Enhanced blood-brain-barrier penetrability and tumor-targeting efficiency by peptide-functionalized poly(amidoamine) dendrimer for the therapy of gliomas
Identifieur interne : 000839 ( Main/Merge ); précédent : 000838; suivant : 000840Enhanced blood-brain-barrier penetrability and tumor-targeting efficiency by peptide-functionalized poly(amidoamine) dendrimer for the therapy of gliomas
Auteurs : Changliang Liu [République populaire de Chine] ; Zijian Zhao [République populaire de Chine] ; Houqian Gao [République populaire de Chine] ; Iman Rostami [République populaire de Chine] ; Qing You [République populaire de Chine] ; Xinru Jia [République populaire de Chine] ; Chen Wang [République populaire de Chine] ; Ling Zhu [République populaire de Chine] ; Yanlian Yang [République populaire de Chine]Source :
- Nanotheranostics [ 2206-7418 ] ; 2019.
Abstract
Glioblastoma is one of the most common primary tumor types of central nervous system (CNS) with high malignance and lethality. Although many treatment options are currently available, the therapy of brain cancers remains challenging because of blood-brain-barrier (BBB) which prevents most of the chemotherapeutics into the CNS. In this work, a poly(amidoamine) dendrimer-based carrier was fabricated and modified with angiopep-2 (Ang2) peptide that has been demonstrated to bind to low density lipoprotein receptor-relative protein-1 (LRP1) on the endothelial cells of BBB and could therefore induce BBB penetration of the carrier. To improve tumor-targeting effect towards the glioma sites, the dendrimer was simultaneously functionalized with an epidermal growth factor receptor (EGFR)-targeting peptide (EP-1) which was screened from a “one-bead one-compound” (OBOC) combinatorial library. EP-1 peptide was demonstrated to have high affinity and specificity to EGFR at both the molecular and cellular levels. The dual-targeting dendrimer exhibited outstanding BBB penetrability and glioma targeting efficiency both
Url:
DOI: 10.7150/ntno.38954
PubMed: 31687320
PubMed Central: 6821994
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PMC:6821994Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Glioblastoma is one of the most common primary tumor types of central nervous system (CNS) with high malignance and lethality. Although many treatment options are currently available, the therapy of brain cancers remains challenging because of blood-brain-barrier (BBB) which prevents most of the chemotherapeutics into the CNS. In this work, a poly(amidoamine) dendrimer-based carrier was fabricated and modified with angiopep-2 (Ang2) peptide that has been demonstrated to bind to low density lipoprotein receptor-relative protein-1 (LRP1) on the endothelial cells of BBB and could therefore induce BBB penetration of the carrier. To improve tumor-targeting effect towards the glioma sites, the dendrimer was simultaneously functionalized with an epidermal growth factor receptor (EGFR)-targeting peptide (EP-1) which was screened from a “one-bead one-compound” (OBOC) combinatorial library. EP-1 peptide was demonstrated to have high affinity and specificity to EGFR at both the molecular and cellular levels. The dual-targeting dendrimer exhibited outstanding BBB penetrability and glioma targeting efficiency both <italic>in vitro</italic>
and <italic>in vivo</italic>
, which strikingly enhanced the anti-gliomas effect of the drugs and prolonged the survival of gliomas-bearing mice. These results show the potential of the dual-targeting dendrimer-based carrier in the therapy of gliomas through enhancing BBB penetrability and tumor targeting.</p>
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<biblStruct><analytic><author><name sortKey="Tan, Z" uniqKey="Tan Z">Z Tan</name>
</author>
<author><name sortKey="Song, L" uniqKey="Song L">L Song</name>
</author>
<author><name sortKey="Wu, W" uniqKey="Wu W">W Wu</name>
</author>
<author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name>
</author>
<author><name sortKey="Zhu, J" uniqKey="Zhu J">J Zhu</name>
</author>
<author><name sortKey="Wu, G" uniqKey="Wu G">G Wu</name>
</author>
</analytic>
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<biblStruct><analytic><author><name sortKey="Van Meir, Eg" uniqKey="Van Meir E">EG Van Meir</name>
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<author><name sortKey="Hadjipanayis, Cg" uniqKey="Hadjipanayis C">CG Hadjipanayis</name>
</author>
<author><name sortKey="Norden, Ad" uniqKey="Norden A">AD Norden</name>
</author>
<author><name sortKey="Shu, Hk" uniqKey="Shu H">HK Shu</name>
</author>
<author><name sortKey="Wen, Py" uniqKey="Wen P">PY Wen</name>
</author>
<author><name sortKey="Olson, Jj" uniqKey="Olson J">JJ Olson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ji, J" uniqKey="Ji J">J Ji</name>
</author>
<author><name sortKey="Xu, R" uniqKey="Xu R">R Xu</name>
</author>
<author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name>
</author>
<author><name sortKey="Han, M" uniqKey="Han M">M Han</name>
</author>
<author><name sortKey="Xu, Y" uniqKey="Xu Y">Y Xu</name>
</author>
<author><name sortKey="Wei, Y" uniqKey="Wei Y">Y Wei</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Furtado, D" uniqKey="Furtado D">D Furtado</name>
</author>
<author><name sortKey="Bjornmalm, M" uniqKey="Bjornmalm M">M Bjornmalm</name>
</author>
<author><name sortKey="Ayton, S" uniqKey="Ayton S">S Ayton</name>
</author>
<author><name sortKey="Bush, Ai" uniqKey="Bush A">AI Bush</name>
</author>
<author><name sortKey="Kempe, K" uniqKey="Kempe K">K Kempe</name>
</author>
<author><name sortKey="Caruso, F" uniqKey="Caruso F">F Caruso</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Abbott, Nj" uniqKey="Abbott N">NJ Abbott</name>
</author>
<author><name sortKey="Ronnback, L" uniqKey="Ronnback L">L Ronnback</name>
</author>
<author><name sortKey="Hansson, E" uniqKey="Hansson E">E Hansson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Armulik, A" uniqKey="Armulik A">A Armulik</name>
</author>
<author><name sortKey="Genove, G" uniqKey="Genove G">G Genove</name>
</author>
<author><name sortKey="Mae, M" uniqKey="Mae M">M Mae</name>
</author>
<author><name sortKey="Nisancioglu, Mh" uniqKey="Nisancioglu M">MH Nisancioglu</name>
</author>
<author><name sortKey="Wallgard, E" uniqKey="Wallgard E">E Wallgard</name>
</author>
<author><name sortKey="Niaudet, C" uniqKey="Niaudet C">C Niaudet</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Daneman, R" uniqKey="Daneman R">R Daneman</name>
</author>
<author><name sortKey="Zhou, L" uniqKey="Zhou L">L Zhou</name>
</author>
<author><name sortKey="Kebede, Aa" uniqKey="Kebede A">AA Kebede</name>
</author>
<author><name sortKey="Barres, Ba" uniqKey="Barres B">BA Barres</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pardridge, Wm" uniqKey="Pardridge W">WM Pardridge</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, R" uniqKey="Yang R">R Yang</name>
</author>
<author><name sortKey="Wei, T" uniqKey="Wei T">T Wei</name>
</author>
<author><name sortKey="Goldberg, H" uniqKey="Goldberg H">H Goldberg</name>
</author>
<author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name>
</author>
<author><name sortKey="Cullion, K" uniqKey="Cullion K">K Cullion</name>
</author>
<author><name sortKey="Kohane, Ds" uniqKey="Kohane D">DS Kohane</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Moseley, Ck" uniqKey="Moseley C">CK Moseley</name>
</author>
<author><name sortKey="Carlin, Sm" uniqKey="Carlin S">SM Carlin</name>
</author>
<author><name sortKey="Neelamegam, R" uniqKey="Neelamegam R">R Neelamegam</name>
</author>
<author><name sortKey="Hooker, Jm" uniqKey="Hooker J">JM Hooker</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lam, Fc" uniqKey="Lam F">FC Lam</name>
</author>
<author><name sortKey="Morton, Sw" uniqKey="Morton S">SW Morton</name>
</author>
<author><name sortKey="Wyckoff, J" uniqKey="Wyckoff J">J Wyckoff</name>
</author>
<author><name sortKey="Vu Han, Tl" uniqKey="Vu Han T">TL Vu Han</name>
</author>
<author><name sortKey="Hwang, Mk" uniqKey="Hwang M">MK Hwang</name>
</author>
<author><name sortKey="Maffa, A" uniqKey="Maffa A">A Maffa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Skinner, M" uniqKey="Skinner M">M Skinner</name>
</author>
<author><name sortKey="Ward, Sm" uniqKey="Ward S">SM Ward</name>
</author>
<author><name sortKey="Emrick, T" uniqKey="Emrick T">T Emrick</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Herve, F" uniqKey="Herve F">F Herve</name>
</author>
<author><name sortKey="Ghinea, N" uniqKey="Ghinea N">N Ghinea</name>
</author>
<author><name sortKey="Scherrmann, Jm" uniqKey="Scherrmann J">JM Scherrmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, L" uniqKey="Liu L">L Liu</name>
</author>
<author><name sortKey="Xu, K" uniqKey="Xu K">K Xu</name>
</author>
<author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name>
</author>
<author><name sortKey="Tan, Pk" uniqKey="Tan P">PK Tan</name>
</author>
<author><name sortKey="Fan, W" uniqKey="Fan W">W Fan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, H" uniqKey="Zhang H">H Zhang</name>
</author>
<author><name sortKey="Wu, Y" uniqKey="Wu Y">Y Wu</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name>
</author>
<author><name sortKey="Tang, Z" uniqKey="Tang Z">Z Tang</name>
</author>
<author><name sortKey="Ren, Y" uniqKey="Ren Y">Y Ren</name>
</author>
<author><name sortKey="Ni, D" uniqKey="Ni D">D Ni</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yun, Sp" uniqKey="Yun S">SP Yun</name>
</author>
<author><name sortKey="Kam, Ti" uniqKey="Kam T">TI Kam</name>
</author>
<author><name sortKey="Panicker, N" uniqKey="Panicker N">N Panicker</name>
</author>
<author><name sortKey="Kim, S" uniqKey="Kim S">S Kim</name>
</author>
<author><name sortKey="Oh, Y" uniqKey="Oh Y">Y Oh</name>
</author>
<author><name sortKey="Park, Js" uniqKey="Park J">JS Park</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Regina, A" uniqKey="Regina A">A Regina</name>
</author>
<author><name sortKey="Demeule, M" uniqKey="Demeule M">M Demeule</name>
</author>
<author><name sortKey="Che, C" uniqKey="Che C">C Che</name>
</author>
<author><name sortKey="Lavallee, I" uniqKey="Lavallee I">I Lavallee</name>
</author>
<author><name sortKey="Poirier, J" uniqKey="Poirier J">J Poirier</name>
</author>
<author><name sortKey="Gabathuler, R" uniqKey="Gabathuler R">R Gabathuler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bertrand, Y" uniqKey="Bertrand Y">Y Bertrand</name>
</author>
<author><name sortKey="Currie, Jc" uniqKey="Currie J">JC Currie</name>
</author>
<author><name sortKey="Poirier, J" uniqKey="Poirier J">J Poirier</name>
</author>
<author><name sortKey="Demeule, M" uniqKey="Demeule M">M Demeule</name>
</author>
<author><name sortKey="Abulrob, A" uniqKey="Abulrob A">A Abulrob</name>
</author>
<author><name sortKey="Fatehi, D" uniqKey="Fatehi D">D Fatehi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thomas, Fc" uniqKey="Thomas F">FC Thomas</name>
</author>
<author><name sortKey="Taskar, K" uniqKey="Taskar K">K Taskar</name>
</author>
<author><name sortKey="Rudraraju, V" uniqKey="Rudraraju V">V Rudraraju</name>
</author>
<author><name sortKey="Goda, S" uniqKey="Goda S">S Goda</name>
</author>
<author><name sortKey="Thorsheim, Hr" uniqKey="Thorsheim H">HR Thorsheim</name>
</author>
<author><name sortKey="Gaasch, Ja" uniqKey="Gaasch J">JA Gaasch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shein, Sa" uniqKey="Shein S">SA Shein</name>
</author>
<author><name sortKey="Kuznetsov, Ii" uniqKey="Kuznetsov I">II Kuznetsov</name>
</author>
<author><name sortKey="Abakumova, To" uniqKey="Abakumova T">TO Abakumova</name>
</author>
<author><name sortKey="Chelushkin, Ps" uniqKey="Chelushkin P">PS Chelushkin</name>
</author>
<author><name sortKey="Melnikov, Pa" uniqKey="Melnikov P">PA Melnikov</name>
</author>
<author><name sortKey="Korchagina, Aa" uniqKey="Korchagina A">AA Korchagina</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Qiao, C" uniqKey="Qiao C">C Qiao</name>
</author>
<author><name sortKey="Yang, J" uniqKey="Yang J">J Yang</name>
</author>
<author><name sortKey="Shen, Q" uniqKey="Shen Q">Q Shen</name>
</author>
<author><name sortKey="Liu, R" uniqKey="Liu R">R Liu</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
</author>
<author><name sortKey="Shi, Y" uniqKey="Shi Y">Y Shi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jia, Y" uniqKey="Jia Y">Y Jia</name>
</author>
<author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name>
</author>
<author><name sortKey="Hu, D" uniqKey="Hu D">D Hu</name>
</author>
<author><name sortKey="Wang, P" uniqKey="Wang P">P Wang</name>
</author>
<author><name sortKey="Liu, Q" uniqKey="Liu Q">Q Liu</name>
</author>
<author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gao, F" uniqKey="Gao F">F Gao</name>
</author>
<author><name sortKey="Xie, Ws" uniqKey="Xie W">WS Xie</name>
</author>
<author><name sortKey="Miao, Yq" uniqKey="Miao Y">YQ Miao</name>
</author>
<author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name>
</author>
<author><name sortKey="Guo, Zh" uniqKey="Guo Z">ZH Guo</name>
</author>
<author><name sortKey="Ghosal, A" uniqKey="Ghosal A">A Ghosal</name>
</author>
<author><name sortKey="Li, Ys" uniqKey="Li Y">YS Li</name>
</author>
<author><name sortKey="Yen, Wei" uniqKey="Yen W">Wei Yen</name>
</author>
<author><name sortKey="Feng, Ss" uniqKey="Feng S">SS Feng</name>
</author>
<author><name sortKey="Zhao, Ly" uniqKey="Zhao L">LY Zhao</name>
</author>
<author><name sortKey="Fan, Hm" uniqKey="Fan H">HM Fan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jiang, Y" uniqKey="Jiang Y">Y Jiang</name>
</author>
<author><name sortKey="Yang, W" uniqKey="Yang W">W Yang</name>
</author>
<author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name>
</author>
<author><name sortKey="Meng, F" uniqKey="Meng F">F Meng</name>
</author>
<author><name sortKey="Zhong, Z" uniqKey="Zhong Z">Z Zhong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, J" uniqKey="Li J">J Li</name>
</author>
<author><name sortKey="Yang, H" uniqKey="Yang H">H Yang</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
<author><name sortKey="Jiang, X" uniqKey="Jiang X">X Jiang</name>
</author>
<author><name sortKey="Guo, Y" uniqKey="Guo Y">Y Guo</name>
</author>
<author><name sortKey="An, S" uniqKey="An S">S An</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Israel, Ll" uniqKey="Israel L">LL Israel</name>
</author>
<author><name sortKey="Braubach, O" uniqKey="Braubach O">O Braubach</name>
</author>
<author><name sortKey="Galstyan, A" uniqKey="Galstyan A">A Galstyan</name>
</author>
<author><name sortKey="Chiechi, A" uniqKey="Chiechi A">A Chiechi</name>
</author>
<author><name sortKey="Shatalova, Es" uniqKey="Shatalova E">ES Shatalova</name>
</author>
<author><name sortKey="Grodzinski, Z" uniqKey="Grodzinski Z">Z Grodzinski</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yan, H" uniqKey="Yan H">H Yan</name>
</author>
<author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name>
</author>
<author><name sortKey="Weng, X" uniqKey="Weng X">X Weng</name>
</author>
<author><name sortKey="Lei, H" uniqKey="Lei H">H Lei</name>
</author>
<author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="You, L" uniqKey="You L">L You</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name>
</author>
<author><name sortKey="Liu T Zhang, Y" uniqKey="Liu T Zhang Y">Y Liu T; Zhang</name>
</author>
<author><name sortKey="Han, X" uniqKey="Han X">X Han</name>
</author>
<author><name sortKey="Wang, T" uniqKey="Wang T">T Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xie, Ws" uniqKey="Xie W">WS Xie</name>
</author>
<author><name sortKey="Gao, Q" uniqKey="Gao Q">Q Gao</name>
</author>
<author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name>
</author>
<author><name sortKey="Guo, Zh" uniqKey="Guo Z">ZH Guo</name>
</author>
<author><name sortKey="Gao, F" uniqKey="Gao F">F Gao</name>
</author>
<author><name sortKey="Wang, Xm" uniqKey="Wang X">XM Wang</name>
</author>
<author><name sortKey="Cai, Q" uniqKey="Cai Q">Q Cai</name>
</author>
<author><name sortKey="Feng, Ss" uniqKey="Feng S">SS Feng</name>
</author>
<author><name sortKey="Fan, Hm" uniqKey="Fan H">HM Fan</name>
</author>
<author><name sortKey="Sun, Xd" uniqKey="Sun X">XD Sun</name>
</author>
<author><name sortKey="Zhao, Ly" uniqKey="Zhao L">LY Zhao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gao, X" uniqKey="Gao X">X Gao</name>
</author>
<author><name sortKey="Yue, Q" uniqKey="Yue Q">Q Yue</name>
</author>
<author><name sortKey="Liu, Z" uniqKey="Liu Z">Z Liu</name>
</author>
<author><name sortKey="Ke, M" uniqKey="Ke M">M Ke</name>
</author>
<author><name sortKey="Zhou, X" uniqKey="Zhou X">X Zhou</name>
</author>
<author><name sortKey="Li, S" uniqKey="Li S">S Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Peng, Xq" uniqKey="Peng X">XQ Peng</name>
</author>
<author><name sortKey="Wang, Bq" uniqKey="Wang B">BQ Wang</name>
</author>
<author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name>
</author>
<author><name sortKey="Zhang, Yh" uniqKey="Zhang Y">YH Zhang</name>
</author>
<author><name sortKey="Liu, Yg" uniqKey="Liu Y">YG Liu</name>
</author>
<author><name sortKey="He, Y" uniqKey="He Y">Y He</name>
</author>
<author><name sortKey="Zhang, C" uniqKey="Zhang C">C Zhang</name>
</author>
<author><name sortKey="Fan, Hm" uniqKey="Fan H">HM Fan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, C" uniqKey="Lee C">C Lee</name>
</author>
<author><name sortKey="Hwang, Hs" uniqKey="Hwang H">HS Hwang</name>
</author>
<author><name sortKey="Lee, S" uniqKey="Lee S">S Lee</name>
</author>
<author><name sortKey="Kim, B" uniqKey="Kim B">B Kim</name>
</author>
<author><name sortKey="Kim, Jo" uniqKey="Kim J">JO Kim</name>
</author>
<author><name sortKey="Oh, Kt" uniqKey="Oh K">KT Oh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, Xl" uniqKey="Liu X">XL Liu</name>
</author>
<author><name sortKey="Peng, Ml" uniqKey="Peng M">ML Peng</name>
</author>
<author><name sortKey="Li, Gl" uniqKey="Li G">GL Li</name>
</author>
<author><name sortKey="Miao, Yq" uniqKey="Miao Y">YQ Miao</name>
</author>
<author><name sortKey="Luo, H" uniqKey="Luo H">H Luo</name>
</author>
<author><name sortKey="Jing, Gy" uniqKey="Jing G">GY Jing</name>
</author>
<author><name sortKey="He, Y" uniqKey="He Y">Y He</name>
</author>
<author><name sortKey="Zhang, C" uniqKey="Zhang C">C Zhang</name>
</author>
<author><name sortKey="Zhang, F" uniqKey="Zhang F">F Zhang</name>
</author>
<author><name sortKey="Fan, Hm" uniqKey="Fan H">HM Fan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kuthala, N" uniqKey="Kuthala N">N Kuthala</name>
</author>
<author><name sortKey="Vankayala, R" uniqKey="Vankayala R">R Vankayala</name>
</author>
<author><name sortKey="Li, Yn" uniqKey="Li Y">YN Li</name>
</author>
<author><name sortKey="Chiang, Cs" uniqKey="Chiang C">CS Chiang</name>
</author>
<author><name sortKey="Hwang, Kc" uniqKey="Hwang K">KC Hwang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Andreone, Bj" uniqKey="Andreone B">BJ Andreone</name>
</author>
<author><name sortKey="Chow, Bw" uniqKey="Chow B">BW Chow</name>
</author>
<author><name sortKey="Tata, A" uniqKey="Tata A">A Tata</name>
</author>
<author><name sortKey="Lacoste, B" uniqKey="Lacoste B">B Lacoste</name>
</author>
<author><name sortKey="Ben Zvi, A" uniqKey="Ben Zvi A">A Ben-Zvi</name>
</author>
<author><name sortKey="Bullock, K" uniqKey="Bullock K">K Bullock</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tuma, Pl" uniqKey="Tuma P">PL Tuma</name>
</author>
<author><name sortKey="Hubbard, Al" uniqKey="Hubbard A">AL Hubbard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Boye, K" uniqKey="Boye K">K Boye</name>
</author>
<author><name sortKey="Pujol, N" uniqKey="Pujol N">N Pujol</name>
</author>
<author><name sortKey="I, Da" uniqKey="I D">DA I</name>
</author>
<author><name sortKey="Chen, Yp" uniqKey="Chen Y">YP Chen</name>
</author>
<author><name sortKey="Daubon, T" uniqKey="Daubon T">T Daubon</name>
</author>
<author><name sortKey="Lee, Yz" uniqKey="Lee Y">YZ Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Warshawsky, I" uniqKey="Warshawsky I">I Warshawsky</name>
</author>
<author><name sortKey="Broze, Gj" uniqKey="Broze G">GJ Broze</name>
</author>
<author><name sortKey="Schwartz, Al" uniqKey="Schwartz A">AL Schwartz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Boado, Rj" uniqKey="Boado R">RJ Boado</name>
</author>
<author><name sortKey="Pardridge, Wm" uniqKey="Pardridge W">WM Pardridge</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Boado, Rj" uniqKey="Boado R">RJ Boado</name>
</author>
<author><name sortKey="Lu, Jz" uniqKey="Lu J">JZ Lu</name>
</author>
<author><name sortKey="Hui, Ekw" uniqKey="Hui E">EKW Hui</name>
</author>
<author><name sortKey="Lin, H" uniqKey="Lin H">H Lin</name>
</author>
<author><name sortKey="Pardridge, Wm" uniqKey="Pardridge W">WM Pardridge</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fan, K" uniqKey="Fan K">K Fan</name>
</author>
<author><name sortKey="Jia, X" uniqKey="Jia X">X Jia</name>
</author>
<author><name sortKey="Zhou, M" uniqKey="Zhou M">M Zhou</name>
</author>
<author><name sortKey="Wang, K" uniqKey="Wang K">K Wang</name>
</author>
<author><name sortKey="Conde, J" uniqKey="Conde J">J Conde</name>
</author>
<author><name sortKey="He, J" uniqKey="He J">J He</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jefferies, Wa" uniqKey="Jefferies W">WA Jefferies</name>
</author>
<author><name sortKey="Brandon, Mr" uniqKey="Brandon M">MR Brandon</name>
</author>
<author><name sortKey="Hunt, Sv" uniqKey="Hunt S">SV Hunt</name>
</author>
<author><name sortKey="Williams, Af" uniqKey="Williams A">AF Williams</name>
</author>
<author><name sortKey="Gatter, Kc" uniqKey="Gatter K">KC Gatter</name>
</author>
<author><name sortKey="Mason, Dy" uniqKey="Mason D">DY Mason</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wu, D" uniqKey="Wu D">D Wu</name>
</author>
<author><name sortKey="Qin, M" uniqKey="Qin M">M Qin</name>
</author>
<author><name sortKey="Xu, D" uniqKey="Xu D">D Xu</name>
</author>
<author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name>
</author>
<author><name sortKey="Liu, C" uniqKey="Liu C">C Liu</name>
</author>
<author><name sortKey="Ren, J" uniqKey="Ren J">J Ren</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Han, L" uniqKey="Han L">L Han</name>
</author>
<author><name sortKey="Liu, C" uniqKey="Liu C">C Liu</name>
</author>
<author><name sortKey="Qi, H" uniqKey="Qi H">H Qi</name>
</author>
<author><name sortKey="Zhou, J" uniqKey="Zhou J">J Zhou</name>
</author>
<author><name sortKey="Wen, J" uniqKey="Wen J">J Wen</name>
</author>
<author><name sortKey="Wu, D" uniqKey="Wu D">D Wu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Demeule, M" uniqKey="Demeule M">M Demeule</name>
</author>
<author><name sortKey="Currie, Jc" uniqKey="Currie J">JC Currie</name>
</author>
<author><name sortKey="Bertrand, Y" uniqKey="Bertrand Y">Y Bertrand</name>
</author>
<author><name sortKey="Che, C" uniqKey="Che C">C Che</name>
</author>
<author><name sortKey="Nguyen, T" uniqKey="Nguyen T">T Nguyen</name>
</author>
<author><name sortKey="Regina, A" uniqKey="Regina A">A Regina</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="He, H" uniqKey="He H">H He</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
</author>
<author><name sortKey="Jia, Xr" uniqKey="Jia X">XR Jia</name>
</author>
<author><name sortKey="Du, J" uniqKey="Du J">J Du</name>
</author>
<author><name sortKey="Ying, X" uniqKey="Ying X">X Ying</name>
</author>
<author><name sortKey="Lu, Wl" uniqKey="Lu W">WL Lu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mahvi, Da" uniqKey="Mahvi D">DA Mahvi</name>
</author>
<author><name sortKey="Liu, R" uniqKey="Liu R">R Liu</name>
</author>
<author><name sortKey="Grinstaff, Mw" uniqKey="Grinstaff M">MW Grinstaff</name>
</author>
<author><name sortKey="Colson, Yl" uniqKey="Colson Y">YL Colson</name>
</author>
<author><name sortKey="Raut, Cp" uniqKey="Raut C">CP Raut</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Svenson, S" uniqKey="Svenson S">S Svenson</name>
</author>
<author><name sortKey="Tomalia, Da" uniqKey="Tomalia D">DA Tomalia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name>
</author>
<author><name sortKey="Ma, Z" uniqKey="Ma Z">Z Ma</name>
</author>
<author><name sortKey="Zhu, S" uniqKey="Zhu S">S Zhu</name>
</author>
<author><name sortKey="Wan, H" uniqKey="Wan H">H Wan</name>
</author>
<author><name sortKey="Yue, J" uniqKey="Yue J">J Yue</name>
</author>
<author><name sortKey="Ma, H" uniqKey="Ma H">H Ma</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name>
</author>
<author><name sortKey="Wei, Z" uniqKey="Wei Z">Z Wei</name>
</author>
<author><name sortKey="Zhang, D" uniqKey="Zhang D">D Zhang</name>
</author>
<author><name sortKey="Ma, H" uniqKey="Ma H">H Ma</name>
</author>
<author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name>
</author>
<author><name sortKey="Bu, X" uniqKey="Bu X">X Bu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Agrawal, P" uniqKey="Agrawal P">P Agrawal</name>
</author>
<author><name sortKey="Gupta, U" uniqKey="Gupta U">U Gupta</name>
</author>
<author><name sortKey="Jain, Nk" uniqKey="Jain N">NK Jain</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Han, L" uniqKey="Han L">L Han</name>
</author>
<author><name sortKey="Huang, R" uniqKey="Huang R">R Huang</name>
</author>
<author><name sortKey="Liu, S" uniqKey="Liu S">S Liu</name>
</author>
<author><name sortKey="Huang, S" uniqKey="Huang S">S Huang</name>
</author>
<author><name sortKey="Jiang, C" uniqKey="Jiang C">C Jiang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kuang, J" uniqKey="Kuang J">J Kuang</name>
</author>
<author><name sortKey="Song, W" uniqKey="Song W">W Song</name>
</author>
<author><name sortKey="Yin, J" uniqKey="Yin J">J Yin</name>
</author>
<author><name sortKey="Zeng, X" uniqKey="Zeng X">X Zeng</name>
</author>
<author><name sortKey="Han, S" uniqKey="Han S">S Han</name>
</author>
<author><name sortKey="Zhao, Yp" uniqKey="Zhao Y">YP Zhao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gray, Bp" uniqKey="Gray B">BP Gray</name>
</author>
<author><name sortKey="Brown, Kc" uniqKey="Brown K">KC Brown</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Geng, L" uniqKey="Geng L">L Geng</name>
</author>
<author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name>
</author>
<author><name sortKey="Yang, X" uniqKey="Yang X">X Yang</name>
</author>
<author><name sortKey="Li, D" uniqKey="Li D">D Li</name>
</author>
<author><name sortKey="Lian, W" uniqKey="Lian W">W Lian</name>
</author>
<author><name sortKey="Xiang, Z" uniqKey="Xiang Z">Z Xiang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, S" uniqKey="Zhao S">S Zhao</name>
</author>
<author><name sortKey="Yang, M" uniqKey="Yang M">M Yang</name>
</author>
<author><name sortKey="Zhou, W" uniqKey="Zhou W">W Zhou</name>
</author>
<author><name sortKey="Zhang, B" uniqKey="Zhang B">B Zhang</name>
</author>
<author><name sortKey="Cheng, Z" uniqKey="Cheng Z">Z Cheng</name>
</author>
<author><name sortKey="Huang, J" uniqKey="Huang J">J Huang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Subik, K" uniqKey="Subik K">K Subik</name>
</author>
<author><name sortKey="Lee, Jf" uniqKey="Lee J">JF Lee</name>
</author>
<author><name sortKey="Baxter, L" uniqKey="Baxter L">L Baxter</name>
</author>
<author><name sortKey="Strzepek, T" uniqKey="Strzepek T">T Strzepek</name>
</author>
<author><name sortKey="Costello, D" uniqKey="Costello D">D Costello</name>
</author>
<author><name sortKey="Crowley, P" uniqKey="Crowley P">P Crowley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wilhelm, S" uniqKey="Wilhelm S">S Wilhelm</name>
</author>
<author><name sortKey="Tavares, Aj" uniqKey="Tavares A">AJ Tavares</name>
</author>
<author><name sortKey="Dai, Q" uniqKey="Dai Q">Q Dai</name>
</author>
<author><name sortKey="Ohta, S" uniqKey="Ohta S">S Ohta</name>
</author>
<author><name sortKey="Audet, J" uniqKey="Audet J">J Audet</name>
</author>
<author><name sortKey="Dvorak, Hf" uniqKey="Dvorak H">HF Dvorak</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vidal, F" uniqKey="Vidal F">F Vidal</name>
</author>
<author><name sortKey="Vasquez, P" uniqKey="Vasquez P">P Vasquez</name>
</author>
<author><name sortKey="Diaz, C" uniqKey="Diaz C">C Diaz</name>
</author>
<author><name sortKey="Nova, D" uniqKey="Nova D">D Nova</name>
</author>
<author><name sortKey="Alderete, J" uniqKey="Alderete J">J Alderete</name>
</author>
<author><name sortKey="Guzman, L" uniqKey="Guzman L">L Guzman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vergara Jaque, A" uniqKey="Vergara Jaque A">A Vergara-Jaque</name>
</author>
<author><name sortKey="Comer, J" uniqKey="Comer J">J Comer</name>
</author>
<author><name sortKey="Monsalve, L" uniqKey="Monsalve L">L Monsalve</name>
</author>
<author><name sortKey="Gonzalez Nilo, Fd" uniqKey="Gonzalez Nilo F">FD Gonzalez-Nilo</name>
</author>
<author><name sortKey="Sandoval, C" uniqKey="Sandoval C">C Sandoval</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name>
</author>
<author><name sortKey="Bryantsev, Vs" uniqKey="Bryantsev V">VS Bryantsev</name>
</author>
<author><name sortKey="Diallo, Ms" uniqKey="Diallo M">MS Diallo</name>
</author>
<author><name sortKey="Goddard Iii, Wa" uniqKey="Goddard Iii W">WA Goddard Iii</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Senapati, S" uniqKey="Senapati S">S Senapati</name>
</author>
<author><name sortKey="Mahanta, Ak" uniqKey="Mahanta A">AK Mahanta</name>
</author>
<author><name sortKey="Kumar, S" uniqKey="Kumar S">S Kumar</name>
</author>
<author><name sortKey="Maiti, P" uniqKey="Maiti P">P Maiti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cao, N" uniqKey="Cao N">N Cao</name>
</author>
<author><name sortKey="Feng, Ss" uniqKey="Feng S">SS Feng</name>
</author>
</analytic>
</biblStruct>
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