Functions and Implications of Autophagy in Colon Cancer
Identifieur interne : 000807 ( Main/Merge ); précédent : 000806; suivant : 000808Functions and Implications of Autophagy in Colon Cancer
Auteurs : Samantha N. Devenport [États-Unis] ; Yatrik M. Shah [États-Unis]Source :
- Cells [ 2073-4409 ] ; 2019.
Abstract
Autophagy is an essential function to breakdown cellular proteins and organelles to recycle for new nutrient building blocks. In colorectal cancer, the importance of autophagy is becoming widely recognized as it demonstrates both pro- and anti-tumorigenic functions. In colon cancer, cell autonomous and non-autonomous roles for autophagy are essential in growth and progression. However, the mechanisms downstream of autophagy (to reduce or enhance tumor growth) are not well known. Additionally, the signals that activate and coordinate autophagy for tumor cell growth and survival are not clear. Here, we highlight the context- and cargo-dependent role of autophagy in proliferation, cell death, and cargo breakdown.
Url:
DOI: 10.3390/cells8111349
PubMed: 31671556
PubMed Central: 6912527
Links toward previous steps (curation, corpus...)
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- to stream Pmc, to step Curation: 000928
- to stream Pmc, to step Checkpoint: 000748
- to stream Ncbi, to step Merge: 000B58
- to stream Ncbi, to step Curation: 000B58
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Links to Exploration step
PMC:6912527Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Autophagy is an essential function to breakdown cellular proteins and organelles to recycle for new nutrient building blocks. In colorectal cancer, the importance of autophagy is becoming widely recognized as it demonstrates both pro- and anti-tumorigenic functions. In colon cancer, cell autonomous and non-autonomous roles for autophagy are essential in growth and progression. However, the mechanisms downstream of autophagy (to reduce or enhance tumor growth) are not well known. Additionally, the signals that activate and coordinate autophagy for tumor cell growth and survival are not clear. Here, we highlight the context- and cargo-dependent role of autophagy in proliferation, cell death, and cargo breakdown.</p>
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