Chloroquine Prevents T Lymphocyte Suppression Induced by Anthrax Lethal Toxin
Identifieur interne : 001023 ( Istex/Curation ); précédent : 001022; suivant : 001024Chloroquine Prevents T Lymphocyte Suppression Induced by Anthrax Lethal Toxin
Auteurs : Mark I. Hirsh [Israël] ; Victoria Cohen [Israël]Source :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2006.
Abstract
Lysosomal processing of lethal toxin (LTX) is a key event in the pathogenesis of anthrax. This study investigated the ability of chloroquine (CQ) to interfere with this processing and thereby to reduce suppression of T lymphocytes. T lymphocytes isolated from blood were activated, by cross-linking of CD3, in both the absence and presence of LTX and CQ and then were assayed by flow cytometry and immunoblotting. LTX was found to disrupt intracellular signaling, and it down-regulated T lymphocyte function. CQ significantly reduced the harmful effects of LTX and protected the activation and cytokine production of T lymphocytes. This effect may indicate a promising strategy in the treatment of anthrax
Url:
DOI: 10.1086/507311
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001023
Links to Exploration step
ISTEX:E714204C932558E1C518E4E17E312EA24F83622ELe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Chloroquine Prevents T Lymphocyte Suppression Induced by Anthrax Lethal Toxin</title>
<author><name sortKey="Hirsh, Mark I" sort="Hirsh, Mark I" uniqKey="Hirsh M" first="Mark I." last="Hirsh">Mark I. Hirsh</name>
<affiliation><mods:affiliation>Laboratory for Shock and Trauma Research, Rambam Medical Center, and</mods:affiliation>
<wicri:noCountry code="subField">and</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>E-mail: hirsh@tx.technion.ac.il</mods:affiliation>
<country wicri:rule="url">Israël</country>
</affiliation>
</author>
<author><name sortKey="Cohen, Victoria" sort="Cohen, Victoria" uniqKey="Cohen V" first="Victoria" last="Cohen">Victoria Cohen</name>
<affiliation><mods:affiliation>Laboratory for Shock and Trauma Research, Rambam Medical Center, and</mods:affiliation>
<wicri:noCountry code="subField">and</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Cancer and Vascular Biology Research Center, Ruth & Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel</mods:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Cancer and Vascular Biology Research Center, Ruth & Bruce Rappaport Faculty of Medicine, Technion, Haifa</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:E714204C932558E1C518E4E17E312EA24F83622E</idno>
<date when="2006" year="2006">2006</date>
<idno type="doi">10.1086/507311</idno>
<idno type="url">https://api.istex.fr/ark:/67375/HXZ-VL0NX5T2-T/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001023</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001023</idno>
<idno type="wicri:Area/Istex/Curation">001023</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Chloroquine Prevents T Lymphocyte Suppression Induced by Anthrax Lethal Toxin<ref type="fn" target="#fn1"></ref>
</title>
<author><name sortKey="Hirsh, Mark I" sort="Hirsh, Mark I" uniqKey="Hirsh M" first="Mark I." last="Hirsh">Mark I. Hirsh</name>
<affiliation><mods:affiliation>Laboratory for Shock and Trauma Research, Rambam Medical Center, and</mods:affiliation>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>E-mail: hirsh@tx.technion.ac.il</mods:affiliation>
<country wicri:rule="url">Israël</country>
</affiliation>
</author>
<author><name sortKey="Cohen, Victoria" sort="Cohen, Victoria" uniqKey="Cohen V" first="Victoria" last="Cohen">Victoria Cohen</name>
<affiliation><mods:affiliation>Laboratory for Shock and Trauma Research, Rambam Medical Center, and</mods:affiliation>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Cancer and Vascular Biology Research Center, Ruth & Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel</mods:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Cancer and Vascular Biology Research Center, Ruth & Bruce Rappaport Faculty of Medicine, Technion, Haifa</wicri:regionArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">The Journal of Infectious Diseases</title>
<title level="j" type="abbrev">The Journal of Infectious Diseases</title>
<idno type="ISSN">0022-1899</idno>
<idno type="eISSN">1537-6613</idno>
<imprint><publisher>The University of Chicago Press</publisher>
<date when="2006-10-01">2006</date>
<biblScope unit="vol">194</biblScope>
<biblScope unit="issue">7</biblScope>
<biblScope unit="page" from="1003">1003</biblScope>
<biblScope unit="page" to="1007">1007</biblScope>
</imprint>
<idno type="ISSN">0022-1899</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0022-1899</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract">Lysosomal processing of lethal toxin (LTX) is a key event in the pathogenesis of anthrax. This study investigated the ability of chloroquine (CQ) to interfere with this processing and thereby to reduce suppression of T lymphocytes. T lymphocytes isolated from blood were activated, by cross-linking of CD3, in both the absence and presence of LTX and CQ and then were assayed by flow cytometry and immunoblotting. LTX was found to disrupt intracellular signaling, and it down-regulated T lymphocyte function. CQ significantly reduced the harmful effects of LTX and protected the activation and cytokine production of T lymphocytes. This effect may indicate a promising strategy in the treatment of anthrax</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001023 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 001023 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Istex |étape= Curation |type= RBID |clé= ISTEX:E714204C932558E1C518E4E17E312EA24F83622E |texte= Chloroquine Prevents T Lymphocyte Suppression Induced by Anthrax Lethal Toxin }}
This area was generated with Dilib version V0.6.33. |