Antiviral Agents in Development for Zika Virus Infections
Identifieur interne : 000A70 ( Main/Merge ); précédent : 000A69; suivant : 000A71Antiviral Agents in Development for Zika Virus Infections
Auteurs : Mariana Baz ; Guy BoivinSource :
- Pharmaceuticals [ 1424-8247 ] ; 2019.
Abstract
In 1947, Zika virus (ZIKV), a mosquito-borne flavivirus was identified in Uganda and subsequently spread to Asia and the Pacific regions. In 2015, it was introduced in Brazil causing an important social and sanitary alarm due to its increased virulence and rapid dissemination. Importantly, ZIKV infections have been associated with severe neurological complications such as Guillain–Barré syndrome and microcephaly in fetuses and newborns. Although enormous efforts were made by investigators in the development of effective countermeasures against ZIKV, there is still no approved specific antiviral drug for the treatment of ZIKV infections. Herein, we review several anti ZIKV candidates including drugs targeting both the virus (structural proteins and enzymes) and cellular elements.
Url:
DOI: 10.3390/ph12030101
PubMed: 31261947
PubMed Central: 6789597
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antiviral Agents in Development for Zika Virus Infections</title><author><name sortKey="Baz, Mariana" sort="Baz, Mariana" uniqKey="Baz M" first="Mariana" last="Baz">Mariana Baz</name></author><author><name sortKey="Boivin, Guy" sort="Boivin, Guy" uniqKey="Boivin G" first="Guy" last="Boivin">Guy Boivin</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31261947</idno><idno type="pmc">6789597</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789597</idno><idno type="RBID">PMC:6789597</idno><idno type="doi">10.3390/ph12030101</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000A93</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A93</idno><idno type="wicri:Area/Pmc/Curation">000A93</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A93</idno><idno type="wicri:Area/Pmc/Checkpoint">000A00</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A00</idno><idno type="wicri:Area/Ncbi/Merge">000745</idno><idno type="wicri:Area/Ncbi/Curation">000745</idno><idno type="wicri:Area/Ncbi/Checkpoint">000745</idno><idno type="wicri:Area/Main/Merge">000A70</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Antiviral Agents in Development for Zika Virus Infections</title><author><name sortKey="Baz, Mariana" sort="Baz, Mariana" uniqKey="Baz M" first="Mariana" last="Baz">Mariana Baz</name></author><author><name sortKey="Boivin, Guy" sort="Boivin, Guy" uniqKey="Boivin G" first="Guy" last="Boivin">Guy Boivin</name></author></analytic><series><title level="j">Pharmaceuticals</title><idno type="eISSN">1424-8247</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In 1947, Zika virus (ZIKV), a mosquito-borne flavivirus was identified in Uganda and subsequently spread to Asia and the Pacific regions. In 2015, it was introduced in Brazil causing an important social and sanitary alarm due to its increased virulence and rapid dissemination. Importantly, ZIKV infections have been associated with severe neurological complications such as Guillain–Barré syndrome and microcephaly in fetuses and newborns. Although enormous efforts were made by investigators in the development of effective countermeasures against ZIKV, there is still no approved specific antiviral drug for the treatment of ZIKV infections. Herein, we review several anti ZIKV candidates including drugs targeting both the virus (structural proteins and enzymes) and cellular elements.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kuno, G" uniqKey="Kuno G">G. Kuno</name></author><author><name sortKey="Chang, G J" uniqKey="Chang G">G.J. Chang</name></author><author><name sortKey="Tsuchiya, K R" uniqKey="Tsuchiya K">K.R. 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