Peripheral blood lymphocyte subpopulations in sarcoidosis
Identifieur interne : 003B15 ( Main/Merge ); précédent : 003B14; suivant : 003B16Peripheral blood lymphocyte subpopulations in sarcoidosis
Auteurs : K. Ramachandar [États-Unis] ; S. D. Douglas [États-Unis] ; L. E. Siltzbach [États-Unis] ; R. N. Taub [États-Unis]Source :
- Cellular Immunology [ 0008-8749 ] ; 1975.
English descriptors
- Teeft :
- Absolute numbers, Cell depletion, Cell numbers, Clinical stage, Drug treatment, Glade, Henle, Immunoglobulin, Kveim, Kveim reactivity, Lancet, Lepromatous leprosy, Lymph nodes, Lymphocyte, Lymphocyte subpopulations, Node, Peripheral blood, Rosette, Sarcoidosis, Sarcoidosis patients, Short communications, Siltzbach, Ster, Subpopulation, Total lymphocyte count.
Abstract
Abstract: We have determined the numbers of thymus-derived (T) and bone marrow-derived (B) lymphocytes in the peripheral blood of 20 patients with sarcoidosis and 15 healthy controls. T cells were estimated from the number of lymphocytes forming rosettes in vitro with unsensitized sheep red blood cells, and B cells were enumerated by immunofluorescent assesssment of membrane-bound immunoglobulins. The total lymphocyte count was lower in patients with sarcoidosis owing to a depletion of T lymphocytes from the blood. Nonetheless, the relative and absolute numbers of B lymphocytes were significantly increased. These alterations in lymphocyte subpopulations did not show any consistent correlation with the duration of the disease, clinical stage, activity, or treatment. Changes in the subpopulations may be related to both decreased cellular immunity and increased reactivity of the antibody-forming system as commonly seen in sarcoidosis.
Url:
DOI: 10.1016/0008-8749(75)90131-8
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002178
- to stream Istex, to step Curation: 002178
- to stream Istex, to step Checkpoint: 002782
Links to Exploration step
ISTEX:75CDF84DEBE9B46FF39F3CD4E6586FFCEDB543FALe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Peripheral blood lymphocyte subpopulations in sarcoidosis</title><author><name sortKey="Ramachandar, K" sort="Ramachandar, K" uniqKey="Ramachandar K" first="K." last="Ramachandar">K. Ramachandar</name></author><author><name sortKey="Douglas, S D" sort="Douglas, S D" uniqKey="Douglas S" first="S. D." last="Douglas">S. D. Douglas</name></author><author><name sortKey="Siltzbach, L E" sort="Siltzbach, L E" uniqKey="Siltzbach L" first="L. E." last="Siltzbach">L. E. Siltzbach</name></author><author><name sortKey="Taub, R N" sort="Taub, R N" uniqKey="Taub R" first="R. N." last="Taub">R. N. Taub</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:75CDF84DEBE9B46FF39F3CD4E6586FFCEDB543FA</idno><date when="1975" year="1975">1975</date><idno type="doi">10.1016/0008-8749(75)90131-8</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-VNZB6HVG-6/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">002178</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002178</idno><idno type="wicri:Area/Istex/Curation">002178</idno><idno type="wicri:Area/Istex/Checkpoint">002782</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">002782</idno><idno type="wicri:doubleKey">0008-8749:1975:Ramachandar K:peripheral:blood:lymphocyte</idno><idno type="wicri:Area/Main/Merge">003B15</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Peripheral blood lymphocyte subpopulations in sarcoidosis</title><author><name sortKey="Ramachandar, K" sort="Ramachandar, K" uniqKey="Ramachandar K" first="K." last="Ramachandar">K. Ramachandar</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Divisions of Hematology and Thoracic Diseases, Department of Medicine, Mount Sinai School of Medicine of The City University of New York, New York</wicri:cityArea></affiliation></author><author><name sortKey="Douglas, S D" sort="Douglas, S D" uniqKey="Douglas S" first="S. D." last="Douglas">S. D. Douglas</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Divisions of Hematology and Thoracic Diseases, Department of Medicine, Mount Sinai School of Medicine of The City University of New York, New York</wicri:cityArea></affiliation></author><author><name sortKey="Siltzbach, L E" sort="Siltzbach, L E" uniqKey="Siltzbach L" first="L. E." last="Siltzbach">L. E. Siltzbach</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Divisions of Hematology and Thoracic Diseases, Department of Medicine, Mount Sinai School of Medicine of The City University of New York, New York</wicri:cityArea></affiliation></author><author><name sortKey="Taub, R N" sort="Taub, R N" uniqKey="Taub R" first="R. N." last="Taub">R. N. Taub</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Divisions of Hematology and Thoracic Diseases, Department of Medicine, Mount Sinai School of Medicine of The City University of New York, New York</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Cellular Immunology</title><title level="j" type="abbrev">YCIMM</title><idno type="ISSN">0008-8749</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1975">1975</date><biblScope unit="volume">16</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="422">422</biblScope><biblScope unit="page" to="426">426</biblScope></imprint><idno type="ISSN">0008-8749</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0008-8749</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Absolute numbers</term><term>Cell depletion</term><term>Cell numbers</term><term>Clinical stage</term><term>Drug treatment</term><term>Glade</term><term>Henle</term><term>Immunoglobulin</term><term>Kveim</term><term>Kveim reactivity</term><term>Lancet</term><term>Lepromatous leprosy</term><term>Lymph nodes</term><term>Lymphocyte</term><term>Lymphocyte subpopulations</term><term>Node</term><term>Peripheral blood</term><term>Rosette</term><term>Sarcoidosis</term><term>Sarcoidosis patients</term><term>Short communications</term><term>Siltzbach</term><term>Ster</term><term>Subpopulation</term><term>Total lymphocyte count</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: We have determined the numbers of thymus-derived (T) and bone marrow-derived (B) lymphocytes in the peripheral blood of 20 patients with sarcoidosis and 15 healthy controls. T cells were estimated from the number of lymphocytes forming rosettes in vitro with unsensitized sheep red blood cells, and B cells were enumerated by immunofluorescent assesssment of membrane-bound immunoglobulins. The total lymphocyte count was lower in patients with sarcoidosis owing to a depletion of T lymphocytes from the blood. Nonetheless, the relative and absolute numbers of B lymphocytes were significantly increased. These alterations in lymphocyte subpopulations did not show any consistent correlation with the duration of the disease, clinical stage, activity, or treatment. Changes in the subpopulations may be related to both decreased cellular immunity and increased reactivity of the antibody-forming system as commonly seen in sarcoidosis.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003B15 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 003B15 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Merge
|type= RBID
|clé= ISTEX:75CDF84DEBE9B46FF39F3CD4E6586FFCEDB543FA
|texte= Peripheral blood lymphocyte subpopulations in sarcoidosis
}}
| This area was generated with Dilib version V0.6.33. |  |