Effects of chloroquine treatment on circulating erythropoietin and inflammatory cytokines in acute malaria
Identifieur interne : 001916 ( Main/Curation ); précédent : 001915; suivant : 001917Effects of chloroquine treatment on circulating erythropoietin and inflammatory cytokines in acute malaria
Auteurs : Adil Ballal [Allemagne] ; Amal Saeed [Allemagne] ; Patricia Rouina [Allemagne] ; Wolfgang Jelkmann [Allemagne]Source :
- Annals of Hematology [ 0939-5555 ] ; 2008-11-20.
English descriptors
- mix :
Abstract
Anemia is a common and serious complication of malaria due to infection, a major health problem in tropical areas. Herein, the relation was investigated between the levels of circulating erythropoietin (EPO) and immunomodulatory cytokines in response to chloroquine treatment. Thirty-seven healthy control subjects and 40 patients with acute infection were included in the study. All subjects were adult male Sudanese. Blood samples were collected before chloroquine administration (25 mg/kg body weight, orally on three consecutive days) and 3 and 30 days after start of the therapy. Measurements included routine hematological parameters and the concentrations of immunoreactive EPO, tumor necrosis factor-α (TNF-α), interleukin 1α (IL-1), IL-6, and interferon γ (INF-γ). Chloroquine treatment led to a decrease in EPO levels in the control subjects but an increase in malaria patients at day 30. The latter was likely due to the anti-inflammatory action of the drug because INF-γ, IL-1, and IL-6 concentrations declined on chloroquine treatment. Based on these findings, we propose that an impaired EPO production in association with a prolonged elevation of certain inflammatory cytokines can contribute to the anemia in some malaria patients which can be reversed by chloroquine therapy.
Url:
DOI: 10.1007/s00277-008-0636-z
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Hal:hal-00535004Le document en format XML
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<front><div type="abstract" xml:lang="en"> <p>Anemia is a common and serious complication of malaria due to infection, a major health problem in tropical areas. Herein, the relation was investigated between the levels of circulating erythropoietin (EPO) and immunomodulatory cytokines in response to chloroquine treatment. Thirty-seven healthy control subjects and 40 patients with acute infection were included in the study. All subjects were adult male Sudanese. Blood samples were collected before chloroquine administration (25 mg/kg body weight, orally on three consecutive days) and 3 and 30 days after start of the therapy. Measurements included routine hematological parameters and the concentrations of immunoreactive EPO, tumor necrosis factor-α (TNF-α), interleukin 1α (IL-1), IL-6, and interferon γ (INF-γ). Chloroquine treatment led to a decrease in EPO levels in the control subjects but an increase in malaria patients at day 30. The latter was likely due to the anti-inflammatory action of the drug because INF-γ, IL-1, and IL-6 concentrations declined on chloroquine treatment. Based on these findings, we propose that an impaired EPO production in association with a prolonged elevation of certain inflammatory cytokines can contribute to the anemia in some malaria patients which can be reversed by chloroquine therapy.</p>
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