Antiplasmodial natural products: an update
Identifieur interne : 000C87 ( Ncbi/Checkpoint ); précédent : 000C86; suivant : 000C88Antiplasmodial natural products: an update
Auteurs : Nasir Tajuddeen ; Fanie R. Van HeerdenSource :
- Malaria Journal [ 1475-2875 ] ; 2019.
Abstract
Malaria remains a significant public health challenge in regions of the world where it is endemic. An unprecedented decline in malaria incidences was recorded during the last decade due to the availability of effective control interventions, such as the deployment of artemisinin-based combination therapy and insecticide-treated nets. However, according to the World Health Organization, malaria is staging a comeback, in part due to the development of drug resistance. Therefore, there is an urgent need to discover new anti-malarial drugs. This article reviews the literature on natural products with antiplasmodial activity that was reported between 2010 and 2017.
Relevant literature was sourced by searching the major scientific databases, including Web of Science, ScienceDirect, Scopus, SciFinder, Pubmed, and Google Scholar, using appropriate keyword combinations.
A total of 1524 compounds from 397 relevant references, assayed against at least one strain of
Url:
DOI: 10.1186/s12936-019-3026-1
PubMed: 31805944
PubMed Central: 6896759
Affiliations:
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PMC:6896759Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Antiplasmodial natural products: an update</title>
<author><name sortKey="Tajuddeen, Nasir" sort="Tajuddeen, Nasir" uniqKey="Tajuddeen N" first="Nasir" last="Tajuddeen">Nasir Tajuddeen</name>
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<author><name sortKey="Van Heerden, Fanie R" sort="Van Heerden, Fanie R" uniqKey="Van Heerden F" first="Fanie R." last="Van Heerden">Fanie R. Van Heerden</name>
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<series><title level="j">Malaria Journal</title>
<idno type="eISSN">1475-2875</idno>
<imprint><date when="2019">2019</date>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p id="Par1">Malaria remains a significant public health challenge in regions of the world where it is endemic. An unprecedented decline in malaria incidences was recorded during the last decade due to the availability of effective control interventions, such as the deployment of artemisinin-based combination therapy and insecticide-treated nets. However, according to the World Health Organization, malaria is staging a comeback, in part due to the development of drug resistance. Therefore, there is an urgent need to discover new anti-malarial drugs. This article reviews the literature on natural products with antiplasmodial activity that was reported between 2010 and 2017.</p>
</sec>
<sec><title>Methods</title>
<p id="Par2">Relevant literature was sourced by searching the major scientific databases, including Web of Science, ScienceDirect, Scopus, SciFinder, Pubmed, and Google Scholar, using appropriate keyword combinations.</p>
</sec>
<sec><title>Results and Discussion</title>
<p id="Par3">A total of 1524 compounds from 397 relevant references, assayed against at least one strain of <italic>Plasmodium</italic>
, were reported in the period under review. Out of these, 39% were described as new natural products, and 29% of the compounds had IC<sub>50</sub>
≤ 3.0 µM against at least one strain of <italic>Plasmodium</italic>
. Several of these compounds have the potential to be developed into viable anti-malarial drugs. Also, some of these compounds could play a role in malaria eradication by targeting gametocytes. However, the research into natural products with potential for blocking the transmission of malaria is still in its infancy stage and needs to be vigorously pursued.</p>
</sec>
</div>
</front>
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<tree><noCountry><name sortKey="Tajuddeen, Nasir" sort="Tajuddeen, Nasir" uniqKey="Tajuddeen N" first="Nasir" last="Tajuddeen">Nasir Tajuddeen</name>
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