Long-term retention of neurotoxic β-carbolines in brain neuromelanin
Identifieur interne : 001D56 ( Istex/Curation ); précédent : 001D55; suivant : 001D57Long-term retention of neurotoxic β-carbolines in brain neuromelanin
Auteurs : A. Ö Stergren [Suède] ; A. Annas [Suède] ; K. Skog [Suède] ; N. G. Lindquist [Suède] ; E. B. Brittebo [Suède]Source :
- Journal of Neural Transmission [ 0300-9564 ] ; 2004-02-01.
English descriptors
Abstract
Summary.: β-Carbolines show structural resemblance to the neurotoxic N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and are metabolized to mitochondrial toxicants. Humans are continuously exposed to low levels of β-carbolines through cooked food, coffee, alcoholic beverages and tobacco smoke. β-Carbolines have previously been detected in higher levels in the pigmented substantia nigra than in the cortex of humans. The distribution of 3H-labelled harman and norharman in the brain of pigmented and albino mice and in frogs (a species having neuromelanin) was studied by tape-section and light-microscopic autoradiography. Furthermore, the binding of these β-carbolines to dopamine–melanin and melanin granules from Sepia officinalis was examined. The results revealed a high affinity binding to melanin and a long-term retention (up to 30 days) in pigmented tissues, including neuromelanin-containing neurons of frogs after a single injection. The role of long-term exposure to food-related β-carbolines and a retention of these compounds in pigment-containing neurons in the induction of idiopathic Parkinson’s disease should be further considered.
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DOI: 10.1007/s00702-003-0080-0
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Ö Stergren</name><affiliation wicri:level="1"><mods:affiliation>Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Pharmaceutical Biosciences, Uppsala University, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Annas, A" sort="Annas, A" uniqKey="Annas A" first="A." last="Annas">A. Annas</name><affiliation wicri:level="1"><mods:affiliation>Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Pharmaceutical Biosciences, Uppsala University, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Skog, K" sort="Skog, K" uniqKey="Skog K" first="K." last="Skog">K. 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Brittebo</name><affiliation wicri:level="1"><mods:affiliation>Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Pharmaceutical Biosciences, Uppsala University, Uppsala</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neural Transmission</title><title level="j" type="sub">Basic neurosciences and genetics, Parkinson's disease and allied conditions, Alzheimer's disease and related disorders, biological psychiatry</title><title level="j" type="abbrev">J Neural Transm</title><idno type="ISSN">0300-9564</idno><idno type="eISSN">1435-1463</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Vienna</pubPlace><date type="published" when="2004-02-01">2004-02-01</date><biblScope unit="volume">111</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="141">141</biblScope><biblScope unit="page" to="157">157</biblScope></imprint><idno type="ISSN">0300-9564</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0300-9564</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Keywords: β-Carbolines, parkinsonism, neuromelanin, harman, norharman, Parkinson’s disease, dopamine–melanin, Sepia officinalis.</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary.: β-Carbolines show structural resemblance to the neurotoxic N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and are metabolized to mitochondrial toxicants. Humans are continuously exposed to low levels of β-carbolines through cooked food, coffee, alcoholic beverages and tobacco smoke. β-Carbolines have previously been detected in higher levels in the pigmented substantia nigra than in the cortex of humans. The distribution of 3H-labelled harman and norharman in the brain of pigmented and albino mice and in frogs (a species having neuromelanin) was studied by tape-section and light-microscopic autoradiography. Furthermore, the binding of these β-carbolines to dopamine–melanin and melanin granules from Sepia officinalis was examined. The results revealed a high affinity binding to melanin and a long-term retention (up to 30 days) in pigmented tissues, including neuromelanin-containing neurons of frogs after a single injection. The role of long-term exposure to food-related β-carbolines and a retention of these compounds in pigment-containing neurons in the induction of idiopathic Parkinson’s disease should be further considered.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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