Circulating Biomarkers From the Phase 1 Trial of Sirolimus and Autophagy Inhibition for Patients With Lymphangioleiomyomatosis.
Identifieur interne : 000C42 ( Main/Merge ); précédent : 000C41; suivant : 000C43Circulating Biomarkers From the Phase 1 Trial of Sirolimus and Autophagy Inhibition for Patients With Lymphangioleiomyomatosis.
Auteurs : Anthony M. Lamattina [États-Unis] ; Angelo Taveira-Dasilva [États-Unis] ; Hilary J. Goldberg [États-Unis] ; Shefali Bagwe [États-Unis] ; Ye Cui [États-Unis] ; Ivan O. Rosas [États-Unis] ; Joel Moss [États-Unis] ; Elizabeth P. Henske [États-Unis] ; Souheil El-Chemaly [États-Unis]Source :
- Chest [ 1931-3543 ] ; 2018.
Descripteurs français
- KwdFr :
- Acetyl-coA carboxylase (sang), Adulte, Antienzymes (administration et posologie), Association de médicaments (), Femelle, Fibrinogène (analyse), Humains, Hydroxychloroquine (administration et posologie), Hydroxychloroquine (effets indésirables), Immunosuppresseurs (administration et posologie), Immunosuppresseurs (effets indésirables), Lymphangioléiomyomatose (diagnostic), Lymphangioléiomyomatose (sang), Lymphangioléiomyomatose (traitement médicamenteux), Maladies pulmonaires (diagnostic), Maladies pulmonaires (sang), Maladies pulmonaires (traitement médicamenteux), Marqueurs biologiques (analyse), Marqueurs biologiques (sang), Récepteur-3 au facteur croissance endothéliale vasculaire (sang), Sirolimus (administration et posologie), Sirolimus (effets indésirables), Surveillance pharmacologique (), Tests de la fonction respiratoire ().
- MESH :
- administration et posologie : Antienzymes, Hydroxychloroquine, Immunosuppresseurs, Sirolimus.
- analyse : Fibrinogène, Marqueurs biologiques.
- diagnostic : Lymphangioléiomyomatose, Maladies pulmonaires.
- effets indésirables : Hydroxychloroquine, Immunosuppresseurs, Sirolimus.
- sang : Acetyl-coA carboxylase, Lymphangioléiomyomatose, Maladies pulmonaires, Marqueurs biologiques, Récepteur-3 au facteur croissance endothéliale vasculaire.
- traitement médicamenteux : Lymphangioléiomyomatose, Maladies pulmonaires.
- Adulte, Association de médicaments, Femelle, Humains, Surveillance pharmacologique, Tests de la fonction respiratoire.
English descriptors
- KwdEn :
- Acetyl-CoA Carboxylase (blood), Adult, Biomarkers (analysis), Biomarkers (blood), Correlation of Data, Drug Monitoring (methods), Drug Therapy, Combination (methods), Enzyme Inhibitors (administration & dosage), Female, Fibrinogen (analysis), Humans, Hydroxychloroquine (administration & dosage), Hydroxychloroquine (adverse effects), Immunosuppressive Agents (administration & dosage), Immunosuppressive Agents (adverse effects), Lung Diseases (blood), Lung Diseases (diagnosis), Lung Diseases (drug therapy), Lymphangioleiomyomatosis (blood), Lymphangioleiomyomatosis (diagnosis), Lymphangioleiomyomatosis (drug therapy), Respiratory Function Tests (methods), Sirolimus (administration & dosage), Sirolimus (adverse effects), Vascular Endothelial Growth Factor Receptor-3 (blood).
- MESH :
- chemical , administration & dosage : Enzyme Inhibitors, Hydroxychloroquine, Immunosuppressive Agents, Sirolimus.
- chemical , adverse effects : Hydroxychloroquine, Immunosuppressive Agents, Sirolimus.
- chemical , analysis : Biomarkers, Fibrinogen.
- chemical , blood : Acetyl-CoA Carboxylase, Biomarkers, Vascular Endothelial Growth Factor Receptor-3.
- blood : Lung Diseases, Lymphangioleiomyomatosis.
- diagnosis : Lung Diseases, Lymphangioleiomyomatosis.
- drug therapy : Lung Diseases, Lymphangioleiomyomatosis.
- methods : Drug Monitoring, Drug Therapy, Combination, Respiratory Function Tests.
- Adult, Correlation of Data, Female, Humans.
Abstract
We have previously conducted the Sirolimus and Autophagy Inhibition in LAM (SAIL) trial, a phase 1 dose-escalation study of the combination of sirolimus and hydroxychloroquine in patients with lymphangioleiomyomatosis (LAM). The goal of the present study was to analyze sera from the SAIL trial to identify novel biomarkers that could shed light into disease pathogenesis and response to therapy.
DOI: 10.1016/j.chest.2018.08.1029
PubMed: 30144422
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pubmed:30144422Le document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acetyl-CoA Carboxylase (blood)</term>
<term>Adult</term>
<term>Biomarkers (analysis)</term>
<term>Biomarkers (blood)</term>
<term>Correlation of Data</term>
<term>Drug Monitoring (methods)</term>
<term>Drug Therapy, Combination (methods)</term>
<term>Enzyme Inhibitors (administration & dosage)</term>
<term>Female</term>
<term>Fibrinogen (analysis)</term>
<term>Humans</term>
<term>Hydroxychloroquine (administration & dosage)</term>
<term>Hydroxychloroquine (adverse effects)</term>
<term>Immunosuppressive Agents (administration & dosage)</term>
<term>Immunosuppressive Agents (adverse effects)</term>
<term>Lung Diseases (blood)</term>
<term>Lung Diseases (diagnosis)</term>
<term>Lung Diseases (drug therapy)</term>
<term>Lymphangioleiomyomatosis (blood)</term>
<term>Lymphangioleiomyomatosis (diagnosis)</term>
<term>Lymphangioleiomyomatosis (drug therapy)</term>
<term>Respiratory Function Tests (methods)</term>
<term>Sirolimus (administration & dosage)</term>
<term>Sirolimus (adverse effects)</term>
<term>Vascular Endothelial Growth Factor Receptor-3 (blood)</term>
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<term>Adulte</term>
<term>Antienzymes (administration et posologie)</term>
<term>Association de médicaments ()</term>
<term>Femelle</term>
<term>Fibrinogène (analyse)</term>
<term>Humains</term>
<term>Hydroxychloroquine (administration et posologie)</term>
<term>Hydroxychloroquine (effets indésirables)</term>
<term>Immunosuppresseurs (administration et posologie)</term>
<term>Immunosuppresseurs (effets indésirables)</term>
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<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antienzymes</term>
<term>Hydroxychloroquine</term>
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<term>Sirolimus</term>
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<term>Maladies pulmonaires</term>
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<term>Lymphangioleiomyomatosis</term>
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<term>Immunosuppresseurs</term>
<term>Sirolimus</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Drug Monitoring</term>
<term>Drug Therapy, Combination</term>
<term>Respiratory Function Tests</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Acetyl-coA carboxylase</term>
<term>Lymphangioléiomyomatose</term>
<term>Maladies pulmonaires</term>
<term>Marqueurs biologiques</term>
<term>Récepteur-3 au facteur croissance endothéliale vasculaire</term>
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<term>Maladies pulmonaires</term>
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<term>Correlation of Data</term>
<term>Female</term>
<term>Humans</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Association de médicaments</term>
<term>Femelle</term>
<term>Humains</term>
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<front><div type="abstract" xml:lang="en">We have previously conducted the Sirolimus and Autophagy Inhibition in LAM (SAIL) trial, a phase 1 dose-escalation study of the combination of sirolimus and hydroxychloroquine in patients with lymphangioleiomyomatosis (LAM). The goal of the present study was to analyze sera from the SAIL trial to identify novel biomarkers that could shed light into disease pathogenesis and response to therapy.</div>
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