Characterizing Disease Manifestations and Treatment Patterns Among Adults with Systemic Sclerosis: A Retrospective Analysis of a US Healthcare Claims Population
Identifieur interne : 000962 ( Main/Merge ); précédent : 000961; suivant : 000963Characterizing Disease Manifestations and Treatment Patterns Among Adults with Systemic Sclerosis: A Retrospective Analysis of a US Healthcare Claims Population
Auteurs : Sara L. Gale [États-Unis] ; Huong Trinh [États-Unis] ; Nitya Mathew [États-Unis] ; Angelika Jahreis [États-Unis] ; Celia J. F. Lin [États-Unis] ; Khaled Sarsour [États-Unis]Source :
- Rheumatology and Therapy [ 2198-6576 ] ; 2019.
Abstract
Real-world use of immunomodulating therapy (IMT) in patients with systemic sclerosis (SSc) was investigated for the first time in a descriptive, retrospective cohort analysis of claims made in a healthcare insurance database to characterize treatment patterns and their alignment with SSc disease manifestations.
Treatment patterns and disease manifestations, symptoms, complications, and comorbidities were assessed in patients with SSc enrolled in a US healthcare claims database who received treatment between January 2006 and December 2013 and for whom data were available 6 months before and 12 months after SSc diagnosis.
Among 7812 eligible patients, 6852 received treatments of interest for SSc and 2404 (30.8%) received IMT during the first year after SSc diagnosis. In the first year after diagnosis, the most common claims were for antibiotics (61.7%), opioids (50.6%), glucocorticoids (46.5%), and proton pump inhibitors (35.4%); the most common organs involved with complications among patients with SSc were lung (30.5%), heart (17.4%), and gastrointestinal tract (22.4%); the most common signs or symptoms were musculoskeletal (16.1%) and fatigue (10.5%); 1035 patients (15.1%) had infections and 14 (0.2%) had malignancies. Among patients who received IMT, 43.8% received at least hydroxychloroquine and 21.1% received at least methotrexate; 460 patients switched to a second IMT, 23.0% to at least methotrexate and 22.8% to at least mycophenolate mofetil. The most common comorbidities reported with first IMT were in lung (11.8%), overlap syndrome (8.4%), heart (5.3%), and gastrointestinal (6.8%) categories.
One-third of patients with SSc in the healthcare claims population received IMTs during the first year after diagnosis. However, patients who received IMTs had disease manifestations similar to those of the overall SSc healthcare claims population.
The online version of this article (10.1007/s40744-019-00181-8) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1007/s40744-019-00181-8
PubMed: 31734871
PubMed Central: 7021840
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Gale</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Genentech, South San Francisco, CA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Genentech, South San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Trinh, Huong" sort="Trinh, Huong" uniqKey="Trinh H" first="Huong" last="Trinh">Huong Trinh</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Genentech, South San Francisco, CA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Genentech, South San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Mathew, Nitya" sort="Mathew, Nitya" uniqKey="Mathew N" first="Nitya" last="Mathew">Nitya Mathew</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Genentech, South San Francisco, CA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Genentech, South San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Jahreis, Angelika" sort="Jahreis, Angelika" uniqKey="Jahreis A" first="Angelika" last="Jahreis">Angelika Jahreis</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Genentech, South San Francisco, CA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Genentech, South San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Lin, Celia J F" sort="Lin, Celia J F" uniqKey="Lin C" first="Celia J. F." last="Lin">Celia J. F. Lin</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Genentech, South San Francisco, CA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Genentech, South San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Sarsour, Khaled" sort="Sarsour, Khaled" uniqKey="Sarsour K" first="Khaled" last="Sarsour">Khaled Sarsour</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Genentech, South San Francisco, CA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Genentech, South San Francisco</wicri:cityArea></affiliation></author></analytic><series><title level="j">Rheumatology and Therapy</title><idno type="ISSN">2198-6576</idno><idno type="eISSN">2198-6584</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Introduction</title><p id="Par1">Real-world use of immunomodulating therapy (IMT) in patients with systemic sclerosis (SSc) was investigated for the first time in a descriptive, retrospective cohort analysis of claims made in a healthcare insurance database to characterize treatment patterns and their alignment with SSc disease manifestations.</p></sec><sec><title>Methods</title><p id="Par2">Treatment patterns and disease manifestations, symptoms, complications, and comorbidities were assessed in patients with SSc enrolled in a US healthcare claims database who received treatment between January 2006 and December 2013 and for whom data were available 6 months before and 12 months after SSc diagnosis.</p></sec><sec><title>Results</title><p id="Par3">Among 7812 eligible patients, 6852 received treatments of interest for SSc and 2404 (30.8%) received IMT during the first year after SSc diagnosis. In the first year after diagnosis, the most common claims were for antibiotics (61.7%), opioids (50.6%), glucocorticoids (46.5%), and proton pump inhibitors (35.4%); the most common organs involved with complications among patients with SSc were lung (30.5%), heart (17.4%), and gastrointestinal tract (22.4%); the most common signs or symptoms were musculoskeletal (16.1%) and fatigue (10.5%); 1035 patients (15.1%) had infections and 14 (0.2%) had malignancies. Among patients who received IMT, 43.8% received at least hydroxychloroquine and 21.1% received at least methotrexate; 460 patients switched to a second IMT, 23.0% to at least methotrexate and 22.8% to at least mycophenolate mofetil. The most common comorbidities reported with first IMT were in lung (11.8%), overlap syndrome (8.4%), heart (5.3%), and gastrointestinal (6.8%) categories.</p></sec><sec><title>Conclusion</title><p id="Par4">One-third of patients with SSc in the healthcare claims population received IMTs during the first year after diagnosis. However, patients who received IMTs had disease manifestations similar to those of the overall SSc healthcare claims population.</p></sec><sec><title>Electronic Supplementary Material</title><p>The online version of this article (10.1007/s40744-019-00181-8) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Nikpour, M" uniqKey="Nikpour M">M Nikpour</name></author><author><name sortKey="Stevens, Wm" uniqKey="Stevens W">WM Stevens</name></author><author><name sortKey="Herrick, Al" uniqKey="Herrick A">AL Herrick</name></author><author><name sortKey="Proudman, Sm" uniqKey="Proudman S">SM Proudman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ioannidis, Jp" uniqKey="Ioannidis J">JP Ioannidis</name></author><author><name sortKey="Vlachoyiannopoulos, Pg" uniqKey="Vlachoyiannopoulos P">PG 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