Enhancement of Quercetin-Induced Apoptosis by Cotreatment with Autophagy Inhibitor Is Associated with Augmentation of BAK-Dependent Mitochondrial Pathway in Jurkat T Cells
Identifieur interne : 000D12 ( Ncbi/Checkpoint ); précédent : 000D11; suivant : 000D13Enhancement of Quercetin-Induced Apoptosis by Cotreatment with Autophagy Inhibitor Is Associated with Augmentation of BAK-Dependent Mitochondrial Pathway in Jurkat T Cells
Auteurs : Eun Ji Ha [Corée du Sud] ; Ki Yun Kim [Corée du Sud] ; Chae Eun Kim [Corée du Sud] ; Do Youn Jun [Corée du Sud] ; Young Ho Kim [Corée du Sud]Source :
- Oxidative Medicine and Cellular Longevity [ 1942-0900 ] ; 2019.
Abstract
A flavonoid antioxidant quercetin promotes dose-dependent activation of the ATM-CHK-p53 pathway, downregulation of antiapoptotic survivin, and upregulation of proapoptotic NOXA in human T cell acute lymphoblastic leukemia Jurkat clones (J/Neo and J/BCL-XL). However, the downregulation of antiapoptotic BAG3 and MCL-1 occurred in J/Neo cells but not in J/BCL-XL cells overexpressing BCL-XL. Additionally, several BCL-XL-sensitive intrinsic mitochondrial apoptotic events including apoptotic sub-G1 cell accumulation, TUNEL-positive DNA fragmentation, BAK activation, mitochondrial membrane potential (
Url:
DOI: 10.1155/2019/7989276
PubMed: 31827702
PubMed Central: 6885204
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000764
- to stream Pmc, to step Curation: 000764
- to stream Pmc, to step Checkpoint: 000777
- to stream Ncbi, to step Merge: 000D12
- to stream Ncbi, to step Curation: 000D12
Links to Exploration step
PMC:6885204Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Enhancement of Quercetin-Induced Apoptosis by Cotreatment with Autophagy Inhibitor Is Associated with Augmentation of BAK-Dependent Mitochondrial Pathway in Jurkat T Cells</title><author><name sortKey="Ha, Eun Ji" sort="Ha, Eun Ji" uniqKey="Ha E" first="Eun Ji" last="Ha">Eun Ji Ha</name><affiliation wicri:level="1"><nlm:aff id="I1">Laboratory of Immunobiology, School of Life Science and Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Laboratory of Immunobiology, School of Life Science and Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu</wicri:regionArea><wicri:noRegion>Daegu</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Ki Yun" sort="Kim, Ki Yun" uniqKey="Kim K" first="Ki Yun" last="Kim">Ki Yun Kim</name><affiliation wicri:level="1"><nlm:aff id="I1">Laboratory of Immunobiology, School of Life Science and Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Laboratory of Immunobiology, School of Life Science and Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu</wicri:regionArea><wicri:noRegion>Daegu</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Chae Eun" sort="Kim, Chae Eun" uniqKey="Kim C" first="Chae Eun" last="Kim">Chae Eun Kim</name><affiliation wicri:level="1"><nlm:aff id="I1">Laboratory of Immunobiology, School of Life Science and Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Laboratory of Immunobiology, School of Life Science and Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu</wicri:regionArea><wicri:noRegion>Daegu</wicri:noRegion></affiliation></author><author><name sortKey="Jun, Do Youn" sort="Jun, Do Youn" uniqKey="Jun D" first="Do Youn" last="Jun">Do Youn Jun</name><affiliation wicri:level="1"><nlm:aff id="I2">Astrogen Inc., Techno-Building 313, Kyungpook National University, Daegu 41566, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Astrogen Inc., Techno-Building 313, Kyungpook National University, Daegu 41566</wicri:regionArea><wicri:noRegion>Daegu 41566</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Young Ho" sort="Kim, Young Ho" uniqKey="Kim Y" first="Young Ho" last="Kim">Young Ho Kim</name><affiliation wicri:level="1"><nlm:aff id="I1">Laboratory of Immunobiology, School of Life Science and Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Laboratory of Immunobiology, School of Life Science and Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu</wicri:regionArea><wicri:noRegion>Daegu</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31827702</idno><idno type="pmc">6885204</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885204</idno><idno type="RBID">PMC:6885204</idno><idno type="doi">10.1155/2019/7989276</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000764</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000764</idno><idno type="wicri:Area/Pmc/Curation">000764</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000764</idno><idno type="wicri:Area/Pmc/Checkpoint">000777</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000777</idno><idno type="wicri:Area/Ncbi/Merge">000D12</idno><idno type="wicri:Area/Ncbi/Curation">000D12</idno><idno type="wicri:Area/Ncbi/Checkpoint">000D12</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Enhancement of Quercetin-Induced Apoptosis by Cotreatment with Autophagy Inhibitor Is Associated with Augmentation of BAK-Dependent Mitochondrial Pathway in Jurkat T Cells</title><author><name sortKey="Ha, Eun Ji" sort="Ha, Eun Ji" uniqKey="Ha E" first="Eun Ji" last="Ha">Eun Ji Ha</name><affiliation wicri:level="1"><nlm:aff id="I1">Laboratory of Immunobiology, School of Life Science and Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Laboratory of Immunobiology, School of Life Science and Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu</wicri:regionArea><wicri:noRegion>Daegu</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Ki Yun" sort="Kim, Ki Yun" uniqKey="Kim K" first="Ki Yun" last="Kim">Ki Yun Kim</name><affiliation wicri:level="1"><nlm:aff id="I1">Laboratory of Immunobiology, School of Life Science and Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Laboratory of Immunobiology, School of Life Science and Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu</wicri:regionArea><wicri:noRegion>Daegu</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Chae Eun" sort="Kim, Chae Eun" uniqKey="Kim C" first="Chae Eun" last="Kim">Chae Eun Kim</name><affiliation wicri:level="1"><nlm:aff id="I1">Laboratory of Immunobiology, School of Life Science and Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Laboratory of Immunobiology, School of Life Science and Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu</wicri:regionArea><wicri:noRegion>Daegu</wicri:noRegion></affiliation></author><author><name sortKey="Jun, Do Youn" sort="Jun, Do Youn" uniqKey="Jun D" first="Do Youn" last="Jun">Do Youn Jun</name><affiliation wicri:level="1"><nlm:aff id="I2">Astrogen Inc., Techno-Building 313, Kyungpook National University, Daegu 41566, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Astrogen Inc., Techno-Building 313, Kyungpook National University, Daegu 41566</wicri:regionArea><wicri:noRegion>Daegu 41566</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Young Ho" sort="Kim, Young Ho" uniqKey="Kim Y" first="Young Ho" last="Kim">Young Ho Kim</name><affiliation wicri:level="1"><nlm:aff id="I1">Laboratory of Immunobiology, School of Life Science and Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Laboratory of Immunobiology, School of Life Science and Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu</wicri:regionArea><wicri:noRegion>Daegu</wicri:noRegion></affiliation></author></analytic><series><title level="j">Oxidative Medicine and Cellular Longevity</title><idno type="ISSN">1942-0900</idno><idno type="eISSN">1942-0994</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>A flavonoid antioxidant quercetin promotes dose-dependent activation of the ATM-CHK-p53 pathway, downregulation of antiapoptotic survivin, and upregulation of proapoptotic NOXA in human T cell acute lymphoblastic leukemia Jurkat clones (J/Neo and J/BCL-XL). However, the downregulation of antiapoptotic BAG3 and MCL-1 occurred in J/Neo cells but not in J/BCL-XL cells overexpressing BCL-XL. Additionally, several BCL-XL-sensitive intrinsic mitochondrial apoptotic events including apoptotic sub-G<sub>1</sub> cell accumulation, TUNEL-positive DNA fragmentation, BAK activation, mitochondrial membrane potential (<italic>Δψ</italic>m) loss, caspase-9/caspase-8/caspase-3 activation, and PARP cleavage were induced only in J/Neo cells. Both cytosolic and mitochondrial ROS levels were elevated in quercetin-treated J/Neo cells; however, the ROS elevations were almost completely abrogated in J/BCL-XL cells, suggesting the ROS elevations were downstream of BCL-XL-sensitive mitochondrial damage and dysfunction. Wild-type A3, FADD-deficient I2.1, and caspase-8-deficient I9.2 Jurkat clones exhibited similar susceptibilities to the cytotoxicity of quercetin, excluding an involvement of extrinsic pathway in triggering the apoptosis. The autophagic events such as attenuation of AKT-mTOR pathway, formation of acridine orange-stainable acidic vesicular organelles, conversion of microtubule-associated protein 1 light chain 3-I (LC3-I) to LC3-II, and downregulation of p62/SQSTM1 level were detected in quercetin-treated J/Neo and J/BCL-XL cells, regardless of BCL-XL overexpression. Cotreatment with the autophagy inhibitor (3-methyladenine, LY294002, or chloroquine) resulted in a significant enhancement of quercetin-induced BAK activation and subsequently the mitochondrial damage-mediated apoptosis pathway by augmenting the downregulation of BAG3 and MCL-1 levels in J/Neo cells. These results demonstrated that quercetin induces intrinsic apoptosis and cytoprotective autophagy, and autophagy inhibition can potentiate BAK-dependent apoptotic activity of quercetin in Jurkat T cells.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Aifantis, I" uniqKey="Aifantis I">I. Aifantis</name></author><author><name sortKey="Raetz, E" uniqKey="Raetz E">E. Raetz</name></author><author><name sortKey="Buonamici, S" uniqKey="Buonamici S">S. Buonamici</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Vlierberghe, P" uniqKey="Van Vlierberghe P">P. Van Vlierberghe</name></author><author><name sortKey="Ferrando, A" uniqKey="Ferrando A">A. Ferrando</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hunger, S P" uniqKey="Hunger S">S. P. Hunger</name></author><author><name sortKey="Lu, X" uniqKey="Lu X">X. Lu</name></author><author><name sortKey="Devidas, M" uniqKey="Devidas M">M. Devidas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Amaravadi, R K" uniqKey="Amaravadi R">R. K. Amaravadi</name></author><author><name sortKey="Thompson, C B" uniqKey="Thompson C">C. B. Thompson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mansilla, S" uniqKey="Mansilla S">S. Mansilla</name></author><author><name sortKey="Llovera, L" uniqKey="Llovera L">L. Llovera</name></author><author><name sortKey="Portugal, J" uniqKey="Portugal J">J. Portugal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ricci, M S" uniqKey="Ricci M">M. S. Ricci</name></author><author><name sortKey="Zong, W X" uniqKey="Zong W">W. X. Zong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kaufmann, S H" uniqKey="Kaufmann S">S. H. Kaufmann</name></author><author><name sortKey="Earnshaw, W C" uniqKey="Earnshaw W">W. C. Earnshaw</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jun, D Y" uniqKey="Jun D">D. Y. Jun</name></author><author><name sortKey="Kim, J S" uniqKey="Kim J">J. S. Kim</name></author><author><name sortKey="Park, H S" uniqKey="Park H">H. S. Park</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fulda, S" uniqKey="Fulda S">S. Fulda</name></author><author><name sortKey="Debatin, K M" uniqKey="Debatin K">K. M. Debatin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Friesen, C" uniqKey="Friesen C">C. Friesen</name></author><author><name sortKey="Herr, I" uniqKey="Herr I">I. Herr</name></author><author><name sortKey="Krammer, P H" uniqKey="Krammer P">P. H. Krammer</name></author><author><name sortKey="Debatin, K M" uniqKey="Debatin K">K. M. Debatin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Desagher, S" uniqKey="Desagher S">S. Desagher</name></author><author><name sortKey="Martinou, J C" uniqKey="Martinou J">J. C. Martinou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Degenhardt, K" uniqKey="Degenhardt K">K. Degenhardt</name></author><author><name sortKey="Mathew, R" uniqKey="Mathew R">R. Mathew</name></author><author><name sortKey="Beaudoin, B" uniqKey="Beaudoin B">B. Beaudoin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, J" uniqKey="Huang J">J. Huang</name></author><author><name sortKey="Klionsky, D J" uniqKey="Klionsky D">D. J. Klionsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Amin, A" uniqKey="Amin A">A. Amin</name></author><author><name sortKey="Gali Muhtasib, H" uniqKey="Gali Muhtasib H">H. Gali-Muhtasib</name></author><author><name sortKey="Ocker, M" uniqKey="Ocker M">M. Ocker</name></author><author><name sortKey="Schneider Stock, R" uniqKey="Schneider Stock R">R. Schneider-Stock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Safarzadeh, E" uniqKey="Safarzadeh E">E. Safarzadeh</name></author><author><name sortKey="Shotorbani, S S" uniqKey="Shotorbani S">S. S. Shotorbani</name></author><author><name sortKey="Baradaran, B" uniqKey="Baradaran B">B. Baradaran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Williamson, G" uniqKey="Williamson G">G. Williamson</name></author><author><name sortKey="Plumb, G W" uniqKey="Plumb G">G. W. Plumb</name></author><author><name sortKey="Uda, Y" uniqKey="Uda Y">Y. Uda</name></author><author><name sortKey="Price, K R" uniqKey="Price K">K. R. Price</name></author><author><name sortKey="Rhodes, M J C" uniqKey="Rhodes M">M. J. C. Rhodes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, M S" uniqKey="Kim M">M. S. Kim</name></author><author><name sortKey="Oh, I T" uniqKey="Oh I">I. T. Oh</name></author><author><name sortKey="Jun, D Y" uniqKey="Jun D">D. Y. Jun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zheng, S Y" uniqKey="Zheng S">S. Y. Zheng</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name></author><author><name sortKey="Jiang, D" uniqKey="Jiang D">D. Jiang</name></author><author><name sortKey="Zhao, J" uniqKey="Zhao J">J. Zhao</name></author><author><name sortKey="Ge, J F" uniqKey="Ge J">J. F. Ge</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cantero, G" uniqKey="Cantero G">G. Cantero</name></author><author><name sortKey="Campanella, C" uniqKey="Campanella C">C. Campanella</name></author><author><name sortKey="Mateos, S" uniqKey="Mateos S">S. Mateos</name></author><author><name sortKey="Cortes, F" uniqKey="Cortes F">F. Cortés</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z. Zhang</name></author><author><name sortKey="Chen, S" uniqKey="Chen S">S. Chen</name></author><author><name sortKey="Mei, H" uniqKey="Mei H">H. Mei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yi, L" uniqKey="Yi L">L. Yi</name></author><author><name sortKey="Zongyuan, Y" uniqKey="Zongyuan Y">Y. Zongyuan</name></author><author><name sortKey="Cheng, G" uniqKey="Cheng G">G. Cheng</name></author><author><name sortKey="Lingyun, Z" uniqKey="Lingyun Z">Z. Lingyun</name></author><author><name sortKey="Guilian, Y" uniqKey="Guilian Y">Y. Guilian</name></author><author><name sortKey="Wei, G" uniqKey="Wei G">G. Wei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ma, Y S" uniqKey="Ma Y">Y.-S. Ma</name></author><author><name sortKey="Yao, C N" uniqKey="Yao C">C.-N. Yao</name></author><author><name sortKey="Liu, H C" uniqKey="Liu H">H.-C. Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shoshan, V" uniqKey="Shoshan V">V. Shoshan</name></author><author><name sortKey="Maclennan, D H" uniqKey="Maclennan D">D. H. MacLennan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ogunbayo, O A" uniqKey="Ogunbayo O">O. A. Ogunbayo</name></author><author><name sortKey="Michelangeli, F" uniqKey="Michelangeli F">F. Michelangeli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cui, X" uniqKey="Cui X">X. Cui</name></author><author><name sortKey="Luo, Y" uniqKey="Luo Y">Y. Luo</name></author><author><name sortKey="Li, C" uniqKey="Li C">C. Li</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name></author><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seo, H S" uniqKey="Seo H">H. S. Seo</name></author><author><name sortKey="Ku, J M" uniqKey="Ku J">J. M. Ku</name></author><author><name sortKey="Choi, H S" uniqKey="Choi H">H.-S. Choi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Granato, M" uniqKey="Granato M">M. Granato</name></author><author><name sortKey="Rizzello, C" uniqKey="Rizzello C">C. Rizzello</name></author><author><name sortKey="Gilardini Montani, M S" uniqKey="Gilardini Montani M">M. S. Gilardini Montani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, H" uniqKey="Kim H">H. Kim</name></author><author><name sortKey="Moon, J Y" uniqKey="Moon J">J. Y. Moon</name></author><author><name sortKey="Ahn, K S" uniqKey="Ahn K">K. S. Ahn</name></author><author><name sortKey="Cho, S K" uniqKey="Cho S">S. K. Cho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsai, T F" uniqKey="Tsai T">T. F. Tsai</name></author><author><name sortKey="Hwang, T S" uniqKey="Hwang T">T. S. Hwang</name></author><author><name sortKey="Lin, J F" uniqKey="Lin J">J. F. Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, D H" uniqKey="Park D">D. H. Park</name></author><author><name sortKey="Lee, S T" uniqKey="Lee S">S. T. Lee</name></author><author><name sortKey="Jun, D Y" uniqKey="Jun D">D. Y. Jun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, K Y" uniqKey="Kim K">K. Y. Kim</name></author><author><name sortKey="Jang, W Y" uniqKey="Jang W">W. Y. Jang</name></author><author><name sortKey="Lee, J Y" uniqKey="Lee J">J. Y. Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zamzami, N" uniqKey="Zamzami N">N. Zamzami</name></author><author><name sortKey="Marchetti, P" uniqKey="Marchetti P">P. Marchetti</name></author><author><name sortKey="Castedo, M" uniqKey="Castedo M">M. Castedo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Petit, P X" uniqKey="Petit P">P. X. Petit</name></author><author><name sortKey="Lecoeur, H" uniqKey="Lecoeur H">H. Lecoeur</name></author><author><name sortKey="Zorn, E" uniqKey="Zorn E">E. Zorn</name></author><author><name sortKey="Dauguet, C" uniqKey="Dauguet C">C. Dauguet</name></author><author><name sortKey="Mignotte, B" uniqKey="Mignotte B">B. Mignotte</name></author><author><name sortKey="Gougeon, M L" uniqKey="Gougeon M">M. L. Gougeon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Han, C R" uniqKey="Han C">C. R. Han</name></author><author><name sortKey="Jun, D Y" uniqKey="Jun D">D. Y. Jun</name></author><author><name sortKey="Kim, Y H" uniqKey="Kim Y">Y. H. Kim</name></author><author><name sortKey="Lee, J Y" uniqKey="Lee J">J. Y. Lee</name></author><author><name sortKey="Kim, Y H" uniqKey="Kim Y">Y. H. Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rainey, N E" uniqKey="Rainey N">N. E. Rainey</name></author><author><name sortKey="Saric, A" uniqKey="Saric A">A. Saric</name></author><author><name sortKey="Leberre, A" uniqKey="Leberre A">A. Leberre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, K Y" uniqKey="Kim K">K. Y. Kim</name></author><author><name sortKey="Hwang, S K" uniqKey="Hwang S">S. K. Hwang</name></author><author><name sortKey="Park, S Y" uniqKey="Park S">S. Y. Park</name></author><author><name sortKey="Kim, M J" uniqKey="Kim M">M. J. Kim</name></author><author><name sortKey="Jun, D Y" uniqKey="Jun D">D. Y. Jun</name></author><author><name sortKey="Kim, Y H" uniqKey="Kim Y">Y. H. Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Riccardi, C" uniqKey="Riccardi C">C. Riccardi</name></author><author><name sortKey="Nicoletti, I" uniqKey="Nicoletti I">I. Nicoletti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Okada, H" uniqKey="Okada H">H. Okada</name></author><author><name sortKey="Mak, T W" uniqKey="Mak T">T. W. Mak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abrahamsen, J F" uniqKey="Abrahamsen J">J. F. Abrahamsen</name></author><author><name sortKey="Bakken, A M" uniqKey="Bakken A">A. M. Bakken</name></author><author><name sortKey="Bruserud, O" uniqKey="Bruserud O">O. Bruserud</name></author><author><name sortKey="Gjertsen, B T" uniqKey="Gjertsen B">B. T. Gjertsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, P" uniqKey="Li P">P. Li</name></author><author><name sortKey="Nijhawan, D" uniqKey="Nijhawan D">D. Nijhawan</name></author><author><name sortKey="Budihardjo, I" uniqKey="Budihardjo I">I. Budihardjo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Westphal, D" uniqKey="Westphal D">D. Westphal</name></author><author><name sortKey="Dewson, G" uniqKey="Dewson G">G. Dewson</name></author><author><name sortKey="Czabotar, P E" uniqKey="Czabotar P">P. E. Czabotar</name></author><author><name sortKey="Kluck, R M" uniqKey="Kluck R">R. M. Kluck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kroemer, G" uniqKey="Kroemer G">G. Kroemer</name></author><author><name sortKey="Galluzzi, L" uniqKey="Galluzzi L">L. Galluzzi</name></author><author><name sortKey="Brenner, C" uniqKey="Brenner C">C. Brenner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, H" uniqKey="Li H">H. Li</name></author><author><name sortKey="Zhu, H" uniqKey="Zhu H">H. Zhu</name></author><author><name sortKey="Xu, C J" uniqKey="Xu C">C. J. Xu</name></author><author><name sortKey="Yuan, J" uniqKey="Yuan J">J. Yuan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Desagher, S" uniqKey="Desagher S">S. Desagher</name></author><author><name sortKey="Osen Sand, A" uniqKey="Osen Sand A">A. Osen-Sand</name></author><author><name sortKey="Nichols, A" uniqKey="Nichols A">A. Nichols</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hirao, A" uniqKey="Hirao A">A. Hirao</name></author><author><name sortKey="Kong, Y Y" uniqKey="Kong Y">Y. Y. Kong</name></author><author><name sortKey="Matsuoka, S" uniqKey="Matsuoka S">S. Matsuoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, J" uniqKey="Smith J">J. Smith</name></author><author><name sortKey="Tho, L M" uniqKey="Tho L">L. M. Tho</name></author><author><name sortKey="Xu, N" uniqKey="Xu N">N. Xu</name></author><author><name sortKey="Gillespie, D A" uniqKey="Gillespie D">D. A. Gillespie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jacquemin, G" uniqKey="Jacquemin G">G. Jacquemin</name></author><author><name sortKey="Granci, V" uniqKey="Granci V">V. Granci</name></author><author><name sortKey="Gallouet, A S" uniqKey="Gallouet A">A. S. Gallouet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, C M" uniqKey="Liu C">C. M. Liu</name></author><author><name sortKey="Ma, J Q" uniqKey="Ma J">J. Q. Ma</name></author><author><name sortKey="Sun, Y Z" uniqKey="Sun Y">Y. Z. Sun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhu, X" uniqKey="Zhu X">X. Zhu</name></author><author><name sortKey="Li, N" uniqKey="Li N">N. Li</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chang, Y F" uniqKey="Chang Y">Y. F. Chang</name></author><author><name sortKey="Chi, C W" uniqKey="Chi C">C. W. Chi</name></author><author><name sortKey="Wang, J J" uniqKey="Wang J">J. J. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, W J" uniqKey="Lee W">W. J. Lee</name></author><author><name sortKey="Hsiao, M" uniqKey="Hsiao M">M. Hsiao</name></author><author><name sortKey="Chang, J L" uniqKey="Chang J">J. L. Chang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, L" uniqKey="Chen L">L. Chen</name></author><author><name sortKey="Liu, T" uniqKey="Liu T">T. Liu</name></author><author><name sortKey="Tran, A" uniqKey="Tran A">A. Tran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ip, W K E" uniqKey="Ip W">W. K. E. Ip</name></author><author><name sortKey="Hoshi, N" uniqKey="Hoshi N">N. Hoshi</name></author><author><name sortKey="Shouval, D S" uniqKey="Shouval D">D. S. Shouval</name></author><author><name sortKey="Snapper, S" uniqKey="Snapper S">S. Snapper</name></author><author><name sortKey="Medzhitov, R" uniqKey="Medzhitov R">R. Medzhitov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kluck, R M" uniqKey="Kluck R">R. M. Kluck</name></author><author><name sortKey="Bossy Wetzel, E" uniqKey="Bossy Wetzel E">E. Bossy-Wetzel</name></author><author><name sortKey="Green, D R" uniqKey="Green D">D. R. Green</name></author><author><name sortKey="Newmeyer, D D" uniqKey="Newmeyer D">D. D. Newmeyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chipuk, J E" uniqKey="Chipuk J">J. E. Chipuk</name></author><author><name sortKey="Green, D R" uniqKey="Green D">D. R. Green</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parrish, A B" uniqKey="Parrish A">A. B. Parrish</name></author><author><name sortKey="Freel, C D" uniqKey="Freel C">C. D. Freel</name></author><author><name sortKey="Kornbluth, S" uniqKey="Kornbluth S">S. Kornbluth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sohn, D" uniqKey="Sohn D">D. Sohn</name></author><author><name sortKey="Schulze Osthoff, K" uniqKey="Schulze Osthoff K">K. Schulze-Osthoff</name></author><author><name sortKey="Janicke, R U" uniqKey="Janicke R">R. U. Janicke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Woo, H J" uniqKey="Woo H">H. J. Woo</name></author><author><name sortKey="Jun, D Y" uniqKey="Jun D">D. Y. Jun</name></author><author><name sortKey="Lee, J Y" uniqKey="Lee J">J. Y. Lee</name></author><author><name sortKey="Woo, M H" uniqKey="Woo M">M. H. Woo</name></author><author><name sortKey="Yang, C H" uniqKey="Yang C">C. H. Yang</name></author><author><name sortKey="Kim, Y H" uniqKey="Kim Y">Y. H. Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Laukens, B" uniqKey="Laukens B">B. Laukens</name></author><author><name sortKey="Jennewein, C" uniqKey="Jennewein C">C. Jennewein</name></author><author><name sortKey="Schenk, B" uniqKey="Schenk B">B. Schenk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mathew, R" uniqKey="Mathew R">R. Mathew</name></author><author><name sortKey="Karantza Wadsworth, V" uniqKey="Karantza Wadsworth V">V. Karantza-Wadsworth</name></author><author><name sortKey="White, E" uniqKey="White E">E. White</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Z J" uniqKey="Yang Z">Z. J. Yang</name></author><author><name sortKey="Chee, C E" uniqKey="Chee C">C. E. Chee</name></author><author><name sortKey="Huang, S" uniqKey="Huang S">S. Huang</name></author><author><name sortKey="Sinicrope, F A" uniqKey="Sinicrope F">F. A. Sinicrope</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, K" uniqKey="Wang K">K. Wang</name></author><author><name sortKey="Liu, R" uniqKey="Liu R">R. Liu</name></author><author><name sortKey="Li, J" uniqKey="Li J">J. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W. Zhang</name></author><author><name sortKey="Lv, Q" uniqKey="Lv Q">Q. Lv</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J. Zhang</name></author><author><name sortKey="Zhu, D" uniqKey="Zhu D">D. Zhu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feng, Y" uniqKey="Feng Y">Y. Feng</name></author><author><name sortKey="He, D" uniqKey="He D">D. He</name></author><author><name sortKey="Yao, Z" uniqKey="Yao Z">Z. Yao</name></author><author><name sortKey="Klionsky, D J" uniqKey="Klionsky D">D. J. Klionsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Datta, S R" uniqKey="Datta S">S. R. Datta</name></author><author><name sortKey="Dudek, H" uniqKey="Dudek H">H. Dudek</name></author><author><name sortKey="Tao, X" uniqKey="Tao X">X. Tao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Del Peso, L" uniqKey="Del Peso L">L. del Peso</name></author><author><name sortKey="Gonzalez Garcia, M" uniqKey="Gonzalez Garcia M">M. Gonzalez-Garcia</name></author><author><name sortKey="Page, C" uniqKey="Page C">C. Page</name></author><author><name sortKey="Herrera, R" uniqKey="Herrera R">R. Herrera</name></author><author><name sortKey="Nunez, G" uniqKey="Nunez G">G. Nunez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Y P" uniqKey="Yang Y">Y. P. Yang</name></author><author><name sortKey="Hu, L F" uniqKey="Hu L">L. F. Hu</name></author><author><name sortKey="Zheng, H F" uniqKey="Zheng H">H. F. Zheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, X" uniqKey="Liu X">X. Liu</name></author><author><name sortKey="Sun, K" uniqKey="Sun K">K. Sun</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H. Wang</name></author><author><name sortKey="Dai, Y" uniqKey="Dai Y">Y. Dai</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Corée du Sud</li></country></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Ha, Eun Ji" sort="Ha, Eun Ji" uniqKey="Ha E" first="Eun Ji" last="Ha">Eun Ji Ha</name></noRegion><name sortKey="Jun, Do Youn" sort="Jun, Do Youn" uniqKey="Jun D" first="Do Youn" last="Jun">Do Youn Jun</name><name sortKey="Kim, Chae Eun" sort="Kim, Chae Eun" uniqKey="Kim C" first="Chae Eun" last="Kim">Chae Eun Kim</name><name sortKey="Kim, Ki Yun" sort="Kim, Ki Yun" uniqKey="Kim K" first="Ki Yun" last="Kim">Ki Yun Kim</name><name sortKey="Kim, Young Ho" sort="Kim, Young Ho" uniqKey="Kim Y" first="Young Ho" last="Kim">Young Ho Kim</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000D12 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 000D12 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Ncbi
|étape= Checkpoint
|type= RBID
|clé= PMC:6885204
|texte= Enhancement of Quercetin-Induced Apoptosis by Cotreatment with Autophagy Inhibitor Is Associated with Augmentation of BAK-Dependent Mitochondrial Pathway in Jurkat T Cells
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:31827702" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |