Anti-cancer effects of CQBTO, a chloroquine, and benzo(e)triazine oxide conjugate.
Identifieur interne : 000A79 ( Main/Curation ); précédent : 000A78; suivant : 000A80Anti-cancer effects of CQBTO, a chloroquine, and benzo(e)triazine oxide conjugate.
Auteurs : Ziyang Guo [République populaire de Chine] ; Hailong Pei [République populaire de Chine] ; Jing Nie [République populaire de Chine] ; Wentao Hu [République populaire de Chine] ; Jian Zhang [République populaire de Chine] ; Jiahan Ding [République populaire de Chine] ; Shuxian Pan [République populaire de Chine] ; Bingyan Li [République populaire de Chine] ; Tom K. Hei [États-Unis] ; Weiqiang Chen [République populaire de Chine] ; Guangming Zhou [République populaire de Chine]Source :
- Chemical biology & drug design [ 1747-0285 ] ; 2019.
Descripteurs français
- KwdFr :
- Animaux, Antinéoplasiques (), Antinéoplasiques (pharmacologie), Antinéoplasiques (usage thérapeutique), Chloroquine (), Humains, Lignée cellulaire tumorale, Modèles animaux de maladie humaine, Points de contrôle de la phase G1 du cycle cellulaire (), Souris, Survie cellulaire (), Triazines (), Tumeurs du poumon (traitement médicamenteux).
- MESH :
- pharmacologie : Antinéoplasiques.
- traitement médicamenteux : Tumeurs du poumon.
- usage thérapeutique : Antinéoplasiques.
- Animaux, Antinéoplasiques, Chloroquine, Humains, Lignée cellulaire tumorale, Modèles animaux de maladie humaine, Points de contrôle de la phase G1 du cycle cellulaire, Souris, Survie cellulaire, Triazines.
English descriptors
- KwdEn :
- Animals, Antineoplastic Agents (chemistry), Antineoplastic Agents (pharmacology), Antineoplastic Agents (therapeutic use), Cell Line, Tumor, Cell Survival (drug effects), Chloroquine (chemistry), Disease Models, Animal, G1 Phase Cell Cycle Checkpoints (drug effects), Humans, Lung Neoplasms (drug therapy), Mice, Triazines (chemistry).
- MESH :
- chemical , chemistry : Antineoplastic Agents, Chloroquine, Triazines.
- chemical , pharmacology : Antineoplastic Agents.
- chemical , therapeutic use : Antineoplastic Agents.
- drug effects : Cell Survival, G1 Phase Cell Cycle Checkpoints.
- drug therapy : Lung Neoplasms.
- Animals, Cell Line, Tumor, Disease Models, Animal, Humans, Mice.
Abstract
Autophagy is a self-protective process, and it confers cancer cells resistance against radio-chemotherapeutics. To induce cancer cell death, a series of compounds of 3-((4-((7-chloroquinolin-4-yl)amino)butyl)amino)-7-substituted benzo[e][1,2,4]triazine 1-oxide or CQBTO containing two critical chemical groups were designed and synthesized. One compound, benzo[e][1,2,4]triazine 1-oxide, yielded free radicals to trigger autophagy, and the other one, chloroquine (CQ), was an inhibitor of autophagy. We hypothesized that the compounds could kill cancer cells effectively by inducing incomplete autophagy.
DOI: 10.1111/cbdd.13477
PubMed: 30637976
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Suzhou</wicri:regionArea><wicri:noRegion>Suzhou</wicri:noRegion></affiliation></author><author><name sortKey="Pan, Shuxian" sort="Pan, Shuxian" uniqKey="Pan S" first="Shuxian" last="Pan">Shuxian Pan</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Institute of Space Life Sciences, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Medical College of Soochow University, Suzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Institute of Space Life Sciences, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Medical College of Soochow University, Suzhou</wicri:regionArea><wicri:noRegion>Suzhou</wicri:noRegion></affiliation></author><author><name sortKey="Li, Bingyan" sort="Li, Bingyan" uniqKey="Li B" first="Bingyan" last="Li">Bingyan Li</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Institute of Space Life Sciences, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Medical College of Soochow University, Suzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Institute of Space Life Sciences, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Medical College of Soochow University, 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Guangming" uniqKey="Zhou G" first="Guangming" last="Zhou">Guangming Zhou</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Institute of Space Life Sciences, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Medical College of Soochow University, Suzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Institute of Space Life Sciences, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Medical College of Soochow University, Suzhou</wicri:regionArea><wicri:noRegion>Suzhou</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno 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sort="Guo, Ziyang" uniqKey="Guo Z" first="Ziyang" last="Guo">Ziyang Guo</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Institute of Space Life Sciences, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Medical College of Soochow University, Suzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Institute of Space Life Sciences, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Medical College of Soochow University, Suzhou</wicri:regionArea><wicri:noRegion>Suzhou</wicri:noRegion></affiliation></author><author><name sortKey="Pei, Hailong" sort="Pei, Hailong" uniqKey="Pei H" first="Hailong" last="Pei">Hailong Pei</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Institute of Space Life Sciences, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Medical College of Soochow University, Suzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Institute of Space Life Sciences, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Medical College of Soochow University, Suzhou</wicri:regionArea><wicri:noRegion>Suzhou</wicri:noRegion></affiliation></author><author><name sortKey="Nie, Jing" sort="Nie, Jing" uniqKey="Nie J" first="Jing" last="Nie">Jing Nie</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Institute of Space Life Sciences, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Medical College of Soochow University, Suzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Institute of Space Life Sciences, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Medical College of Soochow University, Suzhou</wicri:regionArea><wicri:noRegion>Suzhou</wicri:noRegion></affiliation></author><author><name sortKey="Hu, Wentao" sort="Hu, Wentao" uniqKey="Hu W" first="Wentao" last="Hu">Wentao Hu</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Institute of Space Life Sciences, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Medical College of Soochow University, Suzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Institute of Space Life Sciences, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Medical College of Soochow University, Suzhou</wicri:regionArea><wicri:noRegion>Suzhou</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Jian" sort="Zhang, Jian" uniqKey="Zhang J" first="Jian" last="Zhang">Jian Zhang</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Institute of Space Life Sciences, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Medical College of Soochow University, Suzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Institute of Space Life Sciences, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Medical College of Soochow University, Suzhou</wicri:regionArea><wicri:noRegion>Suzhou</wicri:noRegion></affiliation></author><author><name sortKey="Ding, Jiahan" sort="Ding, Jiahan" uniqKey="Ding J" first="Jiahan" last="Ding">Jiahan Ding</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Institute of Space Life Sciences, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Medical College of Soochow University, Suzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Institute of Space Life Sciences, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Medical College of Soochow University, Suzhou</wicri:regionArea><wicri:noRegion>Suzhou</wicri:noRegion></affiliation></author><author><name sortKey="Pan, Shuxian" sort="Pan, Shuxian" uniqKey="Pan S" first="Shuxian" last="Pan">Shuxian Pan</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Institute of Space Life Sciences, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Medical College of Soochow University, Suzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Institute of Space Life Sciences, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Medical College of Soochow University, Suzhou</wicri:regionArea><wicri:noRegion>Suzhou</wicri:noRegion></affiliation></author><author><name sortKey="Li, Bingyan" sort="Li, Bingyan" uniqKey="Li B" first="Bingyan" last="Li">Bingyan Li</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Institute of Space Life Sciences, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Medical College of Soochow University, Suzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Institute of Space Life Sciences, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Medical College of Soochow University, Suzhou</wicri:regionArea><wicri:noRegion>Suzhou</wicri:noRegion></affiliation></author><author><name sortKey="Hei, Tom K" sort="Hei, Tom K" uniqKey="Hei T" first="Tom K" last="Hei">Tom K. Hei</name><affiliation wicri:level="2"><nlm:affiliation>Center for Radiological Research, College of Physician and Surgeons, Columbia University, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Center for Radiological Research, College of Physician and Surgeons, Columbia University, New York</wicri:cityArea></affiliation></author><author><name sortKey="Chen, Weiqiang" sort="Chen, Weiqiang" uniqKey="Chen W" first="Weiqiang" last="Chen">Weiqiang Chen</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou</wicri:regionArea><wicri:noRegion>Lanzhou</wicri:noRegion></affiliation></author><author><name sortKey="Zhou, Guangming" sort="Zhou, Guangming" uniqKey="Zhou G" first="Guangming" last="Zhou">Guangming Zhou</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Institute of Space Life Sciences, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Medical College of Soochow University, Suzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Institute of Space Life Sciences, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Medical College of Soochow University, Suzhou</wicri:regionArea><wicri:noRegion>Suzhou</wicri:noRegion></affiliation></author></analytic><series><title level="j">Chemical biology & drug design</title><idno type="eISSN">1747-0285</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antineoplastic Agents (chemistry)</term><term>Antineoplastic Agents (pharmacology)</term><term>Antineoplastic Agents (therapeutic use)</term><term>Cell Line, Tumor</term><term>Cell Survival (drug effects)</term><term>Chloroquine (chemistry)</term><term>Disease Models, Animal</term><term>G1 Phase Cell Cycle Checkpoints (drug effects)</term><term>Humans</term><term>Lung Neoplasms (drug therapy)</term><term>Mice</term><term>Triazines (chemistry)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antinéoplasiques ()</term><term>Antinéoplasiques (pharmacologie)</term><term>Antinéoplasiques (usage thérapeutique)</term><term>Chloroquine ()</term><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Modèles animaux de maladie humaine</term><term>Points de contrôle de la phase G1 du cycle cellulaire ()</term><term>Souris</term><term>Survie cellulaire ()</term><term>Triazines ()</term><term>Tumeurs du poumon (traitement médicamenteux)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antineoplastic Agents</term><term>Chloroquine</term><term>Triazines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antineoplastic Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Agents</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Survival</term><term>G1 Phase Cell Cycle Checkpoints</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antinéoplasiques</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antinéoplasiques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line, Tumor</term><term>Disease Models, Animal</term><term>Humans</term><term>Mice</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Antinéoplasiques</term><term>Chloroquine</term><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Modèles animaux de maladie humaine</term><term>Points de contrôle de la phase G1 du cycle cellulaire</term><term>Souris</term><term>Survie cellulaire</term><term>Triazines</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Autophagy is a self-protective process, and it confers cancer cells resistance against radio-chemotherapeutics. To induce cancer cell death, a series of compounds of 3-((4-((7-chloroquinolin-4-yl)amino)butyl)amino)-7-substituted benzo[e][1,2,4]triazine 1-oxide or CQBTO containing two critical chemical groups were designed and synthesized. One compound, benzo[e][1,2,4]triazine 1-oxide, yielded free radicals to trigger autophagy, and the other one, chloroquine (CQ), was an inhibitor of autophagy. We hypothesized that the compounds could kill cancer cells effectively by inducing incomplete autophagy.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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