Repurposing Quinacrine against Ebola Virus Infection In Vivo
Identifieur interne : 000466 ( Main/Merge ); précédent : 000465; suivant : 000467Repurposing Quinacrine against Ebola Virus Infection In Vivo
Auteurs : Thomas R. Lane [États-Unis] ; Jason E. Comer [États-Unis] ; Alexander N. Freiberg [États-Unis] ; Peter B. Madrid [États-Unis] ; Sean Ekins [États-Unis]Source :
- Antimicrobial Agents and Chemotherapy [ 0066-4804 ] ; 2019.
Abstract
Quinacrine hydrochloride is a small-molecule, orally bioavailable drug that has been used clinically as an antimalarial and for many other applications. A machine learning model trained on Ebola virus (EBOV) screening data identified quinacrine as a potent (nanomolar)
Url:
DOI: 10.1128/AAC.01142-19
PubMed: 31307979
PubMed Central: 6709481
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PMC:6709481Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Quinacrine hydrochloride is a small-molecule, orally bioavailable drug that has been used clinically as an antimalarial and for many other applications. A machine learning model trained on Ebola virus (EBOV) screening data identified quinacrine as a potent (nanomolar) <italic>in vitro</italic>
inhibitor.</p>
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</front>
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