Transforming growth factor‐beta 1 in humidifier disinfectant‐associated children's interstitial lung disease
Identifieur interne : 002795 ( Istex/Curation ); précédent : 002794; suivant : 002796Transforming growth factor‐beta 1 in humidifier disinfectant‐associated children's interstitial lung disease
Auteurs : Yoon Hee Kim [Corée du Sud] ; Kyung Won Kim [Corée du Sud] ; Kyung Eun Lee [Corée du Sud] ; Mi-Jung Lee [Corée du Sud] ; Sang Kyum Kim [Corée du Sud] ; Se Hoon Kim [Corée du Sud] ; Hyo Sup Shim [Corée du Sud] ; Chang Young Lee [Corée du Sud] ; Myung-Joon Kim [Corée du Sud] ; Myung Hyun Sohn [Corée du Sud] ; Kyu-Earn Kim [Corée du Sud]Source :
- Pediatric Pulmonology [ 8755-6863 ] ; 2016-02.
Abstract
Background: Humidifier disinfectant‐associated children's interstitial lung disease has an unpredictable clinical course with a high morbidity and mortality. Objectives: To evaluate the differences in clinical findings between survivors and non‐survivors of humidifier disinfectant‐associated children's interstitial lung disease. To evaluate dynamic changes in serum cytokines related to inflammation and fibrosis in lung injury, and to determine whether these changes are predictive of survival in this disease. Methods: We evaluated 17 children with humidifier disinfectant‐associated children's interstitial lung disease, from whom serum samples were obtained weekly during hospitalization. The severity of chest tomographic and lung pathologic findings was scored. Levels of several cytokines were measured in the serial serum samples. Results: Seven of the 17 children were survivors. Compared to survivors, non‐survivors had greater ground‐glass attenuation on follow‐up chest tomography, higher admission neutrophil counts, and more macrophages on pathologic findings. Transforming growth factor‐beta 1 persisted at an elevated level (1,000–1,500 pg/ml) in survivors, whereas it decreased abruptly in non‐survivors. At the time of this decrease, non‐survivors had clinical worsening of their respiratory failure. Transforming growth factor‐beta 1 was positively correlated with PaO2/FiO2 (r = 0.481, P < 0.0001). Conclusions: Non‐survivors exhibited more inflammatory clinical findings than survivors. Transforming growth factor‐beta 1 remained elevated in survivors, suggesting that it affected the clinical course of humidifier disinfectant‐associated children's interstitial lung disease. The prognosis of this lung disease may depend more on controlling excessive inflammation and repairing damaged lung than on fibrosis, and transforming growth factor‐beta 1 may play a key role in this process. Pediatr Pulmonol. 2016;51:173–182. © 2015 Wiley Periodicals, Inc.
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DOI: 10.1002/ppul.23226
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Seoul</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Brain Korea 21 PLUS project for Medical Science, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Brain Korea 21 PLUS project for Medical Science, Severance Hospital, Yonsei University College of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Kyung Won" sort="Kim, Kyung Won" uniqKey="Kim K" first="Kyung Won" last="Kim">Kyung Won Kim</name><affiliation wicri:level="1"><mods:affiliation>Department of Pediatrics, Yonsei University College of Medicine, 120‐752, Seoul, Republic of Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Yonsei University College of Medicine, 120‐752, Seoul</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Institute of Allergy, Yonsei University 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Sud</country><wicri:regionArea>Department of Pediatrics, Yonsei University College of Medicine, 120‐752, Seoul</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Institute of Allergy, Yonsei University College of Medicine, 120‐752, Seoul, Republic of Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Institute of Allergy, Yonsei University College of Medicine, 120‐752, Seoul</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Brain Korea 21 PLUS project for Medical Science, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Brain Korea 21 PLUS project for Medical Science, Severance Hospital, Yonsei University College of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Mi Ung" sort="Lee, Mi Ung" uniqKey="Lee M" first="Mi-Jung" last="Lee">Mi-Jung Lee</name><affiliation wicri:level="1"><mods:affiliation>Department of Radiology, Yonsei University College of Medicine, Seoul, Republic of Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Radiology, Yonsei University College of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Sang Kyum" sort="Kim, Sang Kyum" uniqKey="Kim S" first="Sang Kyum" last="Kim">Sang Kyum Kim</name><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, Yonsei University College of Medicine, Seoul, Republic of Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pathology, Yonsei University College of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Se Hoon" sort="Kim, Se Hoon" uniqKey="Kim S" first="Se Hoon" last="Kim">Se Hoon Kim</name><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, Yonsei University College of Medicine, Seoul, Republic of Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pathology, Yonsei University College of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Shim, Hyo Sup" sort="Shim, Hyo Sup" uniqKey="Shim H" first="Hyo Sup" last="Shim">Hyo Sup Shim</name><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, Yonsei University College of Medicine, Seoul, Republic of Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pathology, Yonsei University College of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Chang Young" sort="Lee, Chang Young" uniqKey="Lee C" first="Chang Young" last="Lee">Chang Young Lee</name><affiliation wicri:level="1"><mods:affiliation>Department of Thoracic and Cardiovascular Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Thoracic and Cardiovascular Surgery, Yonsei University College of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Myung Oon" sort="Kim, Myung Oon" uniqKey="Kim M" first="Myung-Joon" last="Kim">Myung-Joon Kim</name><affiliation wicri:level="1"><mods:affiliation>Department of Radiology, Yonsei University College of Medicine, Seoul, Republic of Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Radiology, Yonsei University College of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Sohn, Myung Hyun" sort="Sohn, Myung Hyun" uniqKey="Sohn M" first="Myung Hyun" last="Sohn">Myung Hyun Sohn</name><affiliation wicri:level="1"><mods:affiliation>Department of Pediatrics, Yonsei University College of Medicine, 120‐752, Seoul, Republic of Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Yonsei University College of Medicine, 120‐752, Seoul</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Institute of Allergy, Yonsei University College of Medicine, 120‐752, Seoul, Republic of Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Institute of Allergy, Yonsei University College of Medicine, 120‐752, Seoul</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Brain Korea 21 PLUS project for Medical Science, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Brain Korea 21 PLUS project for Medical Science, Severance Hospital, Yonsei University College of Medicine, Seoul</wicri:regionArea></affiliation><affiliation><mods:affiliation>Correspondence to: Myung Hyun Sohn, MD, PhD, Department of Pediatrics, Severance Hospital, Yonsei University College of Medicine, 50‐1, Yonsei‐ro, Seodaemun‐gu, Seoul 120‐752, South Korea. E‐mail:</mods:affiliation><wicri:noCountry code="subField">E‐mail:</wicri:noCountry></affiliation><affiliation><mods:affiliation>E-mail: mhsohn@yuhs.ac</mods:affiliation><wicri:noCountry code="no comma">E-mail: mhsohn@yuhs.ac</wicri:noCountry></affiliation></author><author><name sortKey="Kim, Kyu Arn" sort="Kim, Kyu Arn" uniqKey="Kim K" first="Kyu-Earn" last="Kim">Kyu-Earn Kim</name><affiliation wicri:level="1"><mods:affiliation>Department of Pediatrics, Yonsei University College of Medicine, 120‐752, Seoul, Republic of Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Yonsei University College of Medicine, 120‐752, Seoul</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Institute of Allergy, Yonsei University College of Medicine, 120‐752, Seoul, Republic of Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Institute of Allergy, Yonsei University College of Medicine, 120‐752, Seoul</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Brain Korea 21 PLUS project for Medical Science, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Brain Korea 21 PLUS project for Medical Science, Severance Hospital, Yonsei University College of Medicine, Seoul</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:DDBC9B8D80C72A9377E5315AA65E3B7A77D7D859</idno><date when="2016" year="2016">2016</date><idno type="doi">10.1002/ppul.23226</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-NB2Q2F03-X/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">002795</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002795</idno><idno 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Seoul</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Brain Korea 21 PLUS project for Medical Science, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Brain Korea 21 PLUS project for Medical Science, Severance Hospital, Yonsei University College of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Kyung Won" sort="Kim, Kyung Won" uniqKey="Kim K" first="Kyung Won" last="Kim">Kyung Won Kim</name><affiliation wicri:level="1"><mods:affiliation>Department of Pediatrics, Yonsei University College of Medicine, 120‐752, Seoul, Republic of Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Yonsei University College of Medicine, 120‐752, Seoul</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Institute of Allergy, Yonsei University College of Medicine, 120‐752, Seoul, Republic of Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Institute of Allergy, Yonsei University College of Medicine, 120‐752, Seoul</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Brain Korea 21 PLUS project for Medical Science, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Brain Korea 21 PLUS project for Medical Science, Severance Hospital, Yonsei University College of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Kyung Eun" sort="Lee, Kyung Eun" uniqKey="Lee K" first="Kyung Eun" last="Lee">Kyung Eun Lee</name><affiliation wicri:level="1"><mods:affiliation>Department of Pediatrics, Yonsei University College of Medicine, 120‐752, Seoul, Republic of Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Yonsei University College of Medicine, 120‐752, Seoul</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Institute of Allergy, Yonsei University College of Medicine, 120‐752, Seoul, Republic of Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Institute of Allergy, Yonsei University College of Medicine, 120‐752, Seoul</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Brain Korea 21 PLUS project for Medical Science, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Brain Korea 21 PLUS project for Medical Science, Severance Hospital, Yonsei University College of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Mi Ung" sort="Lee, Mi Ung" uniqKey="Lee M" first="Mi-Jung" last="Lee">Mi-Jung Lee</name><affiliation wicri:level="1"><mods:affiliation>Department of Radiology, Yonsei University College of Medicine, Seoul, Republic of Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Radiology, Yonsei University College of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Sang Kyum" sort="Kim, Sang Kyum" uniqKey="Kim S" first="Sang Kyum" last="Kim">Sang Kyum Kim</name><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, Yonsei University College of Medicine, Seoul, Republic of Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pathology, Yonsei University College of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Se Hoon" sort="Kim, Se Hoon" uniqKey="Kim S" first="Se Hoon" last="Kim">Se Hoon Kim</name><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, Yonsei University College of Medicine, Seoul, Republic of Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pathology, Yonsei University College of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Shim, Hyo Sup" sort="Shim, Hyo Sup" uniqKey="Shim H" first="Hyo Sup" last="Shim">Hyo Sup Shim</name><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, Yonsei University College of Medicine, Seoul, Republic of Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pathology, Yonsei University College of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Chang Young" sort="Lee, Chang Young" uniqKey="Lee C" first="Chang Young" last="Lee">Chang Young Lee</name><affiliation wicri:level="1"><mods:affiliation>Department of Thoracic and Cardiovascular Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Thoracic and Cardiovascular Surgery, Yonsei University College of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Myung Oon" sort="Kim, Myung Oon" uniqKey="Kim M" first="Myung-Joon" last="Kim">Myung-Joon Kim</name><affiliation wicri:level="1"><mods:affiliation>Department of Radiology, Yonsei University College of Medicine, Seoul, Republic of Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Radiology, Yonsei University College of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Sohn, Myung Hyun" sort="Sohn, Myung Hyun" uniqKey="Sohn M" first="Myung Hyun" last="Sohn">Myung Hyun Sohn</name><affiliation wicri:level="1"><mods:affiliation>Department of Pediatrics, Yonsei University College of Medicine, 120‐752, Seoul, Republic of Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Yonsei University College of Medicine, 120‐752, Seoul</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Institute of Allergy, Yonsei University College of Medicine, 120‐752, Seoul, Republic of Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Institute of Allergy, Yonsei University College of Medicine, 120‐752, Seoul</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Brain Korea 21 PLUS project for Medical Science, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Brain Korea 21 PLUS project for Medical Science, Severance Hospital, Yonsei University College of Medicine, Seoul</wicri:regionArea></affiliation><affiliation><mods:affiliation>Correspondence to: Myung Hyun Sohn, MD, PhD, Department of Pediatrics, Severance Hospital, Yonsei University College of Medicine, 50‐1, Yonsei‐ro, Seodaemun‐gu, Seoul 120‐752, South Korea. E‐mail:</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: mhsohn@yuhs.ac</mods:affiliation></affiliation></author><author><name sortKey="Kim, Kyu Arn" sort="Kim, Kyu Arn" uniqKey="Kim K" first="Kyu-Earn" last="Kim">Kyu-Earn Kim</name><affiliation wicri:level="1"><mods:affiliation>Department of Pediatrics, Yonsei University College of Medicine, 120‐752, Seoul, Republic of Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Yonsei University College of Medicine, 120‐752, Seoul</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Institute of Allergy, Yonsei University College of Medicine, 120‐752, Seoul, Republic of Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Institute of Allergy, Yonsei University College of Medicine, 120‐752, Seoul</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Brain Korea 21 PLUS project for Medical Science, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea</mods:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Brain Korea 21 PLUS project for Medical Science, Severance Hospital, Yonsei University College of Medicine, Seoul</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Pediatric Pulmonology</title><title level="j" type="alt">PEDIATRIC PULMONOLOGY</title><idno type="ISSN">8755-6863</idno><idno type="eISSN">1099-0496</idno><imprint><biblScope unit="vol">51</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="173">173</biblScope><biblScope unit="page" to="182">182</biblScope><biblScope unit="page-count">10</biblScope><date type="published" when="2016-02">2016-02</date></imprint><idno type="ISSN">8755-6863</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">8755-6863</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Humidifier disinfectant‐associated children's interstitial lung disease has an unpredictable clinical course with a high morbidity and mortality. Objectives: To evaluate the differences in clinical findings between survivors and non‐survivors of humidifier disinfectant‐associated children's interstitial lung disease. To evaluate dynamic changes in serum cytokines related to inflammation and fibrosis in lung injury, and to determine whether these changes are predictive of survival in this disease. Methods: We evaluated 17 children with humidifier disinfectant‐associated children's interstitial lung disease, from whom serum samples were obtained weekly during hospitalization. The severity of chest tomographic and lung pathologic findings was scored. Levels of several cytokines were measured in the serial serum samples. Results: Seven of the 17 children were survivors. Compared to survivors, non‐survivors had greater ground‐glass attenuation on follow‐up chest tomography, higher admission neutrophil counts, and more macrophages on pathologic findings. Transforming growth factor‐beta 1 persisted at an elevated level (1,000–1,500 pg/ml) in survivors, whereas it decreased abruptly in non‐survivors. At the time of this decrease, non‐survivors had clinical worsening of their respiratory failure. Transforming growth factor‐beta 1 was positively correlated with PaO2/FiO2 (r = 0.481, P < 0.0001). Conclusions: Non‐survivors exhibited more inflammatory clinical findings than survivors. Transforming growth factor‐beta 1 remained elevated in survivors, suggesting that it affected the clinical course of humidifier disinfectant‐associated children's interstitial lung disease. The prognosis of this lung disease may depend more on controlling excessive inflammation and repairing damaged lung than on fibrosis, and transforming growth factor‐beta 1 may play a key role in this process. Pediatr Pulmonol. 2016;51:173–182. © 2015 Wiley Periodicals, Inc.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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