Severe sepsis and Toll-like receptors
Identifieur interne : 001B12 ( Main/Merge ); précédent : 001B11; suivant : 001B13Severe sepsis and Toll-like receptors
Auteurs : Hongmei Gao [Royaume-Uni] ; Susannah K. Leaver [Royaume-Uni] ; Anne Burke-Gaffney [Royaume-Uni] ; Simon J. Finney [Royaume-Uni]Source :
- Seminars in Immunopathology [ 1863-2297 ] ; 2008-02-01.
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Abstract
Abstract: Severe sepsis dominates the mortality of non-cardiac intensive care units. The ingenious Toll-like receptor (TLR) system can recognise many infectious organisms through relatively few receptors to trigger pro-inflammatory and anti-inflammatory cytokine release. Further complexity arises from positive and negative signalling feedback loops. Severe sepsis may be a consequence of an inappropriately excessive response or inadequate endogenous negative feedback. Therapies targeting these pathways are currently being evaluated. Alternatively, in clinical scenarios such as compensatory anti-inflammatory response syndrome, chronic viral sepsis or inadequate vaccine function, TLR signalling may be inadequate. TLR agonists may augment the innate response and are being investigated.
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DOI: 10.1007/s00281-007-0101-4
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