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Induction of Forkhead Class box O3a and apoptosis by a standardized ginsenoside formulation, KG-135, is potentiated by autophagy blockade in A549 human lung cancer cells.

Identifieur interne : 000D13 ( Main/Merge ); précédent : 000D12; suivant : 000D14

Induction of Forkhead Class box O3a and apoptosis by a standardized ginsenoside formulation, KG-135, is potentiated by autophagy blockade in A549 human lung cancer cells.

Auteurs : Chih-Jung Yao [Taïwan] ; Jyh-Ming Chow [Taïwan] ; Shuang-En Chuang [Taïwan] ; Chia-Lun Chang [Taïwan] ; Ming-De Yan [Taïwan] ; Hsin-Lun Lee [Taïwan] ; I-Chun Lai [Taïwan] ; Pei-Chun Lin [Taïwan] ; Gi-Ming Lai [Taïwan]

Source :

Journal of ginseng research [ 1226-8453 ] ; 2017.

RBID : pubmed:28701864

Abstract

KG-135, a standardized formulation enriched with Rk1, Rg3, and Rg5 ginsenosides, has been shown to inhibit various types of cancer cells; however, the underlying mechanisms are not fully understood. In this study, we explored its effects in A549 human lung cancer cells to investigate the induction of Forkhead Class box O3a (FOXO3a) and autophagy.

DOI: 10.1016/j.jgr.2016.04.003
PubMed: 28701864

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pubmed:28701864

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<front><div type="abstract" xml:lang="en">KG-135, a standardized formulation enriched with Rk1, Rg3, and Rg5 ginsenosides, has been shown to inhibit various types of cancer cells; however, the underlying mechanisms are not fully understood. In this study, we explored its effects in A549 human lung cancer cells to investigate the induction of Forkhead Class box O3a (FOXO3a) and autophagy.</div>
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Induction of Forkhead Class box O3a and apoptosis by a standardized ginsenoside formulation, KG-135, is potentiated by autophagy blockade in A549 human lung cancer cells.

Induction of Forkhead Class box O3a and apoptosis by a standardized ginsenoside formulation, KG-135, is potentiated by autophagy blockade in A549 human lung cancer cells.

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Abstract

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