Paclitaxel-Trastuzumab Mixed Nanovehicle to Target HER2-Overexpressing Tumors
Identifieur interne : 000746 ( Ncbi/Checkpoint ); précédent : 000745; suivant : 000747Paclitaxel-Trastuzumab Mixed Nanovehicle to Target HER2-Overexpressing Tumors
Auteurs : Celia Nieto [Espagne] ; Ariana Centa [Espagne] ; Jesús A. Rodríguez-Rodríguez [Espagne] ; Atanasio Pandiella [Espagne] ; Eva M. Martín Del Valle [Espagne]Source :
- Nanomaterials [ 2079-4991 ] ; 2019.
Abstract
Paclitaxel is one of the most widely used chemotherapeutic agents thanks to its effectiveness and broad spectrum of antitumor activity. However, it has a very poor aqueous solubility and a limited specificity. To solve these handicaps, a novel paclitaxel-trastuzumab targeted transport nanosystem has been developed and characterized in this work to specifically treat cancer cells that overexpress the human epidermal growth factor receptor-2 (HER2). Methods: Alginate and piperazine nanoparticles were synthetized and conjugated with paclitaxel:β-cyclodextrins complexes and trastuzumab. Conjugated nanoparticles (300 nm) were characterized and their internalization in HER2-overexpressing tumor cells was analyzed by immunofluorescence. Its specific antitumor activity was studied
Url:
DOI: 10.3390/nano9070948
PubMed: 31261957
PubMed Central: 6669497
Affiliations:
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PMC:6669497Le document en format XML
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<author><name sortKey="Martin Del Valle, Eva M" sort="Martin Del Valle, Eva M" uniqKey="Martin Del Valle E" first="Eva M." last="Martín Del Valle">Eva M. Martín Del Valle</name>
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<series><title level="j">Nanomaterials</title>
<idno type="eISSN">2079-4991</idno>
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<front><div type="abstract" xml:lang="en"><p>Paclitaxel is one of the most widely used chemotherapeutic agents thanks to its effectiveness and broad spectrum of antitumor activity. However, it has a very poor aqueous solubility and a limited specificity. To solve these handicaps, a novel paclitaxel-trastuzumab targeted transport nanosystem has been developed and characterized in this work to specifically treat cancer cells that overexpress the human epidermal growth factor receptor-2 (HER2). Methods: Alginate and piperazine nanoparticles were synthetized and conjugated with paclitaxel:β-cyclodextrins complexes and trastuzumab. Conjugated nanoparticles (300 nm) were characterized and their internalization in HER2-overexpressing tumor cells was analyzed by immunofluorescence. Its specific antitumor activity was studied <italic>in vitro</italic>
using human cell lines with different levels of HER2-expression. Results: In comparison with free paclitaxel:β-cyclodextrins complexes, the developed conjugated nanovehicle presented specificity for the treatment of HER2-overpressing cells, in which it was internalized by endocytosis. Conclusions: It seems that potentially avoiding the conventional adverse effects of paclitaxel treatment could be possible with the use of the proposed mixed nanovehicle, which improves its bioavailability and targets HER2-positive cancer cells.</p>
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</back>
</TEI>
<affiliations><list><country><li>Espagne</li>
</country>
<region><li>Castille-et-León</li>
</region>
</list>
<tree><country name="Espagne"><region name="Castille-et-León"><name sortKey="Nieto, Celia" sort="Nieto, Celia" uniqKey="Nieto C" first="Celia" last="Nieto">Celia Nieto</name>
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</record>
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