Chloroquine promotes gefitinib-induced apoptosis by inhibiting protective autophagy in cutaneous squamous cell carcinoma
Identifieur interne : 000B27 ( Ncbi/Checkpoint ); précédent : 000B26; suivant : 000B28Chloroquine promotes gefitinib-induced apoptosis by inhibiting protective autophagy in cutaneous squamous cell carcinoma
Auteurs : Chengshan Ou [République populaire de Chine] ; Hongxia Liu [République populaire de Chine] ; Zhenhua Ding [République populaire de Chine] ; Liang Zhou [République populaire de Chine]Source :
- Molecular Medicine Reports [ 1791-2997 ] ; 2019.
Abstract
Aberrant expression of the epidermal growth factor receptor (EGFR) plays vital roles in tumor development and progression. In the present study, ultraviolet irradiation induced the upregulation of EGFR in skin-derived keratinocytes, which may contribute to the development of cutaneous squamous cell carcinoma (CSCC). This was supported by the high expression of EGFR in CSCC clinical samples. Treating A431 CSCC cells with gefitinib, a tyrosine kinase inhibitor, activated the intrinsic mitochondrial apoptotic pathway while inducing protective autophagy. Combined application of chloroquine with gefitinib enhanced the treatment efficacy of gefitinib against CSCC by inhibiting autophagic flux. These findings demonstrated that autophagy inhibition may be an effective strategy for enhancing the sensitivity of EGFR-expressing cells to tyrosine kinase inhibitor treatment. Manipulating pro-survival autophagy by the combined application of chloroquine with gefitinib is a promising approach for improving the efficacy of EGFR inhibitors in cancer treatment. This may contribute to novel EGFR-targeted therapeutic strategies in the near future.
Url:
DOI: 10.3892/mmr.2019.10734
PubMed: 31638204
PubMed Central: 6854599
Affiliations:
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Debnath</name></author><author><name sortKey="Gewirtz, Da" uniqKey="Gewirtz D">DA Gewirtz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dragowska, Wh" uniqKey="Dragowska W">WH Dragowska</name></author><author><name sortKey="Weppler, Sa" uniqKey="Weppler S">SA Weppler</name></author><author><name sortKey="Wang, Jc" uniqKey="Wang J">JC Wang</name></author><author><name sortKey="Wong, Ly" uniqKey="Wong L">LY Wong</name></author><author><name sortKey="Kapanen, Ai" uniqKey="Kapanen A">AI Kapanen</name></author><author><name sortKey="Rawji, Js" uniqKey="Rawji J">JS Rawji</name></author><author><name sortKey="Warburton, C" uniqKey="Warburton C">C Warburton</name></author><author><name sortKey="Qadir, Ma" uniqKey="Qadir M">MA Qadir</name></author><author><name sortKey="Donohue, E" uniqKey="Donohue E">E Donohue</name></author><author><name sortKey="Roberge, M" uniqKey="Roberge M">M Roberge</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Masuelli, L" uniqKey="Masuelli L">L Masuelli</name></author><author><name sortKey="Granato, M" uniqKey="Granato M">M Granato</name></author><author><name sortKey="Benvenuto, M" uniqKey="Benvenuto M">M Benvenuto</name></author><author><name sortKey="Mattera, R" uniqKey="Mattera R">R Mattera</name></author><author><name sortKey="Bernardini, R" uniqKey="Bernardini R">R Bernardini</name></author><author><name sortKey="Mattei, M" uniqKey="Mattei M">M Mattei</name></author><author><name sortKey="D Amati, G" uniqKey="D Amati G">G d'Amati</name></author><author><name sortKey="D Orazi, G" uniqKey="D Orazi G">G D'Orazi</name></author><author><name sortKey="Faggioni, A" uniqKey="Faggioni A">A Faggioni</name></author><author><name sortKey="Bei, R" uniqKey="Bei R">R Bei</name></author><author><name sortKey="Cirone, M" uniqKey="Cirone M">M Cirone</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Ou, Chengshan" sort="Ou, Chengshan" uniqKey="Ou C" first="Chengshan" last="Ou">Chengshan Ou</name></noRegion><name sortKey="Ding, Zhenhua" sort="Ding, Zhenhua" uniqKey="Ding Z" first="Zhenhua" last="Ding">Zhenhua Ding</name><name sortKey="Liu, Hongxia" sort="Liu, Hongxia" uniqKey="Liu H" first="Hongxia" last="Liu">Hongxia Liu</name><name sortKey="Liu, Hongxia" sort="Liu, Hongxia" uniqKey="Liu H" first="Hongxia" last="Liu">Hongxia Liu</name><name sortKey="Zhou, Liang" sort="Zhou, Liang" uniqKey="Zhou L" first="Liang" last="Zhou">Liang Zhou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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