Development of a human immuno-oncology therapeutic agent targeting HER2: targeted delivery of granzyme B
Identifieur interne : 000860 ( Ncbi/Checkpoint ); précédent : 000859; suivant : 000861Development of a human immuno-oncology therapeutic agent targeting HER2: targeted delivery of granzyme B
Auteurs : Lawrence H. Cheung [États-Unis] ; Yunli Zhao [États-Unis] ; Ana Alvarez-Cienfuegos [États-Unis] ; Khalid A. Mohamedali [États-Unis] ; Yu J. Cao [États-Unis, République populaire de Chine] ; Walter N. Hittelman [États-Unis] ; Michael G. Rosenblum [États-Unis]Source :
- Journal of Experimental & Clinical Cancer Research : CR [ 0392-9078 ] ; 2019.
Abstract
Immunotherapeutic approaches designed to augment T and B cell mediated killing of tumor cells has met with clinical success in recent years suggesting tremendous potential for treatment in a broad spectrum of tumor types. After complex recognition of target cells by T and B cells, delivery of the serine protease granzyme B (GrB) to tumor cells comprises the cytotoxic insult resulting in a well-characterized, multimodal apoptotic cascade.
We designed a recombinant fusion construct, GrB-Fc-4D5, composed of a humanized anti-HER2 scFv fused to active GrB for recognition of tumor cells and internal delivery of GrB, simulating T and B cell therapy. We assessed the construct’s antigen-binding specificity and GrB enzymatic activity, as well as in vitro cytotoxicity and internalization into target and control cells. We also assessed pharmacokinetic and toxicology parameters in vivo.
GrB-Fc-4D5 was highly cytotoxic to Her2 positive cells such as SKBR3, MCF7 and MDA-MB-231 with IC50 values of 56, 99 and 27 nM, respectively, and against a panel of HER2+ cell lines regardless of endogenous expression levels of the PI-9 inhibitor. Contemporaneous studies with Kadcyla demonstrated similar levels of in vitro activity against virtually all cells tested. GrB-Fc-4D5 internalized rapidly into target SKOV3 cells within 1 h of exposure rapidly delivering GrB to the cytoplasmic compartment. In keeping with its relatively high molecular weight (160 kDa), the construct demonstrated a terminal-phase serum half-life in mice of 39.2 h. Toxicity studies conducted on BALB/c mice demonstrated no statistically significant changes in SGPT, SGOT or serum LDH. Histopathologic analysis of tissues from treated mice demonstrated no drug-related changes in any tissues examined.
GrB-Fc-4D5 shows excellent, specific cytotoxicity and demonstrates no significant toxicity in normal, antigen-negative murine models. This construct constitutes a novel approach against HER2-expressing tumors and is an excellent candidate for further development.
Url:
DOI: 10.1186/s13046-019-1333-6
PubMed: 31362764
PubMed Central: 6668111
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000110
- to stream Pmc, to step Curation: 000110
- to stream Pmc, to step Checkpoint: 000829
- to stream Ncbi, to step Merge: 000860
- to stream Ncbi, to step Curation: 000860
Links to Exploration step
PMC:6668111Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Development of a human immuno-oncology therapeutic agent targeting HER2: targeted delivery of granzyme B</title>
<author><name sortKey="Cheung, Lawrence H" sort="Cheung, Lawrence H" uniqKey="Cheung L" first="Lawrence H." last="Cheung">Lawrence H. Cheung</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 4776</institution-id>
<institution-id institution-id-type="GRID">grid.240145.6</institution-id>
<institution>Immunopharmacology and Targeted Therapy Laboratory, Department of Experimental Therapeutics, Unit 1950,</institution>
<institution>The University of Texas MD Anderson Cancer Center,</institution>
</institution-wrap>
1515 Holcombe Blvd, Houston, TX 77030 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>1515 Holcombe Blvd, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Zhao, Yunli" sort="Zhao, Yunli" uniqKey="Zhao Y" first="Yunli" last="Zhao">Yunli Zhao</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 4776</institution-id>
<institution-id institution-id-type="GRID">grid.240145.6</institution-id>
<institution>Immunopharmacology and Targeted Therapy Laboratory, Department of Experimental Therapeutics, Unit 1950,</institution>
<institution>The University of Texas MD Anderson Cancer Center,</institution>
</institution-wrap>
1515 Holcombe Blvd, Houston, TX 77030 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>1515 Holcombe Blvd, Houston</wicri:cityArea>
</affiliation>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8645 4345</institution-id>
<institution-id institution-id-type="GRID">grid.412561.5</institution-id>
<institution>Present address: Department of Pharmaceutical Analysis, School of Pharmacy,</institution>
<institution>Shenyang Pharmaceutical University,</institution>
</institution-wrap>
Shenyang, 110016 Liaoning China</nlm:aff>
<wicri:noCountry code="subfield">110016 Liaoning China</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Alvarez Cienfuegos, Ana" sort="Alvarez Cienfuegos, Ana" uniqKey="Alvarez Cienfuegos A" first="Ana" last="Alvarez-Cienfuegos">Ana Alvarez-Cienfuegos</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 4776</institution-id>
<institution-id institution-id-type="GRID">grid.240145.6</institution-id>
<institution>Immunopharmacology and Targeted Therapy Laboratory, Department of Experimental Therapeutics, Unit 1950,</institution>
<institution>The University of Texas MD Anderson Cancer Center,</institution>
</institution-wrap>
1515 Holcombe Blvd, Houston, TX 77030 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>1515 Holcombe Blvd, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mohamedali, Khalid A" sort="Mohamedali, Khalid A" uniqKey="Mohamedali K" first="Khalid A." last="Mohamedali">Khalid A. Mohamedali</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 4776</institution-id>
<institution-id institution-id-type="GRID">grid.240145.6</institution-id>
<institution>Immunopharmacology and Targeted Therapy Laboratory, Department of Experimental Therapeutics, Unit 1950,</institution>
<institution>The University of Texas MD Anderson Cancer Center,</institution>
</institution-wrap>
1515 Holcombe Blvd, Houston, TX 77030 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>1515 Holcombe Blvd, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cao, Yu J" sort="Cao, Yu J" uniqKey="Cao Y" first="Yu J." last="Cao">Yu J. Cao</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 4776</institution-id>
<institution-id institution-id-type="GRID">grid.240145.6</institution-id>
<institution>Immunopharmacology and Targeted Therapy Laboratory, Department of Experimental Therapeutics, Unit 1950,</institution>
<institution>The University of Texas MD Anderson Cancer Center,</institution>
</institution-wrap>
1515 Holcombe Blvd, Houston, TX 77030 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>1515 Holcombe Blvd, Houston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2256 9319</institution-id>
<institution-id institution-id-type="GRID">grid.11135.37</institution-id>
<institution>Present Address: Shenzhen Graduate School, School of Chemical Biology and Biotechnology,</institution>
<institution>Peking University,</institution>
</institution-wrap>
Nanshan, Shenzhen, 518055 China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Nanshan, Shenzhen</wicri:regionArea>
<placeName><settlement type="city">Shenzhen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hittelman, Walter N" sort="Hittelman, Walter N" uniqKey="Hittelman W" first="Walter N." last="Hittelman">Walter N. Hittelman</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 4776</institution-id>
<institution-id institution-id-type="GRID">grid.240145.6</institution-id>
<institution>Immunopharmacology and Targeted Therapy Laboratory, Department of Experimental Therapeutics, Unit 1950,</institution>
<institution>The University of Texas MD Anderson Cancer Center,</institution>
</institution-wrap>
1515 Holcombe Blvd, Houston, TX 77030 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>1515 Holcombe Blvd, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Rosenblum, Michael G" sort="Rosenblum, Michael G" uniqKey="Rosenblum M" first="Michael G." last="Rosenblum">Michael G. Rosenblum</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 4776</institution-id>
<institution-id institution-id-type="GRID">grid.240145.6</institution-id>
<institution>Immunopharmacology and Targeted Therapy Laboratory, Department of Experimental Therapeutics, Unit 1950,</institution>
<institution>The University of Texas MD Anderson Cancer Center,</institution>
</institution-wrap>
1515 Holcombe Blvd, Houston, TX 77030 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>1515 Holcombe Blvd, Houston</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">31362764</idno>
<idno type="pmc">6668111</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668111</idno>
<idno type="RBID">PMC:6668111</idno>
<idno type="doi">10.1186/s13046-019-1333-6</idno>
<date when="2019">2019</date>
<idno type="wicri:Area/Pmc/Corpus">000110</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000110</idno>
<idno type="wicri:Area/Pmc/Curation">000110</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000110</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000829</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000829</idno>
<idno type="wicri:Area/Ncbi/Merge">000860</idno>
<idno type="wicri:Area/Ncbi/Curation">000860</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000860</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Development of a human immuno-oncology therapeutic agent targeting HER2: targeted delivery of granzyme B</title>
<author><name sortKey="Cheung, Lawrence H" sort="Cheung, Lawrence H" uniqKey="Cheung L" first="Lawrence H." last="Cheung">Lawrence H. Cheung</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 4776</institution-id>
<institution-id institution-id-type="GRID">grid.240145.6</institution-id>
<institution>Immunopharmacology and Targeted Therapy Laboratory, Department of Experimental Therapeutics, Unit 1950,</institution>
<institution>The University of Texas MD Anderson Cancer Center,</institution>
</institution-wrap>
1515 Holcombe Blvd, Houston, TX 77030 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>1515 Holcombe Blvd, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Zhao, Yunli" sort="Zhao, Yunli" uniqKey="Zhao Y" first="Yunli" last="Zhao">Yunli Zhao</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 4776</institution-id>
<institution-id institution-id-type="GRID">grid.240145.6</institution-id>
<institution>Immunopharmacology and Targeted Therapy Laboratory, Department of Experimental Therapeutics, Unit 1950,</institution>
<institution>The University of Texas MD Anderson Cancer Center,</institution>
</institution-wrap>
1515 Holcombe Blvd, Houston, TX 77030 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>1515 Holcombe Blvd, Houston</wicri:cityArea>
</affiliation>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8645 4345</institution-id>
<institution-id institution-id-type="GRID">grid.412561.5</institution-id>
<institution>Present address: Department of Pharmaceutical Analysis, School of Pharmacy,</institution>
<institution>Shenyang Pharmaceutical University,</institution>
</institution-wrap>
Shenyang, 110016 Liaoning China</nlm:aff>
<wicri:noCountry code="subfield">110016 Liaoning China</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Alvarez Cienfuegos, Ana" sort="Alvarez Cienfuegos, Ana" uniqKey="Alvarez Cienfuegos A" first="Ana" last="Alvarez-Cienfuegos">Ana Alvarez-Cienfuegos</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 4776</institution-id>
<institution-id institution-id-type="GRID">grid.240145.6</institution-id>
<institution>Immunopharmacology and Targeted Therapy Laboratory, Department of Experimental Therapeutics, Unit 1950,</institution>
<institution>The University of Texas MD Anderson Cancer Center,</institution>
</institution-wrap>
1515 Holcombe Blvd, Houston, TX 77030 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>1515 Holcombe Blvd, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mohamedali, Khalid A" sort="Mohamedali, Khalid A" uniqKey="Mohamedali K" first="Khalid A." last="Mohamedali">Khalid A. Mohamedali</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 4776</institution-id>
<institution-id institution-id-type="GRID">grid.240145.6</institution-id>
<institution>Immunopharmacology and Targeted Therapy Laboratory, Department of Experimental Therapeutics, Unit 1950,</institution>
<institution>The University of Texas MD Anderson Cancer Center,</institution>
</institution-wrap>
1515 Holcombe Blvd, Houston, TX 77030 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>1515 Holcombe Blvd, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cao, Yu J" sort="Cao, Yu J" uniqKey="Cao Y" first="Yu J." last="Cao">Yu J. Cao</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 4776</institution-id>
<institution-id institution-id-type="GRID">grid.240145.6</institution-id>
<institution>Immunopharmacology and Targeted Therapy Laboratory, Department of Experimental Therapeutics, Unit 1950,</institution>
<institution>The University of Texas MD Anderson Cancer Center,</institution>
</institution-wrap>
1515 Holcombe Blvd, Houston, TX 77030 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>1515 Holcombe Blvd, Houston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2256 9319</institution-id>
<institution-id institution-id-type="GRID">grid.11135.37</institution-id>
<institution>Present Address: Shenzhen Graduate School, School of Chemical Biology and Biotechnology,</institution>
<institution>Peking University,</institution>
</institution-wrap>
Nanshan, Shenzhen, 518055 China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Nanshan, Shenzhen</wicri:regionArea>
<placeName><settlement type="city">Shenzhen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hittelman, Walter N" sort="Hittelman, Walter N" uniqKey="Hittelman W" first="Walter N." last="Hittelman">Walter N. Hittelman</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 4776</institution-id>
<institution-id institution-id-type="GRID">grid.240145.6</institution-id>
<institution>Immunopharmacology and Targeted Therapy Laboratory, Department of Experimental Therapeutics, Unit 1950,</institution>
<institution>The University of Texas MD Anderson Cancer Center,</institution>
</institution-wrap>
1515 Holcombe Blvd, Houston, TX 77030 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>1515 Holcombe Blvd, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Rosenblum, Michael G" sort="Rosenblum, Michael G" uniqKey="Rosenblum M" first="Michael G." last="Rosenblum">Michael G. Rosenblum</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 4776</institution-id>
<institution-id institution-id-type="GRID">grid.240145.6</institution-id>
<institution>Immunopharmacology and Targeted Therapy Laboratory, Department of Experimental Therapeutics, Unit 1950,</institution>
<institution>The University of Texas MD Anderson Cancer Center,</institution>
</institution-wrap>
1515 Holcombe Blvd, Houston, TX 77030 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>1515 Holcombe Blvd, Houston</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Experimental & Clinical Cancer Research : CR</title>
<idno type="ISSN">0392-9078</idno>
<idno type="eISSN">1756-9966</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p id="Par1">Immunotherapeutic approaches designed to augment T and B cell mediated killing of tumor cells has met with clinical success in recent years suggesting tremendous potential for treatment in a broad spectrum of tumor types. After complex recognition of target cells by T and B cells, delivery of the serine protease granzyme B (GrB) to tumor cells comprises the cytotoxic insult resulting in a well-characterized, multimodal apoptotic cascade.</p>
</sec>
<sec><title>Methods</title>
<p id="Par2">We designed a recombinant fusion construct, GrB-Fc-4D5, composed of a humanized anti-HER2 scFv fused to active GrB for recognition of tumor cells and internal delivery of GrB, simulating T and B cell therapy. We assessed the construct’s antigen-binding specificity and GrB enzymatic activity, as well as in vitro cytotoxicity and internalization into target and control cells. We also assessed pharmacokinetic and toxicology parameters in vivo.</p>
</sec>
<sec><title>Results</title>
<p id="Par3">GrB-Fc-4D5 was highly cytotoxic to Her2 positive cells such as SKBR3, MCF7 and MDA-MB-231 with IC<sub>50</sub>
values of 56, 99 and 27 nM, respectively, and against a panel of HER2+ cell lines regardless of endogenous expression levels of the PI-9 inhibitor. Contemporaneous studies with Kadcyla demonstrated similar levels of in vitro activity against virtually all cells tested. GrB-Fc-4D5 internalized rapidly into target SKOV3 cells within 1 h of exposure rapidly delivering GrB to the cytoplasmic compartment. In keeping with its relatively high molecular weight (160 kDa), the construct demonstrated a terminal-phase serum half-life in mice of 39.2 h. Toxicity studies conducted on BALB/c mice demonstrated no statistically significant changes in SGPT, SGOT or serum LDH. Histopathologic analysis of tissues from treated mice demonstrated no drug-related changes in any tissues examined.</p>
</sec>
<sec><title>Conclusion</title>
<p id="Par4">GrB-Fc-4D5 shows excellent, specific cytotoxicity and demonstrates no significant toxicity in normal, antigen-negative murine models. This construct constitutes a novel approach against HER2-expressing tumors and is an excellent candidate for further development.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Duong, Cp" uniqKey="Duong C">CP Duong</name>
</author>
<author><name sortKey="Yong, Cs" uniqKey="Yong C">CS Yong</name>
</author>
<author><name sortKey="Kershaw, Mh" uniqKey="Kershaw M">MH Kershaw</name>
</author>
<author><name sortKey="Slaney, Cy" uniqKey="Slaney C">CY Slaney</name>
</author>
<author><name sortKey="Darcy, Pk" uniqKey="Darcy P">PK Darcy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ekkirala, Cr" uniqKey="Ekkirala C">CR Ekkirala</name>
</author>
<author><name sortKey="Cappello, P" uniqKey="Cappello P">P Cappello</name>
</author>
<author><name sortKey="Accolla, Rs" uniqKey="Accolla R">RS Accolla</name>
</author>
<author><name sortKey="Giovarelli, M" uniqKey="Giovarelli M">M Giovarelli</name>
</author>
<author><name sortKey="Romero, I" uniqKey="Romero I">I Romero</name>
</author>
<author><name sortKey="Garrido, C" uniqKey="Garrido C">C Garrido</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Knaus, Ha" uniqKey="Knaus H">HA Knaus</name>
</author>
<author><name sortKey="Kanakry, Cg" uniqKey="Kanakry C">CG Kanakry</name>
</author>
<author><name sortKey="Luznik, L" uniqKey="Luznik L">L Luznik</name>
</author>
<author><name sortKey="Gojo, I" uniqKey="Gojo I">I Gojo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lu, M" uniqKey="Lu M">M Lu</name>
</author>
<author><name sortKey="Huang, B" uniqKey="Huang B">B Huang</name>
</author>
<author><name sortKey="Hanash, Sm" uniqKey="Hanash S">SM Hanash</name>
</author>
<author><name sortKey="Onuchic, Jn" uniqKey="Onuchic J">JN Onuchic</name>
</author>
<author><name sortKey="Ben Jacob, E" uniqKey="Ben Jacob E">E Ben-Jacob</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mostafa, Aa" uniqKey="Mostafa A">AA Mostafa</name>
</author>
<author><name sortKey="Morris, Dg" uniqKey="Morris D">DG Morris</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pahl, J" uniqKey="Pahl J">J Pahl</name>
</author>
<author><name sortKey="Cerwenka, A" uniqKey="Cerwenka A">A Cerwenka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Woo, Sr" uniqKey="Woo S">SR Woo</name>
</author>
<author><name sortKey="Corrales, L" uniqKey="Corrales L">L Corrales</name>
</author>
<author><name sortKey="Gajewski, Tf" uniqKey="Gajewski T">TF Gajewski</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Concha Benavente, F" uniqKey="Concha Benavente F">F Concha-Benavente</name>
</author>
<author><name sortKey="Srivastava, R" uniqKey="Srivastava R">R Srivastava</name>
</author>
<author><name sortKey="Ferrone, S" uniqKey="Ferrone S">S Ferrone</name>
</author>
<author><name sortKey="Ferris, Rl" uniqKey="Ferris R">RL Ferris</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ebstein, F" uniqKey="Ebstein F">F Ebstein</name>
</author>
<author><name sortKey="Keller, M" uniqKey="Keller M">M Keller</name>
</author>
<author><name sortKey="Paschen, A" uniqKey="Paschen A">A Paschen</name>
</author>
<author><name sortKey="Walden, P" uniqKey="Walden P">P Walden</name>
</author>
<author><name sortKey="Seeger, M" uniqKey="Seeger M">M Seeger</name>
</author>
<author><name sortKey="Burger, E" uniqKey="Burger E">E Burger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Page, Db" uniqKey="Page D">DB Page</name>
</author>
<author><name sortKey="Hulett, Tw" uniqKey="Hulett T">TW Hulett</name>
</author>
<author><name sortKey="Hilton, Tl" uniqKey="Hilton T">TL Hilton</name>
</author>
<author><name sortKey="Hu, Hm" uniqKey="Hu H">HM Hu</name>
</author>
<author><name sortKey="Urba, Wj" uniqKey="Urba W">WJ Urba</name>
</author>
<author><name sortKey="Fox, Ba" uniqKey="Fox B">BA Fox</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Steven, A" uniqKey="Steven A">A Steven</name>
</author>
<author><name sortKey="Fisher, Sa" uniqKey="Fisher S">SA Fisher</name>
</author>
<author><name sortKey="Robinson, Bw" uniqKey="Robinson B">BW Robinson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Andrade, F" uniqKey="Andrade F">F Andrade</name>
</author>
<author><name sortKey="Casciola Rosen, La" uniqKey="Casciola Rosen L">LA Casciola-Rosen</name>
</author>
<author><name sortKey="Rosen, A" uniqKey="Rosen A">A Rosen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Andrade, F" uniqKey="Andrade F">F Andrade</name>
</author>
<author><name sortKey="Roy, S" uniqKey="Roy S">S Roy</name>
</author>
<author><name sortKey="Nicholson, D" uniqKey="Nicholson D">D Nicholson</name>
</author>
<author><name sortKey="Thornberry, N" uniqKey="Thornberry N">N Thornberry</name>
</author>
<author><name sortKey="Rosen, A" uniqKey="Rosen A">A Rosen</name>
</author>
<author><name sortKey="Casciola Rosen, L" uniqKey="Casciola Rosen L">L Casciola-Rosen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chinnaiyan, Am" uniqKey="Chinnaiyan A">AM Chinnaiyan</name>
</author>
<author><name sortKey="Hanna, Wl" uniqKey="Hanna W">WL Hanna</name>
</author>
<author><name sortKey="Orth, K" uniqKey="Orth K">K Orth</name>
</author>
<author><name sortKey="Duan, H" uniqKey="Duan H">H Duan</name>
</author>
<author><name sortKey="Poirier, Gg" uniqKey="Poirier G">GG Poirier</name>
</author>
<author><name sortKey="Froelich, Cj" uniqKey="Froelich C">CJ Froelich</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rousalova, I" uniqKey="Rousalova I">I Rousalova</name>
</author>
<author><name sortKey="Krepela, E" uniqKey="Krepela E">E Krepela</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Trapani, Ja" uniqKey="Trapani J">JA Trapani</name>
</author>
<author><name sortKey="Browne, Ka" uniqKey="Browne K">KA Browne</name>
</author>
<author><name sortKey="Smyth, Mj" uniqKey="Smyth M">MJ Smyth</name>
</author>
<author><name sortKey="Jans, Da" uniqKey="Jans D">DA Jans</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Trapani, Ja" uniqKey="Trapani J">JA Trapani</name>
</author>
<author><name sortKey="Smyth, Mj" uniqKey="Smyth M">MJ Smyth</name>
</author>
<author><name sortKey="Apostolidis, Va" uniqKey="Apostolidis V">VA Apostolidis</name>
</author>
<author><name sortKey="Dawson, M" uniqKey="Dawson M">M Dawson</name>
</author>
<author><name sortKey="Browne, Ka" uniqKey="Browne K">KA Browne</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cao, Y" uniqKey="Cao Y">Y Cao</name>
</author>
<author><name sortKey="Mohamedali, Ka" uniqKey="Mohamedali K">KA Mohamedali</name>
</author>
<author><name sortKey="Marks, Jw" uniqKey="Marks J">JW Marks</name>
</author>
<author><name sortKey="Cheung, Lh" uniqKey="Cheung L">LH Cheung</name>
</author>
<author><name sortKey="Hittelman, Wn" uniqKey="Hittelman W">WN Hittelman</name>
</author>
<author><name sortKey="Rosenblum, Mg" uniqKey="Rosenblum M">MG Rosenblum</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kanatani, I" uniqKey="Kanatani I">I Kanatani</name>
</author>
<author><name sortKey="Lin, X" uniqKey="Lin X">X Lin</name>
</author>
<author><name sortKey="Yuan, X" uniqKey="Yuan X">X Yuan</name>
</author>
<author><name sortKey="Manorek, G" uniqKey="Manorek G">G Manorek</name>
</author>
<author><name sortKey="Shang, X" uniqKey="Shang X">X Shang</name>
</author>
<author><name sortKey="Cheung, Lh" uniqKey="Cheung L">LH Cheung</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name>
</author>
<author><name sortKey="Cheung, Lh" uniqKey="Cheung L">LH Cheung</name>
</author>
<author><name sortKey="Hittelman, Wn" uniqKey="Hittelman W">WN Hittelman</name>
</author>
<author><name sortKey="Rosenblum, Mg" uniqKey="Rosenblum M">MG Rosenblum</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name>
</author>
<author><name sortKey="Cheung, Lh" uniqKey="Cheung L">LH Cheung</name>
</author>
<author><name sortKey="Thorpe, P" uniqKey="Thorpe P">P Thorpe</name>
</author>
<author><name sortKey="Rosenblum, Mg" uniqKey="Rosenblum M">MG Rosenblum</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name>
</author>
<author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name>
</author>
<author><name sortKey="Niu, T" uniqKey="Niu T">T Niu</name>
</author>
<author><name sortKey="Cheung, Lh" uniqKey="Cheung L">LH Cheung</name>
</author>
<author><name sortKey="Munshi, A" uniqKey="Munshi A">A Munshi</name>
</author>
<author><name sortKey="Meyn, Re" uniqKey="Meyn R">RE Meyn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mohamedali, Ka" uniqKey="Mohamedali K">KA Mohamedali</name>
</author>
<author><name sortKey="Cao, Y" uniqKey="Cao Y">Y Cao</name>
</author>
<author><name sortKey="Cheung, Lh" uniqKey="Cheung L">LH Cheung</name>
</author>
<author><name sortKey="Hittelman, Wn" uniqKey="Hittelman W">WN Hittelman</name>
</author>
<author><name sortKey="Rosenblum, Mg" uniqKey="Rosenblum M">MG Rosenblum</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mohamedali, Khalid A" uniqKey="Mohamedali K">Khalid A. Mohamedali</name>
</author>
<author><name sortKey="Rosenblum, Michael G" uniqKey="Rosenblum M">Michael G. Rosenblum</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rosenblum, Mg" uniqKey="Rosenblum M">MG Rosenblum</name>
</author>
<author><name sortKey="Barth, S" uniqKey="Barth S">S Barth</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhou, H" uniqKey="Zhou H">H Zhou</name>
</author>
<author><name sortKey="Mohamedali, Ka" uniqKey="Mohamedali K">KA Mohamedali</name>
</author>
<author><name sortKey="Gonzalez Angulo, Am" uniqKey="Gonzalez Angulo A">AM Gonzalez-Angulo</name>
</author>
<author><name sortKey="Cao, Y" uniqKey="Cao Y">Y Cao</name>
</author>
<author><name sortKey="Migliorini, M" uniqKey="Migliorini M">M Migliorini</name>
</author>
<author><name sortKey="Cheung, Lh" uniqKey="Cheung L">LH Cheung</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Akbari, B" uniqKey="Akbari B">B Akbari</name>
</author>
<author><name sortKey="Farajnia, S" uniqKey="Farajnia S">S Farajnia</name>
</author>
<author><name sortKey="Ahdi Khosroshahi, S" uniqKey="Ahdi Khosroshahi S">S Ahdi Khosroshahi</name>
</author>
<author><name sortKey="Safari, F" uniqKey="Safari F">F Safari</name>
</author>
<author><name sortKey="Yousefi, M" uniqKey="Yousefi M">M Yousefi</name>
</author>
<author><name sortKey="Dariushnejad, H" uniqKey="Dariushnejad H">H Dariushnejad</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Allahyari, H" uniqKey="Allahyari H">H Allahyari</name>
</author>
<author><name sortKey="Heidari, S" uniqKey="Heidari S">S Heidari</name>
</author>
<author><name sortKey="Ghamgosha, M" uniqKey="Ghamgosha M">M Ghamgosha</name>
</author>
<author><name sortKey="Saffarian, P" uniqKey="Saffarian P">P Saffarian</name>
</author>
<author><name sortKey="Amani, J" uniqKey="Amani J">J Amani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bolognesi, Andrea" uniqKey="Bolognesi A">Andrea Bolognesi</name>
</author>
<author><name sortKey="Bortolotti, Massimo" uniqKey="Bortolotti M">Massimo Bortolotti</name>
</author>
<author><name sortKey="Maiello, Stefania" uniqKey="Maiello S">Stefania Maiello</name>
</author>
<author><name sortKey="Battelli, Maria" uniqKey="Battelli M">Maria Battelli</name>
</author>
<author><name sortKey="Polito, Letizia" uniqKey="Polito L">Letizia Polito</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jerjian, Tv" uniqKey="Jerjian T">TV Jerjian</name>
</author>
<author><name sortKey="Glode, Ae" uniqKey="Glode A">AE Glode</name>
</author>
<author><name sortKey="Thompson, La" uniqKey="Thompson L">LA Thompson</name>
</author>
<author><name sortKey="O Bryant, Cl" uniqKey="O Bryant C">CL O'Bryant</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Parakh, S" uniqKey="Parakh S">S Parakh</name>
</author>
<author><name sortKey="Parslow, Ac" uniqKey="Parslow A">AC Parslow</name>
</author>
<author><name sortKey="Gan, Hk" uniqKey="Gan H">HK Gan</name>
</author>
<author><name sortKey="Scott, Am" uniqKey="Scott A">AM Scott</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Peters, C" uniqKey="Peters C">C. Peters</name>
</author>
<author><name sortKey="Brown, S" uniqKey="Brown S">S. Brown</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Amoury, M" uniqKey="Amoury M">M Amoury</name>
</author>
<author><name sortKey="Kolberg, K" uniqKey="Kolberg K">K Kolberg</name>
</author>
<author><name sortKey="Pham, At" uniqKey="Pham A">AT Pham</name>
</author>
<author><name sortKey="Hristodorov, D" uniqKey="Hristodorov D">D Hristodorov</name>
</author>
<author><name sortKey="Mladenov, R" uniqKey="Mladenov R">R Mladenov</name>
</author>
<author><name sortKey="Di Fiore, S" uniqKey="Di Fiore S">S Di Fiore</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Caldas, H" uniqKey="Caldas H">H Caldas</name>
</author>
<author><name sortKey="Jaynes, Fo" uniqKey="Jaynes F">FO Jaynes</name>
</author>
<author><name sortKey="Boyer, Mw" uniqKey="Boyer M">MW Boyer</name>
</author>
<author><name sortKey="Hammond, S" uniqKey="Hammond S">S Hammond</name>
</author>
<author><name sortKey="Altura, Ra" uniqKey="Altura R">RA Altura</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lv, Xz" uniqKey="Lv X">XZ Lv</name>
</author>
<author><name sortKey="Zheng, My" uniqKey="Zheng M">MY Zheng</name>
</author>
<author><name sortKey="Lin, Zq" uniqKey="Lin Z">ZQ Lin</name>
</author>
<author><name sortKey="Zhao, M" uniqKey="Zhao M">M Zhao</name>
</author>
<author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name>
</author>
<author><name sortKey="Zeng, Ws" uniqKey="Zeng W">WS Zeng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Niesen, J" uniqKey="Niesen J">J Niesen</name>
</author>
<author><name sortKey="Hehmann Titt, G" uniqKey="Hehmann Titt G">G Hehmann-Titt</name>
</author>
<author><name sortKey="Woitok, M" uniqKey="Woitok M">M Woitok</name>
</author>
<author><name sortKey="Fendel, R" uniqKey="Fendel R">R Fendel</name>
</author>
<author><name sortKey="Barth, S" uniqKey="Barth S">S Barth</name>
</author>
<author><name sortKey="Fischer, R" uniqKey="Fischer R">R Fischer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Oberoi, P" uniqKey="Oberoi P">P Oberoi</name>
</author>
<author><name sortKey="Jabulowsky, Ra" uniqKey="Jabulowsky R">RA Jabulowsky</name>
</author>
<author><name sortKey="Bahr Mahmud, H" uniqKey="Bahr Mahmud H">H Bahr-Mahmud</name>
</author>
<author><name sortKey="Wels, Ws" uniqKey="Wels W">WS Wels</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schiffer, S" uniqKey="Schiffer S">S Schiffer</name>
</author>
<author><name sortKey="Hansen, Hp" uniqKey="Hansen H">HP Hansen</name>
</author>
<author><name sortKey="Hehmann Titt, G" uniqKey="Hehmann Titt G">G Hehmann-Titt</name>
</author>
<author><name sortKey="Huhn, M" uniqKey="Huhn M">M Huhn</name>
</author>
<author><name sortKey="Fischer, R" uniqKey="Fischer R">R Fischer</name>
</author>
<author><name sortKey="Barth, S" uniqKey="Barth S">S Barth</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schiffer, S" uniqKey="Schiffer S">S Schiffer</name>
</author>
<author><name sortKey="Letzian, S" uniqKey="Letzian S">S Letzian</name>
</author>
<author><name sortKey="Jost, E" uniqKey="Jost E">E Jost</name>
</author>
<author><name sortKey="Mladenov, R" uniqKey="Mladenov R">R Mladenov</name>
</author>
<author><name sortKey="Hristodorov, D" uniqKey="Hristodorov D">D Hristodorov</name>
</author>
<author><name sortKey="Huhn, M" uniqKey="Huhn M">M Huhn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name>
</author>
<author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name>
</author>
<author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name>
</author>
<author><name sortKey="Wen, Wh" uniqKey="Wen W">WH Wen</name>
</author>
<author><name sortKey="Zhang, Yh" uniqKey="Zhang Y">YH Zhang</name>
</author>
<author><name sortKey="Wang, Cj" uniqKey="Wang C">CJ Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Weidle, Uh" uniqKey="Weidle U">UH Weidle</name>
</author>
<author><name sortKey="Georges, G" uniqKey="Georges G">G Georges</name>
</author>
<author><name sortKey="Brinkmann, U" uniqKey="Brinkmann U">U Brinkmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Emde, A" uniqKey="Emde A">A Emde</name>
</author>
<author><name sortKey="Kostler, Wj" uniqKey="Kostler W">WJ Kostler</name>
</author>
<author><name sortKey="Yarden, Y" uniqKey="Yarden Y">Y Yarden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Junutula, Jr" uniqKey="Junutula J">JR Junutula</name>
</author>
<author><name sortKey="Flagella, Km" uniqKey="Flagella K">KM Flagella</name>
</author>
<author><name sortKey="Graham, Ra" uniqKey="Graham R">RA Graham</name>
</author>
<author><name sortKey="Parsons, Kl" uniqKey="Parsons K">KL Parsons</name>
</author>
<author><name sortKey="Ha, E" uniqKey="Ha E">E Ha</name>
</author>
<author><name sortKey="Raab, H" uniqKey="Raab H">H Raab</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Murphy, Cg" uniqKey="Murphy C">CG Murphy</name>
</author>
<author><name sortKey="Modi, S" uniqKey="Modi S">S Modi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ayyar, Bv" uniqKey="Ayyar B">BV Ayyar</name>
</author>
<author><name sortKey="Arora, S" uniqKey="Arora S">S Arora</name>
</author>
<author><name sortKey="O Kennedy, R" uniqKey="O Kennedy R">R O'Kennedy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Elgundi, Z" uniqKey="Elgundi Z">Z Elgundi</name>
</author>
<author><name sortKey="Reslan, M" uniqKey="Reslan M">M Reslan</name>
</author>
<author><name sortKey="Cruz, E" uniqKey="Cruz E">E Cruz</name>
</author>
<author><name sortKey="Sifniotis, V" uniqKey="Sifniotis V">V Sifniotis</name>
</author>
<author><name sortKey="Kayser, V" uniqKey="Kayser V">V Kayser</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hendriks, D" uniqKey="Hendriks D">D Hendriks</name>
</author>
<author><name sortKey="Choi, G" uniqKey="Choi G">G Choi</name>
</author>
<author><name sortKey="De Bruyn, M" uniqKey="De Bruyn M">M de Bruyn</name>
</author>
<author><name sortKey="Wiersma, Vr" uniqKey="Wiersma V">VR Wiersma</name>
</author>
<author><name sortKey="Bremer, E" uniqKey="Bremer E">E Bremer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lambert, Jm" uniqKey="Lambert J">JM Lambert</name>
</author>
<author><name sortKey="Morris, Cq" uniqKey="Morris C">CQ Morris</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tolcher, Aw" uniqKey="Tolcher A">AW Tolcher</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Carter, P" uniqKey="Carter P">P Carter</name>
</author>
<author><name sortKey="Presta, L" uniqKey="Presta L">L Presta</name>
</author>
<author><name sortKey="Gorman, Cm" uniqKey="Gorman C">CM Gorman</name>
</author>
<author><name sortKey="Ridgway, Jb" uniqKey="Ridgway J">JB Ridgway</name>
</author>
<author><name sortKey="Henner, D" uniqKey="Henner D">D Henner</name>
</author>
<author><name sortKey="Wong, Wl" uniqKey="Wong W">WL Wong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Haddley, K" uniqKey="Haddley K">K Haddley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Barginear, Mf" uniqKey="Barginear M">MF Barginear</name>
</author>
<author><name sortKey="John, V" uniqKey="John V">V John</name>
</author>
<author><name sortKey="Budman, Dr" uniqKey="Budman D">DR Budman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Elsada, A" uniqKey="Elsada A">A Elsada</name>
</author>
<author><name sortKey="Doss, S" uniqKey="Doss S">S Doss</name>
</author>
<author><name sortKey="Robertson, J" uniqKey="Robertson J">J Robertson</name>
</author>
<author><name sortKey="Adam, Ej" uniqKey="Adam E">EJ Adam</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fabi, A" uniqKey="Fabi A">A Fabi</name>
</author>
<author><name sortKey="De Laurentiis, M" uniqKey="De Laurentiis M">M De Laurentiis</name>
</author>
<author><name sortKey="Caruso, M" uniqKey="Caruso M">M Caruso</name>
</author>
<author><name sortKey="Valle, E" uniqKey="Valle E">E Valle</name>
</author>
<author><name sortKey="Moscetti, L" uniqKey="Moscetti L">L Moscetti</name>
</author>
<author><name sortKey="Santini, D" uniqKey="Santini D">D Santini</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Krop, Ie" uniqKey="Krop I">IE Krop</name>
</author>
<author><name sortKey="Modi, S" uniqKey="Modi S">S Modi</name>
</author>
<author><name sortKey="Lorusso, Pm" uniqKey="Lorusso P">PM LoRusso</name>
</author>
<author><name sortKey="Pegram, M" uniqKey="Pegram M">M Pegram</name>
</author>
<author><name sortKey="Guardino, E" uniqKey="Guardino E">E Guardino</name>
</author>
<author><name sortKey="Althaus, B" uniqKey="Althaus B">B Althaus</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Muller, P" uniqKey="Muller P">P Muller</name>
</author>
<author><name sortKey="Kreuzaler, M" uniqKey="Kreuzaler M">M Kreuzaler</name>
</author>
<author><name sortKey="Khan, T" uniqKey="Khan T">T Khan</name>
</author>
<author><name sortKey="Thommen, Ds" uniqKey="Thommen D">DS Thommen</name>
</author>
<author><name sortKey="Martin, K" uniqKey="Martin K">K Martin</name>
</author>
<author><name sortKey="Glatz, K" uniqKey="Glatz K">K Glatz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Verma, S" uniqKey="Verma S">S Verma</name>
</author>
<author><name sortKey="Miles, D" uniqKey="Miles D">D Miles</name>
</author>
<author><name sortKey="Gianni, L" uniqKey="Gianni L">L Gianni</name>
</author>
<author><name sortKey="Krop, Ie" uniqKey="Krop I">IE Krop</name>
</author>
<author><name sortKey="Welslau, M" uniqKey="Welslau M">M Welslau</name>
</author>
<author><name sortKey="Baselga, J" uniqKey="Baselga J">J Baselga</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Barok, M" uniqKey="Barok M">M Barok</name>
</author>
<author><name sortKey="Joensuu, H" uniqKey="Joensuu H">H Joensuu</name>
</author>
<author><name sortKey="Isola, J" uniqKey="Isola J">J Isola</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name>
</author>
<author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name>
</author>
<author><name sortKey="Xu, Y" uniqKey="Xu Y">Y Xu</name>
</author>
<author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name>
</author>
<author><name sortKey="Chen, X" uniqKey="Chen X">X Chen</name>
</author>
<author><name sortKey="Quan, H" uniqKey="Quan H">H Quan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baldassarre, T" uniqKey="Baldassarre T">T Baldassarre</name>
</author>
<author><name sortKey="Truesdell, P" uniqKey="Truesdell P">P Truesdell</name>
</author>
<author><name sortKey="Craig, Aw" uniqKey="Craig A">AW Craig</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Melo, Gd" uniqKey="De Melo G">GD de Melo</name>
</author>
<author><name sortKey="Jardim, Dl" uniqKey="Jardim D">DL Jardim</name>
</author>
<author><name sortKey="Marchesi, Ms" uniqKey="Marchesi M">MS Marchesi</name>
</author>
<author><name sortKey="Hortobagyi, Gn" uniqKey="Hortobagyi G">GN Hortobagyi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sung, M" uniqKey="Sung M">M Sung</name>
</author>
<author><name sortKey="Tan, X" uniqKey="Tan X">X Tan</name>
</author>
<author><name sortKey="Lu, B" uniqKey="Lu B">B Lu</name>
</author>
<author><name sortKey="Golas, J" uniqKey="Golas J">J Golas</name>
</author>
<author><name sortKey="Hosselet, C" uniqKey="Hosselet C">C Hosselet</name>
</author>
<author><name sortKey="Wang, F" uniqKey="Wang F">F Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Diermeier, S" uniqKey="Diermeier S">S Diermeier</name>
</author>
<author><name sortKey="Horvath, G" uniqKey="Horvath G">G Horvath</name>
</author>
<author><name sortKey="Knuechel Clarke, R" uniqKey="Knuechel Clarke R">R Knuechel-Clarke</name>
</author>
<author><name sortKey="Hofstaedter, F" uniqKey="Hofstaedter F">F Hofstaedter</name>
</author>
<author><name sortKey="Szollosi, J" uniqKey="Szollosi J">J Szollosi</name>
</author>
<author><name sortKey="Brockhoff, G" uniqKey="Brockhoff G">G Brockhoff</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lecher, Jc" uniqKey="Lecher J">JC LeCher</name>
</author>
<author><name sortKey="Nowak, Sj" uniqKey="Nowak S">SJ Nowak</name>
</author>
<author><name sortKey="Mcmurry, Jl" uniqKey="Mcmurry J">JL McMurry</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Diessner, J" uniqKey="Diessner J">J Diessner</name>
</author>
<author><name sortKey="Bruttel, V" uniqKey="Bruttel V">V Bruttel</name>
</author>
<author><name sortKey="Stein, Rg" uniqKey="Stein R">RG Stein</name>
</author>
<author><name sortKey="Horn, E" uniqKey="Horn E">E Horn</name>
</author>
<author><name sortKey="Hausler, Sf" uniqKey="Hausler S">SF Hausler</name>
</author>
<author><name sortKey="Dietl, J" uniqKey="Dietl J">J Dietl</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gall, Va" uniqKey="Gall V">VA Gall</name>
</author>
<author><name sortKey="Philips, Av" uniqKey="Philips A">AV Philips</name>
</author>
<author><name sortKey="Qiao, N" uniqKey="Qiao N">N Qiao</name>
</author>
<author><name sortKey="Clise Dwyer, K" uniqKey="Clise Dwyer K">K Clise-Dwyer</name>
</author>
<author><name sortKey="Perakis, Aa" uniqKey="Perakis A">AA Perakis</name>
</author>
<author><name sortKey="Zhang, M" uniqKey="Zhang M">M Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jernstrom, S" uniqKey="Jernstrom S">S Jernstrom</name>
</author>
<author><name sortKey="Hongisto, V" uniqKey="Hongisto V">V Hongisto</name>
</author>
<author><name sortKey="Leivonen, Sk" uniqKey="Leivonen S">SK Leivonen</name>
</author>
<author><name sortKey="Due, Eu" uniqKey="Due E">EU Due</name>
</author>
<author><name sortKey="Tadele, Ds" uniqKey="Tadele D">DS Tadele</name>
</author>
<author><name sortKey="Edgren, H" uniqKey="Edgren H">H Edgren</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Subik, K" uniqKey="Subik K">K Subik</name>
</author>
<author><name sortKey="Lee, Jf" uniqKey="Lee J">JF Lee</name>
</author>
<author><name sortKey="Baxter, L" uniqKey="Baxter L">L Baxter</name>
</author>
<author><name sortKey="Strzepek, T" uniqKey="Strzepek T">T Strzepek</name>
</author>
<author><name sortKey="Costello, D" uniqKey="Costello D">D Costello</name>
</author>
<author><name sortKey="Crowley, P" uniqKey="Crowley P">P Crowley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, L" uniqKey="Chen L">L Chen</name>
</author>
<author><name sortKey="Zeng, W" uniqKey="Zeng W">W Zeng</name>
</author>
<author><name sortKey="Zheng, H" uniqKey="Zheng H">H Zheng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dalken, B" uniqKey="Dalken B">B Dalken</name>
</author>
<author><name sortKey="Giesubel, U" uniqKey="Giesubel U">U Giesubel</name>
</author>
<author><name sortKey="Knauer, Sk" uniqKey="Knauer S">SK Knauer</name>
</author>
<author><name sortKey="Wels, Ws" uniqKey="Wels W">WS Wels</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kapelski, S" uniqKey="Kapelski S">S Kapelski</name>
</author>
<author><name sortKey="De Almeida, M" uniqKey="De Almeida M">M de Almeida</name>
</author>
<author><name sortKey="Fischer, R" uniqKey="Fischer R">R Fischer</name>
</author>
<author><name sortKey="Barth, S" uniqKey="Barth S">S Barth</name>
</author>
<author><name sortKey="Fendel, R" uniqKey="Fendel R">R Fendel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schiffer, S" uniqKey="Schiffer S">S Schiffer</name>
</author>
<author><name sortKey="Rosinke, R" uniqKey="Rosinke R">R Rosinke</name>
</author>
<author><name sortKey="Jost, E" uniqKey="Jost E">E Jost</name>
</author>
<author><name sortKey="Hehmann Titt, G" uniqKey="Hehmann Titt G">G Hehmann-Titt</name>
</author>
<author><name sortKey="Huhn, M" uniqKey="Huhn M">M Huhn</name>
</author>
<author><name sortKey="Melmer, G" uniqKey="Melmer G">G Melmer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stahnke, B" uniqKey="Stahnke B">B Stahnke</name>
</author>
<author><name sortKey="Thepen, T" uniqKey="Thepen T">T Thepen</name>
</author>
<author><name sortKey="Stocker, M" uniqKey="Stocker M">M Stocker</name>
</author>
<author><name sortKey="Rosinke, R" uniqKey="Rosinke R">R Rosinke</name>
</author>
<author><name sortKey="Jost, E" uniqKey="Jost E">E Jost</name>
</author>
<author><name sortKey="Fischer, R" uniqKey="Fischer R">R Fischer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lambert, Jm" uniqKey="Lambert J">JM Lambert</name>
</author>
<author><name sortKey="Chari, Rv" uniqKey="Chari R">RV Chari</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kaiserman, D" uniqKey="Kaiserman D">D Kaiserman</name>
</author>
<author><name sortKey="Bird, Ch" uniqKey="Bird C">CH Bird</name>
</author>
<author><name sortKey="Sun, J" uniqKey="Sun J">J Sun</name>
</author>
<author><name sortKey="Matthews, A" uniqKey="Matthews A">A Matthews</name>
</author>
<author><name sortKey="Ung, K" uniqKey="Ung K">K Ung</name>
</author>
<author><name sortKey="Whisstock, Jc" uniqKey="Whisstock J">JC Whisstock</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
<li>États-Unis</li>
</country>
<region><li>Guangdong</li>
<li>Texas</li>
</region>
<settlement><li>Shenzhen</li>
</settlement>
</list>
<tree><country name="États-Unis"><region name="Texas"><name sortKey="Cheung, Lawrence H" sort="Cheung, Lawrence H" uniqKey="Cheung L" first="Lawrence H." last="Cheung">Lawrence H. Cheung</name>
</region>
<name sortKey="Alvarez Cienfuegos, Ana" sort="Alvarez Cienfuegos, Ana" uniqKey="Alvarez Cienfuegos A" first="Ana" last="Alvarez-Cienfuegos">Ana Alvarez-Cienfuegos</name>
<name sortKey="Cao, Yu J" sort="Cao, Yu J" uniqKey="Cao Y" first="Yu J." last="Cao">Yu J. Cao</name>
<name sortKey="Hittelman, Walter N" sort="Hittelman, Walter N" uniqKey="Hittelman W" first="Walter N." last="Hittelman">Walter N. Hittelman</name>
<name sortKey="Mohamedali, Khalid A" sort="Mohamedali, Khalid A" uniqKey="Mohamedali K" first="Khalid A." last="Mohamedali">Khalid A. Mohamedali</name>
<name sortKey="Rosenblum, Michael G" sort="Rosenblum, Michael G" uniqKey="Rosenblum M" first="Michael G." last="Rosenblum">Michael G. Rosenblum</name>
<name sortKey="Zhao, Yunli" sort="Zhao, Yunli" uniqKey="Zhao Y" first="Yunli" last="Zhao">Yunli Zhao</name>
</country>
<country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Cao, Yu J" sort="Cao, Yu J" uniqKey="Cao Y" first="Yu J." last="Cao">Yu J. Cao</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000860 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 000860 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Ncbi |étape= Checkpoint |type= RBID |clé= PMC:6668111 |texte= Development of a human immuno-oncology therapeutic agent targeting HER2: targeted delivery of granzyme B }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:31362764" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a ChloroquineV1
This area was generated with Dilib version V0.6.33. |