Autophagy Modulators: Mechanistic Aspects and Drug Delivery Systems
Identifieur interne : 000A45 ( Main/Merge ); précédent : 000A44; suivant : 000A46Autophagy Modulators: Mechanistic Aspects and Drug Delivery Systems
Auteurs : Shima Tavakol ; Milad Ashrafizadeh ; Shuo Deng ; Maryam Azarian [Espagne] ; Asghar Abdoli ; Mahsa Motavaf ; Delaram Poormoghadam ; Hashem Khanbabaei ; Elham Ghasemipour Afshar ; Ali Mandegary ; Abbas Pardakhty ; Celestial T. Yap ; Reza Mohammadinejad [Iran] ; Alan Prem Kumar [Singapour]Source :
- Biomolecules [ 2218-273X ] ; 2019.
Abstract
Autophagy modulation is considered to be a promising programmed cell death mechanism to prevent and cure a great number of disorders and diseases. The crucial step in designing an effective therapeutic approach is to understand the correct and accurate causes of diseases and to understand whether autophagy plays a cytoprotective or cytotoxic/cytostatic role in the progression and prevention of disease. This knowledge will help scientists find approaches to manipulate tumor and pathologic cells in order to enhance cellular sensitivity to therapeutics and treat them. Although some conventional therapeutics suffer from poor solubility, bioavailability and controlled release mechanisms, it appears that novel nanoplatforms overcome these obstacles and have led to the design of a theranostic-controlled drug release system with high solubility and active targeting and stimuli-responsive potentials. In this review, we discuss autophagy modulators-related signaling pathways and some of the drug delivery strategies that have been applied to the field of therapeutic application of autophagy modulators. Moreover, we describe how therapeutics will target various steps of the autophagic machinery. Furthermore, nano drug delivery platforms for autophagy targeting and co-delivery of autophagy modulators with chemotherapeutics/siRNA, are also discussed.
Url:
DOI: 10.3390/biom9100530
PubMed: 31557936
PubMed Central: 6843293
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PMC:6843293Le document en format XML
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<author><name sortKey="Ashrafizadeh, Milad" sort="Ashrafizadeh, Milad" uniqKey="Ashrafizadeh M" first="Milad" last="Ashrafizadeh">Milad Ashrafizadeh</name>
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<affiliation><nlm:aff id="af8-biomolecules-09-00530">Department of Medical Nanotechnology, Faculty of Advanced Sciences & Technology, Pharmaceutical Sciences Branch, Islamic Azad University, (IAUPS), Tehran P.O. Box 1916893813, Iran;<email>parand.pdrm@yahoo.com</email>
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<affiliation><nlm:aff id="af10-biomolecules-09-00530">Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman P.O. Box 7616911319, Iran;<email>elham_gh_afshar@yahoo.com</email>
(E.G.A.);<email>alimandegary@yahoo.com</email>
(A.M.);<email>drpardakhti@yahoo.com</email>
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<affiliation><nlm:aff id="af10-biomolecules-09-00530">Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman P.O. Box 7616911319, Iran;<email>elham_gh_afshar@yahoo.com</email>
(E.G.A.);<email>alimandegary@yahoo.com</email>
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<author><name sortKey="Pardakhty, Abbas" sort="Pardakhty, Abbas" uniqKey="Pardakhty A" first="Abbas" last="Pardakhty">Abbas Pardakhty</name>
<affiliation><nlm:aff id="af10-biomolecules-09-00530">Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman P.O. Box 7616911319, Iran;<email>elham_gh_afshar@yahoo.com</email>
(E.G.A.);<email>alimandegary@yahoo.com</email>
(A.M.);<email>drpardakhti@yahoo.com</email>
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<author><name sortKey="Yap, Celestial T" sort="Yap, Celestial T" uniqKey="Yap C" first="Celestial T." last="Yap">Celestial T. Yap</name>
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(S.D.);<email>phsyapc@nus.edu.sg</email>
(C.T.Y.)</nlm:aff>
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<author><name sortKey="Mohammadinejad, Reza" sort="Mohammadinejad, Reza" uniqKey="Mohammadinejad R" first="Reza" last="Mohammadinejad">Reza Mohammadinejad</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Autophagy Modulators: Mechanistic Aspects and Drug Delivery Systems</title>
<author><name sortKey="Tavakol, Shima" sort="Tavakol, Shima" uniqKey="Tavakol S" first="Shima" last="Tavakol">Shima Tavakol</name>
<affiliation><nlm:aff id="af1-biomolecules-09-00530">Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran P.O. Box 1449614525, Iran;<email>shima.tavakol@yahoo.com</email>
</nlm:aff>
</affiliation>
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<author><name sortKey="Ashrafizadeh, Milad" sort="Ashrafizadeh, Milad" uniqKey="Ashrafizadeh M" first="Milad" last="Ashrafizadeh">Milad Ashrafizadeh</name>
<affiliation><nlm:aff id="af2-biomolecules-09-00530">Department of basic science, Faculty of Veterinary Medicine, University of Tabriz, Tabriz 1455742, Iran;<email>dvm.milad73@yahoo.com</email>
</nlm:aff>
</affiliation>
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<author><name sortKey="Deng, Shuo" sort="Deng, Shuo" uniqKey="Deng S" first="Shuo" last="Deng">Shuo Deng</name>
<affiliation><nlm:aff id="af3-biomolecules-09-00530">Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore;<email>phsdes@nus.edu.sg</email>
(S.D.);<email>phsyapc@nus.edu.sg</email>
(C.T.Y.)</nlm:aff>
</affiliation>
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<author><name sortKey="Azarian, Maryam" sort="Azarian, Maryam" uniqKey="Azarian M" first="Maryam" last="Azarian">Maryam Azarian</name>
<affiliation><nlm:aff id="af4-biomolecules-09-00530">Department of Biology, Science and Research Branch, Islamic Azad University, Tehran 1477893855, Iran;<email>azarian.maryam@gmail.com</email>
</nlm:aff>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="af5-biomolecules-09-00530">Departament de Bioquímica i Biologia Molecular, Institut de Biotecnologia i Biomedicina (IBB), Universitat Autónoma de Barcelona, 08193 Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Departament de Bioquímica i Biologia Molecular, Institut de Biotecnologia i Biomedicina (IBB), Universitat Autónoma de Barcelona, 08193 Barcelona</wicri:regionArea>
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<author><name sortKey="Abdoli, Asghar" sort="Abdoli, Asghar" uniqKey="Abdoli A" first="Asghar" last="Abdoli">Asghar Abdoli</name>
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<author><name sortKey="Motavaf, Mahsa" sort="Motavaf, Mahsa" uniqKey="Motavaf M" first="Mahsa" last="Motavaf">Mahsa Motavaf</name>
<affiliation><nlm:aff id="af7-biomolecules-09-00530">Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran 14115-111, Iran;<email>motavaf.m@gmail.com</email>
</nlm:aff>
</affiliation>
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<author><name sortKey="Poormoghadam, Delaram" sort="Poormoghadam, Delaram" uniqKey="Poormoghadam D" first="Delaram" last="Poormoghadam">Delaram Poormoghadam</name>
<affiliation><nlm:aff id="af8-biomolecules-09-00530">Department of Medical Nanotechnology, Faculty of Advanced Sciences & Technology, Pharmaceutical Sciences Branch, Islamic Azad University, (IAUPS), Tehran P.O. Box 1916893813, Iran;<email>parand.pdrm@yahoo.com</email>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Khanbabaei, Hashem" sort="Khanbabaei, Hashem" uniqKey="Khanbabaei H" first="Hashem" last="Khanbabaei">Hashem Khanbabaei</name>
<affiliation><nlm:aff id="af9-biomolecules-09-00530">Medical Physics Department, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 61357-15794, Iran;<email>khanbabaie.mph@gmail.com</email>
</nlm:aff>
</affiliation>
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<author><name sortKey="Ghasemipour Afshar, Elham" sort="Ghasemipour Afshar, Elham" uniqKey="Ghasemipour Afshar E" first="Elham" last="Ghasemipour Afshar">Elham Ghasemipour Afshar</name>
<affiliation><nlm:aff id="af10-biomolecules-09-00530">Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman P.O. Box 7616911319, Iran;<email>elham_gh_afshar@yahoo.com</email>
(E.G.A.);<email>alimandegary@yahoo.com</email>
(A.M.);<email>drpardakhti@yahoo.com</email>
(A.P.)</nlm:aff>
</affiliation>
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<author><name sortKey="Mandegary, Ali" sort="Mandegary, Ali" uniqKey="Mandegary A" first="Ali" last="Mandegary">Ali Mandegary</name>
<affiliation><nlm:aff id="af10-biomolecules-09-00530">Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman P.O. Box 7616911319, Iran;<email>elham_gh_afshar@yahoo.com</email>
(E.G.A.);<email>alimandegary@yahoo.com</email>
(A.M.);<email>drpardakhti@yahoo.com</email>
(A.P.)</nlm:aff>
</affiliation>
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<author><name sortKey="Pardakhty, Abbas" sort="Pardakhty, Abbas" uniqKey="Pardakhty A" first="Abbas" last="Pardakhty">Abbas Pardakhty</name>
<affiliation><nlm:aff id="af10-biomolecules-09-00530">Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman P.O. Box 7616911319, Iran;<email>elham_gh_afshar@yahoo.com</email>
(E.G.A.);<email>alimandegary@yahoo.com</email>
(A.M.);<email>drpardakhti@yahoo.com</email>
(A.P.)</nlm:aff>
</affiliation>
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<author><name sortKey="Yap, Celestial T" sort="Yap, Celestial T" uniqKey="Yap C" first="Celestial T." last="Yap">Celestial T. Yap</name>
<affiliation><nlm:aff id="af3-biomolecules-09-00530">Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore;<email>phsdes@nus.edu.sg</email>
(S.D.);<email>phsyapc@nus.edu.sg</email>
(C.T.Y.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mohammadinejad, Reza" sort="Mohammadinejad, Reza" uniqKey="Mohammadinejad R" first="Reza" last="Mohammadinejad">Reza Mohammadinejad</name>
<affiliation wicri:level="1"><nlm:aff id="af11-biomolecules-09-00530">Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman P.O. Box 1355576169, Iran</nlm:aff>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman P.O. Box 1355576169</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Kumar, Alan Prem" sort="Kumar, Alan Prem" uniqKey="Kumar A" first="Alan Prem" last="Kumar">Alan Prem Kumar</name>
<affiliation wicri:level="4"><nlm:aff id="af12-biomolecules-09-00530">Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117 600, Singapore</nlm:aff>
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<wicri:regionArea>Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117 600</wicri:regionArea>
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<affiliation wicri:level="4"><nlm:aff id="af13-biomolecules-09-00530">Cancer Science Institute of Singapore, National University of Singapore, Singapore 1192288, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Cancer Science Institute of Singapore, National University of Singapore, Singapore 1192288</wicri:regionArea>
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<front><div type="abstract" xml:lang="en"><p>Autophagy modulation is considered to be a promising programmed cell death mechanism to prevent and cure a great number of disorders and diseases. The crucial step in designing an effective therapeutic approach is to understand the correct and accurate causes of diseases and to understand whether autophagy plays a cytoprotective or cytotoxic/cytostatic role in the progression and prevention of disease. This knowledge will help scientists find approaches to manipulate tumor and pathologic cells in order to enhance cellular sensitivity to therapeutics and treat them. Although some conventional therapeutics suffer from poor solubility, bioavailability and controlled release mechanisms, it appears that novel nanoplatforms overcome these obstacles and have led to the design of a theranostic-controlled drug release system with high solubility and active targeting and stimuli-responsive potentials. In this review, we discuss autophagy modulators-related signaling pathways and some of the drug delivery strategies that have been applied to the field of therapeutic application of autophagy modulators. Moreover, we describe how therapeutics will target various steps of the autophagic machinery. Furthermore, nano drug delivery platforms for autophagy targeting and co-delivery of autophagy modulators with chemotherapeutics/siRNA, are also discussed.</p>
</div>
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</author>
<author><name sortKey="Ahmadi, Z" uniqKey="Ahmadi Z">Z. Ahmadi</name>
</author>
<author><name sortKey="Mohammadinejad, R" uniqKey="Mohammadinejad R">R. Mohammadinejad</name>
</author>
<author><name sortKey="Kaviyani, N" uniqKey="Kaviyani N">N. Kaviyani</name>
</author>
<author><name sortKey="Tavakol, S" uniqKey="Tavakol S">S. Tavakol</name>
</author>
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<biblStruct><analytic><author><name sortKey="Mohammadinejad, R" uniqKey="Mohammadinejad R">R. Mohammadinejad</name>
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<author><name sortKey="Ahmadi, Z" uniqKey="Ahmadi Z">Z. Ahmadi</name>
</author>
<author><name sortKey="Tavakol, S" uniqKey="Tavakol S">S. Tavakol</name>
</author>
<author><name sortKey="Ashrafizadeh, M" uniqKey="Ashrafizadeh M">M. Ashrafizadeh</name>
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<author><name sortKey="Mohammadinejad, R" uniqKey="Mohammadinejad R">R. Mohammadinejad</name>
</author>
<author><name sortKey="Tavakol, S" uniqKey="Tavakol S">S. Tavakol</name>
</author>
<author><name sortKey="Ahmadi, Z" uniqKey="Ahmadi Z">Z. Ahmadi</name>
</author>
<author><name sortKey="Roomiani, S" uniqKey="Roomiani S">S. Roomiani</name>
</author>
<author><name sortKey="Katebi, M" uniqKey="Katebi M">M. Katebi</name>
</author>
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<biblStruct><analytic><author><name sortKey="Ashrafizadeh, M" uniqKey="Ashrafizadeh M">M. Ashrafizadeh</name>
</author>
<author><name sortKey="Yaribeygi, H" uniqKey="Yaribeygi H">H. Yaribeygi</name>
</author>
<author><name sortKey="Atkin, S L" uniqKey="Atkin S">S.L. Atkin</name>
</author>
<author><name sortKey="Sahebkar, A" uniqKey="Sahebkar A">A. Sahebkar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ahmadi, Z" uniqKey="Ahmadi Z">Z. Ahmadi</name>
</author>
<author><name sortKey="Roomiani, S" uniqKey="Roomiani S">S. Roomiani</name>
</author>
<author><name sortKey="Bemani, N" uniqKey="Bemani N">N. Bemani</name>
</author>
<author><name sortKey="Ashrafizadeh, M" uniqKey="Ashrafizadeh M">M. Ashrafizadeh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Levine, B" uniqKey="Levine B">B. Levine</name>
</author>
<author><name sortKey="Kroemer, G" uniqKey="Kroemer G">G. Kroemer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lin, Y" uniqKey="Lin Y">Y. Lin</name>
</author>
<author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name>
</author>
<author><name sortKey="An, H W" uniqKey="An H">H.-W. An</name>
</author>
<author><name sortKey="Qi, B" uniqKey="Qi B">B. Qi</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J. Wang</name>
</author>
<author><name sortKey="Wang, L" uniqKey="Wang L">L. Wang</name>
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