Hydroxychloroquine ototoxicity in a child with idiopathic pulmonary haemosiderosis
Identifieur interne : 002278 ( Main/Merge ); précédent : 002277; suivant : 002279Hydroxychloroquine ototoxicity in a child with idiopathic pulmonary haemosiderosis
Auteurs : Miguel B. Coutinho [Portugal] ; Idalinda Duarte [Portugal]Source :
- International journal of pediatric otorhinolaryngology [ 0165-5876 ] ; 2002.
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- Pascal (Inist)
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Abstract
Hydroxychloroquine, a quinoline compound, rarely causes ototoxicity. According to the few reports in existence, hydroxychloroquine-induced ototoxicity occurred following prolonged therapy in adult patients with rheumatoid arthritis and lupus erythematosus. We report a case of unilateral sensorineural hearing loss in a 7-year-old girl with idiopathic pulmonary haemosiderosis, after 2 years of hydroxychloroquine treatment. Sensorineural hearing loss has previously been reported with hydroxychloroquine treatment, but this is the first report in a child and associated to idiopathic pulmonary haemosiderosis and has the characteristic of being unilateral.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Hydroxychloroquine ototoxicity in a child with idiopathic pulmonary haemosiderosis</title><author><name sortKey="Coutinho, Miguel B" sort="Coutinho, Miguel B" uniqKey="Coutinho M" first="Miguel B." last="Coutinho">Miguel B. Coutinho</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Otolaryngology, Hospital de Crianças Maria Pia, Rua da Boavista 827</s1><s2>4050-111 Porto</s2><s3>PRT</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Portugal</country><wicri:noRegion>4050-111 Porto</wicri:noRegion></affiliation></author><author><name sortKey="Duarte, Idalinda" sort="Duarte, Idalinda" uniqKey="Duarte I" first="Idalinda" last="Duarte">Idalinda Duarte</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Otolaryngology, Hospital de Crianças Maria Pia, Rua da Boavista 827</s1><s2>4050-111 Porto</s2><s3>PRT</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Portugal</country><wicri:noRegion>4050-111 Porto</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">02-0175389</idno><date when="2002">2002</date><idno type="stanalyst">PASCAL 02-0175389 INIST</idno><idno type="RBID">Pascal:02-0175389</idno><idno type="wicri:Area/PascalFrancis/Corpus">000056</idno><idno type="wicri:Area/PascalFrancis/Curation">000010</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000056</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000056</idno><idno type="wicri:doubleKey">0165-5876:2002:Coutinho M:hydroxychloroquine:ototoxicity:in</idno><idno type="wicri:Area/Main/Merge">002278</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Hydroxychloroquine ototoxicity in a child with idiopathic pulmonary haemosiderosis</title><author><name sortKey="Coutinho, Miguel B" sort="Coutinho, Miguel B" uniqKey="Coutinho M" first="Miguel B." last="Coutinho">Miguel B. Coutinho</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Otolaryngology, Hospital de Crianças Maria Pia, Rua da Boavista 827</s1><s2>4050-111 Porto</s2><s3>PRT</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Portugal</country><wicri:noRegion>4050-111 Porto</wicri:noRegion></affiliation></author><author><name sortKey="Duarte, Idalinda" sort="Duarte, Idalinda" uniqKey="Duarte I" first="Idalinda" last="Duarte">Idalinda Duarte</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Otolaryngology, Hospital de Crianças Maria Pia, Rua da Boavista 827</s1><s2>4050-111 Porto</s2><s3>PRT</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Portugal</country><wicri:noRegion>4050-111 Porto</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">International journal of pediatric otorhinolaryngology</title><title level="j" type="abbreviated">Int. j. pediatr. otorhinolaryngol.</title><idno type="ISSN">0165-5876</idno><imprint><date when="2002">2002</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">International journal of pediatric otorhinolaryngology</title><title level="j" type="abbreviated">Int. j. pediatr. otorhinolaryngol.</title><idno type="ISSN">0165-5876</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age 2-9</term><term>Audiometry</term><term>Case study</term><term>Chemotherapy</term><term>Complication</term><term>Diagnosis</term><term>Ear</term><term>Exploration</term><term>Female</term><term>Hemosiderosis</term><term>Hydroxychloroquine</term><term>Idiopathic</term><term>Lung</term><term>Ototoxicity</term><term>Perception hearing loss</term><term>Pigments</term><term>Quinolone derivatives</term><term>Secondary effect</term><term>Symptomatology</term><term>Treatment</term><term>Unilateral</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Hémosidérose</term><term>Poumon</term><term>Idiopathique</term><term>Traitement</term><term>Chimiothérapie</term><term>Hydroxychloroquine</term><term>Quinolone dérivé</term><term>Complication</term><term>Symptomatologie</term><term>Surdité perception</term><term>Unilatéral</term><term>Effet secondaire</term><term>Ototoxicité</term><term>Exploration</term><term>Diagnostic</term><term>Etude cas</term><term>Femelle</term><term>Age 2-9</term><term>Audiométrie</term><term>Pigment</term><term>Oreille</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hydroxychloroquine, a quinoline compound, rarely causes ototoxicity. According to the few reports in existence, hydroxychloroquine-induced ototoxicity occurred following prolonged therapy in adult patients with rheumatoid arthritis and lupus erythematosus. We report a case of unilateral sensorineural hearing loss in a 7-year-old girl with idiopathic pulmonary haemosiderosis, after 2 years of hydroxychloroquine treatment. Sensorineural hearing loss has previously been reported with hydroxychloroquine treatment, but this is the first report in a child and associated to idiopathic pulmonary haemosiderosis and has the characteristic of being unilateral.</div></front></TEI><affiliations><list><country><li>Portugal</li></country></list><tree><country name="Portugal"><noRegion><name sortKey="Coutinho, Miguel B" sort="Coutinho, Miguel B" uniqKey="Coutinho M" first="Miguel B." last="Coutinho">Miguel B. Coutinho</name></noRegion><name sortKey="Duarte, Idalinda" sort="Duarte, Idalinda" uniqKey="Duarte I" first="Idalinda" last="Duarte">Idalinda Duarte</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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