Folliculitis decalvans: a multicentre review of 82 patients
Identifieur interne : 001E06 ( Istex/Curation ); précédent : 001E05; suivant : 001E07Folliculitis decalvans: a multicentre review of 82 patients
Auteurs : S. Va Alván [Espagne] ; A. M. Molina-Ruiz [Espagne] ; P. Fernández-Crehuet [Espagne] ; A. R. Rodrigues-Barata [Espagne] ; S. Arias-Santiago [Espagne] ; C. Serrano-Falc N [Espagne] ; A. Martorell-Calatayud [Espagne] ; D. Barco [Espagne] ; B. Pérez [Espagne] ; S. Serrano [Espagne] ; L. Requena [Espagne] ; R. Grimalt [Espagne] ; J. Paoli [Suède] ; P. Jaén [Espagne] ; F. M. Camacho [Espagne]Source :
- Journal of the European Academy of Dermatology and Venereology [ 0926-9959 ] ; 2015-09.
Abstract
Background: Folliculitis decalvans (FD) is a rare neutrophilic scarring alopecia that represents a therapeutic challenge for dermatologists. Objective: To describe the epidemiology, comorbidities, clinical presentation, diagnostic findings and therapeutic options in a large series of patients with FD. Methods: This retrospective multicentre review includes patients diagnosed with FD based on clinical and histopathologic findings. The clinical severity was determined by the maximum diameter of the largest alopecic patch (slight: <2 cm, moderate: 2–4.99 cm, severe: 5 cm or more). Response to therapy was assessed as improvement, worsening or stabilization depending on the clinical symptoms (pruritus and trichodynia), inflammatory signs (erythema, pustules and crusts) and the extension of the alopecic patch. Results: Overall, 82 patients (52 males and 30 females) with a mean age of 35 years were included. No significant comorbidities were present. A family history was present in three males. Severe FD was observed in 17 patients (21%). The independent factors associated with severe FD after multivariate analysis were: onset of FD before 25 years of age and presence of pustules. Oral antibiotics (tetracyclines and the combination of clindamycin and rifampicin) improved 90% and 100% of the patients, with a mean duration of response of 4.6 and 7.2 months respectively. Conclusions: The onset of FD before 25 years of age and the presence of pustules within the alopecic patch were associated with severe FD. Tetracyclines and the combination of clindamycin and rifampicin were the most useful treatments.
Url:
DOI: 10.1111/jdv.12993
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001E06
Links to Exploration step
ISTEX:96F36E7CCEBC7973CA91B8E4DE6A22D5C917D0ABLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Folliculitis decalvans: a multicentre review of 82 patients</title><author><name sortKey="Va Alvan, S" sort="Va Alvan, S" uniqKey="Va Alvan S" first="S." last="Va Alván">S. Va Alván</name><affiliation wicri:level="1"><mods:affiliation>Hospital Ramón y Cajal, IRYCIS, Universidad de Alcalá, Madrid, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Ramón y Cajal, IRYCIS, Universidad de Alcalá, Madrid</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: sergiovano@yahoo.es</mods:affiliation><country wicri:rule="url">Espagne</country></affiliation></author><author><name sortKey="Molina Uiz, A M" sort="Molina Uiz, A M" uniqKey="Molina Uiz A" first="A. M." last="Molina-Ruiz">A. M. Molina-Ruiz</name><affiliation wicri:level="1"><mods:affiliation>Fundación Jiménez Diaz, Madrid, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Fundación Jiménez Diaz, Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Fernandez Rehuet, P" sort="Fernandez Rehuet, P" uniqKey="Fernandez Rehuet P" first="P." last="Fernández-Crehuet">P. Fernández-Crehuet</name><affiliation wicri:level="1"><mods:affiliation>Alto Guadalquivir de Andújar, Jaén, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Alto Guadalquivir de Andújar, Jaén</wicri:regionArea></affiliation></author><author><name sortKey="Rodrigues Arata, A R" sort="Rodrigues Arata, A R" uniqKey="Rodrigues Arata A" first="A. R." last="Rodrigues-Barata">A. R. Rodrigues-Barata</name><affiliation wicri:level="1"><mods:affiliation>Grupo Pedro Jaén, Madrid, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Grupo Pedro Jaén, Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Arias Antiago, S" sort="Arias Antiago, S" uniqKey="Arias Antiago S" first="S." last="Arias-Santiago">S. Arias-Santiago</name><affiliation wicri:level="1"><mods:affiliation>Unidad de Dermatología Hospital Virgen de las Nieves, Instituto de Investigaciones Biosanitarias IBS, Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unidad de Dermatología Hospital Virgen de las Nieves, Instituto de Investigaciones Biosanitarias IBS, Hospitales Universitarios de Granada/Universidad de Granada, Granada</wicri:regionArea></affiliation></author><author><name sortKey="Serrano Alc N, C" sort="Serrano Alc N, C" uniqKey="Serrano Alc N C" first="C." last="Serrano-Falc N">C. Serrano-Falc N</name><affiliation wicri:level="1"><mods:affiliation>Guadix, Granada, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Guadix, Granada</wicri:regionArea></affiliation></author><author><name sortKey="Martorell Alatayud, A" sort="Martorell Alatayud, A" uniqKey="Martorell Alatayud A" first="A." last="Martorell-Calatayud">A. Martorell-Calatayud</name><affiliation wicri:level="1"><mods:affiliation>Manises, Valencia, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Manises, Valencia</wicri:regionArea></affiliation></author><author><name sortKey="Barco, D" sort="Barco, D" uniqKey="Barco D" first="D." last="Barco">D. Barco</name><affiliation wicri:level="1"><mods:affiliation>Teknon, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Teknon, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Perez, B" sort="Perez, B" uniqKey="Perez B" first="B." last="Pérez">B. Pérez</name><affiliation wicri:level="1"><mods:affiliation>Hospital Ramón y Cajal, IRYCIS, Universidad de Alcalá, Madrid, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Ramón y Cajal, IRYCIS, Universidad de Alcalá, Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Serrano, S" sort="Serrano, S" uniqKey="Serrano S" first="S." last="Serrano">S. Serrano</name><affiliation wicri:level="1"><mods:affiliation>Universidad de Granada, Granada, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Universidad de Granada, Granada</wicri:regionArea></affiliation></author><author><name sortKey="Requena, L" sort="Requena, L" uniqKey="Requena L" first="L." last="Requena">L. Requena</name><affiliation wicri:level="1"><mods:affiliation>Fundación Jiménez Diaz, Madrid, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Fundación Jiménez Diaz, Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Grimalt, R" sort="Grimalt, R" uniqKey="Grimalt R" first="R." last="Grimalt">R. Grimalt</name><affiliation wicri:level="1"><mods:affiliation>Universitat Internacional de Catalunya, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Universitat Internacional de Catalunya, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Paoli, J" sort="Paoli, J" uniqKey="Paoli J" first="J." last="Paoli">J. Paoli</name><affiliation wicri:level="1"><mods:affiliation>Sahlgrenska University Hospital, Gothenburg, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Sahlgrenska University Hospital, Gothenburg</wicri:regionArea></affiliation></author><author><name sortKey="Jaen, P" sort="Jaen, P" uniqKey="Jaen P" first="P." last="Jaén">P. Jaén</name><affiliation wicri:level="1"><mods:affiliation>Hospital Ramón y Cajal, IRYCIS, Universidad de Alcalá, Madrid, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Ramón y Cajal, IRYCIS, Universidad de Alcalá, Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Camacho, F M" sort="Camacho, F M" uniqKey="Camacho F" first="F. M." last="Camacho">F. M. Camacho</name><affiliation wicri:level="1"><mods:affiliation>Virgen Macarena, Sevilla, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Virgen Macarena, Sevilla</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:96F36E7CCEBC7973CA91B8E4DE6A22D5C917D0AB</idno><date when="2015" year="2015">2015</date><idno type="doi">10.1111/jdv.12993</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-P9W0PD31-G/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001E06</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001E06</idno><idno type="wicri:Area/Istex/Curation">001E06</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Folliculitis decalvans: a multicentre review of 82 patients</title><author><name sortKey="Va Alvan, S" sort="Va Alvan, S" uniqKey="Va Alvan S" first="S." last="Va Alván">S. Va Alván</name><affiliation wicri:level="1"><mods:affiliation>Hospital Ramón y Cajal, IRYCIS, Universidad de Alcalá, Madrid, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Ramón y Cajal, IRYCIS, Universidad de Alcalá, Madrid</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: sergiovano@yahoo.es</mods:affiliation><country wicri:rule="url">Espagne</country></affiliation></author><author><name sortKey="Molina Uiz, A M" sort="Molina Uiz, A M" uniqKey="Molina Uiz A" first="A. M." last="Molina-Ruiz">A. M. Molina-Ruiz</name><affiliation wicri:level="1"><mods:affiliation>Fundación Jiménez Diaz, Madrid, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Fundación Jiménez Diaz, Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Fernandez Rehuet, P" sort="Fernandez Rehuet, P" uniqKey="Fernandez Rehuet P" first="P." last="Fernández-Crehuet">P. Fernández-Crehuet</name><affiliation wicri:level="1"><mods:affiliation>Alto Guadalquivir de Andújar, Jaén, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Alto Guadalquivir de Andújar, Jaén</wicri:regionArea></affiliation></author><author><name sortKey="Rodrigues Arata, A R" sort="Rodrigues Arata, A R" uniqKey="Rodrigues Arata A" first="A. R." last="Rodrigues-Barata">A. R. Rodrigues-Barata</name><affiliation wicri:level="1"><mods:affiliation>Grupo Pedro Jaén, Madrid, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Grupo Pedro Jaén, Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Arias Antiago, S" sort="Arias Antiago, S" uniqKey="Arias Antiago S" first="S." last="Arias-Santiago">S. Arias-Santiago</name><affiliation wicri:level="1"><mods:affiliation>Unidad de Dermatología Hospital Virgen de las Nieves, Instituto de Investigaciones Biosanitarias IBS, Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unidad de Dermatología Hospital Virgen de las Nieves, Instituto de Investigaciones Biosanitarias IBS, Hospitales Universitarios de Granada/Universidad de Granada, Granada</wicri:regionArea></affiliation></author><author><name sortKey="Serrano Alc N, C" sort="Serrano Alc N, C" uniqKey="Serrano Alc N C" first="C." last="Serrano-Falc N">C. Serrano-Falc N</name><affiliation wicri:level="1"><mods:affiliation>Guadix, Granada, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Guadix, Granada</wicri:regionArea></affiliation></author><author><name sortKey="Martorell Alatayud, A" sort="Martorell Alatayud, A" uniqKey="Martorell Alatayud A" first="A." last="Martorell-Calatayud">A. Martorell-Calatayud</name><affiliation wicri:level="1"><mods:affiliation>Manises, Valencia, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Manises, Valencia</wicri:regionArea></affiliation></author><author><name sortKey="Barco, D" sort="Barco, D" uniqKey="Barco D" first="D." last="Barco">D. Barco</name><affiliation wicri:level="1"><mods:affiliation>Teknon, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Teknon, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Perez, B" sort="Perez, B" uniqKey="Perez B" first="B." last="Pérez">B. Pérez</name><affiliation wicri:level="1"><mods:affiliation>Hospital Ramón y Cajal, IRYCIS, Universidad de Alcalá, Madrid, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Ramón y Cajal, IRYCIS, Universidad de Alcalá, Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Serrano, S" sort="Serrano, S" uniqKey="Serrano S" first="S." last="Serrano">S. Serrano</name><affiliation wicri:level="1"><mods:affiliation>Universidad de Granada, Granada, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Universidad de Granada, Granada</wicri:regionArea></affiliation></author><author><name sortKey="Requena, L" sort="Requena, L" uniqKey="Requena L" first="L." last="Requena">L. Requena</name><affiliation wicri:level="1"><mods:affiliation>Fundación Jiménez Diaz, Madrid, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Fundación Jiménez Diaz, Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Grimalt, R" sort="Grimalt, R" uniqKey="Grimalt R" first="R." last="Grimalt">R. Grimalt</name><affiliation wicri:level="1"><mods:affiliation>Universitat Internacional de Catalunya, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Universitat Internacional de Catalunya, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Paoli, J" sort="Paoli, J" uniqKey="Paoli J" first="J." last="Paoli">J. Paoli</name><affiliation wicri:level="1"><mods:affiliation>Sahlgrenska University Hospital, Gothenburg, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Sahlgrenska University Hospital, Gothenburg</wicri:regionArea></affiliation></author><author><name sortKey="Jaen, P" sort="Jaen, P" uniqKey="Jaen P" first="P." last="Jaén">P. Jaén</name><affiliation wicri:level="1"><mods:affiliation>Hospital Ramón y Cajal, IRYCIS, Universidad de Alcalá, Madrid, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Ramón y Cajal, IRYCIS, Universidad de Alcalá, Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Camacho, F M" sort="Camacho, F M" uniqKey="Camacho F" first="F. M." last="Camacho">F. M. Camacho</name><affiliation wicri:level="1"><mods:affiliation>Virgen Macarena, Sevilla, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Virgen Macarena, Sevilla</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of the European Academy of Dermatology and Venereology</title><title level="j" type="alt">JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY</title><idno type="ISSN">0926-9959</idno><idno type="eISSN">1468-3083</idno><imprint><biblScope unit="vol">29</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1750">1750</biblScope><biblScope unit="page" to="1757">1757</biblScope><biblScope unit="page-count">8</biblScope><date type="published" when="2015-09">2015-09</date></imprint><idno type="ISSN">0926-9959</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0926-9959</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Background: Folliculitis decalvans (FD) is a rare neutrophilic scarring alopecia that represents a therapeutic challenge for dermatologists. Objective: To describe the epidemiology, comorbidities, clinical presentation, diagnostic findings and therapeutic options in a large series of patients with FD. Methods: This retrospective multicentre review includes patients diagnosed with FD based on clinical and histopathologic findings. The clinical severity was determined by the maximum diameter of the largest alopecic patch (slight: <2 cm, moderate: 2–4.99 cm, severe: 5 cm or more). Response to therapy was assessed as improvement, worsening or stabilization depending on the clinical symptoms (pruritus and trichodynia), inflammatory signs (erythema, pustules and crusts) and the extension of the alopecic patch. Results: Overall, 82 patients (52 males and 30 females) with a mean age of 35 years were included. No significant comorbidities were present. A family history was present in three males. Severe FD was observed in 17 patients (21%). The independent factors associated with severe FD after multivariate analysis were: onset of FD before 25 years of age and presence of pustules. Oral antibiotics (tetracyclines and the combination of clindamycin and rifampicin) improved 90% and 100% of the patients, with a mean duration of response of 4.6 and 7.2 months respectively. Conclusions: The onset of FD before 25 years of age and the presence of pustules within the alopecic patch were associated with severe FD. Tetracyclines and the combination of clindamycin and rifampicin were the most useful treatments.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001E06 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 001E06 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Istex
|étape= Curation
|type= RBID
|clé= ISTEX:96F36E7CCEBC7973CA91B8E4DE6A22D5C917D0AB
|texte= Folliculitis decalvans: a multicentre review of 82 patients
}}
| This area was generated with Dilib version V0.6.33. |  |