Sirt6-induced autophagy restricted TREM-1-mediated pyroptosis in ox-LDL-treated endothelial cells: relevance to prognostication of patients with acute myocardial infarction
Identifieur interne : 000545 ( Ncbi/Checkpoint ); précédent : 000544; suivant : 000546Sirt6-induced autophagy restricted TREM-1-mediated pyroptosis in ox-LDL-treated endothelial cells: relevance to prognostication of patients with acute myocardial infarction
Auteurs : Ye Zi ; Yao Yi-An ; Ji Bing ; Lai Yan ; Tong Jing ; Guan Chun-Yu ; Ping Fan ; Lin Hao ; Tang Jia-Ni ; Hou Han-Jin ; Chen Fei ; Liu Xue-BoSource :
- Cell Death Discovery [ 2058-7716 ] ; 2019.
Abstract
Inflammation mediated by myeloid cells trigger receptors 1 (TREM-1) is important for atherosclerosis development, while sirtuin 6 (Sirt6) levels decrease in atheroscleoritc plaque. Here we demonstrate that oxidatively modified low density lipoprotein (ox-LDL)-treated endothelial cells (ECs) exhibited increased TREM-1-mediated pyroptosis and decreased Sirt6-induced autophagy. We show that high sTREM-1 and low sSirt6 levels were independent predictors of boosted endothelial microparticles (EMPs) on admission, and were associated with increased risk for all-cause mortality and major adverse cardiovascular events (MACE) at median 24 months (interquartile range, 18–26) follow-up in acute myocardial infarction (AMI) patients. Additionally, blockage of Sirt6-induced autophagy led to augmented TREM-1-mediated pyroptosis, whereas Sirt6 overexpression attenuated ECs inflammation and pyroptosis following ox-LDL treatment. Our findings indicate that TREM-1 and in a reversed trend Sirt6 appeared to be markers of endothelial inflammation with potential for use in risk stratification.
Url:
DOI: 10.1038/s41420-019-0168-4
PubMed: 30993014
PubMed Central: 6461678
Affiliations:
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Bing</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Yan, Lai" sort="Yan, Lai" uniqKey="Yan L" first="Lai" last="Yan">Lai Yan</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Jing, Tong" sort="Jing, Tong" uniqKey="Jing T" first="Tong" last="Jing">Tong Jing</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Chun Yu, Guan" sort="Chun Yu, Guan" uniqKey="Chun Yu G" first="Guan" last="Chun-Yu">Guan Chun-Yu</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Fan, Ping" sort="Fan, Ping" uniqKey="Fan P" first="Ping" last="Fan">Ping Fan</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Hao, Lin" sort="Hao, Lin" uniqKey="Hao L" first="Lin" last="Hao">Lin Hao</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Jia Ni, Tang" sort="Jia Ni, Tang" uniqKey="Jia Ni T" first="Tang" last="Jia-Ni">Tang Jia-Ni</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Han Jin, Hou" sort="Han Jin, Hou" uniqKey="Han Jin H" first="Hou" last="Han-Jin">Hou Han-Jin</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Fei, Chen" sort="Fei, Chen" uniqKey="Fei C" first="Chen" last="Fei">Chen Fei</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Xue Bo, Liu" sort="Xue Bo, Liu" uniqKey="Xue Bo L" first="Liu" last="Xue-Bo">Liu Xue-Bo</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Cell Death Discovery</title><idno type="eISSN">2058-7716</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Inflammation mediated by myeloid cells trigger receptors 1 (TREM-1) is important for atherosclerosis development, while sirtuin 6 (Sirt6) levels decrease in atheroscleoritc plaque. Here we demonstrate that oxidatively modified low density lipoprotein (ox-LDL)-treated endothelial cells (ECs) exhibited increased TREM-1-mediated pyroptosis and decreased Sirt6-induced autophagy. We show that high sTREM-1 and low sSirt6 levels were independent predictors of boosted endothelial microparticles (EMPs) on admission, and were associated with increased risk for all-cause mortality and major adverse cardiovascular events (MACE) at median 24 months (interquartile range, 18–26) follow-up in acute myocardial infarction (AMI) patients. Additionally, blockage of Sirt6-induced autophagy led to augmented TREM-1-mediated pyroptosis, whereas Sirt6 overexpression attenuated ECs inflammation and pyroptosis following ox-LDL treatment. Our findings indicate that TREM-1 and in a reversed trend Sirt6 appeared to be markers of endothelial inflammation with potential for use in risk stratification.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Libby, P" uniqKey="Libby P">P Libby</name></author><author><name sortKey="Ridker, Pm" uniqKey="Ridker P">PM Ridker</name></author><author><name sortKey="Hansson, Gk" uniqKey="Hansson G">GK Hansson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ridker, Pm" uniqKey="Ridker P">PM Ridker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, My" uniqKey="Wu M">MY Wu</name></author><author><name sortKey="Li, Cj" uniqKey="Li C">CJ Li</name></author><author><name sortKey="Hou, Mf" uniqKey="Hou M">MF Hou</name></author><author><name sortKey="Chu, Py" uniqKey="Chu P">PY Chu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Yk" uniqKey="Wang Y">YK Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tong, J" uniqKey="Tong J">J Tong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Welsh, P" uniqKey="Welsh P">P Welsh</name></author><author><name sortKey="Grassia, G" uniqKey="Grassia G">G Grassia</name></author><author><name sortKey="Botha, S" uniqKey="Botha S">S Botha</name></author><author><name sortKey="Sattar, N" uniqKey="Sattar N">N Sattar</name></author><author><name sortKey="Maffia, P" uniqKey="Maffia P">P Maffia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miao, Ea" uniqKey="Miao E">EA Miao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miao, Ea" uniqKey="Miao E">EA Miao</name></author><author><name sortKey="Rajan, Jv" uniqKey="Rajan J">JV Rajan</name></author><author><name sortKey="Aderem, A" uniqKey="Aderem A">A Aderem</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, X" uniqKey="Wu X">X Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, J" uniqKey="Lin J">J Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Claude Taupin, A" uniqKey="Claude Taupin A">A Claude-Taupin</name></author><author><name sortKey="Bissa, B" uniqKey="Bissa B">B Bissa</name></author><author><name sortKey="Jia, J" uniqKey="Jia J">J Jia</name></author><author><name sortKey="Gu, Y" uniqKey="Gu Y">Y Gu</name></author><author><name sortKey="Deretic, V" uniqKey="Deretic V">V Deretic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, F" uniqKey="Chen F">F Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Galluzzi, L" uniqKey="Galluzzi L">L Galluzzi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gibot, S" uniqKey="Gibot S">S Gibot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Joffre, J" uniqKey="Joffre J">J Joffre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, F" uniqKey="Wang F">F Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Conti, V" uniqKey="Conti V">V Conti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="D Nofrio, N" uniqKey="D Nofrio N">N D’Onofrio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thygesen, K" uniqKey="Thygesen K">K Thygesen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bergsbaken, T" uniqKey="Bergsbaken T">T Bergsbaken</name></author><author><name sortKey="Fink, Sl" uniqKey="Fink S">SL Fink</name></author><author><name sortKey="Cookson, Bt" uniqKey="Cookson B">BT Cookson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shi, J" uniqKey="Shi J">J Shi</name></author><author><name sortKey="Gao, W" uniqKey="Gao W">W Gao</name></author><author><name sortKey="Shao, F" uniqKey="Shao F">F Shao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lai, D" uniqKey="Lai D">D Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zanoni, I" uniqKey="Zanoni I">I Zanoni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, Wt" uniqKey="He W">WT He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boufenzer, A" uniqKey="Boufenzer A">A Boufenzer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zysset, D" uniqKey="Zysset D">D Zysset</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thorsen, Su" uniqKey="Thorsen S">SU Thorsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Subramanian, S" uniqKey="Subramanian S">S Subramanian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kutikhin, Ad" uniqKey="Kutikhin A">AD Kutikhin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ohtani, K" uniqKey="Ohtani K">K Ohtani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Delgado, M" uniqKey="Delgado M">M Delgado</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tammaro, A" uniqKey="Tammaro A">A Tammaro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kokten, T" uniqKey="Kokten T">T Kökten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name></author><author><name sortKey="Zhu, X" uniqKey="Zhu X">X Zhu</name></author><author><name sortKey="Xiong, L" uniqKey="Xiong L">L Xiong</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Ren, J" uniqKey="Ren J">J Ren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pu, Q" uniqKey="Pu Q">Q Pu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suzuki, T" uniqKey="Suzuki T">T Suzuki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yuan, L" uniqKey="Yuan L">L Yuan</name></author><author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name></author><author><name sortKey="Deng, H" uniqKey="Deng H">H Deng</name></author><author><name sortKey="Gao, C" uniqKey="Gao C">C Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, C" uniqKey="Jiang C">C Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, Wt" uniqKey="Wong W">WT Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamamoto, H" uniqKey="Yamamoto H">H Yamamoto</name></author><author><name sortKey="Schoonjans, K" uniqKey="Schoonjans K">K Schoonjans</name></author><author><name sortKey="Auwerx, J" uniqKey="Auwerx J">J Auwerx</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, J" uniqKey="He J">J He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kang, L" uniqKey="Kang L">L Kang</name></author><author><name sortKey="Hu, J" uniqKey="Hu J">J Hu</name></author><author><name sortKey="Weng, Y" uniqKey="Weng Y">Y Weng</name></author><author><name sortKey="Jia, J" uniqKey="Jia J">J Jia</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name 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