Dermatomyositis: factors predicting relapse
Identifieur interne : 002965 ( Istex/Curation ); précédent : 002964; suivant : 002966Dermatomyositis: factors predicting relapse
Auteurs : V. Vuong [France] ; T. A. Duong [France] ; J. Aouizerate [France] ; F. J. Authier [France] ; S. Ingen-Housz-Oro [France] ; L. Valeyrie-Allanore [France] ; N. Ortonne [France] ; P. Wolkenstein [France] ; R. K. Gherardi [France] ; O. Chosidow [France] ; A. Cosnes [France] ; E. Sbidian [France]Source :
- Journal of the European Academy of Dermatology and Venereology [ 0926-9959 ] ; 2016-05.
Abstract
Background: The course of dermatomyositis (DM) can be chronic with relapses, which are associated with major morbidity. Objective: The aim of this study was to identify presentation features that predict DM relapses. Methods: We retrospectively reviewed data of patients with DM recorded from 1990 to 2011, including muscle biopsy results. Characteristics of patients with and without relapses were compared. Hazard ratios (HRs) were estimated using a Cox model. Results: We identified 34 patients, with a mean age of 46 ± 17 years (range, 18–77) and 24 (71%) women. The muscle and skin abnormalities relapsed in 21 (61%) patients. By univariate analysis, two presentation features were significantly associated with a subsequently relapsing course, namely, dysphonia [HR = 3.2 (1.2–8.5)] and greater skin lesion severity defined as a Cutaneous Disease Area Severity Index [CDASI] > 20 [HR = 3.5 (1.2–7.9)]. Conclusion: Dysphonia and skin lesion severity at disease onset must be recorded, as they significantly predict a relapsing disease course.
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DOI: 10.1111/jdv.13516
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Ortonne</name><affiliation wicri:level="1"><mods:affiliation>AP‐HP, Département de Pathologie, Centre de référence des pathologies neuromusculaires, Hôpitaux universitaires Henri Mondor, Créteil, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP‐HP, Département de Pathologie, Centre de référence des pathologies neuromusculaires, Hôpitaux universitaires Henri Mondor, Créteil</wicri:regionArea></affiliation></author><author><name sortKey="Wolkenstein, P" sort="Wolkenstein, P" uniqKey="Wolkenstein P" first="P." last="Wolkenstein">P. 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Chosidow</name><affiliation wicri:level="1"><mods:affiliation>AP‐HP, DHU‐VIC, Service de Dermatologie, Hôpitaux universitaires Henri Mondor, Créteil, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP‐HP, DHU‐VIC, Service de Dermatologie, Hôpitaux universitaires Henri Mondor, Créteil</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Université Paris Est, IMRB, EA 7379 EpiDermE, Créteil, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Est, IMRB, EA 7379 EpiDermE, Créteil</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Université Paris Est, INSERM, CIC 1430, Créteil, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Est, INSERM, CIC 1430, Créteil</wicri:regionArea></affiliation></author><author><name sortKey="Cosnes, A" sort="Cosnes, A" uniqKey="Cosnes A" first="A." last="Cosnes">A. 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Vuong</name><affiliation wicri:level="1"><mods:affiliation>AP‐HP, DHU‐VIC, Service de Dermatologie, Hôpitaux universitaires Henri Mondor, Créteil, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP‐HP, DHU‐VIC, Service de Dermatologie, Hôpitaux universitaires Henri Mondor, Créteil</wicri:regionArea></affiliation></author><author><name sortKey="Duong, T A" sort="Duong, T A" uniqKey="Duong T" first="T. A." last="Duong">T. A. Duong</name><affiliation wicri:level="1"><mods:affiliation>AP‐HP, DHU‐VIC, Service de Dermatologie, Hôpitaux universitaires Henri Mondor, Créteil, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP‐HP, DHU‐VIC, Service de Dermatologie, Hôpitaux universitaires Henri Mondor, Créteil</wicri:regionArea></affiliation></author><author><name sortKey="Aouizerate, J" sort="Aouizerate, J" uniqKey="Aouizerate J" first="J." last="Aouizerate">J. Aouizerate</name><affiliation wicri:level="1"><mods:affiliation>AP‐HP, Département de Pathologie, Centre de référence des pathologies neuromusculaires, Hôpitaux universitaires Henri Mondor, Créteil, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP‐HP, Département de Pathologie, Centre de référence des pathologies neuromusculaires, Hôpitaux universitaires Henri Mondor, Créteil</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Université Paris Est, IMRB, INSERM U955‐Unité 10, Créteil, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Est, IMRB, INSERM U955‐Unité 10, Créteil</wicri:regionArea></affiliation></author><author><name sortKey="Authier, F J" sort="Authier, F J" uniqKey="Authier F" first="F. J." last="Authier">F. J. Authier</name><affiliation wicri:level="1"><mods:affiliation>AP‐HP, Département de Pathologie, Centre de référence des pathologies neuromusculaires, Hôpitaux universitaires Henri Mondor, Créteil, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP‐HP, Département de Pathologie, Centre de référence des pathologies neuromusculaires, Hôpitaux universitaires Henri Mondor, Créteil</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Université Paris Est, IMRB, INSERM U955‐Unité 10, Créteil, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Est, IMRB, INSERM U955‐Unité 10, Créteil</wicri:regionArea></affiliation></author><author><name sortKey="Ingen Ousz Ro, S" sort="Ingen Ousz Ro, S" uniqKey="Ingen Ousz Ro S" first="S." last="Ingen-Housz-Oro">S. Ingen-Housz-Oro</name><affiliation wicri:level="1"><mods:affiliation>AP‐HP, DHU‐VIC, Service de Dermatologie, Hôpitaux universitaires Henri Mondor, Créteil, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP‐HP, DHU‐VIC, Service de Dermatologie, Hôpitaux universitaires Henri Mondor, Créteil</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Université Paris Est, IMRB, EA 7379 EpiDermE, Créteil, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Est, IMRB, EA 7379 EpiDermE, Créteil</wicri:regionArea></affiliation></author><author><name sortKey="Valeyrie Llanore, L" sort="Valeyrie Llanore, L" uniqKey="Valeyrie Llanore L" first="L." last="Valeyrie-Allanore">L. Valeyrie-Allanore</name><affiliation wicri:level="1"><mods:affiliation>AP‐HP, DHU‐VIC, Service de Dermatologie, Hôpitaux universitaires Henri Mondor, Créteil, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP‐HP, DHU‐VIC, Service de Dermatologie, Hôpitaux universitaires Henri Mondor, Créteil</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Université Paris Est, IMRB, EA 7379 EpiDermE, Créteil, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Est, IMRB, EA 7379 EpiDermE, Créteil</wicri:regionArea></affiliation></author><author><name sortKey="Ortonne, N" sort="Ortonne, N" uniqKey="Ortonne N" first="N." last="Ortonne">N. Ortonne</name><affiliation wicri:level="1"><mods:affiliation>AP‐HP, Département de Pathologie, Centre de référence des pathologies neuromusculaires, Hôpitaux universitaires Henri Mondor, Créteil, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP‐HP, Département de Pathologie, Centre de référence des pathologies neuromusculaires, Hôpitaux universitaires Henri Mondor, Créteil</wicri:regionArea></affiliation></author><author><name sortKey="Wolkenstein, P" sort="Wolkenstein, P" uniqKey="Wolkenstein P" first="P." last="Wolkenstein">P. Wolkenstein</name><affiliation wicri:level="1"><mods:affiliation>AP‐HP, DHU‐VIC, Service de Dermatologie, Hôpitaux universitaires Henri Mondor, Créteil, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP‐HP, DHU‐VIC, Service de Dermatologie, Hôpitaux universitaires Henri Mondor, Créteil</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Université Paris Est, IMRB, EA 7379 EpiDermE, Créteil, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Est, IMRB, EA 7379 EpiDermE, Créteil</wicri:regionArea></affiliation></author><author><name sortKey="Gherardi, R K" sort="Gherardi, R K" uniqKey="Gherardi R" first="R. K." last="Gherardi">R. K. Gherardi</name><affiliation wicri:level="1"><mods:affiliation>AP‐HP, Département de Pathologie, Centre de référence des pathologies neuromusculaires, Hôpitaux universitaires Henri Mondor, Créteil, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP‐HP, Département de Pathologie, Centre de référence des pathologies neuromusculaires, Hôpitaux universitaires Henri Mondor, Créteil</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Université Paris Est, IMRB, INSERM U955‐Unité 10, Créteil, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Est, IMRB, INSERM U955‐Unité 10, Créteil</wicri:regionArea></affiliation></author><author><name sortKey="Chosidow, O" sort="Chosidow, O" uniqKey="Chosidow O" first="O." last="Chosidow">O. Chosidow</name><affiliation wicri:level="1"><mods:affiliation>AP‐HP, DHU‐VIC, Service de Dermatologie, Hôpitaux universitaires Henri Mondor, Créteil, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP‐HP, DHU‐VIC, Service de Dermatologie, Hôpitaux universitaires Henri Mondor, Créteil</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Université Paris Est, IMRB, EA 7379 EpiDermE, Créteil, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Est, IMRB, EA 7379 EpiDermE, Créteil</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Université Paris Est, INSERM, CIC 1430, Créteil, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Est, INSERM, CIC 1430, Créteil</wicri:regionArea></affiliation></author><author><name sortKey="Cosnes, A" sort="Cosnes, A" uniqKey="Cosnes A" first="A." last="Cosnes">A. Cosnes</name><affiliation wicri:level="1"><mods:affiliation>AP‐HP, DHU‐VIC, Service de Dermatologie, Hôpitaux universitaires Henri Mondor, Créteil, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP‐HP, DHU‐VIC, Service de Dermatologie, Hôpitaux universitaires Henri Mondor, Créteil</wicri:regionArea></affiliation></author><author><name sortKey="Sbidian, E" sort="Sbidian, E" uniqKey="Sbidian E" first="E." last="Sbidian">E. Sbidian</name><affiliation wicri:level="1"><mods:affiliation>AP‐HP, DHU‐VIC, Service de Dermatologie, Hôpitaux universitaires Henri Mondor, Créteil, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP‐HP, DHU‐VIC, Service de Dermatologie, Hôpitaux universitaires Henri Mondor, Créteil</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Université Paris Est, IMRB, EA 7379 EpiDermE, Créteil, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Est, IMRB, EA 7379 EpiDermE, Créteil</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Université Paris Est, INSERM, CIC 1430, Créteil, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Est, INSERM, CIC 1430, Créteil</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: emilie.sbidian@hmn.aphp.fr</mods:affiliation><country wicri:rule="url">France</country></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of the European Academy of Dermatology and Venereology</title><title level="j" type="alt">JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY</title><idno type="ISSN">0926-9959</idno><idno type="eISSN">1468-3083</idno><imprint><biblScope unit="vol">30</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="813">813</biblScope><biblScope unit="page" to="818">818</biblScope><biblScope unit="page-count">6</biblScope><date type="published" when="2016-05">2016-05</date></imprint><idno type="ISSN">0926-9959</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0926-9959</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Background: The course of dermatomyositis (DM) can be chronic with relapses, which are associated with major morbidity. Objective: The aim of this study was to identify presentation features that predict DM relapses. Methods: We retrospectively reviewed data of patients with DM recorded from 1990 to 2011, including muscle biopsy results. Characteristics of patients with and without relapses were compared. Hazard ratios (HRs) were estimated using a Cox model. Results: We identified 34 patients, with a mean age of 46 ± 17 years (range, 18–77) and 24 (71%) women. The muscle and skin abnormalities relapsed in 21 (61%) patients. By univariate analysis, two presentation features were significantly associated with a subsequently relapsing course, namely, dysphonia [HR = 3.2 (1.2–8.5)] and greater skin lesion severity defined as a Cutaneous Disease Area Severity Index [CDASI] > 20 [HR = 3.5 (1.2–7.9)]. Conclusion: Dysphonia and skin lesion severity at disease onset must be recorded, as they significantly predict a relapsing disease course.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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