Hydroxychloroquine suppresses lung tumorigenesis via inducing FoxO3a nuclear translocation through STAT3 inactivation.
Identifieur interne : 000137 ( Main/Curation ); précédent : 000136; suivant : 000138Hydroxychloroquine suppresses lung tumorigenesis via inducing FoxO3a nuclear translocation through STAT3 inactivation.
Auteurs : Xin Lyu [République populaire de Chine] ; Lizhong Zeng [République populaire de Chine] ; Hua Zhang [République populaire de Chine] ; Yue Ke [République populaire de Chine] ; Xuan Liu [République populaire de Chine] ; Nannan Zhao [République populaire de Chine] ; Jingyan Yuan [République populaire de Chine] ; Guoan Chen [République populaire de Chine] ; Shuanying Yang [République populaire de Chine]Source :
- Life sciences [ 1879-0631 ] ; 2020.
Descripteurs français
- KwdFr :
- Adénocarcinome (métabolisme), Adénocarcinome (traitement médicamenteux), Animaux, Antinéoplasiques (usage thérapeutique), Apoptose (), Cellules A549, Cycle cellulaire (), Facteur de transcription STAT-3 (métabolisme), Femelle, Humains, Hydroxychloroquine (usage thérapeutique), Lignée cellulaire tumorale, Protéine O3 à motif en tête de fourche (métabolisme), Régulation de l'expression des gènes tumoraux (), Souris nude, Transplantation tumorale, Transport nucléaire actif (), Tumeurs du poumon (métabolisme), Tumeurs du poumon (traitement médicamenteux).
- MESH :
- métabolisme : Adénocarcinome, Facteur de transcription STAT-3, Protéine O3 à motif en tête de fourche, Tumeurs du poumon.
- traitement médicamenteux : Adénocarcinome, Tumeurs du poumon.
- usage thérapeutique : Antinéoplasiques, Hydroxychloroquine.
- Animaux, Apoptose, Cellules A549, Cycle cellulaire, Femelle, Humains, Lignée cellulaire tumorale, Régulation de l'expression des gènes tumoraux, Souris nude, Transplantation tumorale, Transport nucléaire actif.
English descriptors
- KwdEn :
- A549 Cells, Active Transport, Cell Nucleus (drug effects), Adenocarcinoma (drug therapy), Adenocarcinoma (metabolism), Animals, Antineoplastic Agents (therapeutic use), Apoptosis (drug effects), Cell Cycle (drug effects), Cell Line, Tumor, Female, Forkhead Box Protein O3 (metabolism), Gene Expression Regulation, Neoplastic (drug effects), Humans, Hydroxychloroquine (therapeutic use), Lung Neoplasms (drug therapy), Lung Neoplasms (metabolism), Mice, Nude, Neoplasm Transplantation, STAT3 Transcription Factor (metabolism).
- MESH :
- chemical , metabolism : Forkhead Box Protein O3, STAT3 Transcription Factor.
- chemical , therapeutic use : Antineoplastic Agents, Hydroxychloroquine.
- drug effects : Active Transport, Cell Nucleus, Apoptosis, Cell Cycle, Gene Expression Regulation, Neoplastic.
- drug therapy : Adenocarcinoma, Lung Neoplasms.
- metabolism : Adenocarcinoma, Lung Neoplasms.
- A549 Cells, Animals, Cell Line, Tumor, Female, Humans, Mice, Nude, Neoplasm Transplantation.
Abstract
Hydroxychloroquine exhibits synergistic anticancer properties as an adjuvant. However, the role and molecular mechanisms underlying of HCQ as monotherapy for lung adenocarcinoma (LUAD) have yet to be elucidated.
DOI: 10.1016/j.lfs.2020.117366
PubMed: 32001266
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pubmed:32001266Le document en format XML
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<term>Animals</term>
<term>Antineoplastic Agents (therapeutic use)</term>
<term>Apoptosis (drug effects)</term>
<term>Cell Cycle (drug effects)</term>
<term>Cell Line, Tumor</term>
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<term>Cell Cycle</term>
<term>Gene Expression Regulation, Neoplastic</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Adenocarcinoma</term>
<term>Lung Neoplasms</term>
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<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Adenocarcinoma</term>
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<term>Facteur de transcription STAT-3</term>
<term>Protéine O3 à motif en tête de fourche</term>
<term>Tumeurs du poumon</term>
</keywords>
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<term>Tumeurs du poumon</term>
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<term>Hydroxychloroquine</term>
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<term>Female</term>
<term>Humans</term>
<term>Mice, Nude</term>
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<term>Cellules A549</term>
<term>Cycle cellulaire</term>
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<term>Lignée cellulaire tumorale</term>
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<front><div type="abstract" xml:lang="en">Hydroxychloroquine exhibits synergistic anticancer properties as an adjuvant. However, the role and molecular mechanisms underlying of HCQ as monotherapy for lung adenocarcinoma (LUAD) have yet to be elucidated.</div>
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