High-Throughput Screening and Identification of Potent Broad-Spectrum Inhibitors of Coronaviruses
Identifieur interne : 000779 ( Main/Exploration ); précédent : 000778; suivant : 000780High-Throughput Screening and Identification of Potent Broad-Spectrum Inhibitors of Coronaviruses
Auteurs : Liang Shen [République populaire de Chine] ; Junwei Niu [République populaire de Chine] ; Chunhua Wang [République populaire de Chine] ; Baoying Huang [République populaire de Chine] ; Wenling Wang [République populaire de Chine] ; Na Zhu [République populaire de Chine] ; Yao Deng [République populaire de Chine] ; Huijuan Wang [République populaire de Chine] ; Fei Ye [République populaire de Chine] ; Shan Cen [République populaire de Chine] ; Wenjie Tan [République populaire de Chine]Source :
- Journal of Virology [ 0022-538X ] ; 2019.
Abstract
Currently, there is no approved therapy to treat coronavirus infection; therefore, broad-spectrum inhibitors of emerging and endemic CoVs are needed. Based on our high-throughput screening assay using a compound library, we identified seven compounds with broad-spectrum efficacy against the replication of four CoVs
Url:
DOI: 10.1128/JVI.00023-19
PubMed: 30918074
PubMed Central: 6613765
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Currently, there is no approved therapy to treat coronavirus infection; therefore, broad-spectrum inhibitors of emerging and endemic CoVs are needed. Based on our high-throughput screening assay using a compound library, we identified seven compounds with broad-spectrum efficacy against the replication of four CoVs <italic>in vitro</italic>
. Additionally, one compound (lycorine) was found to protect BALB/c mice against HCoV-OC43-induced lethality by decreasing viral load in the central nervous system. This inhibitor might offer promising therapeutic possibilities for combatting novel CoV infections in the future.</p>
</div>
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<name sortKey="Ye, Fei" sort="Ye, Fei" uniqKey="Ye F" first="Fei" last="Ye">Fei Ye</name>
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