Imipramine and chloroquine induced alterations in phospholipid content of rat lung
Identifieur interne : 000918 ( Istex/Curation ); précédent : 000917; suivant : 000919Imipramine and chloroquine induced alterations in phospholipid content of rat lung
Auteurs : R. Gr Bner ; W. MeerbachSource :
- Experimental pathology [ 0232-1513 ] ; 1983.
English descriptors
- KwdEn :
- Teeft :
- Acetic acid, Alveolar, Alveolar macrophages, Alveolar maerophages, Alveolar surface, Alveolar surfactant, Alveolar surfactant level, Amphiphilic, Amphiphilic drugs, Biochemical studies, Cell sediment, Chloroquine, Chloroquine causes, Control animals, Control value, Data points, Different sensitivity, Drug metabolism, Drug treatment, Experimental values, Huge amount, Imipramine, Imipramine administration, Important role, Largest increase, Lavage, Lavage fluid, Lavaged, Lavaged lung tissue, Lipid, Lung lavage fluid, Lung tissue, Macro phages, Macrophage, Metabolism, Other hand, Other routes, Phospholipid content, Pneumocytes type, Relative amounts, Relative contents, Residual lung tissue, Statistical comparison, Surfactant, Surfactant clearance, Surfactant elearance, Surfactant metabolism, Surfactant origin, Whole macrophage fraction.
Abstract
Summary: The influence of the amphiphilic drugs imipramine (150 mg/kg b. w./day) and chloroquine (75 mg/kg b. w./day) on the phospholipid (PL) -metabolism of rat lung, its PL-content and PL-composition were measured in the cell free lung lavage fluid (alveolar surfactant), in the free alveolar cells (mainly alveolar macrophages), and in the residual lung tissue. In addition to the long-term administration (15 applications during a period of 3 weeks), the influence of short-term administration (2 or 4 applications, resp., during a period of 2 or 4 days) was examined. The alveolar macrophages show the largest increase in PL-content. As revealed by its composition the stored PL are of surfactant origin. In chloroquine treated rats the number of macrophages is increased as well. The concentration of stored PL is higher in macrophages of imipramine treated rats. The excessive accumulation of PL in this animal group possibly impairs the clearance function of alveolar macrophages. This is suggested to be the reason for the accumulation of alveolar surfactant in imipramine treated rats. The influence of the drugs on the PL-content of the residual lung tissue was weak. The results of this study show that amphiphilic drugs cause an accumulation of surfactant-PL within the alveolar macrophages and can promote the alveolar surfactant content even after short-term application. The role of alveolar macrophages in alveolar surfactant catabolism is demonstrated.
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DOI: 10.1016/S0232-1513(83)80013-9
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R. Gr Bner<affiliation><mods:affiliation>Medical Acaademy of Erfurt, GDR, Department of Pathology (Head: Prof. Dr. sc. med. D. Schreiber)</mods:affiliation><wicri:noCountry code="subField">Schreiber)</wicri:noCountry></affiliation><affiliation><mods:affiliation>Medical Acaademy of Erfurt, GDR, Department of Pathology (Head: Prof. Dr. sc. med. D. Schreiber)</mods:affiliation><wicri:noCountry code="subField">Schreiber)</wicri:noCountry></affiliation>Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Imipramine and chloroquine induced alterations in phospholipid content of rat lung</title><author><name sortKey="Gr Bner, R" sort="Gr Bner, R" uniqKey="Gr Bner R" first="R." last="Gr Bner">R. Gr Bner</name><affiliation><mods:affiliation>Medical Acaademy of Erfurt, GDR, Department of Pathology (Head: Prof. Dr. sc. med. D. Schreiber)</mods:affiliation><wicri:noCountry code="subField">Schreiber)</wicri:noCountry></affiliation></author><author><name sortKey="Meerbach, W" sort="Meerbach, W" uniqKey="Meerbach W" first="W." last="Meerbach">W. Meerbach</name><affiliation><mods:affiliation>Medical Acaademy of Erfurt, GDR, Department of Pathology (Head: Prof. Dr. sc. med. D. Schreiber)</mods:affiliation><wicri:noCountry code="subField">Schreiber)</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:86F0DE6061057772AC2C2793D1BFDCDD369E8FD2</idno><date when="1983" year="1983">1983</date><idno type="doi">10.1016/S0232-1513(83)80013-9</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-9PTW61RH-8/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000918</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000918</idno><idno type="wicri:Area/Istex/Curation">000918</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Imipramine and chloroquine induced alterations in phospholipid content of rat lung</title><author><name sortKey="Gr Bner, R" sort="Gr Bner, R" uniqKey="Gr Bner R" first="R." last="Gr Bner">R. Gr Bner</name><affiliation><mods:affiliation>Medical Acaademy of Erfurt, GDR, Department of Pathology (Head: Prof. Dr. sc. med. D. Schreiber)</mods:affiliation><wicri:noCountry code="subField">Schreiber)</wicri:noCountry></affiliation></author><author><name sortKey="Meerbach, W" sort="Meerbach, W" uniqKey="Meerbach W" first="W." last="Meerbach">W. Meerbach</name><affiliation><mods:affiliation>Medical Acaademy of Erfurt, GDR, Department of Pathology (Head: Prof. Dr. sc. med. D. Schreiber)</mods:affiliation><wicri:noCountry code="subField">Schreiber)</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Experimental pathology</title><title level="j" type="abbrev">ETPOLD</title><idno type="ISSN">0232-1513</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1983">1983</date><biblScope unit="volume">24</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="253">253</biblScope><biblScope unit="page" to="259">259</biblScope></imprint><idno type="ISSN">0232-1513</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0232-1513</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>alveolar macrophage</term><term>amphiphilic drugs</term><term>chloroquine</term><term>imipramine</term><term>lung</term><term>phospholipid content</term><term>phospholipidosis</term><term>rat</term><term>surfactant</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Acetic acid</term><term>Alveolar</term><term>Alveolar macrophages</term><term>Alveolar maerophages</term><term>Alveolar surface</term><term>Alveolar surfactant</term><term>Alveolar surfactant level</term><term>Amphiphilic</term><term>Amphiphilic drugs</term><term>Biochemical studies</term><term>Cell sediment</term><term>Chloroquine</term><term>Chloroquine causes</term><term>Control animals</term><term>Control value</term><term>Data points</term><term>Different sensitivity</term><term>Drug metabolism</term><term>Drug treatment</term><term>Experimental values</term><term>Huge amount</term><term>Imipramine</term><term>Imipramine administration</term><term>Important role</term><term>Largest increase</term><term>Lavage</term><term>Lavage fluid</term><term>Lavaged</term><term>Lavaged lung tissue</term><term>Lipid</term><term>Lung lavage fluid</term><term>Lung tissue</term><term>Macro phages</term><term>Macrophage</term><term>Metabolism</term><term>Other hand</term><term>Other routes</term><term>Phospholipid content</term><term>Pneumocytes type</term><term>Relative amounts</term><term>Relative contents</term><term>Residual lung tissue</term><term>Statistical comparison</term><term>Surfactant</term><term>Surfactant clearance</term><term>Surfactant elearance</term><term>Surfactant metabolism</term><term>Surfactant origin</term><term>Whole macrophage fraction</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: The influence of the amphiphilic drugs imipramine (150 mg/kg b. w./day) and chloroquine (75 mg/kg b. w./day) on the phospholipid (PL) -metabolism of rat lung, its PL-content and PL-composition were measured in the cell free lung lavage fluid (alveolar surfactant), in the free alveolar cells (mainly alveolar macrophages), and in the residual lung tissue. In addition to the long-term administration (15 applications during a period of 3 weeks), the influence of short-term administration (2 or 4 applications, resp., during a period of 2 or 4 days) was examined. The alveolar macrophages show the largest increase in PL-content. As revealed by its composition the stored PL are of surfactant origin. In chloroquine treated rats the number of macrophages is increased as well. The concentration of stored PL is higher in macrophages of imipramine treated rats. The excessive accumulation of PL in this animal group possibly impairs the clearance function of alveolar macrophages. This is suggested to be the reason for the accumulation of alveolar surfactant in imipramine treated rats. The influence of the drugs on the PL-content of the residual lung tissue was weak. The results of this study show that amphiphilic drugs cause an accumulation of surfactant-PL within the alveolar macrophages and can promote the alveolar surfactant content even after short-term application. The role of alveolar macrophages in alveolar surfactant catabolism is demonstrated.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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