Targeting Autophagy for Cancer Treatment and Tumor Chemosensitization
Identifieur interne : 000396 ( Main/Merge ); précédent : 000395; suivant : 000397Targeting Autophagy for Cancer Treatment and Tumor Chemosensitization
Auteurs : Marta Pérez-Hernández [Espagne] ; Alain Arias [Chili] ; David Martínez-García [Espagne] ; Ricardo Pérez-Tomás [Espagne] ; Roberto Quesada ; Vanessa Soto-Cerrato [Espagne]Source :
- Cancers [ 2072-6694 ] ; 2019.
Abstract
Autophagy is a tightly regulated catabolic process that facilitates nutrient recycling from damaged organelles and other cellular components through lysosomal degradation. Deregulation of this process has been associated with the development of several pathophysiological processes, such as cancer and neurodegenerative diseases. In cancer, autophagy has opposing roles, being either cytoprotective or cytotoxic. Thus, deciphering the role of autophagy in each tumor context is crucial. Moreover, autophagy has been shown to contribute to chemoresistance in some patients. In this regard, autophagy modulation has recently emerged as a promising therapeutic strategy for the treatment and chemosensitization of tumors, and has already demonstrated positive clinical results in patients. In this review, the dual role of autophagy during carcinogenesis is discussed and current therapeutic strategies aimed at targeting autophagy for the treatment of cancer, both under preclinical and clinical development, are presented. The use of autophagy modulators in combination therapies, in order to overcome drug resistance during cancer treatment, is also discussed as well as the potential challenges and limitations for the use of these novel therapeutic strategies in the clinic.
Url:
DOI: 10.3390/cancers11101599
PubMed: 31635099
PubMed Central: 6826429
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000902
- to stream Pmc, to step Curation: 000902
- to stream Pmc, to step Checkpoint: 000357
- to stream Ncbi, to step Merge: 000B23
- to stream Ncbi, to step Curation: 000B23
- to stream Ncbi, to step Checkpoint: 000B23
Links to Exploration step
PMC:6826429Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Autophagy is a tightly regulated catabolic process that facilitates nutrient recycling from damaged organelles and other cellular components through lysosomal degradation. Deregulation of this process has been associated with the development of several pathophysiological processes, such as cancer and neurodegenerative diseases. In cancer, autophagy has opposing roles, being either cytoprotective or cytotoxic. Thus, deciphering the role of autophagy in each tumor context is crucial. Moreover, autophagy has been shown to contribute to chemoresistance in some patients. In this regard, autophagy modulation has recently emerged as a promising therapeutic strategy for the treatment and chemosensitization of tumors, and has already demonstrated positive clinical results in patients. In this review, the dual role of autophagy during carcinogenesis is discussed and current therapeutic strategies aimed at targeting autophagy for the treatment of cancer, both under preclinical and clinical development, are presented. The use of autophagy modulators in combination therapies, in order to overcome drug resistance during cancer treatment, is also discussed as well as the potential challenges and limitations for the use of these novel therapeutic strategies in the clinic.</p>
</div>
</front>
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