Glycolytic suppression dramatically changes the intracellular metabolic profile of multiple cancer cell lines in a mitochondrial metabolism-dependent manner
Identifieur interne : 000792 ( Main/Curation ); précédent : 000791; suivant : 000793Glycolytic suppression dramatically changes the intracellular metabolic profile of multiple cancer cell lines in a mitochondrial metabolism-dependent manner
Auteurs : Reika Shiratori ; Kenta Furuichi ; Masashi Yamaguchi ; Natsumi Miyazaki ; Haruna Aoki ; Hiroji Chibana ; Kousei Ito ; Shigeki AokiSource :
- Scientific Reports [ 2045-2322 ] ; 2019.
Abstract
Most cancer cells rely on glycolysis to generate ATP, even when oxygen is available. However, merely inhibiting the glycolysis is insufficient for the eradication of cancer cells. One main reason for this is that cancer cells have the potential to adapt their metabolism to their environmental conditions. In this study, we investigated how cancer cells modify their intracellular metabolism when glycolysis is suppressed, using PANC-1 pancreatic cancer cells and two other solid tumor cell lines, A549 and HeLa. Our study revealed that glycolytically suppressed cells upregulated mitochondrial function and relied on oxidative phosphorylation (OXPHOS) to obtain the ATP necessary for their survival. Dynamic changes in intracellular metabolic profiles were also observed, reflected by the reduced levels of TCA cycle intermediates and elevated levels of most amino acids. Glutamine and glutamate were important for this metabolic reprogramming, as these were largely consumed by influx into the TCA cycle when the glycolytic pathway was suppressed. During the reprogramming process, activated autophagy was involved in modulating mitochondrial function. We conclude that upon glycolytic suppression in multiple types of tumor cells, intracellular energy metabolism is reprogrammed toward mitochondrial OXPHOS in an autophagy-dependent manner to ensure cellular survival.
Url:
DOI: 10.1038/s41598-019-55296-3
PubMed: 31822748
PubMed Central: 6904735
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000198
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000198
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000733
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000D10
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :000D10
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000D10
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :000792
Links to Exploration step
PMC:6904735Curation
No country items
Reika Shiratori<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0370 1101</institution-id><institution-id institution-id-type="GRID">grid.136304.3</institution-id><institution>Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences,</institution><institution>Chiba University,</institution></institution-wrap>Inohana 1-8-1, Chuo-ku, Chiba-city, Chiba 260-8675 Japan</nlm:aff><wicri:noCountry code="subfield">Chiba 260-8675 Japan</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0370 1101</institution-id><institution-id institution-id-type="GRID">grid.136304.3</institution-id><institution>Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences,</institution><institution>Chiba University,</institution></institution-wrap>Inohana 1-8-1, Chuo-ku, Chiba-city, Chiba 260-8675 Japan</nlm:aff><wicri:noCountry code="subfield">Chiba 260-8675 Japan</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0370 1101</institution-id><institution-id institution-id-type="GRID">grid.136304.3</institution-id><institution>Medical Mycology Research Center,</institution><institution>Chiba University,</institution></institution-wrap>Inohana 1-8-1, Chuo-ku, Chiba-city, Chiba 260-8673 Japan</nlm:aff><wicri:noCountry code="subfield">Chiba 260-8673 Japan</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0370 1101</institution-id><institution-id institution-id-type="GRID">grid.136304.3</institution-id><institution>Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences,</institution><institution>Chiba University,</institution></institution-wrap>Inohana 1-8-1, Chuo-ku, Chiba-city, Chiba 260-8675 Japan</nlm:aff><wicri:noCountry code="subfield">Chiba 260-8675 Japan</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0370 1101</institution-id><institution-id institution-id-type="GRID">grid.136304.3</institution-id><institution>Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences,</institution><institution>Chiba University,</institution></institution-wrap>Inohana 1-8-1, Chuo-ku, Chiba-city, Chiba 260-8675 Japan</nlm:aff><wicri:noCountry code="subfield">Chiba 260-8675 Japan</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0370 1101</institution-id><institution-id institution-id-type="GRID">grid.136304.3</institution-id><institution>Medical Mycology Research Center,</institution><institution>Chiba University,</institution></institution-wrap>Inohana 1-8-1, Chuo-ku, Chiba-city, Chiba 260-8673 Japan</nlm:aff><wicri:noCountry code="subfield">Chiba 260-8673 Japan</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0370 1101</institution-id><institution-id institution-id-type="GRID">grid.136304.3</institution-id><institution>Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences,</institution><institution>Chiba University,</institution></institution-wrap>Inohana 1-8-1, Chuo-ku, Chiba-city, Chiba 260-8675 Japan</nlm:aff><wicri:noCountry code="subfield">Chiba 260-8675 Japan</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0370 1101</institution-id><institution-id institution-id-type="GRID">grid.136304.3</institution-id><institution>Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences,</institution><institution>Chiba University,</institution></institution-wrap>Inohana 1-8-1, Chuo-ku, Chiba-city, Chiba 260-8675 Japan</nlm:aff><wicri:noCountry code="subfield">Chiba 260-8675 Japan</wicri:noCountry></affiliation>Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Glycolytic suppression dramatically changes the intracellular metabolic profile of multiple cancer cell lines in a mitochondrial metabolism-dependent manner</title><author><name sortKey="Shiratori, Reika" sort="Shiratori, Reika" uniqKey="Shiratori R" first="Reika" last="Shiratori">Reika Shiratori</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0370 1101</institution-id><institution-id institution-id-type="GRID">grid.136304.3</institution-id><institution>Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences,</institution><institution>Chiba University,</institution></institution-wrap>Inohana 1-8-1, Chuo-ku, Chiba-city, Chiba 260-8675 Japan</nlm:aff><wicri:noCountry code="subfield">Chiba 260-8675 Japan</wicri:noCountry></affiliation></author><author><name sortKey="Furuichi, Kenta" sort="Furuichi, Kenta" uniqKey="Furuichi K" first="Kenta" last="Furuichi">Kenta Furuichi</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0370 1101</institution-id><institution-id institution-id-type="GRID">grid.136304.3</institution-id><institution>Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences,</institution><institution>Chiba University,</institution></institution-wrap>Inohana 1-8-1, Chuo-ku, Chiba-city, Chiba 260-8675 Japan</nlm:aff><wicri:noCountry code="subfield">Chiba 260-8675 Japan</wicri:noCountry></affiliation></author><author><name sortKey="Yamaguchi, Masashi" sort="Yamaguchi, Masashi" uniqKey="Yamaguchi M" first="Masashi" last="Yamaguchi">Masashi Yamaguchi</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0370 1101</institution-id><institution-id institution-id-type="GRID">grid.136304.3</institution-id><institution>Medical Mycology Research Center,</institution><institution>Chiba University,</institution></institution-wrap>Inohana 1-8-1, Chuo-ku, Chiba-city, Chiba 260-8673 Japan</nlm:aff><wicri:noCountry code="subfield">Chiba 260-8673 Japan</wicri:noCountry></affiliation></author><author><name sortKey="Miyazaki, Natsumi" sort="Miyazaki, Natsumi" uniqKey="Miyazaki N" first="Natsumi" last="Miyazaki">Natsumi Miyazaki</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0370 1101</institution-id><institution-id institution-id-type="GRID">grid.136304.3</institution-id><institution>Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences,</institution><institution>Chiba University,</institution></institution-wrap>Inohana 1-8-1, Chuo-ku, Chiba-city, Chiba 260-8675 Japan</nlm:aff><wicri:noCountry code="subfield">Chiba 260-8675 Japan</wicri:noCountry></affiliation></author><author><name sortKey="Aoki, Haruna" sort="Aoki, Haruna" uniqKey="Aoki H" first="Haruna" last="Aoki">Haruna Aoki</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0370 1101</institution-id><institution-id institution-id-type="GRID">grid.136304.3</institution-id><institution>Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences,</institution><institution>Chiba University,</institution></institution-wrap>Inohana 1-8-1, Chuo-ku, Chiba-city, Chiba 260-8675 Japan</nlm:aff><wicri:noCountry code="subfield">Chiba 260-8675 Japan</wicri:noCountry></affiliation></author><author><name sortKey="Chibana, Hiroji" sort="Chibana, Hiroji" uniqKey="Chibana H" first="Hiroji" last="Chibana">Hiroji Chibana</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0370 1101</institution-id><institution-id institution-id-type="GRID">grid.136304.3</institution-id><institution>Medical Mycology Research Center,</institution><institution>Chiba University,</institution></institution-wrap>Inohana 1-8-1, Chuo-ku, Chiba-city, Chiba 260-8673 Japan</nlm:aff><wicri:noCountry code="subfield">Chiba 260-8673 Japan</wicri:noCountry></affiliation></author><author><name sortKey="Ito, Kousei" sort="Ito, Kousei" uniqKey="Ito K" first="Kousei" last="Ito">Kousei Ito</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0370 1101</institution-id><institution-id institution-id-type="GRID">grid.136304.3</institution-id><institution>Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences,</institution><institution>Chiba University,</institution></institution-wrap>Inohana 1-8-1, Chuo-ku, Chiba-city, Chiba 260-8675 Japan</nlm:aff><wicri:noCountry code="subfield">Chiba 260-8675 Japan</wicri:noCountry></affiliation></author><author><name sortKey="Aoki, Shigeki" sort="Aoki, Shigeki" uniqKey="Aoki S" first="Shigeki" last="Aoki">Shigeki Aoki</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0370 1101</institution-id><institution-id institution-id-type="GRID">grid.136304.3</institution-id><institution>Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences,</institution><institution>Chiba University,</institution></institution-wrap>Inohana 1-8-1, Chuo-ku, Chiba-city, Chiba 260-8675 Japan</nlm:aff><wicri:noCountry code="subfield">Chiba 260-8675 Japan</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31822748</idno><idno type="pmc">6904735</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904735</idno><idno type="RBID">PMC:6904735</idno><idno type="doi">10.1038/s41598-019-55296-3</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000198</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000198</idno><idno type="wicri:Area/Pmc/Curation">000198</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000198</idno><idno type="wicri:Area/Pmc/Checkpoint">000733</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000733</idno><idno type="wicri:Area/Ncbi/Merge">000D10</idno><idno type="wicri:Area/Ncbi/Curation">000D10</idno><idno type="wicri:Area/Ncbi/Checkpoint">000D10</idno><idno type="wicri:Area/Main/Merge">000792</idno><idno type="wicri:Area/Main/Curation">000792</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Glycolytic suppression dramatically changes the intracellular metabolic profile of multiple cancer cell lines in a mitochondrial metabolism-dependent manner</title><author><name sortKey="Shiratori, Reika" sort="Shiratori, Reika" uniqKey="Shiratori R" first="Reika" last="Shiratori">Reika Shiratori</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0370 1101</institution-id><institution-id institution-id-type="GRID">grid.136304.3</institution-id><institution>Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences,</institution><institution>Chiba University,</institution></institution-wrap>Inohana 1-8-1, Chuo-ku, Chiba-city, Chiba 260-8675 Japan</nlm:aff><wicri:noCountry code="subfield">Chiba 260-8675 Japan</wicri:noCountry></affiliation></author><author><name sortKey="Furuichi, Kenta" sort="Furuichi, Kenta" uniqKey="Furuichi K" first="Kenta" last="Furuichi">Kenta Furuichi</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0370 1101</institution-id><institution-id institution-id-type="GRID">grid.136304.3</institution-id><institution>Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences,</institution><institution>Chiba University,</institution></institution-wrap>Inohana 1-8-1, Chuo-ku, Chiba-city, Chiba 260-8675 Japan</nlm:aff><wicri:noCountry code="subfield">Chiba 260-8675 Japan</wicri:noCountry></affiliation></author><author><name sortKey="Yamaguchi, Masashi" sort="Yamaguchi, Masashi" uniqKey="Yamaguchi M" first="Masashi" last="Yamaguchi">Masashi Yamaguchi</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0370 1101</institution-id><institution-id institution-id-type="GRID">grid.136304.3</institution-id><institution>Medical Mycology Research Center,</institution><institution>Chiba University,</institution></institution-wrap>Inohana 1-8-1, Chuo-ku, Chiba-city, Chiba 260-8673 Japan</nlm:aff><wicri:noCountry code="subfield">Chiba 260-8673 Japan</wicri:noCountry></affiliation></author><author><name sortKey="Miyazaki, Natsumi" sort="Miyazaki, Natsumi" uniqKey="Miyazaki N" first="Natsumi" last="Miyazaki">Natsumi Miyazaki</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0370 1101</institution-id><institution-id institution-id-type="GRID">grid.136304.3</institution-id><institution>Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences,</institution><institution>Chiba University,</institution></institution-wrap>Inohana 1-8-1, Chuo-ku, Chiba-city, Chiba 260-8675 Japan</nlm:aff><wicri:noCountry code="subfield">Chiba 260-8675 Japan</wicri:noCountry></affiliation></author><author><name sortKey="Aoki, Haruna" sort="Aoki, Haruna" uniqKey="Aoki H" first="Haruna" last="Aoki">Haruna Aoki</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0370 1101</institution-id><institution-id institution-id-type="GRID">grid.136304.3</institution-id><institution>Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences,</institution><institution>Chiba University,</institution></institution-wrap>Inohana 1-8-1, Chuo-ku, Chiba-city, Chiba 260-8675 Japan</nlm:aff><wicri:noCountry code="subfield">Chiba 260-8675 Japan</wicri:noCountry></affiliation></author><author><name sortKey="Chibana, Hiroji" sort="Chibana, Hiroji" uniqKey="Chibana H" first="Hiroji" last="Chibana">Hiroji Chibana</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0370 1101</institution-id><institution-id institution-id-type="GRID">grid.136304.3</institution-id><institution>Medical Mycology Research Center,</institution><institution>Chiba University,</institution></institution-wrap>Inohana 1-8-1, Chuo-ku, Chiba-city, Chiba 260-8673 Japan</nlm:aff><wicri:noCountry code="subfield">Chiba 260-8673 Japan</wicri:noCountry></affiliation></author><author><name sortKey="Ito, Kousei" sort="Ito, Kousei" uniqKey="Ito K" first="Kousei" last="Ito">Kousei Ito</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0370 1101</institution-id><institution-id institution-id-type="GRID">grid.136304.3</institution-id><institution>Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences,</institution><institution>Chiba University,</institution></institution-wrap>Inohana 1-8-1, Chuo-ku, Chiba-city, Chiba 260-8675 Japan</nlm:aff><wicri:noCountry code="subfield">Chiba 260-8675 Japan</wicri:noCountry></affiliation></author><author><name sortKey="Aoki, Shigeki" sort="Aoki, Shigeki" uniqKey="Aoki S" first="Shigeki" last="Aoki">Shigeki Aoki</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0370 1101</institution-id><institution-id institution-id-type="GRID">grid.136304.3</institution-id><institution>Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences,</institution><institution>Chiba University,</institution></institution-wrap>Inohana 1-8-1, Chuo-ku, Chiba-city, Chiba 260-8675 Japan</nlm:aff><wicri:noCountry code="subfield">Chiba 260-8675 Japan</wicri:noCountry></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Most cancer cells rely on glycolysis to generate ATP, even when oxygen is available. However, merely inhibiting the glycolysis is insufficient for the eradication of cancer cells. One main reason for this is that cancer cells have the potential to adapt their metabolism to their environmental conditions. In this study, we investigated how cancer cells modify their intracellular metabolism when glycolysis is suppressed, using PANC-1 pancreatic cancer cells and two other solid tumor cell lines, A549 and HeLa. Our study revealed that glycolytically suppressed cells upregulated mitochondrial function and relied on oxidative phosphorylation (OXPHOS) to obtain the ATP necessary for their survival. Dynamic changes in intracellular metabolic profiles were also observed, reflected by the reduced levels of TCA cycle intermediates and elevated levels of most amino acids. Glutamine and glutamate were important for this metabolic reprogramming, as these were largely consumed by influx into the TCA cycle when the glycolytic pathway was suppressed. During the reprogramming process, activated autophagy was involved in modulating mitochondrial function. We conclude that upon glycolytic suppression in multiple types of tumor cells, intracellular energy metabolism is reprogrammed toward mitochondrial OXPHOS in an autophagy-dependent manner to ensure cellular survival.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Vander Heiden, Mg" uniqKey="Vander Heiden M">MG Vander Heiden</name></author><author><name sortKey="Cantley, Lc" uniqKey="Cantley L">LC Cantley</name></author><author><name sortKey="Thompson, Cb" uniqKey="Thompson C">CB Thompson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bonnet, S" uniqKey="Bonnet S">S Bonnet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Busk, M" uniqKey="Busk M">M Busk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pfeiffer, T" uniqKey="Pfeiffer T">T Pfeiffer</name></author><author><name sortKey="Schuster, S" uniqKey="Schuster S">S Schuster</name></author><author><name sortKey="Bonhoeffer, S" uniqKey="Bonhoeffer S">S Bonhoeffer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lunt, Sy" uniqKey="Lunt S">SY Lunt</name></author><author><name sortKey="Vander Heiden, Mg" uniqKey="Vander Heiden M">MG Vander Heiden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hu, Cj" uniqKey="Hu C">CJ Hu</name></author><author><name sortKey="Wang, Ly" uniqKey="Wang L">LY Wang</name></author><author><name sortKey="Chodosh, La" uniqKey="Chodosh L">LA Chodosh</name></author><author><name sortKey="Keith, B" uniqKey="Keith B">B Keith</name></author><author><name sortKey="Simon, Mc" uniqKey="Simon M">MC Simon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kirito, K" uniqKey="Kirito K">K Kirito</name></author><author><name sortKey="Hu, Y" uniqKey="Hu Y">Y Hu</name></author><author><name sortKey="Komatsu, N" uniqKey="Komatsu N">N Komatsu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Galluzzi, L" uniqKey="Galluzzi L">L Galluzzi</name></author><author><name sortKey="Kepp, O" uniqKey="Kepp O">O Kepp</name></author><author><name sortKey="Vander Heiden, Mg" uniqKey="Vander Heiden M">MG Vander Heiden</name></author><author><name sortKey="Kroemer, G" uniqKey="Kroemer G">G Kroemer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gautier, El" uniqKey="Gautier E">EL Gautier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dwarakanath, B" uniqKey="Dwarakanath B">B Dwarakanath</name></author><author><name sortKey="Jain, V" uniqKey="Jain V">V Jain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ganapathy Kanniappan, S" uniqKey="Ganapathy Kanniappan S">S Ganapathy-Kanniappan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jae, Hj" uniqKey="Jae H">HJ Jae</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maschek, G" uniqKey="Maschek G">G Maschek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jin, L" uniqKey="Jin L">L Jin</name></author><author><name sortKey="Alesi, Gn" uniqKey="Alesi G">GN Alesi</name></author><author><name sortKey="Kang, S" uniqKey="Kang S">S Kang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kang, Yp" uniqKey="Kang Y">YP Kang</name></author><author><name sortKey="Ward, Np" uniqKey="Ward N">NP Ward</name></author><author><name sortKey="Denicola, Gm" uniqKey="Denicola G">GM DeNicola</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hirayama, A" uniqKey="Hirayama A">A Hirayama</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramautar, R" uniqKey="Ramautar R">R Ramautar</name></author><author><name sortKey="Mayboroda, Oa" uniqKey="Mayboroda O">OA Mayboroda</name></author><author><name sortKey="Somsen, Gw" uniqKey="Somsen G">GW Somsen</name></author><author><name sortKey="De Jong, Gj" uniqKey="De Jong G">GJ de Jong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Soga, T" uniqKey="Soga T">T Soga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Soga, T" uniqKey="Soga T">T Soga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Satoh, K" uniqKey="Satoh K">K Satoh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saraei, P" uniqKey="Saraei P">P Saraei</name></author><author><name sortKey="Asadi, I" uniqKey="Asadi I">I Asadi</name></author><author><name sortKey="Kakar, Ma" uniqKey="Kakar M">MA Kakar</name></author><author><name sortKey="Moradi Kor, N" uniqKey="Moradi Kor N">N Moradi-Kor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jain, N" uniqKey="Jain N">N Jain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hulea, L" uniqKey="Hulea L">L Hulea</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hirao, T" uniqKey="Hirao T">T Hirao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pollyea, Da" uniqKey="Pollyea D">DA Pollyea</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boudreau, A" uniqKey="Boudreau A">A Boudreau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Padua, Mc" uniqKey="De Padua M">MC de Padua</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pusapati, Rv" uniqKey="Pusapati R">RV Pusapati</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kawaguchi, M" uniqKey="Kawaguchi M">M Kawaguchi</name></author><author><name sortKey="Aoki, S" uniqKey="Aoki S">S Aoki</name></author><author><name sortKey="Hirao, T" uniqKey="Hirao T">T Hirao</name></author><author><name sortKey="Morita, M" uniqKey="Morita M">M Morita</name></author><author><name sortKey="Ito, K" uniqKey="Ito K">K Ito</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rossignol, R" uniqKey="Rossignol R">R Rossignol</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reers, M" uniqKey="Reers M">M Reers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deberardinis, Rj" uniqKey="Deberardinis R">RJ DeBerardinis</name></author><author><name sortKey="Cheng, T" uniqKey="Cheng T">T Cheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Katayama, H" uniqKey="Katayama H">H Katayama</name></author><author><name sortKey="Kogure, T" uniqKey="Kogure T">T Kogure</name></author><author><name sortKey="Mizushima, N" uniqKey="Mizushima N">N Mizushima</name></author><author><name sortKey="Yoshimori, T" uniqKey="Yoshimori T">T Yoshimori</name></author><author><name sortKey="Miyawaki, A" uniqKey="Miyawaki A">A Miyawaki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shanware, Np" uniqKey="Shanware N">NP Shanware</name></author><author><name sortKey="Mullen, Ar" uniqKey="Mullen A">AR Mullen</name></author><author><name sortKey="Deberardinis, Rj" uniqKey="Deberardinis R">RJ DeBerardinis</name></author><author><name sortKey="Abraham, Rt" uniqKey="Abraham R">RT Abraham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kovacevic, Z" uniqKey="Kovacevic Z">Z Kovacevic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jin, L" uniqKey="Jin L">L Jin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Son, J" uniqKey="Son J">J Son</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aoki, S" uniqKey="Aoki S">S Aoki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kongara, S" uniqKey="Kongara S">S Kongara</name></author><author><name sortKey="Karantza, V" uniqKey="Karantza V">V Karantza</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bar Peled, L" uniqKey="Bar Peled L">L Bar-Peled</name></author><author><name sortKey="Sabatini, Dm" uniqKey="Sabatini D">DM Sabatini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ukai, H" uniqKey="Ukai H">H Ukai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lorin, S" uniqKey="Lorin S">S Lorin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Duran, Rv" uniqKey="Duran R">RV Duran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mishra, P" uniqKey="Mishra P">P Mishra</name></author><author><name sortKey="Chan, Dc" uniqKey="Chan D">DC Chan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kanki, T" uniqKey="Kanki T">T Kanki</name></author><author><name sortKey="Furukawa, K" uniqKey="Furukawa K">K Furukawa</name></author><author><name sortKey="Yamashita, S" uniqKey="Yamashita S">S Yamashita</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Youle, Rj" uniqKey="Youle R">RJ Youle</name></author><author><name sortKey="Narendra, Dp" uniqKey="Narendra D">DP Narendra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Melser, S" uniqKey="Melser S">S Melser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Egan, Df" uniqKey="Egan D">DF Egan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Manic, G" uniqKey="Manic G">G Manic</name></author><author><name sortKey="Obrist, F" uniqKey="Obrist F">F Obrist</name></author><author><name sortKey="Kroemer, G" uniqKey="Kroemer G">G Kroemer</name></author><author><name sortKey="Vitale, I" uniqKey="Vitale I">I Vitale</name></author><author><name sortKey="Galluzzi, L" uniqKey="Galluzzi L">L Galluzzi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="White, E" uniqKey="White E">E White</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Narendra, Dp" uniqKey="Narendra D">DP Narendra</name></author><author><name sortKey="Youle, Rj" uniqKey="Youle R">RJ Youle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matsuda, N" uniqKey="Matsuda N">N Matsuda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Narendra, Dp" uniqKey="Narendra D">DP Narendra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cesari, R" uniqKey="Cesari R">R Cesari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Denison, Sr" uniqKey="Denison S">SR Denison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Villa, E" uniqKey="Villa E">E Villa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jia, D" uniqKey="Jia D">D Jia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fujita, M" uniqKey="Fujita M">M Fujita</name></author><author><name sortKey="Imadome, K" uniqKey="Imadome K">K Imadome</name></author><author><name sortKey="Imai, T" uniqKey="Imai T">T Imai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamaguchi, M" uniqKey="Yamaguchi M">M Yamaguchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamaguchi, M" uniqKey="Yamaguchi M">M Yamaguchi</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000792 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 000792 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Curation
|type= RBID
|clé= PMC:6904735
|texte= Glycolytic suppression dramatically changes the intracellular metabolic profile of multiple cancer cell lines in a mitochondrial metabolism-dependent manner
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Curation/RBID.i -Sk "pubmed:31822748" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Curation/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |