Tumour necrosis factor α inhibitor treatment for sarcoidosis refractory to conventional treatments: a report of five patients
Identifieur interne : 001048 ( Istex/Curation ); précédent : 001047; suivant : 001049Tumour necrosis factor α inhibitor treatment for sarcoidosis refractory to conventional treatments: a report of five patients
Auteurs : C. Pritchard [États-Unis] ; K. Nadarajah [États-Unis]Source :
- Annals of the Rheumatic Diseases [ 0003-4967 ] ; 2004-03.
English descriptors
- KwdEn :
- Teeft :
- Active disease, Adhesion molecules, Approximate duration, Arthralgia, Assistive devices, Case reports, Caucasian woman, Conventional treatments, Cyclosporin, Cytokine, Daily methotrexate, Differential efficacy, Dosing interval, Gait dysfunction, Glucocorticoid, Glucocorticoids hydroxychloroquine, Granuloma, Human alveolar macrophages, Human mouse antibody, Hydroxychloroquine, Inflammatory, Infliximab, Infliximab treatment, Infusion, Inhibitor, Inhibitor treatment, Macrophage, Magnetic resonance imaging, Maximum dosage, Methotrexate, Months cyclosporin, Nadarajah, Necrosis, Neurosarcoidosis, Other immunomodulatory treatments, Other patients, Pulmonary disease, Pulmonary sarcoidosis, Refractory sarcoidosis, Respir crit care, Rheumatoid, Rheumatoid arthritis, Sarcoid, Sarcoid endometritis, Sarcoid uveitis, Sarcoidosis, Sarcoidosis vasc, Skin nodules, Thoracic spine, Tnfa, Tnfa inhibitor treatment, Tnfa inhibitors, Tumour, Tumour necrosis factor, Uveitis.
Abstract
Objective: To study the effectiveness of tumour necrosis factor α (TNFα) inhibitor treatment for sarcoidosis refractory to conventional treatments. Methods: Five patients (two men, three women) were treated with infliximab. All patients received a loading dose of 3 mg/kg at 0, 2, and 6 weeks and then maintenance infusions every 4–8 weeks. Patients had their dose increased or the dosing interval reduced when the disease relapsed. These patients had active disease despite treatment with corticosteroids and other immunomodulatory agents. All patients had a negative tuberculin skin test. Results: Sarcoidosis in all patients improved significantly without any serious adverse reactions. Conclusion: This study suggests that TNFα is effective in patients for whom conventional treatment fails.
Url:
DOI: 10.1136/ard.2002.004226
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<series><title level="j">Annals of the Rheumatic Diseases</title>
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<term>CT, computed tomography</term>
<term>IL, interleukin</term>
<term>MRI, magnetic resonance imaging</term>
<term>TNFα, tumour necrosis factor α</term>
<term>infliximab</term>
<term>sarcoidosis</term>
<term>tumour necrosis factor α</term>
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<keywords scheme="Teeft" xml:lang="en"><term>Active disease</term>
<term>Adhesion molecules</term>
<term>Approximate duration</term>
<term>Arthralgia</term>
<term>Assistive devices</term>
<term>Case reports</term>
<term>Caucasian woman</term>
<term>Conventional treatments</term>
<term>Cyclosporin</term>
<term>Cytokine</term>
<term>Daily methotrexate</term>
<term>Differential efficacy</term>
<term>Dosing interval</term>
<term>Gait dysfunction</term>
<term>Glucocorticoid</term>
<term>Glucocorticoids hydroxychloroquine</term>
<term>Granuloma</term>
<term>Human alveolar macrophages</term>
<term>Human mouse antibody</term>
<term>Hydroxychloroquine</term>
<term>Inflammatory</term>
<term>Infliximab</term>
<term>Infliximab treatment</term>
<term>Infusion</term>
<term>Inhibitor</term>
<term>Inhibitor treatment</term>
<term>Macrophage</term>
<term>Magnetic resonance imaging</term>
<term>Maximum dosage</term>
<term>Methotrexate</term>
<term>Months cyclosporin</term>
<term>Nadarajah</term>
<term>Necrosis</term>
<term>Neurosarcoidosis</term>
<term>Other immunomodulatory treatments</term>
<term>Other patients</term>
<term>Pulmonary disease</term>
<term>Pulmonary sarcoidosis</term>
<term>Refractory sarcoidosis</term>
<term>Respir crit care</term>
<term>Rheumatoid</term>
<term>Rheumatoid arthritis</term>
<term>Sarcoid</term>
<term>Sarcoid endometritis</term>
<term>Sarcoid uveitis</term>
<term>Sarcoidosis</term>
<term>Sarcoidosis vasc</term>
<term>Skin nodules</term>
<term>Thoracic spine</term>
<term>Tnfa</term>
<term>Tnfa inhibitor treatment</term>
<term>Tnfa inhibitors</term>
<term>Tumour</term>
<term>Tumour necrosis factor</term>
<term>Uveitis</term>
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<front><div type="abstract" xml:lang="en">Objective: To study the effectiveness of tumour necrosis factor α (TNFα) inhibitor treatment for sarcoidosis refractory to conventional treatments. Methods: Five patients (two men, three women) were treated with infliximab. All patients received a loading dose of 3 mg/kg at 0, 2, and 6 weeks and then maintenance infusions every 4–8 weeks. Patients had their dose increased or the dosing interval reduced when the disease relapsed. These patients had active disease despite treatment with corticosteroids and other immunomodulatory agents. All patients had a negative tuberculin skin test. Results: Sarcoidosis in all patients improved significantly without any serious adverse reactions. Conclusion: This study suggests that TNFα is effective in patients for whom conventional treatment fails.</div>
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