Distinct Expression of Mas1-Related G-Protein-Coupled Receptor B4 in Dorsal Root and Trigeminal Ganglia—Implications for Altered Behaviors in Acid-Sensing Ion Channel 3-Deficient Mice
Identifieur interne : 001231 ( Main/Merge ); précédent : 001230; suivant : 001232Distinct Expression of Mas1-Related G-Protein-Coupled Receptor B4 in Dorsal Root and Trigeminal Ganglia—Implications for Altered Behaviors in Acid-Sensing Ion Channel 3-Deficient Mice
Auteurs : Ya-Han Huang [Taïwan] ; Chin-Yu Chang [Taïwan] ; Chih-Cheng Chen [Taïwan] ; Chih-Dong Yang [Taïwan] ; Wei-Hsin Sun [Taïwan]Source :
- Journal of Molecular Neuroscience [ 0895-8696 ] ; 2013-11-01.
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Abstract
Abstract: Mas1-related G-protein-coupled receptors (Mrgprs), comprising more than 50 distinct members, are specifically expressed in primary sensory neurons. Reflecting the diversity and specificity of stimuli they detect, Mrgprs are involved in pain, touch, and itch-related behaviors. Sensory–neuron-specific acid-sensing ion channel 3 (ASIC3) is essential for touch and inflammatory pain, but mice lacking ASIC3 have complex behavioral alterations in various modalities of pain and touch. To understand whether Mrgprs are involved in complex behavioral alterations found in ASIC3-deficient mice, we examined Mrgpr gene expression in ASIC3−/− mice. Only MrgprB4 expression has shown significant change. MrgprB4 expression was increased in ASIC3−/− dorsal root ganglia (DRG) but decreased in ASIC3−/− trigeminal ganglia. The distinct alterations in DRG and trigeminal ganglia imply that MrgprB4 could have multiple functions. Given that MrgprB4 is expressed in neurons that may detect gentle touch and that ASIC3−/− mice have altered sensitivity of mechanoreceptors for light touch, the expression change of MrgprB4 is more likely related to the altered touch behaviors of ASIC3−/− mice.
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DOI: 10.1007/s12031-013-0070-0
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Distinct Expression of Mas1-Related G-Protein-Coupled Receptor B4 in Dorsal Root and Trigeminal Ganglia—Implications for Altered Behaviors in Acid-Sensing Ion Channel 3-Deficient Mice</title><author><name sortKey="Huang, Ya Han" sort="Huang, Ya Han" uniqKey="Huang Y" first="Ya-Han" last="Huang">Ya-Han Huang</name></author><author><name sortKey="Chang, Chin Yu" sort="Chang, Chin Yu" uniqKey="Chang C" first="Chin-Yu" last="Chang">Chin-Yu Chang</name></author><author><name sortKey="Chen, Chih Cheng" sort="Chen, Chih Cheng" uniqKey="Chen C" first="Chih-Cheng" last="Chen">Chih-Cheng Chen</name></author><author><name sortKey="Yang, Chih Dong" sort="Yang, Chih Dong" uniqKey="Yang C" first="Chih-Dong" last="Yang">Chih-Dong Yang</name></author><author><name sortKey="Sun, Wei Hsin" sort="Sun, Wei Hsin" uniqKey="Sun W" first="Wei-Hsin" last="Sun">Wei-Hsin Sun</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:8D581CF7D8D9F6E7566B53244D62DA2DAFF64F0C</idno><date when="2013" year="2013">2013</date><idno type="doi">10.1007/s12031-013-0070-0</idno><idno type="url">https://api.istex.fr/ark:/67375/VQC-324BMQ1Q-R/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">002922</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002922</idno><idno type="wicri:Area/Istex/Curation">002922</idno><idno type="wicri:Area/Istex/Checkpoint">000282</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000282</idno><idno type="wicri:doubleKey">0895-8696:2013:Huang Y:distinct:expression:of</idno><idno type="wicri:Area/Main/Merge">001231</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Distinct Expression of Mas1-Related G-Protein-Coupled Receptor B4 in Dorsal Root and Trigeminal Ganglia—Implications for Altered Behaviors in Acid-Sensing Ion Channel 3-Deficient Mice</title><author><name sortKey="Huang, Ya Han" sort="Huang, Ya Han" uniqKey="Huang Y" first="Ya-Han" last="Huang">Ya-Han Huang</name><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Life Sciences, National Central University, Jhongda Road 300, 32054, Jhongli</wicri:regionArea><wicri:noRegion>Jhongli</wicri:noRegion></affiliation></author><author><name sortKey="Chang, Chin Yu" sort="Chang, Chin Yu" uniqKey="Chang C" first="Chin-Yu" last="Chang">Chin-Yu Chang</name><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Life Sciences, National Central University, Jhongda Road 300, 32054, Jhongli</wicri:regionArea><wicri:noRegion>Jhongli</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Chih Cheng" sort="Chen, Chih Cheng" uniqKey="Chen C" first="Chih-Cheng" last="Chen">Chih-Cheng Chen</name><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Biomedical Sciences, Academia Sinica, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Chih Dong" sort="Yang, Chih Dong" uniqKey="Yang C" first="Chih-Dong" last="Yang">Chih-Dong Yang</name><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Landseed Hospital, Jhongli</wicri:regionArea><wicri:noRegion>Jhongli</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Wei Hsin" sort="Sun, Wei Hsin" uniqKey="Sun W" first="Wei-Hsin" last="Sun">Wei-Hsin Sun</name><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Life Sciences, National Central University, Jhongda Road 300, 32054, Jhongli</wicri:regionArea><wicri:noRegion>Jhongli</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Systems Biology and Bioinformatics, National Central University, Jhongli</wicri:regionArea><wicri:noRegion>Jhongli</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Taïwan</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Molecular Neuroscience</title><title level="j" type="abbrev">J Mol Neurosci</title><idno type="ISSN">0895-8696</idno><idno type="eISSN">1559-1166</idno><imprint><publisher>Springer US; http://www.springer-ny.com</publisher><pubPlace>Boston</pubPlace><date type="published" when="2013-11-01">2013-11-01</date><biblScope unit="volume">51</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="820">820</biblScope><biblScope unit="page" to="834">834</biblScope></imprint><idno type="ISSN">0895-8696</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0895-8696</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ASIC3</term><term>Dorsal root ganglion</term><term>Mas1-related G-protein-coupled receptor B4</term><term>Nociceptors</term><term>Trigeminal ganglion</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Mas1-related G-protein-coupled receptors (Mrgprs), comprising more than 50 distinct members, are specifically expressed in primary sensory neurons. Reflecting the diversity and specificity of stimuli they detect, Mrgprs are involved in pain, touch, and itch-related behaviors. Sensory–neuron-specific acid-sensing ion channel 3 (ASIC3) is essential for touch and inflammatory pain, but mice lacking ASIC3 have complex behavioral alterations in various modalities of pain and touch. To understand whether Mrgprs are involved in complex behavioral alterations found in ASIC3-deficient mice, we examined Mrgpr gene expression in ASIC3−/− mice. Only MrgprB4 expression has shown significant change. MrgprB4 expression was increased in ASIC3−/− dorsal root ganglia (DRG) but decreased in ASIC3−/− trigeminal ganglia. The distinct alterations in DRG and trigeminal ganglia imply that MrgprB4 could have multiple functions. Given that MrgprB4 is expressed in neurons that may detect gentle touch and that ASIC3−/− mice have altered sensitivity of mechanoreceptors for light touch, the expression change of MrgprB4 is more likely related to the altered touch behaviors of ASIC3−/− mice.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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