PRIMACENES: novel non-cytotoxic primaquine-ferrocene conjugates with anti-Pneumocystis carinii activity
Identifieur interne : 001638 ( Main/Curation ); précédent : 001637; suivant : 001639PRIMACENES: novel non-cytotoxic primaquine-ferrocene conjugates with anti-Pneumocystis carinii activity
Auteurs : Joana Matos [Portugal] ; Nuno Vale [Portugal] ; Margaret S. Collins [États-Unis] ; Jiri Gut [États-Unis] ; Philip J. Rosenthal [États-Unis] ; Melanie T. Cushion [États-Unis] ; Rui Moreira [Portugal] ; Paula Gomes [Portugal]Source :
- MedChemComm [ 2040-2503 ] ; 2010.
English descriptors
- Teeft :
Abstract
Primacenes, novel ferroceneprimaquine conjugates, were synthesized and screened for their antimalarial and anti-pneumocystis activity. Primacenes obtained by coupling primaquine amino acid derivatives to ferrocenoic acid were significantly active against Pneumocystis carinii and devoid of cytotoxicity, thus being more selective than the parent drug.
Url:
DOI: 10.1039/c0md00082e
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ISTEX:774B7597D3CEB6C72515DF622204D302B91A3299Le document en format XML
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<term>Carinii</term>
<term>Chem</term>
<term>Clogp values</term>
<term>Ferrocene core</term>
<term>Ferrocenecarboxylic acid</term>
<term>Gomes</term>
<term>Immunocompromised individuals</term>
<term>Moreira</term>
<term>Novel conjugates</term>
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<front><div type="abstract">Primacenes, novel ferroceneprimaquine conjugates, were synthesized and screened for their antimalarial and anti-pneumocystis activity. Primacenes obtained by coupling primaquine amino acid derivatives to ferrocenoic acid were significantly active against Pneumocystis carinii and devoid of cytotoxicity, thus being more selective than the parent drug.</div>
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