Recent Advances in Understanding FOXN3 in Breast Cancer, and Other Malignancies
Identifieur interne : 000714 ( Ncbi/Checkpoint ); précédent : 000713; suivant : 000715Recent Advances in Understanding FOXN3 in Breast Cancer, and Other Malignancies
Auteurs : Xiangyi Kong [République populaire de Chine] ; Jie Zhai [République populaire de Chine] ; Chengrui Yan [République populaire de Chine] ; Yan Song [République populaire de Chine] ; Jing Wang [République populaire de Chine] ; Xiaofeng Bai [République populaire de Chine] ; James A. L. Brown [Irlande (pays)] ; Yi Fang [République populaire de Chine]Source :
- Frontiers in Oncology [ 2234-943X ] ; 2019.
Abstract
FOXN3 (forkhead box N3; CHES1: check point suppressor 1) belongs to the forkhead box (FOX) protein family. FOXN3 displays transcriptional inhibitory activity, and is involved in cell cycle regulation and tumorigenesis. FOXN3 is a tumor suppresser and alterations in FOXN3 are found in of a variety of cancers including melanoma, osteosarcoma, and hepatocellular carcinoma. While the roles of FOXN3 role in some cancers have been explored, its role in breast cancer remains unclear. Here we describe current state of knowledge of FOXN3 functions, and focus on its roles (known and potential) in breast cancer.
Url:
DOI: 10.3389/fonc.2019.00234
PubMed: 31214487
PubMed Central: 6555274
Affiliations:
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PMC:6555274Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>FOXN3 (forkhead box N3; CHES1: check point suppressor 1) belongs to the forkhead box (FOX) protein family. FOXN3 displays transcriptional inhibitory activity, and is involved in cell cycle regulation and tumorigenesis. FOXN3 is a tumor suppresser and alterations in FOXN3 are found in of a variety of cancers including melanoma, osteosarcoma, and hepatocellular carcinoma. While the roles of FOXN3 role in some cancers have been explored, its role in breast cancer remains unclear. Here we describe current state of knowledge of FOXN3 functions, and focus on its roles (known and potential) in breast cancer.</p>
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</back>
</TEI>
<affiliations><list><country><li>Irlande (pays)</li>
<li>République populaire de Chine</li>
</country>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Kong, Xiangyi" sort="Kong, Xiangyi" uniqKey="Kong X" first="Xiangyi" last="Kong">Xiangyi Kong</name>
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<name sortKey="Song, Yan" sort="Song, Yan" uniqKey="Song Y" first="Yan" last="Song">Yan Song</name>
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</affiliations>
</record>
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