Aptamers as Delivery Agents of siRNA and Chimeric Formulations for the Treatment of Cancer
Identifieur interne : 000A66 ( Main/Exploration ); précédent : 000A65; suivant : 000A67Aptamers as Delivery Agents of siRNA and Chimeric Formulations for the Treatment of Cancer
Auteurs : Ana Paula Dinis Ano Bom ; Patrícia Cristina Da Costa Neves ; Carlos Eduardo Bonacossa De Almeida ; Dilson Silva ; Sotiris MissailidisSource :
- Pharmaceutics [ 1999-4923 ] ; 2019.
Abstract
Both aptamers and siRNA technologies have now reached maturity, and both have been validated with a product in the market. However, although pegaptanib reached the market some time ago, there has been a slow process for new aptamers to follow. Today, some 40 aptamers are in the market, but many in combination with siRNAs, in the form of specific delivery agents. This combination offers the potential to explore the high affinity and specificity of aptamers, the silencing power of siRNA, and, at times, the cytotoxicity of chemotherapy molecules in powerful combinations that promise to delivery new and potent therapies. In this review, we report new developments in the field, following up from our previous work, more specifically on the use of aptamers as delivery agents of siRNA in nanoparticle formulations, alone or in combination with chemotherapy, for the treatment of cancer.
Url:
DOI: 10.3390/pharmaceutics11120684
PubMed: 31888119
PubMed Central: 6956146
Affiliations:
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Le document en format XML
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<author><name sortKey="Da Costa Neves, Patricia Cristina" sort="Da Costa Neves, Patricia Cristina" uniqKey="Da Costa Neves P" first="Patrícia Cristina" last="Da Costa Neves">Patrícia Cristina Da Costa Neves</name>
<affiliation><nlm:aff id="af1-pharmaceutics-11-00684">Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), Fundação Oswaldo Cruz. Av. Brasil, 4365-Manguinhos, Rio de Janeiro/RJ CEP 21040-900, Brazil;<email>adinis@bio.fiocruz.br</email>
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<author><name sortKey="Bonacossa De Almeida, Carlos Eduardo" sort="Bonacossa De Almeida, Carlos Eduardo" uniqKey="Bonacossa De Almeida C" first="Carlos Eduardo" last="Bonacossa De Almeida">Carlos Eduardo Bonacossa De Almeida</name>
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<front><div type="abstract" xml:lang="en"><p>Both aptamers and siRNA technologies have now reached maturity, and both have been validated with a product in the market. However, although pegaptanib reached the market some time ago, there has been a slow process for new aptamers to follow. Today, some 40 aptamers are in the market, but many in combination with siRNAs, in the form of specific delivery agents. This combination offers the potential to explore the high affinity and specificity of aptamers, the silencing power of siRNA, and, at times, the cytotoxicity of chemotherapy molecules in powerful combinations that promise to delivery new and potent therapies. In this review, we report new developments in the field, following up from our previous work, more specifically on the use of aptamers as delivery agents of siRNA in nanoparticle formulations, alone or in combination with chemotherapy, for the treatment of cancer.</p>
</div>
</front>
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</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Bonacossa De Almeida, Carlos Eduardo" sort="Bonacossa De Almeida, Carlos Eduardo" uniqKey="Bonacossa De Almeida C" first="Carlos Eduardo" last="Bonacossa De Almeida">Carlos Eduardo Bonacossa De Almeida</name>
<name sortKey="Da Costa Neves, Patricia Cristina" sort="Da Costa Neves, Patricia Cristina" uniqKey="Da Costa Neves P" first="Patrícia Cristina" last="Da Costa Neves">Patrícia Cristina Da Costa Neves</name>
<name sortKey="Dinis Ano Bom, Ana Paula" sort="Dinis Ano Bom, Ana Paula" uniqKey="Dinis Ano Bom A" first="Ana Paula" last="Dinis Ano Bom">Ana Paula Dinis Ano Bom</name>
<name sortKey="Missailidis, Sotiris" sort="Missailidis, Sotiris" uniqKey="Missailidis S" first="Sotiris" last="Missailidis">Sotiris Missailidis</name>
<name sortKey="Silva, Dilson" sort="Silva, Dilson" uniqKey="Silva D" first="Dilson" last="Silva">Dilson Silva</name>
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