Fusobacterium nucleatum Promotes Metastasis in Colorectal Cancer by Activating Autophagy Signaling via the Upregulation of CARD3 Expression
Identifieur interne : 000D97 ( Ncbi/Checkpoint ); précédent : 000D96; suivant : 000D98Fusobacterium nucleatum Promotes Metastasis in Colorectal Cancer by Activating Autophagy Signaling via the Upregulation of CARD3 Expression
Auteurs : Yongyu Chen [République populaire de Chine] ; Yan Chen [République populaire de Chine] ; Jixiang Zhang [République populaire de Chine] ; Pan Cao [République populaire de Chine] ; Wenhao Su [République populaire de Chine] ; Yunchao Deng [République populaire de Chine] ; Na Zhan [République populaire de Chine] ; Xiangsheng Fu [République populaire de Chine] ; Yun Huang [États-Unis] ; Weiguo Dong [République populaire de Chine]Source :
- Theranostics [ 1838-7640 ] ; 2020.
Abstract
Url:
DOI: 10.7150/thno.38870
PubMed: 31903123
PubMed Central: 6929621
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000824
- to stream Pmc, to step Curation: 000824
- to stream Pmc, to step Checkpoint: 000220
- to stream Ncbi, to step Merge: 000D97
- to stream Ncbi, to step Curation: 000D97
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PMC:6929621Le document en format XML
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Promotes Metastasis in Colorectal Cancer by Activating Autophagy Signaling via the Upregulation of CARD3 Expression</title>
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<author><name sortKey="Deng, Yunchao" sort="Deng, Yunchao" uniqKey="Deng Y" first="Yunchao" last="Deng">Yunchao Deng</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>Fusobacterium nucleatum</italic>
Promotes Metastasis in Colorectal Cancer by Activating Autophagy Signaling via the Upregulation of CARD3 Expression</title>
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<author><name sortKey="Zhang, Jixiang" sort="Zhang, Jixiang" uniqKey="Zhang J" first="Jixiang" last="Zhang">Jixiang Zhang</name>
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<author><name sortKey="Deng, Yunchao" sort="Deng, Yunchao" uniqKey="Deng Y" first="Yunchao" last="Deng">Yunchao Deng</name>
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<author><name sortKey="Fu, Xiangsheng" sort="Fu, Xiangsheng" uniqKey="Fu X" first="Xiangsheng" last="Fu">Xiangsheng Fu</name>
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<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
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<author><name sortKey="Huang, Yun" sort="Huang, Yun" uniqKey="Huang Y" first="Yun" last="Huang">Yun Huang</name>
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<author><name sortKey="Dong, Weiguo" sort="Dong, Weiguo" uniqKey="Dong W" first="Weiguo" last="Dong">Weiguo Dong</name>
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</author>
</analytic>
<series><title level="j">Theranostics</title>
<idno type="eISSN">1838-7640</idno>
<imprint><date when="2020">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><bold>Aims</bold>
: We aimed to measure the abundance of <italic>Fusobacterium nucleatum</italic>
(<italic>F. nucleatum</italic>
) in colorectal cancer (CRC) tissues from patients and to uncover the function of this bacterium in colorectal tumor metastasis.</p>
<p><bold>Methods</bold>
: We collected metastatic and non-metastatic CRC tissues to analyze <italic>F. nucleatum</italic>
abundance. Cells were incubated with <italic>F. nucleatum</italic>
or chloroquine (CQ) or were transfected with CARD3-targeting siRNA; the expression of mRNAs and proteins was then measured. CRC cells stably transfected with shRNA-luc were mixed with <italic>F. nucleatum</italic>
and intravenously injected into BALB/cJ mice. APC<sup>Min/+</sup>
, CARD3<sup>-/-</sup>
and CARD3<sup>wt</sup>
C57BL mice were given <italic>F. nucleatum</italic>
; some mice were given azoxymethane (AOM) and dextran sodium sulfate (DSS).</p>
<p><bold>Results</bold>
: <italic>F. nucleatum</italic>
was abundant in CRC tissues from patients with metastasis. <italic>F. nucleatum</italic>
infection increased CRC cell motility and upregulated the expression of CARD3, LC3-II, Beclin1 and Vimentin, and downregulated the expression of E-cadherin and P62 in CRC cells. These effects were attenuated by treatment with CQ, siCARD3 or both. APC<sup>Min/+</sup>
mice gavaged with <italic>F. nucleatum</italic>
developed more aggressive tumors than control mice. After AOM/DSS administration, the colorectums of CARD3<sup>-/-</sup>
mice had fewer tumors than those of control mice. Tumors from CARD3<sup>-/-</sup>
mice had lower levels of LC3-II and Beclin1 and higher levels of P62 than those from control mice. BALB/cJ mice injected with both CT26-luc cells and <italic>F. nucleatum</italic>
formed more metastases than control mice. CQ treatment, CARD3 knockdown or both reduced the ability of CT26-luc cells to form metastases <italic>in vivo</italic>
.</p>
<p><bold>Conclusions</bold>
: <italic>F. nucleatum</italic>
is enriched in CRC tissues from patients with metastasis. <italic>F. nucleatum</italic>
orchestrates CARD3 and autophagy to control CRC metastasis. Measuring and targeting <italic>F. nucleatum</italic>
and its associated pathways will yield approaches for the prevention and treatment of CRC metastasis.</p>
</div>
</front>
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</analytic>
</biblStruct>
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</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
<li>États-Unis</li>
</country>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Chen, Yongyu" sort="Chen, Yongyu" uniqKey="Chen Y" first="Yongyu" last="Chen">Yongyu Chen</name>
</noRegion>
<name sortKey="Cao, Pan" sort="Cao, Pan" uniqKey="Cao P" first="Pan" last="Cao">Pan Cao</name>
<name sortKey="Cao, Pan" sort="Cao, Pan" uniqKey="Cao P" first="Pan" last="Cao">Pan Cao</name>
<name sortKey="Chen, Yan" sort="Chen, Yan" uniqKey="Chen Y" first="Yan" last="Chen">Yan Chen</name>
<name sortKey="Chen, Yan" sort="Chen, Yan" uniqKey="Chen Y" first="Yan" last="Chen">Yan Chen</name>
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<name sortKey="Deng, Yunchao" sort="Deng, Yunchao" uniqKey="Deng Y" first="Yunchao" last="Deng">Yunchao Deng</name>
<name sortKey="Dong, Weiguo" sort="Dong, Weiguo" uniqKey="Dong W" first="Weiguo" last="Dong">Weiguo Dong</name>
<name sortKey="Dong, Weiguo" sort="Dong, Weiguo" uniqKey="Dong W" first="Weiguo" last="Dong">Weiguo Dong</name>
<name sortKey="Fu, Xiangsheng" sort="Fu, Xiangsheng" uniqKey="Fu X" first="Xiangsheng" last="Fu">Xiangsheng Fu</name>
<name sortKey="Su, Wenhao" sort="Su, Wenhao" uniqKey="Su W" first="Wenhao" last="Su">Wenhao Su</name>
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<name sortKey="Zhan, Na" sort="Zhan, Na" uniqKey="Zhan N" first="Na" last="Zhan">Na Zhan</name>
<name sortKey="Zhan, Na" sort="Zhan, Na" uniqKey="Zhan N" first="Na" last="Zhan">Na Zhan</name>
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<name sortKey="Zhang, Jixiang" sort="Zhang, Jixiang" uniqKey="Zhang J" first="Jixiang" last="Zhang">Jixiang Zhang</name>
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<name sortKey="Zhang, Jixiang" sort="Zhang, Jixiang" uniqKey="Zhang J" first="Jixiang" last="Zhang">Jixiang Zhang</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Huang, Yun" sort="Huang, Yun" uniqKey="Huang Y" first="Yun" last="Huang">Yun Huang</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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