New Horizons in KRAS-Mutant Lung Cancer: Dawn After Darkness
Identifieur interne : 000593 ( Main/Merge ); précédent : 000592; suivant : 000594New Horizons in KRAS-Mutant Lung Cancer: Dawn After Darkness
Auteurs : Haitang Yang [Suisse] ; Shun-Qing Liang [Suisse, États-Unis] ; Ralph A. Schmid [Suisse] ; Ren-Wang Peng [Suisse]Source :
- Frontiers in Oncology [ 2234-943X ] ; 2019.
Abstract
In non-small cell lung cancer (NSCLC), the most frequent oncogenic mutation in western countries is
Url:
DOI: 10.3389/fonc.2019.00953
PubMed: 31612108
PubMed Central: 6773824
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000982
- to stream Pmc, to step Curation: 000982
- to stream Pmc, to step Checkpoint: 000544
- to stream Ncbi, to step Merge: 000B02
- to stream Ncbi, to step Curation: 000B02
- to stream Ncbi, to step Checkpoint: 000B02
Links to Exploration step
PMC:6773824Le document en format XML
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<author><name sortKey="Liang, Shun Qing" sort="Liang, Shun Qing" uniqKey="Liang S" first="Shun-Qing" last="Liang">Shun-Qing Liang</name>
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<author><name sortKey="Peng, Ren Wang" sort="Peng, Ren Wang" uniqKey="Peng R" first="Ren-Wang" last="Peng">Ren-Wang Peng</name>
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<series><title level="j">Frontiers in Oncology</title>
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<front><div type="abstract" xml:lang="en"><p>In non-small cell lung cancer (NSCLC), the most frequent oncogenic mutation in western countries is <italic>KRAS</italic>
, for which, however, there remains no clinically approved targeted therapies. Recent progress on high biological heterogeneity including diverse <italic>KRAS</italic>
point mutations, varying dependence on mutant <italic>KRAS</italic>
, wide spectrum of other co-occurring genetic alterations, as well as distinct cellular status across the epithelial-to-mesenchymal transition (EMT), has not only deepened our understanding about the pathobiology of <italic>KRAS</italic>
-mutant NSCLC but also brought about unprecedented new hopes for precision treatment of patients. In this review, we provide an update on the most recent advances in <italic>KRAS</italic>
-mutant lung cancer, with a focus on mechanistic insights into tumor heterogeneity, the potential clinic implications and new therapies on horizons tailored for <italic>KRAS</italic>
-mutant lung cancer.</p>
</div>
</front>
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