Regulation of mammalian target of rapamycin complex 1 (mTORC1) by hypoxia: causes and consequences
Identifieur interne : 002075 ( Istex/Curation ); précédent : 002074; suivant : 002076Regulation of mammalian target of rapamycin complex 1 (mTORC1) by hypoxia: causes and consequences
Auteurs : Hakan Cam [États-Unis] ; Peter J. Houghton [États-Unis]Source :
- Targeted Oncology [ 1776-2596 ] ; 2011-06-01.
English descriptors
- KwdEn :
Abstract
Abstract: Integration of cellular and extracellular signals maintains tissue homeostasis under conditions of normal proliferation and stress. A central player in regulating responses to stress is the serine/threonine kinase mammalian target of rapamycin (mTOR). In many cancers, mTOR complex 1 (mTORC1) signaling is enhanced, even under conditions where such signaling should be suppressed. This article reviews some of the details that are emerging on how low oxygen (hypoxia) regulates mTORC1 signaling, and the consequences for dysregulation in pediatric solid tumors.
Url:
DOI: 10.1007/s11523-011-0173-x
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002075
Links to Exploration step
ISTEX:F1064D2DBB4FD8CB85F6C810F2993D7501833905Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Regulation of mammalian target of rapamycin complex 1 (mTORC1) by hypoxia: causes and consequences</title>
<author><name sortKey="Cam, Hakan" sort="Cam, Hakan" uniqKey="Cam H" first="Hakan" last="Cam">Hakan Cam</name>
<affiliation wicri:level="1"><mods:affiliation>Center for Childhood Cancer, Nationwide Children’s Hospital, 700 Children’s Drive, 43205, Columbus, OH, USA</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Childhood Cancer, Nationwide Children’s Hospital, 700 Children’s Drive, 43205, Columbus, OH</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Houghton, Peter J" sort="Houghton, Peter J" uniqKey="Houghton P" first="Peter J." last="Houghton">Peter J. Houghton</name>
<affiliation wicri:level="1"><mods:affiliation>Center for Childhood Cancer, Nationwide Children’s Hospital, 700 Children’s Drive, 43205, Columbus, OH, USA</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Childhood Cancer, Nationwide Children’s Hospital, 700 Children’s Drive, 43205, Columbus, OH</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation>E-mail: Peter.Houghton@nationwidechildrens.org</mods:affiliation>
<wicri:noCountry code="no comma">E-mail: Peter.Houghton@nationwidechildrens.org</wicri:noCountry>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:F1064D2DBB4FD8CB85F6C810F2993D7501833905</idno>
<date when="2011" year="2011">2011</date>
<idno type="doi">10.1007/s11523-011-0173-x</idno>
<idno type="url">https://api.istex.fr/ark:/67375/VQC-WLDLF82V-X/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">002075</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002075</idno>
<idno type="wicri:Area/Istex/Curation">002075</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Regulation of mammalian target of rapamycin complex 1 (mTORC1) by hypoxia: causes and consequences</title>
<author><name sortKey="Cam, Hakan" sort="Cam, Hakan" uniqKey="Cam H" first="Hakan" last="Cam">Hakan Cam</name>
<affiliation wicri:level="1"><mods:affiliation>Center for Childhood Cancer, Nationwide Children’s Hospital, 700 Children’s Drive, 43205, Columbus, OH, USA</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Childhood Cancer, Nationwide Children’s Hospital, 700 Children’s Drive, 43205, Columbus, OH</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Houghton, Peter J" sort="Houghton, Peter J" uniqKey="Houghton P" first="Peter J." last="Houghton">Peter J. Houghton</name>
<affiliation wicri:level="1"><mods:affiliation>Center for Childhood Cancer, Nationwide Children’s Hospital, 700 Children’s Drive, 43205, Columbus, OH, USA</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Childhood Cancer, Nationwide Children’s Hospital, 700 Children’s Drive, 43205, Columbus, OH</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation>E-mail: Peter.Houghton@nationwidechildrens.org</mods:affiliation>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Targeted Oncology</title>
<title level="j" type="abbrev">Targ Oncol</title>
<idno type="ISSN">1776-2596</idno>
<idno type="eISSN">1776-260X</idno>
<imprint><publisher>Springer-Verlag</publisher>
<pubPlace>Paris</pubPlace>
<date type="published" when="2011-06-01">2011-06-01</date>
<biblScope unit="volume">6</biblScope>
<biblScope unit="issue">2</biblScope>
<biblScope unit="page" from="95">95</biblScope>
<biblScope unit="page" to="102">102</biblScope>
</imprint>
<idno type="ISSN">1776-2596</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">1776-2596</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Hypoxia</term>
<term>Pediatric malignancies</term>
<term>mTORC1 signaling</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: Integration of cellular and extracellular signals maintains tissue homeostasis under conditions of normal proliferation and stress. A central player in regulating responses to stress is the serine/threonine kinase mammalian target of rapamycin (mTOR). In many cancers, mTOR complex 1 (mTORC1) signaling is enhanced, even under conditions where such signaling should be suppressed. This article reviews some of the details that are emerging on how low oxygen (hypoxia) regulates mTORC1 signaling, and the consequences for dysregulation in pediatric solid tumors.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002075 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 002075 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Istex |étape= Curation |type= RBID |clé= ISTEX:F1064D2DBB4FD8CB85F6C810F2993D7501833905 |texte= Regulation of mammalian target of rapamycin complex 1 (mTORC1) by hypoxia: causes and consequences }}
This area was generated with Dilib version V0.6.33. |