Thrombin Induces Angiotensin II-Mediated Senescence in Atrial Endothelial Cells: Impact on Pro-Remodeling Patterns
Identifieur interne : 000A79 ( Ncbi/Checkpoint ); précédent : 000A78; suivant : 000A80Thrombin Induces Angiotensin II-Mediated Senescence in Atrial Endothelial Cells: Impact on Pro-Remodeling Patterns
Auteurs : Hira Hasan [France] ; Sin-Hee Park [France] ; Cyril Auger [France] ; Eugenia Belcastro [France] ; Kensuke Matsushita [France] ; Benjamin Marchandot ; Hyun-Ho Lee [France] ; Abdul Wahid Qureshi [France] ; Gilles Kauffenstein [France] ; Patrick Ohlmann ; Valérie B. Schini-Kerth [France] ; Laurence Jesel [France] ; Olivier Morel [France]Source :
- Journal of Clinical Medicine [ 2077-0383 ] ; 2019.
Abstract
Background: Besides its well-known functions in hemostasis, thrombin plays a role in various non-hemostatic biological and pathophysiologic processes. We examined the potential of thrombin to promote premature atrial endothelial cells (ECs) senescence. Methods and Results: Primary ECs were isolated from porcine atrial tissue. Endothelial senescence was assessed by measuring beta-galactosidase (SA-β-gal) activity using flow cytometry, oxidative stress using the redox-sensitive probe dihydroethidium, protein level by Western blot, and matrix metalloproteinases (MMPs) activity using zymography. Atrial endothelial senescence was induced by thrombin at clinically relevant concentrations. Thrombin induced the up-regulation of p53, a key regulator in cellular senescence and of p21 and p16, two cyclin-dependent kinase inhibitors. Nicotinamide adenine dinucleotide phosphate NADPH oxidase, cyclooxygenases and the mitochondrial respiration complex contributed to oxidative stress and senescence. Enhanced expression levels of vascular cell adhesion molecule (VCAM)-1, tissue factor, transforming growth factor (TGF)-β and MMP-2 and 9 characterized the senescence-associated secretory phenotype of atrial ECs. In addition, the pro-senescence endothelial response to thrombin was associated with an overexpression of both angiotensin converting enzyme and AT1 receptors and was inhibited by perindoprilat and losartan. Conclusions: Thrombin promotes premature ageing and senescence of atrial ECs and may pave the way to deleterious remodeling of atrial tissue by a local up-regulation of the angiotensin system and by promoting pro-inflammatory, pro-thrombotic, pro-fibrotic and pro-remodeling responses. Hence, targeting thrombin and/or angiotensin systems may efficiently prevent atrial endothelial senescence.
Url:
DOI: 10.3390/jcm8101570
PubMed: 31581517
PubMed Central: 6833093
Affiliations:
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Thrombin Induces Angiotensin II-Mediated Senescence in Atrial Endothelial Cells: Impact on Pro-Remodeling Patterns</title>
<author><name sortKey="Hasan, Hira" sort="Hasan, Hira" uniqKey="Hasan H" first="Hira" last="Hasan">Hira Hasan</name>
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<placeName><region type="region" nuts="2">Hauts-de-France</region>
<region type="old region" nuts="2">Picardie</region>
<settlement type="city">FR-67401 Strasbourg</settlement>
</placeName>
<orgName type="university">Université de Strasbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Ohlmann, Patrick" sort="Ohlmann, Patrick" uniqKey="Ohlmann P" first="Patrick" last="Ohlmann">Patrick Ohlmann</name>
<affiliation><nlm:aff id="af2-jcm-08-01570">Pôle d’Activité Médico-Chirurgicale Cardio-Vasculaire, Nouvel Hôpital Civil, Centre Hospitalier Universitaire, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, BP 426-67091 France</nlm:aff>
<wicri:noCountry code="subfield">BP 426-67091 France</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Schini Kerth, Valerie B" sort="Schini Kerth, Valerie B" uniqKey="Schini Kerth V" first="Valérie B" last="Schini-Kerth">Valérie B. Schini-Kerth</name>
<affiliation wicri:level="4"><nlm:aff id="af1-jcm-08-01570">INSERM UMR1260 Regenerative NanoMedicine, Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg, Faculté de Pharmacie, BP 60024 FR-67401 Strasbourg, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM UMR1260 Regenerative NanoMedicine, Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg, Faculté de Pharmacie, BP 60024 FR-67401 Strasbourg</wicri:regionArea>
<placeName><region type="region" nuts="2">Hauts-de-France</region>
<region type="old region" nuts="2">Picardie</region>
<settlement type="city">FR-67401 Strasbourg</settlement>
</placeName>
<orgName type="university">Université de Strasbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Jesel, Laurence" sort="Jesel, Laurence" uniqKey="Jesel L" first="Laurence" last="Jesel">Laurence Jesel</name>
<affiliation wicri:level="4"><nlm:aff id="af1-jcm-08-01570">INSERM UMR1260 Regenerative NanoMedicine, Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg, Faculté de Pharmacie, BP 60024 FR-67401 Strasbourg, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM UMR1260 Regenerative NanoMedicine, Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg, Faculté de Pharmacie, BP 60024 FR-67401 Strasbourg</wicri:regionArea>
<placeName><region type="region" nuts="2">Hauts-de-France</region>
<region type="old region" nuts="2">Picardie</region>
<settlement type="city">FR-67401 Strasbourg</settlement>
</placeName>
<orgName type="university">Université de Strasbourg</orgName>
</affiliation>
<affiliation><nlm:aff id="af2-jcm-08-01570">Pôle d’Activité Médico-Chirurgicale Cardio-Vasculaire, Nouvel Hôpital Civil, Centre Hospitalier Universitaire, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, BP 426-67091 France</nlm:aff>
<wicri:noCountry code="subfield">BP 426-67091 France</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Morel, Olivier" sort="Morel, Olivier" uniqKey="Morel O" first="Olivier" last="Morel">Olivier Morel</name>
<affiliation wicri:level="4"><nlm:aff id="af1-jcm-08-01570">INSERM UMR1260 Regenerative NanoMedicine, Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg, Faculté de Pharmacie, BP 60024 FR-67401 Strasbourg, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM UMR1260 Regenerative NanoMedicine, Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg, Faculté de Pharmacie, BP 60024 FR-67401 Strasbourg</wicri:regionArea>
<placeName><region type="region" nuts="2">Hauts-de-France</region>
<region type="old region" nuts="2">Picardie</region>
<settlement type="city">FR-67401 Strasbourg</settlement>
</placeName>
<orgName type="university">Université de Strasbourg</orgName>
</affiliation>
<affiliation><nlm:aff id="af2-jcm-08-01570">Pôle d’Activité Médico-Chirurgicale Cardio-Vasculaire, Nouvel Hôpital Civil, Centre Hospitalier Universitaire, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, BP 426-67091 France</nlm:aff>
<wicri:noCountry code="subfield">BP 426-67091 France</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Clinical Medicine</title>
<idno type="eISSN">2077-0383</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
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<profileDesc><textClass></textClass>
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<front><div type="abstract" xml:lang="en"><p>Background: Besides its well-known functions in hemostasis, thrombin plays a role in various non-hemostatic biological and pathophysiologic processes. We examined the potential of thrombin to promote premature atrial endothelial cells (ECs) senescence. Methods and Results: Primary ECs were isolated from porcine atrial tissue. Endothelial senescence was assessed by measuring beta-galactosidase (SA-β-gal) activity using flow cytometry, oxidative stress using the redox-sensitive probe dihydroethidium, protein level by Western blot, and matrix metalloproteinases (MMPs) activity using zymography. Atrial endothelial senescence was induced by thrombin at clinically relevant concentrations. Thrombin induced the up-regulation of p53, a key regulator in cellular senescence and of p21 and p16, two cyclin-dependent kinase inhibitors. Nicotinamide adenine dinucleotide phosphate NADPH oxidase, cyclooxygenases and the mitochondrial respiration complex contributed to oxidative stress and senescence. Enhanced expression levels of vascular cell adhesion molecule (VCAM)-1, tissue factor, transforming growth factor (TGF)-β and MMP-2 and 9 characterized the senescence-associated secretory phenotype of atrial ECs. In addition, the pro-senescence endothelial response to thrombin was associated with an overexpression of both angiotensin converting enzyme and AT1 receptors and was inhibited by perindoprilat and losartan. Conclusions: Thrombin promotes premature ageing and senescence of atrial ECs and may pave the way to deleterious remodeling of atrial tissue by a local up-regulation of the angiotensin system and by promoting pro-inflammatory, pro-thrombotic, pro-fibrotic and pro-remodeling responses. Hence, targeting thrombin and/or angiotensin systems may efficiently prevent atrial endothelial senescence.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Watson, T" uniqKey="Watson T">T. Watson</name>
</author>
<author><name sortKey="Shantsila, E" uniqKey="Shantsila E">E. Shantsila</name>
</author>
<author><name sortKey="Lip, G Y" uniqKey="Lip G">G.Y. Lip</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jesel, L" uniqKey="Jesel L">L. Jesel</name>
</author>
<author><name sortKey="Abbas, M" uniqKey="Abbas M">M. Abbas</name>
</author>
<author><name sortKey="Toti, F" uniqKey="Toti F">F. Toti</name>
</author>
<author><name sortKey="Cohen, A" uniqKey="Cohen A">A. Cohen</name>
</author>
<author><name sortKey="Arentz, T" uniqKey="Arentz T">T. Arentz</name>
</author>
<author><name sortKey="Morel, O" uniqKey="Morel O">O. Morel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ederhy, S" uniqKey="Ederhy S">S. Ederhy</name>
</author>
<author><name sortKey="Di Angelantonio, E" uniqKey="Di Angelantonio E">E. Di Angelantonio</name>
</author>
<author><name sortKey="Mallat, Z" uniqKey="Mallat Z">Z. Mallat</name>
</author>
<author><name sortKey="Hugel, B" uniqKey="Hugel B">B. Hugel</name>
</author>
<author><name sortKey="Janower, S" uniqKey="Janower S">S. Janower</name>
</author>
<author><name sortKey="Meuleman, C" uniqKey="Meuleman C">C. Meuleman</name>
</author>
<author><name sortKey="Boccara, F" uniqKey="Boccara F">F. Boccara</name>
</author>
<author><name sortKey="Freyssinet, J M" uniqKey="Freyssinet J">J.-M. Freyssinet</name>
</author>
<author><name sortKey="Tedgui, A" uniqKey="Tedgui A">A. Tedgui</name>
</author>
<author><name sortKey="Cohen, A" uniqKey="Cohen A">A. Cohen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Simak, J" uniqKey="Simak J">J. Simak</name>
</author>
<author><name sortKey="Gelderman, M P" uniqKey="Gelderman M">M.P. Gelderman</name>
</author>
<author><name sortKey="Yu, H" uniqKey="Yu H">H. Yu</name>
</author>
<author><name sortKey="Wright, V" uniqKey="Wright V">V. Wright</name>
</author>
<author><name sortKey="Baird, A E" uniqKey="Baird A">A.E. Baird</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Morel, O" uniqKey="Morel O">O. Morel</name>
</author>
<author><name sortKey="Florence, T" uniqKey="Florence T">T. Florence</name>
</author>
<author><name sortKey="Benedicte, H" uniqKey="Benedicte H">H. Bénédicte</name>
</author>
<author><name sortKey="Babe, B" uniqKey="Babe B">B. Babé</name>
</author>
<author><name sortKey="Laurence, C J" uniqKey="Laurence C">C.J. Laurence</name>
</author>
<author><name sortKey="Francoise, D G" uniqKey="Francoise D">D.G. Françoise</name>
</author>
<author><name sortKey="Freyssinet, J M" uniqKey="Freyssinet J">J.M. Freyssinet</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Altieri, P" uniqKey="Altieri P">P. Altieri</name>
</author>
<author><name sortKey="Bertolotto, M" uniqKey="Bertolotto M">M. Bertolotto</name>
</author>
<author><name sortKey="Fabbi, P" uniqKey="Fabbi P">P. Fabbi</name>
</author>
<author><name sortKey="Sportelli, E" uniqKey="Sportelli E">E. Sportelli</name>
</author>
<author><name sortKey="Balbi, M" uniqKey="Balbi M">M. Balbi</name>
</author>
<author><name sortKey="Santini, F" uniqKey="Santini F">F. Santini</name>
</author>
<author><name sortKey="Brunelli, C" uniqKey="Brunelli C">C. Brunelli</name>
</author>
<author><name sortKey="Canepa, M" uniqKey="Canepa M">M. Canepa</name>
</author>
<author><name sortKey="Montecucco, F" uniqKey="Montecucco F">F. Montecucco</name>
</author>
<author><name sortKey="Ameri, P" uniqKey="Ameri P">P. Ameri</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jumeau, C" uniqKey="Jumeau C">C. Jumeau</name>
</author>
<author><name sortKey="Rupin, A" uniqKey="Rupin A">A. Rupin</name>
</author>
<author><name sortKey="Chieng Yane, P" uniqKey="Chieng Yane P">P. Chieng-Yane</name>
</author>
<author><name sortKey="Mougenot, N" uniqKey="Mougenot N">N. Mougenot</name>
</author>
<author><name sortKey="Zahr, N" uniqKey="Zahr N">N. Zahr</name>
</author>
<author><name sortKey="David Dufilho, M" uniqKey="David Dufilho M">M. David-Dufilho</name>
</author>
<author><name sortKey="Hatem, S N" uniqKey="Hatem S">S.N. Hatem</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chang, C J" uniqKey="Chang C">C.-J. Chang</name>
</author>
<author><name sortKey="Chen, Y C" uniqKey="Chen Y">Y.-C. Chen</name>
</author>
<author><name sortKey="Kao, Y H" uniqKey="Kao Y">Y.-H. Kao</name>
</author>
<author><name sortKey="Lin, Y K" uniqKey="Lin Y">Y.-K. Lin</name>
</author>
<author><name sortKey="Chen, S A" uniqKey="Chen S">S.-A. Chen</name>
</author>
<author><name sortKey="Chen, Y J" uniqKey="Chen Y">Y.-J. Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Henri, M H S" uniqKey="Henri M">M.H.S. Henri</name>
</author>
<author><name sortKey="Anne, M D J" uniqKey="Anne M">M.D.J. Anne</name>
</author>
<author><name sortKey="Sander, V" uniqKey="Sander V">V. Sander</name>
</author>
<author><name sortKey="Hetty, C D B" uniqKey="Hetty C">C.D.B. Hetty</name>
</author>
<author><name sortKey="Alexander, H M" uniqKey="Alexander H">H.M. Alexander</name>
</author>
<author><name sortKey="Dennis, H L" uniqKey="Dennis H">H.L. Dennis</name>
</author>
<author><name sortKey="Michiel, R" uniqKey="Michiel R">R. Michiel</name>
</author>
<author><name sortKey="Arne, V H" uniqKey="Arne V">V.H. Arne</name>
</author>
<author><name sortKey="Marion, K" uniqKey="Marion K">K. Marion</name>
</author>
<author><name sortKey="Stijn, L" uniqKey="Stijn L">L. Stijn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Phillip, C D" uniqKey="Phillip C">C.D. Phillip</name>
</author>
<author><name sortKey="Ingrid, J A" uniqKey="Ingrid J">J.A. Ingrid</name>
</author>
<author><name sortKey="Shufang, G" uniqKey="Shufang G">G. Shufang</name>
</author>
<author><name sortKey="Katy, S" uniqKey="Katy S">S. Katy</name>
</author>
<author><name sortKey="Yoshiyuki, H" uniqKey="Yoshiyuki H">H. Yoshiyuki</name>
</author>
<author><name sortKey="Linda, M M" uniqKey="Linda M">M.M. Linda</name>
</author>
<author><name sortKey="Peter, C L" uniqKey="Peter C">C.L. Peter</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Carlquist, J F" uniqKey="Carlquist J">J.F. Carlquist</name>
</author>
<author><name sortKey="Knight, S" uniqKey="Knight S">S. Knight</name>
</author>
<author><name sortKey="Cawthon, R M" uniqKey="Cawthon R">R.M. Cawthon</name>
</author>
<author><name sortKey="Le, V T" uniqKey="Le V">V.T. Le</name>
</author>
<author><name sortKey="Bunch, T J" uniqKey="Bunch T">T.J. Bunch</name>
</author>
<author><name sortKey="Horne, B D" uniqKey="Horne B">B.D. Horne</name>
</author>
<author><name sortKey="Rollo, J S" uniqKey="Rollo J">J.S. Rollo</name>
</author>
<author><name sortKey="Huntinghouse, J A" uniqKey="Huntinghouse J">J.A. Huntinghouse</name>
</author>
<author><name sortKey="Muhlestein, J B" uniqKey="Muhlestein J">J.B. Muhlestein</name>
</author>
<author><name sortKey="Anderson, J L" uniqKey="Anderson J">J.L. Anderson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xie, J" uniqKey="Xie J">J. Xie</name>
</author>
<author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. Chen</name>
</author>
<author><name sortKey="Hu, C" uniqKey="Hu C">C. Hu</name>
</author>
<author><name sortKey="Pan, Q" uniqKey="Pan Q">Q. Pan</name>
</author>
<author><name sortKey="Wang, B" uniqKey="Wang B">B. Wang</name>
</author>
<author><name sortKey="Li, X" uniqKey="Li X">X. Li</name>
</author>
<author><name sortKey="Geng, J" uniqKey="Geng J">J. Geng</name>
</author>
<author><name sortKey="Xu, B" uniqKey="Xu B">B. Xu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Watanabe, S" uniqKey="Watanabe S">S. Watanabe</name>
</author>
<author><name sortKey="Kawamoto, S" uniqKey="Kawamoto S">S. Kawamoto</name>
</author>
<author><name sortKey="Ohtani, N" uniqKey="Ohtani N">N. Ohtani</name>
</author>
<author><name sortKey="Hara, E" uniqKey="Hara E">E. Hara</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yin, H" uniqKey="Yin H">H. Yin</name>
</author>
<author><name sortKey="Pickering, J G" uniqKey="Pickering J">J.G. Pickering</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Abbas, M" uniqKey="Abbas M">M. Abbas</name>
</author>
<author><name sortKey="Jesel, L" uniqKey="Jesel L">L. Jesel</name>
</author>
<author><name sortKey="Auger, C" uniqKey="Auger C">C. Auger</name>
</author>
<author><name sortKey="Amoura, L" uniqKey="Amoura L">L. Amoura</name>
</author>
<author><name sortKey="Messas, N" uniqKey="Messas N">N. Messas</name>
</author>
<author><name sortKey="Manin, G" uniqKey="Manin G">G. Manin</name>
</author>
<author><name sortKey="Rumig, C" uniqKey="Rumig C">C. Rumig</name>
</author>
<author><name sortKey="Le N Gonzalez, A J" uniqKey="Le N Gonzalez A">A.J. León-González</name>
</author>
<author><name sortKey="Ribeiro, T P" uniqKey="Ribeiro T">T.P. Ribeiro</name>
</author>
<author><name sortKey="Silva, G C" uniqKey="Silva G">G.C. Silva</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mann, K G" uniqKey="Mann K">K.G. Mann</name>
</author>
<author><name sortKey="Brummel, K" uniqKey="Brummel K">K. Brummel</name>
</author>
<author><name sortKey="Butenas, S" uniqKey="Butenas S">S. Butenas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cotgreave, I" uniqKey="Cotgreave I">I. Cotgreave</name>
</author>
<author><name sortKey="Moldeus, P" uniqKey="Moldeus P">P. Moldeus</name>
</author>
<author><name sortKey="Schuppe, I" uniqKey="Schuppe I">I. Schuppe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kurz, D J" uniqKey="Kurz D">D.J. Kurz</name>
</author>
<author><name sortKey="Decary, S" uniqKey="Decary S">S. Decary</name>
</author>
<author><name sortKey="Hong, Y" uniqKey="Hong Y">Y. Hong</name>
</author>
<author><name sortKey="Erusalimsky, J D" uniqKey="Erusalimsky J">J.D. Erusalimsky</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sonia, K B" uniqKey="Sonia K">K.B. Sonia</name>
</author>
<author><name sortKey="Noureddine, I K" uniqKey="Noureddine I">I.K. Noureddine</name>
</author>
<author><name sortKey="Thais, P R" uniqKey="Thais P">P.R. Thais</name>
</author>
<author><name sortKey="Grazielle, C S" uniqKey="Grazielle C">C.S. Grazielle</name>
</author>
<author><name sortKey="Malak, A" uniqKey="Malak A">A. Malak</name>
</author>
<author><name sortKey="Marouane, K" uniqKey="Marouane K">K. Marouane</name>
</author>
<author><name sortKey="Jung, L" uniqKey="Jung L">L. Jung</name>
</author>
<author><name sortKey="Florence, T" uniqKey="Florence T">T. Florence</name>
</author>
<author><name sortKey="Cyril, A" uniqKey="Cyril A">A. Cyril</name>
</author>
<author><name sortKey="Valerie, B" uniqKey="Valerie B">B. Valérie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hu, X" uniqKey="Hu X">X. Hu</name>
</author>
<author><name sortKey="Beeton, C" uniqKey="Beeton C">C. Beeton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Polyakova, V" uniqKey="Polyakova V">V. Polyakova</name>
</author>
<author><name sortKey="Miyagawa, S" uniqKey="Miyagawa S">S. Miyagawa</name>
</author>
<author><name sortKey="Szalay, Z" uniqKey="Szalay Z">Z. Szalay</name>
</author>
<author><name sortKey="Risteli, J" uniqKey="Risteli J">J. Risteli</name>
</author>
<author><name sortKey="Kostin, S" uniqKey="Kostin S">S. Kostin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Anne, W" uniqKey="Anne W">W. Anné</name>
</author>
<author><name sortKey="Willems, R" uniqKey="Willems R">R. Willems</name>
</author>
<author><name sortKey="Roskams, T" uniqKey="Roskams T">T. Roskams</name>
</author>
<author><name sortKey="Sergeant, P" uniqKey="Sergeant P">P. Sergeant</name>
</author>
<author><name sortKey="Herijgers, P" uniqKey="Herijgers P">P. Herijgers</name>
</author>
<author><name sortKey="Holemans, P" uniqKey="Holemans P">P. Holemans</name>
</author>
<author><name sortKey="Ector, H" uniqKey="Ector H">H. Ector</name>
</author>
<author><name sortKey="Heidbuchel, H" uniqKey="Heidbuchel H">H. Heidbüchel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bukowska, A" uniqKey="Bukowska A">A. Bukowska</name>
</author>
<author><name sortKey="Zacharias, I" uniqKey="Zacharias I">I. Zacharias</name>
</author>
<author><name sortKey="Weinert, S" uniqKey="Weinert S">S. Weinert</name>
</author>
<author><name sortKey="Skopp, K" uniqKey="Skopp K">K. Skopp</name>
</author>
<author><name sortKey="Hartmann, C" uniqKey="Hartmann C">C. Hartmann</name>
</author>
<author><name sortKey="Huth, C" uniqKey="Huth C">C. Huth</name>
</author>
<author><name sortKey="Goette, A" uniqKey="Goette A">A. Goette</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Park, T H" uniqKey="Park T">T.H. Park</name>
</author>
<author><name sortKey="Mchowat, J" uniqKey="Mchowat J">J. McHowat</name>
</author>
<author><name sortKey="A Wolf, R" uniqKey="A Wolf R">R. A Wolf</name>
</author>
<author><name sortKey="Corr, P B" uniqKey="Corr P">P.B. Corr</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Burger, D" uniqKey="Burger D">D. Burger</name>
</author>
<author><name sortKey="Turner, M" uniqKey="Turner M">M. Turner</name>
</author>
<author><name sortKey="Munkonda, M N" uniqKey="Munkonda M">M.N. Munkonda</name>
</author>
<author><name sortKey="Touyz, R M" uniqKey="Touyz R">R.M. Touyz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sanada, F" uniqKey="Sanada F">F. Sanada</name>
</author>
<author><name sortKey="Taniyama, Y" uniqKey="Taniyama Y">Y. Taniyama</name>
</author>
<author><name sortKey="Muratsu, J" uniqKey="Muratsu J">J. Muratsu</name>
</author>
<author><name sortKey="Otsu, R" uniqKey="Otsu R">R. Otsu</name>
</author>
<author><name sortKey="Iwabayashi, M" uniqKey="Iwabayashi M">M. Iwabayashi</name>
</author>
<author><name sortKey="Carracedo, M" uniqKey="Carracedo M">M. Carracedo</name>
</author>
<author><name sortKey="Rakugi, H" uniqKey="Rakugi H">H. Rakugi</name>
</author>
<author><name sortKey="Morishita, R" uniqKey="Morishita R">R. Morishita</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, Z" uniqKey="Yang Z">Z. Yang</name>
</author>
<author><name sortKey="Arnet, U" uniqKey="Arnet U">U. Arnet</name>
</author>
<author><name sortKey="Bauer, E" uniqKey="Bauer E">E. Bauer</name>
</author>
<author><name sortKey="Von Segesser, L" uniqKey="Von Segesser L">L. Von Segesser</name>
</author>
<author><name sortKey="Siebenmann, R" uniqKey="Siebenmann R">R. Siebenmann</name>
</author>
<author><name sortKey="Turina, M" uniqKey="Turina M">M. Turina</name>
</author>
<author><name sortKey="Luscher, T F" uniqKey="Luscher T">T.F. Luscher</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kang, K W" uniqKey="Kang K">K.W. Kang</name>
</author>
<author><name sortKey="Choi, S Y" uniqKey="Choi S">S.Y. Choi</name>
</author>
<author><name sortKey="Cho, M K" uniqKey="Cho M">M.K. Cho</name>
</author>
<author><name sortKey="Lee, C H" uniqKey="Lee C">C.H. Lee</name>
</author>
<author><name sortKey="Kim, S G" uniqKey="Kim S">S.G. Kim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Akar, J G" uniqKey="Akar J">J.G. Akar</name>
</author>
<author><name sortKey="Jeske, W" uniqKey="Jeske W">W. Jeske</name>
</author>
<author><name sortKey="Wilber, D J" uniqKey="Wilber D">D.J. Wilber</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name>
</author>
<author><name sortKey="Chen, F" uniqKey="Chen F">F. Chen</name>
</author>
<author><name sortKey="Deng, L" uniqKey="Deng L">L. Deng</name>
</author>
<author><name sortKey="Lin, K" uniqKey="Lin K">K. Lin</name>
</author>
<author><name sortKey="Shi, X" uniqKey="Shi X">X. Shi</name>
</author>
<author><name sortKey="Zhaoliang, S" uniqKey="Zhaoliang S">S. Zhaoliang</name>
</author>
<author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Spronk, H M" uniqKey="Spronk H">H.M. Spronk</name>
</author>
<author><name sortKey="De Jong, A M" uniqKey="De Jong A">A.M. De Jong</name>
</author>
<author><name sortKey="Crijns, H J" uniqKey="Crijns H">H.J. Crijns</name>
</author>
<author><name sortKey="Schotten, U" uniqKey="Schotten U">U. Schotten</name>
</author>
<author><name sortKey="Van Gelder, I C" uniqKey="Van Gelder I">I.C. Van Gelder</name>
</author>
<author><name sortKey="Cate, H T" uniqKey="Cate H">H.T. Cate</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jansen, H J" uniqKey="Jansen H">H.J. Jansen</name>
</author>
<author><name sortKey="Mackasey, M" uniqKey="Mackasey M">M. Mackasey</name>
</author>
<author><name sortKey="Moghtadaei, M" uniqKey="Moghtadaei M">M. Moghtadaei</name>
</author>
<author><name sortKey="Belke, D D" uniqKey="Belke D">D.D. Belke</name>
</author>
<author><name sortKey="Egom, E E" uniqKey="Egom E">E.E. Egom</name>
</author>
<author><name sortKey="Tuomi, J M" uniqKey="Tuomi J">J.M. Tuomi</name>
</author>
<author><name sortKey="Rafferty, S A" uniqKey="Rafferty S">S.A. Rafferty</name>
</author>
<author><name sortKey="Kirkby, A W" uniqKey="Kirkby A">A.W. Kirkby</name>
</author>
<author><name sortKey="Rose, R A" uniqKey="Rose R">R.A. Rose</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Harling, L" uniqKey="Harling L">L. Harling</name>
</author>
<author><name sortKey="Lambert, J" uniqKey="Lambert J">J. Lambert</name>
</author>
<author><name sortKey="Ashrafian, H" uniqKey="Ashrafian H">H. Ashrafian</name>
</author>
<author><name sortKey="Darzi, A" uniqKey="Darzi A">A. Darzi</name>
</author>
<author><name sortKey="Gooderham, N J" uniqKey="Gooderham N">N.J. Gooderham</name>
</author>
<author><name sortKey="Athanasiou, T" uniqKey="Athanasiou T">T. Athanasiou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Verdejo, H" uniqKey="Verdejo H">H. Verdejo</name>
</author>
<author><name sortKey="Roldan, J" uniqKey="Roldan J">J. Roldán</name>
</author>
<author><name sortKey="Garcia, L" uniqKey="Garcia L">L. Garcia</name>
</author>
<author><name sortKey="Del Campo, A" uniqKey="Del Campo A">A. Del Campo</name>
</author>
<author><name sortKey="Becerra, E" uniqKey="Becerra E">E. Becerra</name>
</author>
<author><name sortKey="Chiong, M" uniqKey="Chiong M">M. Chiong</name>
</author>
<author><name sortKey="Mellado, R" uniqKey="Mellado R">R. Mellado</name>
</author>
<author><name sortKey="Garcia, A" uniqKey="Garcia A">A. Garcia</name>
</author>
<author><name sortKey="Zalaquett, R" uniqKey="Zalaquett R">R. Zalaquett</name>
</author>
<author><name sortKey="Braun, S" uniqKey="Braun S">S. Braun</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Polejaeva, I A" uniqKey="Polejaeva I">I.A. Polejaeva</name>
</author>
<author><name sortKey="Ranjan, R" uniqKey="Ranjan R">R. Ranjan</name>
</author>
<author><name sortKey="Davies, C J" uniqKey="Davies C">C.J. Davies</name>
</author>
<author><name sortKey="Regouski, M" uniqKey="Regouski M">M. Regouski</name>
</author>
<author><name sortKey="Hall, J" uniqKey="Hall J">J. Hall</name>
</author>
<author><name sortKey="Olsen, A L" uniqKey="Olsen A">A.L. Olsen</name>
</author>
<author><name sortKey="Meng, Q" uniqKey="Meng Q">Q. Meng</name>
</author>
<author><name sortKey="Rutigliano, H M" uniqKey="Rutigliano H">H.M.1 Rutigliano</name>
</author>
<author><name sortKey="Dosdall, D J" uniqKey="Dosdall D">D.J. Dosdall</name>
</author>
<author><name sortKey="Angel, N A" uniqKey="Angel N">N.A. Angel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Verheule, S" uniqKey="Verheule S">S. Verheule</name>
</author>
<author><name sortKey="Sato, T" uniqKey="Sato T">T. Sato</name>
</author>
<author><name sortKey="Everett, T" uniqKey="Everett T">T. Everett</name>
</author>
<author><name sortKey="Engle, S K" uniqKey="Engle S">S.K. Engle</name>
</author>
<author><name sortKey="Otten, D" uniqKey="Otten D">D. Otten</name>
</author>
<author><name sortKey="Der Lohe, M R V" uniqKey="Der Lohe M">M.R.-V. Der Lohe</name>
</author>
<author><name sortKey="Nakajima, H O" uniqKey="Nakajima H">H.O. Nakajima</name>
</author>
<author><name sortKey="Nakajima, H" uniqKey="Nakajima H">H. Nakajima</name>
</author>
<author><name sortKey="Field, L J" uniqKey="Field L">L.J. Field</name>
</author>
<author><name sortKey="Olgin, J E" uniqKey="Olgin J">J.E. Olgin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tang, H" uniqKey="Tang H">H. Tang</name>
</author>
<author><name sortKey="Low, B" uniqKey="Low B">B. Low</name>
</author>
<author><name sortKey="Rutherford, S A" uniqKey="Rutherford S">S.A. Rutherford</name>
</author>
<author><name sortKey="Hao, Q" uniqKey="Hao Q">Q. Hao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Abe, I" uniqKey="Abe I">I. Abe</name>
</author>
<author><name sortKey="Teshima, Y" uniqKey="Teshima Y">Y. Teshima</name>
</author>
<author><name sortKey="Kondo, H" uniqKey="Kondo H">H. Kondo</name>
</author>
<author><name sortKey="Kaku, H" uniqKey="Kaku H">H. Kaku</name>
</author>
<author><name sortKey="Kira, S" uniqKey="Kira S">S. Kira</name>
</author>
<author><name sortKey="Ikebe, Y" uniqKey="Ikebe Y">Y. Ikebe</name>
</author>
<author><name sortKey="Saito, S" uniqKey="Saito S">S. Saito</name>
</author>
<author><name sortKey="Fukui, A" uniqKey="Fukui A">A. Fukui</name>
</author>
<author><name sortKey="Shinohara, T" uniqKey="Shinohara T">T. Shinohara</name>
</author>
<author><name sortKey="Yufu, K" uniqKey="Yufu K">K. Yufu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kaireviciute, D" uniqKey="Kaireviciute D">D. Kaireviciute</name>
</author>
<author><name sortKey="Lip, G Y H" uniqKey="Lip G">G.Y.H. Lip</name>
</author>
<author><name sortKey="Balakrishnan, B" uniqKey="Balakrishnan B">B. Balakrishnan</name>
</author>
<author><name sortKey="Uzdavinys, G" uniqKey="Uzdavinys G">G. Uzdavinys</name>
</author>
<author><name sortKey="Norkunas, G" uniqKey="Norkunas G">G. Norkunas</name>
</author>
<author><name sortKey="Kalinauskas, G" uniqKey="Kalinauskas G">G. Kalinauskas</name>
</author>
<author><name sortKey="Sirvydis, V" uniqKey="Sirvydis V">V. Sirvydis</name>
</author>
<author><name sortKey="Aidietis, A" uniqKey="Aidietis A">A. Aidietis</name>
</author>
<author><name sortKey="Zanetto, U" uniqKey="Zanetto U">U. Zanetto</name>
</author>
<author><name sortKey="Sihota, H" uniqKey="Sihota H">H. Sihota</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xu, J" uniqKey="Xu J">J. Xu</name>
</author>
<author><name sortKey="Cui, G" uniqKey="Cui G">G. Cui</name>
</author>
<author><name sortKey="Esmailian, F" uniqKey="Esmailian F">F. Esmailian</name>
</author>
<author><name sortKey="Plunkett, M" uniqKey="Plunkett M">M. Plunkett</name>
</author>
<author><name sortKey="Marelli, D" uniqKey="Marelli D">D. Marelli</name>
</author>
<author><name sortKey="Ardehali, A" uniqKey="Ardehali A">A. Ardehali</name>
</author>
<author><name sortKey="Odim, J" uniqKey="Odim J">J. Odim</name>
</author>
<author><name sortKey="Laks, H" uniqKey="Laks H">H. Laks</name>
</author>
<author><name sortKey="Sen, L" uniqKey="Sen L">L. Sen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sonin, D L" uniqKey="Sonin D">D.L. Sonin</name>
</author>
<author><name sortKey="Wakatsuki, T" uniqKey="Wakatsuki T">T. Wakatsuki</name>
</author>
<author><name sortKey="Routhu, K V" uniqKey="Routhu K">K.V. Routhu</name>
</author>
<author><name sortKey="Harmann, L M" uniqKey="Harmann L">L.M. Harmann</name>
</author>
<author><name sortKey="Petersen, M" uniqKey="Petersen M">M. Petersen</name>
</author>
<author><name sortKey="Meyer, J" uniqKey="Meyer J">J. Meyer</name>
</author>
<author><name sortKey="Strande, J L" uniqKey="Strande J">J.L. Strande</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Watson, T" uniqKey="Watson T">T. Watson</name>
</author>
<author><name sortKey="Karthikeyan, V J" uniqKey="Karthikeyan V">V.J. Karthikeyan</name>
</author>
<author><name sortKey="Lip, G Y" uniqKey="Lip G">G.Y. Lip</name>
</author>
<author><name sortKey="Beevers, D G" uniqKey="Beevers D">D.G. Beevers</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Hauts-de-France</li>
<li>Picardie</li>
</region>
<settlement><li>FR-67401 Strasbourg</li>
</settlement>
<orgName><li>Université de Strasbourg</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Marchandot, Benjamin" sort="Marchandot, Benjamin" uniqKey="Marchandot B" first="Benjamin" last="Marchandot">Benjamin Marchandot</name>
<name sortKey="Ohlmann, Patrick" sort="Ohlmann, Patrick" uniqKey="Ohlmann P" first="Patrick" last="Ohlmann">Patrick Ohlmann</name>
</noCountry>
<country name="France"><region name="Hauts-de-France"><name sortKey="Hasan, Hira" sort="Hasan, Hira" uniqKey="Hasan H" first="Hira" last="Hasan">Hira Hasan</name>
</region>
<name sortKey="Auger, Cyril" sort="Auger, Cyril" uniqKey="Auger C" first="Cyril" last="Auger">Cyril Auger</name>
<name sortKey="Belcastro, Eugenia" sort="Belcastro, Eugenia" uniqKey="Belcastro E" first="Eugenia" last="Belcastro">Eugenia Belcastro</name>
<name sortKey="Jesel, Laurence" sort="Jesel, Laurence" uniqKey="Jesel L" first="Laurence" last="Jesel">Laurence Jesel</name>
<name sortKey="Kauffenstein, Gilles" sort="Kauffenstein, Gilles" uniqKey="Kauffenstein G" first="Gilles" last="Kauffenstein">Gilles Kauffenstein</name>
<name sortKey="Lee, Hyun Ho" sort="Lee, Hyun Ho" uniqKey="Lee H" first="Hyun-Ho" last="Lee">Hyun-Ho Lee</name>
<name sortKey="Matsushita, Kensuke" sort="Matsushita, Kensuke" uniqKey="Matsushita K" first="Kensuke" last="Matsushita">Kensuke Matsushita</name>
<name sortKey="Morel, Olivier" sort="Morel, Olivier" uniqKey="Morel O" first="Olivier" last="Morel">Olivier Morel</name>
<name sortKey="Park, Sin Hee" sort="Park, Sin Hee" uniqKey="Park S" first="Sin-Hee" last="Park">Sin-Hee Park</name>
<name sortKey="Qureshi, Abdul Wahid" sort="Qureshi, Abdul Wahid" uniqKey="Qureshi A" first="Abdul Wahid" last="Qureshi">Abdul Wahid Qureshi</name>
<name sortKey="Schini Kerth, Valerie B" sort="Schini Kerth, Valerie B" uniqKey="Schini Kerth V" first="Valérie B" last="Schini-Kerth">Valérie B. Schini-Kerth</name>
</country>
</tree>
</affiliations>
</record>
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