Antiplasmodial benzophenones from the trunk latex of Moronobea coccinea (Clusiaceae).
Identifieur interne : 001774 ( Main/Curation ); précédent : 001773; suivant : 001775Antiplasmodial benzophenones from the trunk latex of Moronobea coccinea (Clusiaceae).
Auteurs : Guillaume Marti [France] ; Véronique Eparvier [France] ; Christian Moretti [France] ; Sophie Susplugas ; Soizic Prado [France] ; Philippe Grellier [France] ; Pascal Retailleau [France] ; Françoise Guéritte [France] ; Marc Litaudon [France]Source :
- Phytochemistry [ 0031-9422 ] ; 2009-01.
Abstract
In an effort to find antimalarial drugs, a systematic in vitro evaluation on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) was undertaken on sixty plant extracts collected in French Guiana. The methanol extract obtained from the latex of Moronobea coccinea exhibited a strong antiplasmodial activity (95% at 10microg/ml). The phytochemical investigation of this extract led to the isolation of eleven polycyclic polyprenylated acylphloroglucinols (PPAPs), from which eight showed potent antiplasmodial activity with IC50 ranged from 3.3microM to 37.2microM.
Url:
DOI: 10.1016/j.phytochem.2008.10.005
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Hal:hal-00373615Le document en format XML
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<idno type="DOI">10.1016/j.phytochem.2008.10.005</idno>
<series><title level="j">Phytochemistry</title>
<idno type="ISSN">0031-9422</idno>
<imprint><date type="datePub">2009-01</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en"> <p>In an effort to find antimalarial drugs, a systematic in vitro evaluation on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) was undertaken on sixty plant extracts collected in French Guiana. The methanol extract obtained from the latex of Moronobea coccinea exhibited a strong antiplasmodial activity (95% at 10microg/ml). The phytochemical investigation of this extract led to the isolation of eleven polycyclic polyprenylated acylphloroglucinols (PPAPs), from which eight showed potent antiplasmodial activity with IC50 ranged from 3.3microM to 37.2microM.</p>
</div>
</front>
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