Idiopathic subglottic stenosis is associated with activation of the inflammatory IL‐17A/IL‐23 axis
Identifieur interne : 002B04 ( Istex/Curation ); précédent : 002B03; suivant : 002B05Idiopathic subglottic stenosis is associated with activation of the inflammatory IL‐17A/IL‐23 axis
Auteurs : Alexander Gelbard [États-Unis] ; Nicolas-George Katsantonis ; Masanobu Mizuta ; Dawn Newcomb ; Joseph Rotsinger ; Bernard Rousseau ; James J. Daniero ; Eric S. Edell ; Dale C. Ekbom ; Jan L. Kasperbauer ; Alexander T. Hillel [États-Unis] ; Liying Yang [États-Unis] ; C. Gaelyn Garrett ; James L. Netterville ; Christopher T. Wootten ; David O. Francis ; Charles Stratton ; Kevin Jenkins ; Tracy L. Mcgregor ; Jennifer A. Gaddy [États-Unis] ; Timothy S. Blackwell [États-Unis] ; Wonder P. DrakeSource :
- The Laryngoscope [ 0023-852X ] ; 2016-11.
Abstract
Objectives/Hypothesis: Idiopathic subglottic stenosis (iSGS) is a rare and devastating extrathoracic obstruction involving the lower laryngeal and upper tracheal airway. It arises without known antecedent injury or associated disease process. Persistent mucosal inflammation and a localized fibrotic response are hallmarks of the disease. Despite the initial clinical description of iSGS more than 40 year ago, there have been no substantive investigations into the pathogenesis of this enigmatic and progressive airway obstruction. In these studies, we present the initial characterization of the molecular pathogenesis underlying the fibrosing phenotype of iSGS. Methods: Utilizing 20 human iSGS and healthy control specimens, we applied histologic, immunohistochemical, molecular, and immunologic techniques. Results: We demonstrate significant activation of the canonical IL‐23/IL‐17A pathway in the tracheal mucosa of iSGS patients, as well as identify γδ T cells as the primary cellular source of IL‐17A. Conclusion: Our results suggest that aberrant mucosal immune activation is a component in of the pathogenesis of iSGS. Most critically, our work offers new targets for future therapeutic intervention. Level of Evidence: NA Laryngoscope, 126:E356–E361, 2016
Url:
DOI: 10.1002/lary.26098
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Nicolas-George Katsantonis<affiliation><mods:affiliation>Department of Otolaryngology, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Otolaryngology, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Medicine, Division of Pulmonary and Critical Care, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Medicine, Division of Infectious Disease, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Otolaryngology, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Otolaryngology, University of Virginia Health System, Virginia, Charlottesville</mods:affiliation><wicri:noCountry code="subField">Charlottesville</wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Medicine, Division of Pulmonary & Critical Care, Mayo Clinic, Minnesota, Rochester</mods:affiliation><wicri:noCountry code="subField">Rochester</wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Otolaryngology, Mayo Clinic, Minnesota, Rochester</mods:affiliation><wicri:noCountry code="subField">Rochester</wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Otolaryngology, Mayo Clinic, Minnesota, Rochester</mods:affiliation><wicri:noCountry code="subField">Rochester</wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Otolaryngology, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Otolaryngology, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Otolaryngology, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Otolaryngology, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Pathology, Microbiology and Immunology, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Pathology, Microbiology and Immunology, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Pediatrics, Division of Medical Genetics, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Medicine, Division of Infectious Disease, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation>Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Idiopathic subglottic stenosis is associated with activation of the inflammatory IL‐17A/IL‐23 axis</title><author><name sortKey="Gelbard, Alexander" sort="Gelbard, Alexander" uniqKey="Gelbard A" first="Alexander" last="Gelbard">Alexander Gelbard</name><affiliation><mods:affiliation>Department of Otolaryngology, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: alexander.gelbard@vanderbilt.edu</mods:affiliation><country wicri:rule="url">États-Unis</country></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: alexander.gelbard@vanderbilt.edu</mods:affiliation><country wicri:rule="url">États-Unis</country></affiliation></author><author><name sortKey="Katsantonis, Nicolas Eorge" sort="Katsantonis, Nicolas Eorge" uniqKey="Katsantonis N" first="Nicolas-George" last="Katsantonis">Nicolas-George Katsantonis</name><affiliation><mods:affiliation>Department of Otolaryngology, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation></author><author><name sortKey="Mizuta, Masanobu" sort="Mizuta, Masanobu" uniqKey="Mizuta M" first="Masanobu" last="Mizuta">Masanobu Mizuta</name><affiliation><mods:affiliation>Department of Otolaryngology, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation></author><author><name sortKey="Newcomb, Dawn" sort="Newcomb, Dawn" uniqKey="Newcomb D" first="Dawn" last="Newcomb">Dawn Newcomb</name><affiliation><mods:affiliation>Department of Medicine, Division of Pulmonary and Critical Care, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation></author><author><name sortKey="Rotsinger, Joseph" sort="Rotsinger, Joseph" uniqKey="Rotsinger J" first="Joseph" last="Rotsinger">Joseph Rotsinger</name><affiliation><mods:affiliation>Department of Medicine, Division of Infectious Disease, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation></author><author><name sortKey="Rousseau, Bernard" sort="Rousseau, Bernard" uniqKey="Rousseau B" first="Bernard" last="Rousseau">Bernard Rousseau</name><affiliation><mods:affiliation>Department of Otolaryngology, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation></author><author><name sortKey="Daniero, James J" sort="Daniero, James J" uniqKey="Daniero J" first="James J." last="Daniero">James J. Daniero</name><affiliation><mods:affiliation>Department of Otolaryngology, University of Virginia Health System, Virginia, Charlottesville</mods:affiliation><wicri:noCountry code="subField">Charlottesville</wicri:noCountry></affiliation></author><author><name sortKey="Edell, Eric S" sort="Edell, Eric S" uniqKey="Edell E" first="Eric S." last="Edell">Eric S. Edell</name><affiliation><mods:affiliation>Department of Medicine, Division of Pulmonary & Critical Care, Mayo Clinic, Minnesota, Rochester</mods:affiliation><wicri:noCountry code="subField">Rochester</wicri:noCountry></affiliation></author><author><name sortKey="Ekbom, Dale C" sort="Ekbom, Dale C" uniqKey="Ekbom D" first="Dale C." last="Ekbom">Dale C. Ekbom</name><affiliation><mods:affiliation>Department of Otolaryngology, Mayo Clinic, Minnesota, Rochester</mods:affiliation><wicri:noCountry code="subField">Rochester</wicri:noCountry></affiliation></author><author><name sortKey="Kasperbauer, Jan L" sort="Kasperbauer, Jan L" uniqKey="Kasperbauer J" first="Jan L." last="Kasperbauer">Jan L. Kasperbauer</name><affiliation><mods:affiliation>Department of Otolaryngology, Mayo Clinic, Minnesota, Rochester</mods:affiliation><wicri:noCountry code="subField">Rochester</wicri:noCountry></affiliation></author><author><name sortKey="Hillel, Alexander T" sort="Hillel, Alexander T" uniqKey="Hillel A" first="Alexander T." last="Hillel">Alexander T. Hillel</name><affiliation wicri:level="3"><mods:affiliation>Department of Otolaryngology, Johns Hopkins, Maryland, Baltimore</mods:affiliation><country>États-Unis</country><placeName><settlement type="city">Baltimore</settlement><region type="state">Maryland</region></placeName><wicri:orgArea>Department of Otolaryngology, Johns Hopkins, Maryland</wicri:orgArea></affiliation></author><author><name sortKey="Yang, Liying" sort="Yang, Liying" uniqKey="Yang L" first="Liying" last="Yang">Liying Yang</name><affiliation wicri:level="1"><mods:affiliation>Department of Medicine, New York University School of Medicine, New York, New York, U.S.A.</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, New York University School of Medicine, New York, New York</wicri:regionArea></affiliation></author><author><name sortKey="Garrett, C Gaelyn" sort="Garrett, C Gaelyn" uniqKey="Garrett C" first="C. Gaelyn" last="Garrett">C. Gaelyn Garrett</name><affiliation><mods:affiliation>Department of Otolaryngology, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation></author><author><name sortKey="Netterville, James L" sort="Netterville, James L" uniqKey="Netterville J" first="James L." last="Netterville">James L. Netterville</name><affiliation><mods:affiliation>Department of Otolaryngology, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation></author><author><name sortKey="Wootten, Christopher T" sort="Wootten, Christopher T" uniqKey="Wootten C" first="Christopher T." last="Wootten">Christopher T. Wootten</name><affiliation><mods:affiliation>Department of Otolaryngology, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation></author><author><name sortKey="Francis, David O" sort="Francis, David O" uniqKey="Francis D" first="David O." last="Francis">David O. Francis</name><affiliation><mods:affiliation>Department of Otolaryngology, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation></author><author><name sortKey="Stratton, Charles" sort="Stratton, Charles" uniqKey="Stratton C" first="Charles" last="Stratton">Charles Stratton</name><affiliation><mods:affiliation>Department of Pathology, Microbiology and Immunology, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation></author><author><name sortKey="Jenkins, Kevin" sort="Jenkins, Kevin" uniqKey="Jenkins K" first="Kevin" last="Jenkins">Kevin Jenkins</name><affiliation><mods:affiliation>Department of Pathology, Microbiology and Immunology, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation></author><author><name sortKey="Mcgregor, Tracy L" sort="Mcgregor, Tracy L" uniqKey="Mcgregor T" first="Tracy L." last="Mcgregor">Tracy L. Mcgregor</name><affiliation><mods:affiliation>Department of Pediatrics, Division of Medical Genetics, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation></author><author><name sortKey="Gaddy, Jennifer A" sort="Gaddy, Jennifer A" uniqKey="Gaddy J" first="Jennifer A." last="Gaddy">Jennifer A. Gaddy</name><affiliation wicri:level="2"><mods:affiliation>Department of Medicine, Division of Infectious Disease, Vanderbilt University, Nashville, Tennessee</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Department of Medicine, Division of Infectious Disease, Vanderbilt University, Nashville</wicri:cityArea></affiliation><affiliation><mods:affiliation>Veterans Affairs Tennessee Valley Healthcare Services, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation></author><author><name sortKey="Blackwell, Timothy S" sort="Blackwell, Timothy S" uniqKey="Blackwell T" first="Timothy S." last="Blackwell">Timothy S. Blackwell</name><affiliation wicri:level="2"><mods:affiliation>Department of Medicine, Division of Pulmonary and Critical Care, Vanderbilt University, Nashville, Tennessee</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Department of Medicine, Division of Pulmonary and Critical Care, Vanderbilt University, Nashville</wicri:cityArea></affiliation><affiliation><mods:affiliation>Veterans Affairs Tennessee Valley Healthcare Services, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation></author><author><name sortKey="Drake, Wonder P" sort="Drake, Wonder P" uniqKey="Drake W" first="Wonder P." last="Drake">Wonder P. Drake</name><affiliation><mods:affiliation>Department of Medicine, Division of Infectious Disease, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:13E739FB49F85F9EFE1951C06A08DBA995D2B08C</idno><date when="2016" year="2016">2016</date><idno type="doi">10.1002/lary.26098</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-2XQF4TL9-X/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">002B04</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002B04</idno><idno type="wicri:Area/Istex/Curation">002B04</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Idiopathic subglottic stenosis is associated with activation of the inflammatory IL‐17A/IL‐23 axis</title><author><name sortKey="Gelbard, Alexander" sort="Gelbard, Alexander" uniqKey="Gelbard A" first="Alexander" last="Gelbard">Alexander Gelbard</name><affiliation><mods:affiliation>Department of Otolaryngology, Vanderbilt University, Tennessee, Nashville</mods:affiliation></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: alexander.gelbard@vanderbilt.edu</mods:affiliation><country wicri:rule="url">États-Unis</country></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: alexander.gelbard@vanderbilt.edu</mods:affiliation><country wicri:rule="url">États-Unis</country></affiliation></author><author><name sortKey="Katsantonis, Nicolas Eorge" sort="Katsantonis, Nicolas Eorge" uniqKey="Katsantonis N" first="Nicolas-George" last="Katsantonis">Nicolas-George Katsantonis</name><affiliation><mods:affiliation>Department of Otolaryngology, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation></author><author><name sortKey="Mizuta, Masanobu" sort="Mizuta, Masanobu" uniqKey="Mizuta M" first="Masanobu" last="Mizuta">Masanobu Mizuta</name><affiliation><mods:affiliation>Department of Otolaryngology, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation></author><author><name sortKey="Newcomb, Dawn" sort="Newcomb, Dawn" uniqKey="Newcomb D" first="Dawn" last="Newcomb">Dawn Newcomb</name><affiliation><mods:affiliation>Department of Medicine, Division of Pulmonary and Critical Care, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation></author><author><name sortKey="Rotsinger, Joseph" sort="Rotsinger, Joseph" uniqKey="Rotsinger J" first="Joseph" last="Rotsinger">Joseph Rotsinger</name><affiliation><mods:affiliation>Department of Medicine, Division of Infectious Disease, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation></author><author><name sortKey="Rousseau, Bernard" sort="Rousseau, Bernard" uniqKey="Rousseau B" first="Bernard" last="Rousseau">Bernard Rousseau</name><affiliation><mods:affiliation>Department of Otolaryngology, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation></author><author><name sortKey="Daniero, James J" sort="Daniero, James J" uniqKey="Daniero J" first="James J." last="Daniero">James J. Daniero</name><affiliation><mods:affiliation>Department of Otolaryngology, University of Virginia Health System, Virginia, Charlottesville</mods:affiliation><wicri:noCountry code="subField">Charlottesville</wicri:noCountry></affiliation></author><author><name sortKey="Edell, Eric S" sort="Edell, Eric S" uniqKey="Edell E" first="Eric S." last="Edell">Eric S. Edell</name><affiliation><mods:affiliation>Department of Medicine, Division of Pulmonary & Critical Care, Mayo Clinic, Minnesota, Rochester</mods:affiliation><wicri:noCountry code="subField">Rochester</wicri:noCountry></affiliation></author><author><name sortKey="Ekbom, Dale C" sort="Ekbom, Dale C" uniqKey="Ekbom D" first="Dale C." last="Ekbom">Dale C. Ekbom</name><affiliation><mods:affiliation>Department of Otolaryngology, Mayo Clinic, Minnesota, Rochester</mods:affiliation><wicri:noCountry code="subField">Rochester</wicri:noCountry></affiliation></author><author><name sortKey="Kasperbauer, Jan L" sort="Kasperbauer, Jan L" uniqKey="Kasperbauer J" first="Jan L." last="Kasperbauer">Jan L. Kasperbauer</name><affiliation><mods:affiliation>Department of Otolaryngology, Mayo Clinic, Minnesota, Rochester</mods:affiliation><wicri:noCountry code="subField">Rochester</wicri:noCountry></affiliation></author><author><name sortKey="Hillel, Alexander T" sort="Hillel, Alexander T" uniqKey="Hillel A" first="Alexander T." last="Hillel">Alexander T. Hillel</name><affiliation wicri:level="3"><mods:affiliation>Department of Otolaryngology, Johns Hopkins, Maryland, Baltimore</mods:affiliation><country>États-Unis</country><placeName><settlement type="city">Baltimore</settlement><region type="state">Maryland</region></placeName><wicri:orgArea>Department of Otolaryngology, Johns Hopkins, Maryland</wicri:orgArea></affiliation></author><author><name sortKey="Yang, Liying" sort="Yang, Liying" uniqKey="Yang L" first="Liying" last="Yang">Liying Yang</name><affiliation wicri:level="1"><mods:affiliation>Department of Medicine, New York University School of Medicine, New York, New York, U.S.A.</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, New York University School of Medicine, New York, New York</wicri:regionArea></affiliation></author><author><name sortKey="Garrett, C Gaelyn" sort="Garrett, C Gaelyn" uniqKey="Garrett C" first="C. Gaelyn" last="Garrett">C. Gaelyn Garrett</name><affiliation><mods:affiliation>Department of Otolaryngology, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation></author><author><name sortKey="Netterville, James L" sort="Netterville, James L" uniqKey="Netterville J" first="James L." last="Netterville">James L. Netterville</name><affiliation><mods:affiliation>Department of Otolaryngology, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation></author><author><name sortKey="Wootten, Christopher T" sort="Wootten, Christopher T" uniqKey="Wootten C" first="Christopher T." last="Wootten">Christopher T. Wootten</name><affiliation><mods:affiliation>Department of Otolaryngology, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation></author><author><name sortKey="Francis, David O" sort="Francis, David O" uniqKey="Francis D" first="David O." last="Francis">David O. Francis</name><affiliation><mods:affiliation>Department of Otolaryngology, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation></author><author><name sortKey="Stratton, Charles" sort="Stratton, Charles" uniqKey="Stratton C" first="Charles" last="Stratton">Charles Stratton</name><affiliation><mods:affiliation>Department of Pathology, Microbiology and Immunology, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation></author><author><name sortKey="Jenkins, Kevin" sort="Jenkins, Kevin" uniqKey="Jenkins K" first="Kevin" last="Jenkins">Kevin Jenkins</name><affiliation><mods:affiliation>Department of Pathology, Microbiology and Immunology, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation></author><author><name sortKey="Mcgregor, Tracy L" sort="Mcgregor, Tracy L" uniqKey="Mcgregor T" first="Tracy L." last="Mcgregor">Tracy L. Mcgregor</name><affiliation><mods:affiliation>Department of Pediatrics, Division of Medical Genetics, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation></author><author><name sortKey="Gaddy, Jennifer A" sort="Gaddy, Jennifer A" uniqKey="Gaddy J" first="Jennifer A." last="Gaddy">Jennifer A. Gaddy</name><affiliation wicri:level="2"><mods:affiliation>Department of Medicine, Division of Infectious Disease, Vanderbilt University, Nashville, Tennessee</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Department of Medicine, Division of Infectious Disease, Vanderbilt University, Nashville</wicri:cityArea></affiliation><affiliation><mods:affiliation>Veterans Affairs Tennessee Valley Healthcare Services, Tennessee, Nashville</mods:affiliation></affiliation></author><author><name sortKey="Blackwell, Timothy S" sort="Blackwell, Timothy S" uniqKey="Blackwell T" first="Timothy S." last="Blackwell">Timothy S. Blackwell</name><affiliation wicri:level="2"><mods:affiliation>Department of Medicine, Division of Pulmonary and Critical Care, Vanderbilt University, Nashville, Tennessee</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Department of Medicine, Division of Pulmonary and Critical Care, Vanderbilt University, Nashville</wicri:cityArea></affiliation><affiliation><mods:affiliation>Veterans Affairs Tennessee Valley Healthcare Services, Tennessee, Nashville</mods:affiliation></affiliation></author><author><name sortKey="Drake, Wonder P" sort="Drake, Wonder P" uniqKey="Drake W" first="Wonder P." last="Drake">Wonder P. Drake</name><affiliation><mods:affiliation>Department of Medicine, Division of Infectious Disease, Vanderbilt University, Tennessee, Nashville</mods:affiliation><wicri:noCountry code="subField">Nashville</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">The Laryngoscope</title><title level="j" type="alt">THE LARYNGOSCOPE</title><idno type="ISSN">0023-852X</idno><idno type="eISSN">1531-4995</idno><imprint><biblScope unit="vol">126</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="E356">E356</biblScope><biblScope unit="page" to="E361">E361</biblScope><biblScope unit="page-count">6</biblScope><date type="published" when="2016-11">2016-11</date></imprint><idno type="ISSN">0023-852X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0023-852X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Objectives/Hypothesis: Idiopathic subglottic stenosis (iSGS) is a rare and devastating extrathoracic obstruction involving the lower laryngeal and upper tracheal airway. It arises without known antecedent injury or associated disease process. Persistent mucosal inflammation and a localized fibrotic response are hallmarks of the disease. Despite the initial clinical description of iSGS more than 40 year ago, there have been no substantive investigations into the pathogenesis of this enigmatic and progressive airway obstruction. In these studies, we present the initial characterization of the molecular pathogenesis underlying the fibrosing phenotype of iSGS. Methods: Utilizing 20 human iSGS and healthy control specimens, we applied histologic, immunohistochemical, molecular, and immunologic techniques. Results: We demonstrate significant activation of the canonical IL‐23/IL‐17A pathway in the tracheal mucosa of iSGS patients, as well as identify γδ T cells as the primary cellular source of IL‐17A. Conclusion: Our results suggest that aberrant mucosal immune activation is a component in of the pathogenesis of iSGS. Most critically, our work offers new targets for future therapeutic intervention. Level of Evidence: NA Laryngoscope, 126:E356–E361, 2016</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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