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Interaction of Artemisinins with Oxyhemoglobin Hb–FeII, Hb–FeII, CarboxyHb–FeII, Heme–FeII, and Carboxyheme FeII: Significance for Mode of Action and Implications for Therapy of Cerebral Malaria

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Interaction of Artemisinins with Oxyhemoglobin Hb–FeII, Hb–FeII, CarboxyHb–FeII, Heme–FeII, and Carboxyheme FeII: Significance for Mode of Action and Implications for Therapy of Cerebral Malaria

Auteurs : Paolo Coghi ; Nicoletta Basilico [Italie] ; Donatella Taramelli [Italie] ; Wing-Chi Chan ; Richard Haynes [Hong Kong] ; Diego Monti [Italie]

Source :

ChemMedChem [ 1860-7179 ] ; 2009-12-07.

RBID : ISTEX:12ED754EC10BF49C6D9F4C68A0EE9F2D45257D27

English descriptors

Teeft :
- Absorption spectra, Absorption spectrum, Agents chemother, Alkylation, Angew, Antimalarial, Antimalarial activities, Antimalarial activity, Aqueous buffer, Artemisinin, Artemisinins, Artemisone, Artesunate, Biochem, Cerebral malaria, Ch3cn, Ch3cn buffer, Chem, Chemmedchem, Derivative, Dithionite, Dmso, Dmso buffer, Falciparum parasites, Feii, Ferrous, Ferrous heme, Ferrous iron, Gmbh, Haynes, Heme, Human hemoglobin, Kgaa, Lmax, Meunier, Monti, Parasite, Same procedure, Sodium dithionite, Soret band, Standard microaerophilic conditions, Verlag, Verlag gmbh, Weinheim, Weinheim chemmedchem.

Abstract

In line with the enhancement of antimalarial activities of the current clinical artemisinins against parasites cultured under CO, the artemisinins are unaffected in vitro by carboxyhemoglobin (CO–Hb–FeII) or CO–heme–FeII, but are competitively decomposed by Hb–FeII or heme–FeII. In the latter case, the heme studies are greatly facilitated by solubilization of the heme in aqueous medium by use of arginine. None of the Hb species has an appreciable effect on artemisone, or on other aminoartemisinins, and antimalarial activities are either less affected or remain essentially unchanged against parasites cultured under standard microaerophilic conditions or under CO. The findings not only indicate that artemisinins do not require Hb–FeII or heme–FeII for promotion of antimalarial activity, but are also important in relation to the therapy of severe/complicated or cerebral malaria.

The antimalarial activities of Hb–FeII and heme–FeII‐susceptible artemisinins against parasites cultured under CO are substantially increased with respect to parasites cultured under microaerophilic conditions, in accord with observed inertness to CO–Hb–FeII and CO–heme–FeII. Aminoartemisinins display similar activities toward parasites cultured under these separate conditions, in line with their relative inertness to all heme species under biological conditions.

Url:

https://api.istex.fr/ark:/67375/WNG-6L3FZ557-R/fulltext.pdf

DOI: 10.1002/cmdc.200900342

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Paolo Coghi

<affiliation><mods:affiliation>Dipartimento Chimica Organica e Industriale, CNR‐ISTM, Via G. Venezian 21, 20133 Milano (Italy), Fax: (+39) 02‐50314072</mods:affiliation>
<wicri:noCountry code="subField">(+39) 02‐50314072</wicri:noCountry>
</affiliation>

Wing-Chi Chan

<affiliation><mods:affiliation>Department of Chemistry, Institute of Molecular Technology for Drug Discovery and Synthesis, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong (PR China), Fax: (+852) 2358‐1594</mods:affiliation>
<wicri:noCountry code="subField">(+852) 2358‐1594</wicri:noCountry>
</affiliation>

Le document en format XML

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<term>Alkylation</term>
<term>Angew</term>
<term>Antimalarial</term>
<term>Antimalarial activities</term>
<term>Antimalarial activity</term>
<term>Aqueous buffer</term>
<term>Artemisinin</term>
<term>Artemisinins</term>
<term>Artemisone</term>
<term>Artesunate</term>
<term>Biochem</term>
<term>Cerebral malaria</term>
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<term>Chemmedchem</term>
<term>Derivative</term>
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<term>Falciparum parasites</term>
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<term>Haynes</term>
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<term>Lmax</term>
<term>Meunier</term>
<term>Monti</term>
<term>Parasite</term>
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<term>Sodium dithionite</term>
<term>Soret band</term>
<term>Standard microaerophilic conditions</term>
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<front><div type="abstract" xml:lang="en">In line with the enhancement of antimalarial activities of the current clinical artemisinins against parasites cultured under CO, the artemisinins are unaffected in vitro by carboxyhemoglobin (CO–Hb–FeII) or CO–heme–FeII, but are competitively decomposed by Hb–FeII or heme–FeII. In the latter case, the heme studies are greatly facilitated by solubilization of the heme in aqueous medium by use of arginine. None of the Hb species has an appreciable effect on artemisone, or on other aminoartemisinins, and antimalarial activities are either less affected or remain essentially unchanged against parasites cultured under standard microaerophilic conditions or under CO. The findings not only indicate that artemisinins do not require Hb–FeII or heme–FeII for promotion of antimalarial activity, but are also important in relation to the therapy of severe/complicated or cerebral malaria.</div>
<div type="abstract" xml:lang="en">The antimalarial activities of Hb–FeII and heme–FeII‐susceptible artemisinins against parasites cultured under CO are substantially increased with respect to parasites cultured under microaerophilic conditions, in accord with observed inertness to CO–Hb–FeII and CO–heme–FeII. Aminoartemisinins display similar activities toward parasites cultured under these separate conditions, in line with their relative inertness to all heme species under biological conditions.</div>
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Interaction of Artemisinins with Oxyhemoglobin Hb–FeII, Hb–FeII, CarboxyHb–FeII, Heme–FeII, and Carboxyheme FeII: Significance for Mode of Action and Implications for Therapy of Cerebral Malaria

Interaction of Artemisinins with Oxyhemoglobin Hb–FeII, Hb–FeII, CarboxyHb–FeII, Heme–FeII, and Carboxyheme FeII: Significance for Mode of Action and Implications for Therapy of Cerebral Malaria

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Abstract

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