attard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, X" uniqKey="Chen X">X Chen</name>
</author>
<author><name sortKey="Chou, Cy" uniqKey="Chou C">CY Chou</name>
</author>
<author><name sortKey="Chang, Gg" uniqKey="Chang G">GG Chang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cheng, Kw" uniqKey="Cheng K">KW Cheng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name>
</author>
<author><name sortKey="Wurm, T" uniqKey="Wurm T">T Wurm</name>
</author>
<author><name sortKey="Britton, P" uniqKey="Britton P">P Britton</name>
</author>
<author><name sortKey="Brooks, G" uniqKey="Brooks G">G Brooks</name>
</author>
<author><name sortKey="Hiscox, Ja" uniqKey="Hiscox J">JA Hiscox</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rainsford, Kd" uniqKey="Rainsford K">KD Rainsford</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Garcia, Cc" uniqKey="Garcia C">CC Garcia</name>
</author>
<author><name sortKey="Guabiraba, R" uniqKey="Guabiraba R">R Guabiraba</name>
</author>
<author><name sortKey="Soriani, Fm" uniqKey="Soriani F">FM Soriani</name>
</author>
<author><name sortKey="Teixeira, Mm" uniqKey="Teixeira M">MM Teixeira</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Silvestri, M" uniqKey="Silvestri M">M Silvestri</name>
</author>
<author><name sortKey="Rossi, Ga" uniqKey="Rossi G">GA Rossi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Srinivasan, V" uniqKey="Srinivasan V">V Srinivasan</name>
</author>
<author><name sortKey="Mohamed, M" uniqKey="Mohamed M">M Mohamed</name>
</author>
<author><name sortKey="Kato, H" uniqKey="Kato H">H Kato</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tan, Dx" uniqKey="Tan D">DX Tan</name>
</author>
<author><name sortKey="Korkmaz, A" uniqKey="Korkmaz A">A Korkmaz</name>
</author>
<author><name sortKey="Reiter, Rj" uniqKey="Reiter R">RJ Reiter</name>
</author>
<author><name sortKey="Manchester, Lc" uniqKey="Manchester L">LC Manchester</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tan, Dx" uniqKey="Tan D">DX Tan</name>
</author>
<author><name sortKey="Manchester, Lc" uniqKey="Manchester L">LC Manchester</name>
</author>
<author><name sortKey="Terron, Mp" uniqKey="Terron M">MP Terron</name>
</author>
<author><name sortKey="Flores, Lj" uniqKey="Flores L">LJ Flores</name>
</author>
<author><name sortKey="Reiter, Rj" uniqKey="Reiter R">RJ Reiter</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Galano, A" uniqKey="Galano A">A Galano</name>
</author>
<author><name sortKey="Tan, Dx" uniqKey="Tan D">DX Tan</name>
</author>
<author><name sortKey="Reiter, Rj" uniqKey="Reiter R">RJ Reiter</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xiao, J" uniqKey="Xiao J">J Xiao</name>
</author>
<author><name sortKey="Shimada, M" uniqKey="Shimada M">M Shimada</name>
</author>
<author><name sortKey="Liu, W" uniqKey="Liu W">W Liu</name>
</author>
<author><name sortKey="Hu, D" uniqKey="Hu D">D Hu</name>
</author>
<author><name sortKey="Matsumori, A" uniqKey="Matsumori A">A Matsumori</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Manli" uniqKey="Wang M">Manli Wang</name>
</author>
<author><name sortKey="Cao, Ruiyuan" uniqKey="Cao R">Ruiyuan Cao</name>
</author>
<author><name sortKey="Zhang, Leike" uniqKey="Zhang L">Leike Zhang</name>
</author>
<author><name sortKey="Yang, Xinglou" uniqKey="Yang X">Xinglou Yang</name>
</author>
<author><name sortKey="Liu, Jia" uniqKey="Liu J">Jia Liu</name>
</author>
<author><name sortKey="Xu, Mingyue" uniqKey="Xu M">Mingyue Xu</name>
</author>
<author><name sortKey="Shi, Zhengli" uniqKey="Shi Z">Zhengli Shi</name>
</author>
<author><name sortKey="Hu, Zhihong" uniqKey="Hu Z">Zhihong Hu</name>
</author>
<author><name sortKey="Zhong, Wu" uniqKey="Zhong W">Wu Zhong</name>
</author>
<author><name sortKey="Xiao, Gengfu" uniqKey="Xiao G">Gengfu Xiao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tan, X" uniqKey="Tan X">X Tan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kindrachuk, J" uniqKey="Kindrachuk J">J Kindrachuk</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lewis, El" uniqKey="Lewis E">EL Lewis</name>
</author>
<author><name sortKey="Harbour, Da" uniqKey="Harbour D">DA Harbour</name>
</author>
<author><name sortKey="Beringer, Je" uniqKey="Beringer J">JE Beringer</name>
</author>
<author><name sortKey="Grinsted, J" uniqKey="Grinsted J">J Grinsted</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhou, Wb" uniqKey="Zhou W">WB Zhou</name>
</author>
<author><name sortKey="Ding, Q" uniqKey="Ding Q">Q Ding</name>
</author>
<author><name sortKey="Chen, L" uniqKey="Chen L">L Chen</name>
</author>
<author><name sortKey="Liu, Xa" uniqKey="Liu X">XA Liu</name>
</author>
<author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cong, Y" uniqKey="Cong Y">Y Cong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schwarz, S" uniqKey="Schwarz S">S Schwarz</name>
</author>
<author><name sortKey="Wang, K" uniqKey="Wang K">K Wang</name>
</author>
<author><name sortKey="Yu, W" uniqKey="Yu W">W Yu</name>
</author>
<author><name sortKey="Sun, B" uniqKey="Sun B">B Sun</name>
</author>
<author><name sortKey="Schwarz, W" uniqKey="Schwarz W">W Schwarz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ho, Ty" uniqKey="Ho T">TY Ho</name>
</author>
<author><name sortKey="Wu, Sl" uniqKey="Wu S">SL Wu</name>
</author>
<author><name sortKey="Chen, Jc" uniqKey="Chen J">JC Chen</name>
</author>
<author><name sortKey="Li, Cc" uniqKey="Li C">CC Li</name>
</author>
<author><name sortKey="Hsiang, Cy" uniqKey="Hsiang C">CY Hsiang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lambert, Dw" uniqKey="Lambert D">DW Lambert</name>
</author>
<author><name sortKey="Clarke, Ne" uniqKey="Clarke N">NE Clarke</name>
</author>
<author><name sortKey="Hooper, Nm" uniqKey="Hooper N">NM Hooper</name>
</author>
<author><name sortKey="Turner, Aj" uniqKey="Turner A">AJ Turner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dai, J" uniqKey="Dai J">J Dai</name>
</author>
<author><name sortKey="Inscho, Ew" uniqKey="Inscho E">EW Inscho</name>
</author>
<author><name sortKey="Yuan, L" uniqKey="Yuan L">L Yuan</name>
</author>
<author><name sortKey="Hill, Sm" uniqKey="Hill S">SM Hill</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fung, Ts" uniqKey="Fung T">TS Fung</name>
</author>
<author><name sortKey="Liu, Dx" uniqKey="Liu D">DX Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Biedenkopf, N" uniqKey="Biedenkopf N">N Biedenkopf</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Muller, C" uniqKey="Muller C">C Muller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Halder, Ak" uniqKey="Halder A">AK Halder</name>
</author>
<author><name sortKey="Dutta, P" uniqKey="Dutta P">P Dutta</name>
</author>
<author><name sortKey="Kundu, M" uniqKey="Kundu M">M Kundu</name>
</author>
<author><name sortKey="Basu, S" uniqKey="Basu S">S Basu</name>
</author>
<author><name sortKey="Nasipuri, M" uniqKey="Nasipuri M">M Nasipuri</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bedi, O" uniqKey="Bedi O">O Bedi</name>
</author>
<author><name sortKey="Dhawan, V" uniqKey="Dhawan V">V Dhawan</name>
</author>
<author><name sortKey="Sharma, Pl" uniqKey="Sharma P">PL Sharma</name>
</author>
<author><name sortKey="Kumar, P" uniqKey="Kumar P">P Kumar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, Q" uniqKey="Li Q">Q Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Kim, Jh" uniqKey="Kim J">JH Kim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gupta, A" uniqKey="Gupta A">A Gupta</name>
</author>
<author><name sortKey="Gulati, S" uniqKey="Gulati S">S Gulati</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chiang, Cw" uniqKey="Chiang C">CW Chiang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kumar, S" uniqKey="Kumar S">S Kumar</name>
</author>
<author><name sortKey="Stecher, G" uniqKey="Stecher G">G Stecher</name>
</author>
<author><name sortKey="Li, M" uniqKey="Li M">M Li</name>
</author>
<author><name sortKey="Knyaz, C" uniqKey="Knyaz C">C Knyaz</name>
</author>
<author><name sortKey="Tamura, K" uniqKey="Tamura K">K Tamura</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kuleshov, Mv" uniqKey="Kuleshov M">MV Kuleshov</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Law, V" uniqKey="Law V">V Law</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, H" uniqKey="Yang H">H Yang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gaulton, A" uniqKey="Gaulton A">A Gaulton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, Tq" uniqKey="Liu T">TQ Liu</name>
</author>
<author><name sortKey="Lin, Ym" uniqKey="Lin Y">YM Lin</name>
</author>
<author><name sortKey="Wen, X" uniqKey="Wen X">X Wen</name>
</author>
<author><name sortKey="Jorissen, Rn" uniqKey="Jorissen R">RN Jorissen</name>
</author>
<author><name sortKey="Gilson, Mk" uniqKey="Gilson M">MK Gilson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pawson, Aj" uniqKey="Pawson A">AJ Pawson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Apweiler, R" uniqKey="Apweiler R">R Apweiler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Coordinators, Nr" uniqKey="Coordinators N">NR Coordinators</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Smith, In" uniqKey="Smith I">IN Smith</name>
</author>
<author><name sortKey="Thacker, S" uniqKey="Thacker S">S Thacker</name>
</author>
<author><name sortKey="Seyfi, M" uniqKey="Seyfi M">M Seyfi</name>
</author>
<author><name sortKey="Cheng, F" uniqKey="Cheng F">F Cheng</name>
</author>
<author><name sortKey="Eng, C" uniqKey="Eng C">C Eng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reghunathan, R" uniqKey="Reghunathan R">R Reghunathan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Josset, L" uniqKey="Josset L">L Josset</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yuan, S" uniqKey="Yuan S">S Yuan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sirota, M" uniqKey="Sirota M">M Sirota</name>
</author>
</analytic>
</biblStruct>
</listBibl>
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<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Ohio</li>
</region>
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<name sortKey="Cheng, Feixiong" sort="Cheng, Feixiong" uniqKey="Cheng F" first="Feixiong" last="Cheng">Feixiong Cheng</name>
<name sortKey="Hou, Yuan" sort="Hou, Yuan" uniqKey="Hou Y" first="Yuan" last="Hou">Yuan Hou</name>
<name sortKey="Huang, Yin" sort="Huang, Yin" uniqKey="Huang Y" first="Yin" last="Huang">Yin Huang</name>
<name sortKey="Martin, William" sort="Martin, William" uniqKey="Martin W" first="William" last="Martin">William Martin</name>
<name sortKey="Shen, Jiayu" sort="Shen, Jiayu" uniqKey="Shen J" first="Jiayu" last="Shen">Jiayu Shen</name>
</country>
</tree>
</affiliations>
</record>
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