ChloroquineV1, Main, Merge, bibRecord, 000807

Functions and Implications of Autophagy in Colon Cancer

Identifieur interne : 000807 ( Main/Merge ); précédent : 000806; suivant : 000808

Functions and Implications of Autophagy in Colon Cancer

Auteurs : Samantha N. Devenport [États-Unis] ; Yatrik M. Shah [États-Unis]

Source :

Cells [ 2073-4409 ] ; 2019.

RBID : PMC:6912527

Abstract

Autophagy is an essential function to breakdown cellular proteins and organelles to recycle for new nutrient building blocks. In colorectal cancer, the importance of autophagy is becoming widely recognized as it demonstrates both pro- and anti-tumorigenic functions. In colon cancer, cell autonomous and non-autonomous roles for autophagy are essential in growth and progression. However, the mechanisms downstream of autophagy (to reduce or enhance tumor growth) are not well known. Additionally, the signals that activate and coordinate autophagy for tumor cell growth and survival are not clear. Here, we highlight the context- and cargo-dependent role of autophagy in proliferation, cell death, and cargo breakdown.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912527

DOI: 10.3390/cells8111349
PubMed: 31671556
PubMed Central: 6912527

Links toward previous steps (curation, corpus...)

to stream Pmc, to step Corpus: 000928
to stream Pmc, to step Curation: 000928
to stream Pmc, to step Checkpoint: 000748
to stream Ncbi, to step Merge: 000B58
to stream Ncbi, to step Curation: 000B58
to stream Ncbi, to step Checkpoint: 000B58

Links to Exploration step

PMC:6912527

Le document en format XML

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</div1>
</back>
</TEI>
</record>

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Functions and Implications of Autophagy in Colon Cancer

Functions and Implications of Autophagy in Colon Cancer

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