The cat is out of the bag: How parasites know their hosts
Identifieur interne : 000351 ( Main/Curation ); précédent : 000350; suivant : 000352The cat is out of the bag: How parasites know their hosts
Auteurs : Elizabeth D. English ; Boris StriepenSource :
- PLoS Biology [ 1544-9173 ] ; 2019.
Abstract
Url:
DOI: 10.1371/journal.pbio.3000446
PubMed: 31487278
PubMed Central: 6748446
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PMC:6748446Le document en format XML
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<front><div type="abstract" xml:lang="en"><p><italic>Toxoplasma gondii</italic>
is a remarkably successful protozoan parasite that infects a third of the human population, along with most mammals and birds. However, the sexual portion of the parasite’s life cycle is narrowly limited to cats. How parasites distinguish between hosts has long been a mystery. A new study reveals that <italic>Toxoplasma</italic>
identifies cats based on a single fatty acid, linoleic acid. Experimental manipulation of fatty acid metabolism by drug treatment turns a mouse into a cat in the “eye” of the parasite. This new model enables genetic crosses of an important human pathogen without the use of companion animals and opens the door to future discovery.</p>
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