B lymphocyte stimulator modulates number and function of endothelial progenitor cells in systemic lupus erythematosus
Identifieur interne : 000A16 ( Main/Merge ); précédent : 000A15; suivant : 000A17B lymphocyte stimulator modulates number and function of endothelial progenitor cells in systemic lupus erythematosus
Auteurs : Francesca Romana Spinelli ; Cristiana Barbati ; Fulvia Cecarelli ; Francesca Morello ; Tania Colasanti ; Marta Vomero ; Laura Massaro ; Valeria Orefice ; Cristiano Alessandri ; Guido Valesini ; Fabrizio ContiSource :
- Arthritis Research & Therapy [ 1478-6354 ] ; 2019.
Abstract
Circulating endothelial progenitor cells (EPCs) are biologic markers of endothelial function. In patients with systemic lupus erythematosus (SLE), the numerical reduction and functional impairment of EPCs contribute to the endothelial dysfunction.
Through ex vivo and in vitro studies, we aimed at evaluating the effects of B lymphocyte stimulator (BLyS) on EPC colonies and endothelial cells and also investigating BLyS receptor expression on these cells.
EPCs were isolated from peripheral blood mononuclear cells (PBMC). In order to evaluate their ability to form colonies, EPCs were cultured on fibronectin-coated dishes and incubated with BlyS alone or BlyS and belimumab. Apoptosis of EPCs and endothelial cell line EA.hy926 was evaluated after 6, 12, and 24 h of incubation with BLyS and after 6 h with BLyS and belimumab. The expression of B cell activating factor-receptor (BAFF-R), B cell maturation antigen (BCMA), and transmembrane activator and calcium modulator and cyclophilin ligand (CAML) interactor (TACI) on EPCs and EA.hy926 was analyzed by cytofluorimetry.
The number of EPC colonies was lower in patients than in controls. Moreover, the colonies from SLE patients were poorly organized compared to controls; the addition of belimumab restored the colony structure. Incubation with BLyS induced apoptosis of EPCs and EA.hy926 that was inhibited by the co-incubation with belimumab. BAFF-R and BCMA were expressed on both EPCs and EA.hy926, while TACI was expressed only on EPCs.
EPCs and endothelial cells preferentially express BAFF-R which could be involved in the pro-apoptotic effect of BlyS. Belimumab administration seems to restore the quantitative and qualitative changes of EPC colonies both ex vivo and in vitro
Url:
DOI: 10.1186/s13075-019-2015-7
PubMed: 31752963
PubMed Central: 6868730
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000033
- to stream Pmc, to step Curation: 000033
- to stream Pmc, to step Checkpoint: 000952
- to stream Ncbi, to step Merge: 000C33
- to stream Ncbi, to step Curation: 000C33
- to stream Ncbi, to step Checkpoint: 000C33
Links to Exploration step
PMC:6868730Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">B lymphocyte stimulator modulates number and function of endothelial progenitor cells in systemic lupus erythematosus</title><author><name sortKey="Spinelli, Francesca Romana" sort="Spinelli, Francesca Romana" uniqKey="Spinelli F" first="Francesca Romana" last="Spinelli">Francesca Romana Spinelli</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Barbati, Cristiana" sort="Barbati, Cristiana" uniqKey="Barbati C" first="Cristiana" last="Barbati">Cristiana Barbati</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Cecarelli, Fulvia" sort="Cecarelli, Fulvia" uniqKey="Cecarelli F" first="Fulvia" last="Cecarelli">Fulvia Cecarelli</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Morello, Francesca" sort="Morello, Francesca" uniqKey="Morello F" first="Francesca" last="Morello">Francesca Morello</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Colasanti, Tania" sort="Colasanti, Tania" uniqKey="Colasanti T" first="Tania" last="Colasanti">Tania Colasanti</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Vomero, Marta" sort="Vomero, Marta" uniqKey="Vomero M" first="Marta" last="Vomero">Marta Vomero</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Massaro, Laura" sort="Massaro, Laura" uniqKey="Massaro L" first="Laura" last="Massaro">Laura Massaro</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Orefice, Valeria" sort="Orefice, Valeria" uniqKey="Orefice V" first="Valeria" last="Orefice">Valeria Orefice</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Alessandri, Cristiano" sort="Alessandri, Cristiano" uniqKey="Alessandri C" first="Cristiano" last="Alessandri">Cristiano Alessandri</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Valesini, Guido" sort="Valesini, Guido" uniqKey="Valesini G" first="Guido" last="Valesini">Guido Valesini</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Conti, Fabrizio" sort="Conti, Fabrizio" uniqKey="Conti F" first="Fabrizio" last="Conti">Fabrizio Conti</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31752963</idno><idno type="pmc">6868730</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868730</idno><idno type="RBID">PMC:6868730</idno><idno type="doi">10.1186/s13075-019-2015-7</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000033</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000033</idno><idno type="wicri:Area/Pmc/Curation">000033</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000033</idno><idno type="wicri:Area/Pmc/Checkpoint">000952</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000952</idno><idno type="wicri:Area/Ncbi/Merge">000C33</idno><idno type="wicri:Area/Ncbi/Curation">000C33</idno><idno type="wicri:Area/Ncbi/Checkpoint">000C33</idno><idno type="wicri:doubleKey">1478-6354:2019:Spinelli F:b:lymphocyte:stimulator</idno><idno type="wicri:Area/Main/Merge">000A16</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">B lymphocyte stimulator modulates number and function of endothelial progenitor cells in systemic lupus erythematosus</title><author><name sortKey="Spinelli, Francesca Romana" sort="Spinelli, Francesca Romana" uniqKey="Spinelli F" first="Francesca Romana" last="Spinelli">Francesca Romana Spinelli</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Barbati, Cristiana" sort="Barbati, Cristiana" uniqKey="Barbati C" first="Cristiana" last="Barbati">Cristiana Barbati</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Cecarelli, Fulvia" sort="Cecarelli, Fulvia" uniqKey="Cecarelli F" first="Fulvia" last="Cecarelli">Fulvia Cecarelli</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Morello, Francesca" sort="Morello, Francesca" uniqKey="Morello F" first="Francesca" last="Morello">Francesca Morello</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Colasanti, Tania" sort="Colasanti, Tania" uniqKey="Colasanti T" first="Tania" last="Colasanti">Tania Colasanti</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Vomero, Marta" sort="Vomero, Marta" uniqKey="Vomero M" first="Marta" last="Vomero">Marta Vomero</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Massaro, Laura" sort="Massaro, Laura" uniqKey="Massaro L" first="Laura" last="Massaro">Laura Massaro</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Orefice, Valeria" sort="Orefice, Valeria" uniqKey="Orefice V" first="Valeria" last="Orefice">Valeria Orefice</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Alessandri, Cristiano" sort="Alessandri, Cristiano" uniqKey="Alessandri C" first="Cristiano" last="Alessandri">Cristiano Alessandri</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Valesini, Guido" sort="Valesini, Guido" uniqKey="Valesini G" first="Guido" last="Valesini">Guido Valesini</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Conti, Fabrizio" sort="Conti, Fabrizio" uniqKey="Conti F" first="Fabrizio" last="Conti">Fabrizio Conti</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Arthritis Research & Therapy</title><idno type="ISSN">1478-6354</idno><idno type="eISSN">1478-6362</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p id="Par1">Circulating endothelial progenitor cells (EPCs) are biologic markers of endothelial function. In patients with systemic lupus erythematosus (SLE), the numerical reduction and functional impairment of EPCs contribute to the endothelial dysfunction.</p><p id="Par2">Through ex vivo and in vitro studies, we aimed at evaluating the effects of B lymphocyte stimulator (BLyS) on EPC colonies and endothelial cells and also investigating BLyS receptor expression on these cells.</p></sec><sec><title>Methods</title><p id="Par3">EPCs were isolated from peripheral blood mononuclear cells (PBMC). In order to evaluate their ability to form colonies, EPCs were cultured on fibronectin-coated dishes and incubated with BlyS alone or BlyS and belimumab. Apoptosis of EPCs and endothelial cell line EA.hy926 was evaluated after 6, 12, and 24 h of incubation with BLyS and after 6 h with BLyS and belimumab. The expression of B cell activating factor-receptor (BAFF-R), B cell maturation antigen (BCMA), and transmembrane activator and calcium modulator and cyclophilin ligand (CAML) interactor (TACI) on EPCs and EA.hy926 was analyzed by cytofluorimetry.</p></sec><sec><title>Results</title><p id="Par4">The number of EPC colonies was lower in patients than in controls. Moreover, the colonies from SLE patients were poorly organized compared to controls; the addition of belimumab restored the colony structure. Incubation with BLyS induced apoptosis of EPCs and EA.hy926 that was inhibited by the co-incubation with belimumab. BAFF-R and BCMA were expressed on both EPCs and EA.hy926, while TACI was expressed only on EPCs.</p></sec><sec><title>Conclusions</title><p id="Par5">EPCs and endothelial cells preferentially express BAFF-R which could be involved in the pro-apoptotic effect of BlyS. Belimumab administration seems to restore the quantitative and qualitative changes of EPC colonies both ex vivo and in vitro<bold>.</bold></p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Asahara, T" uniqKey="Asahara T">T Asahara</name></author><author><name sortKey="Murohara, T" uniqKey="Murohara T">T Murohara</name></author><author><name sortKey="Sullivan, A" uniqKey="Sullivan A">A Sullivan</name></author><author><name sortKey="Silver, M" uniqKey="Silver M">M Silver</name></author><author><name sortKey="Van Der Zee, R" uniqKey="Van Der Zee R">R van der Zee</name></author><author><name sortKey="Li, T" uniqKey="Li T">T Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Werner, N" uniqKey="Werner N">N Werner</name></author><author><name sortKey="Kosiol, S" uniqKey="Kosiol S">S Kosiol</name></author><author><name sortKey="Schiegl, T" uniqKey="Schiegl T">T Schiegl</name></author><author><name sortKey="Ahlers, P" uniqKey="Ahlers P">P Ahlers</name></author><author><name sortKey="Walenta, K" uniqKey="Walenta K">K Walenta</name></author><author><name sortKey="Link, A" uniqKey="Link A">A Link</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sen, S" uniqKey="Sen S">S Sen</name></author><author><name sortKey="Mcdonald, Sp" uniqKey="Mcdonald S">SP McDonald</name></author><author><name sortKey="Coates, Pt" uniqKey="Coates P">PT Coates</name></author><author><name sortKey="Bonder, Cs" uniqKey="Bonder C">CS Bonder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spinelli, Fr" uniqKey="Spinelli F">FR Spinelli</name></author><author><name sortKey="Metere, A" uniqKey="Metere A">A Metere</name></author><author><name sortKey="Barbati, C" uniqKey="Barbati C">C Barbati</name></author><author><name sortKey="Pierdominici, M" uniqKey="Pierdominici M">M Pierdominici</name></author><author><name sortKey="Iannuccelli, C" uniqKey="Iannuccelli C">C Iannuccelli</name></author><author><name sortKey="Lucchino, B" uniqKey="Lucchino B">B Lucchino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Symmons, Dp" uniqKey="Symmons D">DP Symmons</name></author><author><name sortKey="Gabriel, Se" uniqKey="Gabriel S">SE Gabriel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tselios, K" uniqKey="Tselios K">K Tselios</name></author><author><name sortKey="Gladman, Dd" uniqKey="Gladman D">DD Gladman</name></author><author><name sortKey="Su, J" uniqKey="Su J">J Su</name></author><author><name sortKey="Ace, O" uniqKey="Ace O">O Ace</name></author><author><name sortKey="Urowitz, Mb" uniqKey="Urowitz M">MB Urowitz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Denny, Mf" uniqKey="Denny M">MF Denny</name></author><author><name sortKey="Thacker, S" uniqKey="Thacker S">S Thacker</name></author><author><name sortKey="Mehta, H" uniqKey="Mehta H">H Mehta</name></author><author><name sortKey="Somers, Ec" uniqKey="Somers E">EC Somers</name></author><author><name sortKey="Dodick, T" uniqKey="Dodick T">T Dodick</name></author><author><name sortKey="Barrat, Fj" uniqKey="Barrat F">FJ Barrat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Py" uniqKey="Lee P">PY Lee</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Richards, Hb" uniqKey="Richards H">HB Richards</name></author><author><name sortKey="Chan, Fs" uniqKey="Chan F">FS Chan</name></author><author><name sortKey="Zhuang, H" uniqKey="Zhuang H">H Zhuang</name></author><author><name sortKey="Narain, S" uniqKey="Narain S">S Narain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moonen, Jr" uniqKey="Moonen J">JR Moonen</name></author><author><name sortKey="De Leeuw, K" uniqKey="De Leeuw K">K de Leeuw</name></author><author><name sortKey="Van Seijen, Xj" uniqKey="Van Seijen X">XJ van Seijen</name></author><author><name sortKey="Kallenberg, Cg" uniqKey="Kallenberg C">CG Kallenberg</name></author><author><name sortKey="Van Luyn, Mj" uniqKey="Van Luyn M">MJ van Luyn</name></author><author><name sortKey="Bijl, M" uniqKey="Bijl M">M Bijl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Westerweel, Pe" uniqKey="Westerweel P">PE Westerweel</name></author><author><name sortKey="Luijten, Rk" uniqKey="Luijten R">RK Luijten</name></author><author><name sortKey="Hoefer, Ie" uniqKey="Hoefer I">IE Hoefer</name></author><author><name sortKey="Koomans, Ha" uniqKey="Koomans H">HA Koomans</name></author><author><name sortKey="Derksen, Rh" uniqKey="Derksen R">RH Derksen</name></author><author><name sortKey="Verhaar, Mc" uniqKey="Verhaar M">MC Verhaar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Conti, F" uniqKey="Conti F">F Conti</name></author><author><name sortKey="Spinelli, Fr" uniqKey="Spinelli F">FR Spinelli</name></author><author><name sortKey="Alessandri, C" uniqKey="Alessandri C">C Alessandri</name></author><author><name sortKey="Pacelli, M" uniqKey="Pacelli M">M Pacelli</name></author><author><name sortKey="Ceccarelli, F" uniqKey="Ceccarelli F">F Ceccarelli</name></author><author><name sortKey="Marocchi, E" uniqKey="Marocchi E">E Marocchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cates, Am" uniqKey="Cates A">AM Cates</name></author><author><name sortKey="Holden, Vi" uniqKey="Holden V">VI Holden</name></author><author><name sortKey="Myers, Em" uniqKey="Myers E">EM Myers</name></author><author><name sortKey="Smith, Ck" uniqKey="Smith C">CK Smith</name></author><author><name sortKey="Kaplan, Mj" uniqKey="Kaplan M">MJ Kaplan</name></author><author><name sortKey="Kahlenberg, Jm" uniqKey="Kahlenberg J">JM Kahlenberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jacob, N" uniqKey="Jacob N">N Jacob</name></author><author><name sortKey="Stohl, W" uniqKey="Stohl W">W Stohl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kyaw, T" uniqKey="Kyaw T">T Kyaw</name></author><author><name sortKey="Tipping, P" uniqKey="Tipping P">P Tipping</name></author><author><name sortKey="Bobik, A" uniqKey="Bobik A">A Bobik</name></author><author><name sortKey="Toh, Bh" uniqKey="Toh B">BH Toh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hochberg, Mc" uniqKey="Hochberg M">MC Hochberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vasa, M" uniqKey="Vasa M">M Vasa</name></author><author><name sortKey="Fichtlscherer, S" uniqKey="Fichtlscherer S">S Fichtlscherer</name></author><author><name sortKey="Aicher, A" uniqKey="Aicher A">A Aicher</name></author><author><name sortKey="Adler, K" uniqKey="Adler K">K Adler</name></author><author><name sortKey="Urbich, C" uniqKey="Urbich C">C Urbich</name></author><author><name sortKey="Martin, H" uniqKey="Martin H">H Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fadini, Gp" uniqKey="Fadini G">GP Fadini</name></author><author><name sortKey="Losordo, D" uniqKey="Losordo D">D Losordo</name></author><author><name sortKey="Dimmeler, S" uniqKey="Dimmeler S">S Dimmeler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Burger, D" uniqKey="Burger D">D Burger</name></author><author><name sortKey="Touyz, Rm" uniqKey="Touyz R">RM Touyz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ebner, P" uniqKey="Ebner P">P Ebner</name></author><author><name sortKey="Picard, F" uniqKey="Picard F">F Picard</name></author><author><name sortKey="Richter, J" uniqKey="Richter J">J Richter</name></author><author><name sortKey="Darrelmann, E" uniqKey="Darrelmann E">E Darrelmann</name></author><author><name sortKey="Schneider, M" uniqKey="Schneider M">M Schneider</name></author><author><name sortKey="Strauer, Be" uniqKey="Strauer B">BE Strauer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baker, Jf" uniqKey="Baker J">JF Baker</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author><author><name sortKey="Imadojemu, S" uniqKey="Imadojemu S">S Imadojemu</name></author><author><name sortKey="Sharpe, A" uniqKey="Sharpe A">A Sharpe</name></author><author><name sortKey="Patil, S" uniqKey="Patil S">S Patil</name></author><author><name sortKey="Moore, Js" uniqKey="Moore J">JS Moore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Castejon, R" uniqKey="Castejon R">R Castejon</name></author><author><name sortKey="Jimenez Ortiz, C" uniqKey="Jimenez Ortiz C">C Jimenez-Ortiz</name></author><author><name sortKey="Valero Gonzalez, S" uniqKey="Valero Gonzalez S">S Valero-Gonzalez</name></author><author><name sortKey="Rosado, S" uniqKey="Rosado S">S Rosado</name></author><author><name sortKey="Mellor, S" uniqKey="Mellor S">S Mellor</name></author><author><name sortKey="Yebra Bango, M" uniqKey="Yebra Bango M">M Yebra-Bango</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grisar, J" uniqKey="Grisar J">J Grisar</name></author><author><name sortKey="Steiner, Cw" uniqKey="Steiner C">CW Steiner</name></author><author><name sortKey="Bonelli, M" uniqKey="Bonelli M">M Bonelli</name></author><author><name sortKey="Karonitsch, T" uniqKey="Karonitsch T">T Karonitsch</name></author><author><name sortKey="Schwarzinger, I" uniqKey="Schwarzinger I">I Schwarzinger</name></author><author><name sortKey="Weigel, G" uniqKey="Weigel G">G Weigel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deng, Xl" uniqKey="Deng X">XL Deng</name></author><author><name sortKey="Li, Xx" uniqKey="Li X">XX Li</name></author><author><name sortKey="Liu, Xy" uniqKey="Liu X">XY Liu</name></author><author><name sortKey="Sun, L" uniqKey="Sun L">L Sun</name></author><author><name sortKey="Liu, R" uniqKey="Liu R">R Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peichev, M" uniqKey="Peichev M">M Peichev</name></author><author><name sortKey="Naiyer, Aj" uniqKey="Naiyer A">AJ Naiyer</name></author><author><name sortKey="Pereira, D" uniqKey="Pereira D">D Pereira</name></author><author><name sortKey="Zhu, Z" uniqKey="Zhu Z">Z Zhu</name></author><author><name sortKey="Lane, Wj" uniqKey="Lane W">WJ Lane</name></author><author><name sortKey="Williams, M" uniqKey="Williams M">M Williams</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haque, S" uniqKey="Haque S">S Haque</name></author><author><name sortKey="Alexander, My" uniqKey="Alexander M">MY Alexander</name></author><author><name sortKey="Bruce, In" uniqKey="Bruce I">IN Bruce</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Banchereau, J" uniqKey="Banchereau J">J Banchereau</name></author><author><name sortKey="Pascual, V" uniqKey="Pascual V">V Pascual</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kahlenberg, Jm" uniqKey="Kahlenberg J">JM Kahlenberg</name></author><author><name sortKey="Thacker, Sg" uniqKey="Thacker S">SG Thacker</name></author><author><name sortKey="Berthier, Cc" uniqKey="Berthier C">CC Berthier</name></author><author><name sortKey="Cohen, Cd" uniqKey="Cohen C">CD Cohen</name></author><author><name sortKey="Kretzler, M" uniqKey="Kretzler M">M Kretzler</name></author><author><name sortKey="Kaplan, Mj" uniqKey="Kaplan M">MJ Kaplan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sage, Ap" uniqKey="Sage A">AP Sage</name></author><author><name sortKey="Tsiantoulas, D" uniqKey="Tsiantoulas D">D Tsiantoulas</name></author><author><name sortKey="Baker, L" uniqKey="Baker L">L Baker</name></author><author><name sortKey="Harrison, J" uniqKey="Harrison J">J Harrison</name></author><author><name sortKey="Masters, L" uniqKey="Masters L">L Masters</name></author><author><name sortKey="Murphy, D" uniqKey="Murphy D">D Murphy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kyaw, T" uniqKey="Kyaw T">T Kyaw</name></author><author><name sortKey="Cui, P" uniqKey="Cui P">P Cui</name></author><author><name sortKey="Tay, C" uniqKey="Tay C">C Tay</name></author><author><name sortKey="Kanellakis, P" uniqKey="Kanellakis P">P Kanellakis</name></author><author><name sortKey="Hosseini, H" uniqKey="Hosseini H">H Hosseini</name></author><author><name sortKey="Liu, E" uniqKey="Liu E">E Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Theodorou, E" uniqKey="Theodorou E">E Theodorou</name></author><author><name sortKey="Nezos, A" uniqKey="Nezos A">A Nezos</name></author><author><name sortKey="Antypa, E" uniqKey="Antypa E">E Antypa</name></author><author><name sortKey="Ioakeimidis, D" uniqKey="Ioakeimidis D">D Ioakeimidis</name></author><author><name sortKey="Koutsilieris, M" uniqKey="Koutsilieris M">M Koutsilieris</name></author><author><name sortKey="Tektonidou, M" uniqKey="Tektonidou M">M Tektonidou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suso, Jp" uniqKey="Suso J">JP Suso</name></author><author><name sortKey="Posso Osorio, I" uniqKey="Posso Osorio I">I Posso-Osorio</name></author><author><name sortKey="Jimenez, Ca" uniqKey="Jimenez C">CA Jiménez</name></author><author><name sortKey="Naranjo Escobar, J" uniqKey="Naranjo Escobar J">J Naranjo-Escobar</name></author><author><name sortKey="Ospina, Fe" uniqKey="Ospina F">FE Ospina</name></author><author><name sortKey="Sanchez, A" uniqKey="Sanchez A">A Sánchez</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A16 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 000A16 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Merge
|type= RBID
|clé= PMC:6868730
|texte= B lymphocyte stimulator modulates number and function of endothelial progenitor cells in systemic lupus erythematosus
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:31752963" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |