Plasmodium falciparum susceptibility to standard and potential anti-malarial drugs in Dakar, Senegal, during the 2013–2014 malaria season
Identifieur interne : 000E55 ( Main/Merge ); précédent : 000E54; suivant : 000E56Plasmodium falciparum susceptibility to standard and potential anti-malarial drugs in Dakar, Senegal, during the 2013–2014 malaria season
Auteurs : Bécaye Fall [Sénégal] ; Cheikhou Camara [Sénégal] ; Mansour Fall [Sénégal] ; Aminata Nakoulima [Sénégal] ; Pierre Dionne [Sénégal] ; Bakary Diatta [Sénégal] ; Yaya Diemé [Sénégal] ; Boubacar Wade [Sénégal] ; Bruno Pradines [Sénégal]Source :
- Malaria Journal [ 1475-2875 ] ; 2015-02-16.
Descripteurs français
- Wicri :
- geographic : Sénégal.
English descriptors
- mix :
Abstract
Background: In 2006, the Senegalese National Malaria Control Programme recommended artemisinin-based combination therapy (ACT) as the first-line treatment for uncomplicated malaria. Since the introduction of ACT, there have been very few reports on the level of Plasmodium falciparum resistance to anti-malarial drugs. An ex vivo susceptibility study was conducted on local isolates obtained from the Hôpital Principal de Dakar (Dakar, Senegal) from November 2013 to January 2014. Methods: Eighteen P. falciparum isolates were sussessfully assessed for ex vivo susceptibility to chloroquine (CQ), quinine (QN), monodesethylamodiaquine (MDAQ), the active metabolite of amodiaquine, mefloquine (MQ), lumefantrine (LMF), artesunate (AS), dihydroartemisinin (DHA), the active metabolite of artemisinin derivatives, pyronaridine (PND), piperaquine (PPQ), and, Proveblue (PVB), a methylene blue preparation, using the HRP2-based ELISA test. Results: The prevalence of isolates with reduced susceptibility was 55.6% for MQ, 50% for CQ, 5.6% for QN and MDAQ, and 0% for DHA, AS and LMF. The mean IC 50 for PND, PPQ and PVB were 5.8 nM, 32.2 nM and 5.3 nM, respectively. Conclusions: The prevalence of isolates with a reduced susceptibility to MQ remains high and stable in Dakar. Since 2004, the prevalence of CQ resistance decreased, but rebounded in 2013 in Dakar. PND, PPQ and PVB showed high in vitro activity in P. falciparum parasites from Dakar.
Url:
DOI: 10.1186/s12936-015-0589-3
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Hal:hal-01220028Le document en format XML
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<ref type="url">http://www.hopitalprincipal.sn/</ref>
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<tutelle active="#struct-352262" type="direct"><org type="institution" xml:id="struct-352262" status="INCOMING"> <orgName>Fédération des laboratoires</orgName>
<desc> <address> <country key="FR"></country>
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</hal:affiliation>
<country>Sénégal</country>
</affiliation>
</author>
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<idno type="DOI">10.1186/s12936-015-0589-3</idno>
<series><title level="j">Malaria Journal</title>
<idno type="ISSN">1475-2875</idno>
<imprint><date type="datePub">2015-02-16</date>
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<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Anti-malarial</term>
<term>In vitro</term>
<term>Malaria</term>
<term>Methylene blue</term>
<term>Plasmodium falciparum</term>
<term>Proveblue</term>
<term>Resistance</term>
<term>Senegal</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Sénégal</term>
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<front><div type="abstract" xml:lang="en"> <p>Background: In 2006, the Senegalese National Malaria Control Programme recommended artemisinin-based combination therapy (ACT) as the first-line treatment for uncomplicated malaria. Since the introduction of ACT, there have been very few reports on the level of Plasmodium falciparum resistance to anti-malarial drugs. An ex vivo susceptibility study was conducted on local isolates obtained from the Hôpital Principal de Dakar (Dakar, Senegal) from November 2013 to January 2014. Methods: Eighteen P. falciparum isolates were sussessfully assessed for ex vivo susceptibility to chloroquine (CQ), quinine (QN), monodesethylamodiaquine (MDAQ), the active metabolite of amodiaquine, mefloquine (MQ), lumefantrine (LMF), artesunate (AS), dihydroartemisinin (DHA), the active metabolite of artemisinin derivatives, pyronaridine (PND), piperaquine (PPQ), and, Proveblue (PVB), a methylene blue preparation, using the HRP2-based ELISA test. Results: The prevalence of isolates with reduced susceptibility was 55.6% for MQ, 50% for CQ, 5.6% for QN and MDAQ, and 0% for DHA, AS and LMF. The mean IC 50 for PND, PPQ and PVB were 5.8 nM, 32.2 nM and 5.3 nM, respectively. Conclusions: The prevalence of isolates with a reduced susceptibility to MQ remains high and stable in Dakar. Since 2004, the prevalence of CQ resistance decreased, but rebounded in 2013 in Dakar. PND, PPQ and PVB showed high in vitro activity in P. falciparum parasites from Dakar.</p>
</div>
</front>
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