Changes in novel biomarkers of disease activity in juvenile and adult dermatomyositis are sensitive biomarkers of disease course
Identifieur interne : 002741 ( Istex/Curation ); précédent : 002740; suivant : 002742Changes in novel biomarkers of disease activity in juvenile and adult dermatomyositis are sensitive biomarkers of disease course
Auteurs : Ann M. Reed [États-Unis] ; Erik Peterson ; Hatice Bilgic ; Steven R. Ytterberg [États-Unis] ; Shreyasee Amin [États-Unis] ; Molly S. Hein [États-Unis] ; Cynthia S. Crowson [États-Unis] ; Floranne Ernste [États-Unis] ; Emily Baechler GillespieSource :
- Arthritis & Rheumatism [ 0004-3591 ] ; 2012-12.
Abstract
Objective: Muscle enzyme levels are insensitive markers of disease activity in juvenile and adult dermatomyositis (DM), especially during the active treatment phase. To improve our ability to monitor DM disease activity longitudinally, especially in the presence of immunomodulating agents, we prospectively evaluated whether interferon (IFN)–dependent peripheral blood gene and chemokine signatures could serve as sensitive and responsive biomarkers for change in disease activity in adult and juvenile DM. Methods: Peripheral blood and clinical data were collected from 51 patients with juvenile or adult DM prospectively over 2 study visits. We performed disease activity measurements and calculated whole‐blood type I IFN gene and chemokine scores. We also measured serum levels of other proinflammatory cytokines, including interleukin‐6 (IL‐6). Results: Changes in juvenile and adult DM global disease activity correlated positively and significantly with changes in the type I IFN gene score before adjustment for medication use (r = 0.33, P = 0.023) and with changes in the IFN chemokine score before and after adjustment for medication use (r = 0.53, P < 0.001 and r = 0.50, P < 0.001, respectively). Changes in muscle and extramuscular visual analog scale (VAS) scores correlated positively with changes in IFN gene and chemokine scores (P = 0.002, P < 0.001, P = 0.095, P < 0.001). Serum levels of IL‐6, IL‐8, and tumor necrosis factor α (TNFα) correlated positively with changes in global, muscle, and extramuscular VAS scores (P < 0.05). Conclusion: Our findings suggest that changes in type I IFN gene and chemokine scores as well as in levels of IL‐6, IL‐8, and TNFα may serve as sensitive and responsive longitudinal biomarkers of change in disease activity in juvenile and adult DM, even in the presence of immunomodulating agents.
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DOI: 10.1002/art.34659
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Erik Peterson<affiliation><mods:affiliation>University of Minnesota, Minneapolis</mods:affiliation><wicri:noCountry code="subField">Minneapolis</wicri:noCountry></affiliation><affiliation><mods:affiliation>University of Minnesota, Minneapolis</mods:affiliation><wicri:noCountry code="subField">Minneapolis</wicri:noCountry></affiliation><affiliation><mods:affiliation>University of Minnesota, Minneapolis</mods:affiliation><wicri:noCountry code="subField">Minneapolis</wicri:noCountry></affiliation>Le document en format XML
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Reed</name><affiliation wicri:level="2"><mods:affiliation>Mayo Clinic, Rochester, Minnesota</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Mayo Clinic, Rochester</wicri:cityArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: reed.ann18@mayo.edu</mods:affiliation><country wicri:rule="url">États-Unis</country></affiliation><affiliation wicri:level="2"><mods:affiliation>Correspondence address: Mayo Clinic, Division of Rheumatology, E15, 200 First Street SW, Rochester, MN 55905</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Correspondence address: Mayo Clinic, Division of Rheumatology, E15, 200 First Street SW, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Peterson, Erik" sort="Peterson, Erik" uniqKey="Peterson E" first="Erik" last="Peterson">Erik Peterson</name><affiliation><mods:affiliation>University of Minnesota, Minneapolis</mods:affiliation><wicri:noCountry code="subField">Minneapolis</wicri:noCountry></affiliation></author><author><name sortKey="Bilgic, Hatice" sort="Bilgic, Hatice" uniqKey="Bilgic H" first="Hatice" last="Bilgic">Hatice Bilgic</name><affiliation><mods:affiliation>University of Minnesota, Minneapolis</mods:affiliation><wicri:noCountry code="subField">Minneapolis</wicri:noCountry></affiliation></author><author><name sortKey="Ytterberg, Steven R" sort="Ytterberg, Steven R" uniqKey="Ytterberg S" first="Steven R." last="Ytterberg">Steven R. Ytterberg</name><affiliation wicri:level="2"><mods:affiliation>Mayo Clinic, Rochester, Minnesota</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Mayo Clinic, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Amin, Shreyasee" sort="Amin, Shreyasee" uniqKey="Amin S" first="Shreyasee" last="Amin">Shreyasee Amin</name><affiliation wicri:level="2"><mods:affiliation>Mayo Clinic, Rochester, Minnesota</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Mayo Clinic, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Hein, Molly S" sort="Hein, Molly S" uniqKey="Hein M" first="Molly S." last="Hein">Molly S. Hein</name><affiliation wicri:level="2"><mods:affiliation>Mayo Clinic, Rochester, Minnesota</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Mayo Clinic, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Crowson, Cynthia S" sort="Crowson, Cynthia S" uniqKey="Crowson C" first="Cynthia S." last="Crowson">Cynthia S. Crowson</name><affiliation wicri:level="2"><mods:affiliation>Mayo Clinic, Rochester, Minnesota</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Mayo Clinic, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Ernste, Floranne" sort="Ernste, Floranne" uniqKey="Ernste F" first="Floranne" last="Ernste">Floranne Ernste</name><affiliation wicri:level="2"><mods:affiliation>Mayo Clinic, Rochester, Minnesota</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Mayo Clinic, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Gillespie, Emily Baechler" sort="Gillespie, Emily Baechler" uniqKey="Gillespie E" first="Emily Baechler" last="Gillespie">Emily Baechler Gillespie</name><affiliation><mods:affiliation>University of Minnesota, Minneapolis</mods:affiliation><wicri:noCountry code="subField">Minneapolis</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Arthritis & Rheumatism</title><title level="j" type="alt">ARTHRITIS AND RHEUMATISM</title><idno type="ISSN">0004-3591</idno><idno type="eISSN">1529-0131</idno><imprint><biblScope unit="vol">64</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="4078">4078</biblScope><biblScope unit="page" to="4086">4086</biblScope><biblScope unit="page-count">9</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2012-12">2012-12</date></imprint><idno type="ISSN">0004-3591</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0004-3591</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: Muscle enzyme levels are insensitive markers of disease activity in juvenile and adult dermatomyositis (DM), especially during the active treatment phase. To improve our ability to monitor DM disease activity longitudinally, especially in the presence of immunomodulating agents, we prospectively evaluated whether interferon (IFN)–dependent peripheral blood gene and chemokine signatures could serve as sensitive and responsive biomarkers for change in disease activity in adult and juvenile DM. Methods: Peripheral blood and clinical data were collected from 51 patients with juvenile or adult DM prospectively over 2 study visits. We performed disease activity measurements and calculated whole‐blood type I IFN gene and chemokine scores. We also measured serum levels of other proinflammatory cytokines, including interleukin‐6 (IL‐6). Results: Changes in juvenile and adult DM global disease activity correlated positively and significantly with changes in the type I IFN gene score before adjustment for medication use (r = 0.33, P = 0.023) and with changes in the IFN chemokine score before and after adjustment for medication use (r = 0.53, P < 0.001 and r = 0.50, P < 0.001, respectively). Changes in muscle and extramuscular visual analog scale (VAS) scores correlated positively with changes in IFN gene and chemokine scores (P = 0.002, P < 0.001, P = 0.095, P < 0.001). Serum levels of IL‐6, IL‐8, and tumor necrosis factor α (TNFα) correlated positively with changes in global, muscle, and extramuscular VAS scores (P < 0.05). Conclusion: Our findings suggest that changes in type I IFN gene and chemokine scores as well as in levels of IL‐6, IL‐8, and TNFα may serve as sensitive and responsive longitudinal biomarkers of change in disease activity in juvenile and adult DM, even in the presence of immunomodulating agents.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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