Comparison of the Ames assay and the induction of sister chromatid exchanges: Results with ten pharmaceuticals and five selected agents
Identifieur interne : 000846 ( Istex/Curation ); précédent : 000845; suivant : 000847Comparison of the Ames assay and the induction of sister chromatid exchanges: Results with ten pharmaceuticals and five selected agents
Auteurs : Esmail K. Shubber [Iraq] ; David Jacobson-Kram [États-Unis] ; Jerry R. Williams [États-Unis]Source :
- Cell Biology and Toxicology [ 0742-2091 ] ; 1986-09-01.
English descriptors
- KwdEn :
- Teeft :
- Ames, Ames assay, Ames strains, Ames test, Amoscanate, Animal carcinogen, Annual meeting, Anthelmintic drugs, Antiamoebic drug, Antimalarial drug, Antimalarial drugs, Antischistosomal, Antischistosomal drug, Antischistosomal drugs, Assay, Azide, Bacterial culture, Bromide, Bueding, Carcinogen, Cell biology, Cell cultures, Cell lines, Cellular progression, Chinese hamster ovary, Chloroquine, Chloroquine diphosphate, Chromatid, Chromosomal damage, Colony formation, Crystal violet, Culture medium, Cultured cells, Dimethyl sulfoxide, Disease control, Drug exposure, Endpoint, Environmental mutagen society, Ethidium bromide, Fetal calf serum, Final concentration, Genetic toxicity, Genotoxic activity, Hamster, High potency, Human beings, Human cells, Human populations, Hycanthone, Induction, Intercalating agents, Johns hopkins university, Laboratory animals, Liver microsomes, Lucanthone, Mammalian cells, Metabolic activation, Mouse lymphoma cells, Mutagen, Mutagenic, Mutagenic activity, Mutagenicity, Mutagenicity studies, Mutagenicity tests, Mutat, Mutation, National institutes, Negative results, Niridazole, Oltipraz, Oxaminiquine, Personal communication, Pharmaceutical agents, Positive results, Praziquantel, Primaquine, Qualitative results, Quantitative data, Rodent cells, Salmonella, Salmonella strains, Salmonella typhimurium, Schistosoma mansoni, Schistosomiasis treatment, Shubber, Sister chromatid exchange, Sister chromatid exchanges, Sodium azide, Test system, Test systems, Tester, Tester strains, Toxicity, Toxicology, Typhimurium.
Abstract
: Seven antischistosomal drugs, two antimalarial drugs, and one antiamoebic drug were tested in all five Ames strains for induction of mutation, as well as for induction of cytotoxicity, inhibition of cellular progression, and the induction of sister chromatid exchanges in two cultured mammalian cell lines. We found that two agents shown to be negative in the Ames test were positive for sister chromatid exchange induction. Based on qualitative and quantitative evaluation, we find that all but three of the pharmaceuticals should be considered to be potential human carcinogens.
Url:
DOI: 10.1007/BF00121853
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ISTEX:9CCD52450D6D2B31713B80FB2DEFD6C6EFE7855FLe document en format XML
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<term>mutagen screening</term>
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<term>Ames assay</term>
<term>Ames strains</term>
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<term>Animal carcinogen</term>
<term>Annual meeting</term>
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<term>Bromide</term>
<term>Bueding</term>
<term>Carcinogen</term>
<term>Cell biology</term>
<term>Cell cultures</term>
<term>Cell lines</term>
<term>Cellular progression</term>
<term>Chinese hamster ovary</term>
<term>Chloroquine</term>
<term>Chloroquine diphosphate</term>
<term>Chromatid</term>
<term>Chromosomal damage</term>
<term>Colony formation</term>
<term>Crystal violet</term>
<term>Culture medium</term>
<term>Cultured cells</term>
<term>Dimethyl sulfoxide</term>
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<term>Drug exposure</term>
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<term>Fetal calf serum</term>
<term>Final concentration</term>
<term>Genetic toxicity</term>
<term>Genotoxic activity</term>
<term>Hamster</term>
<term>High potency</term>
<term>Human beings</term>
<term>Human cells</term>
<term>Human populations</term>
<term>Hycanthone</term>
<term>Induction</term>
<term>Intercalating agents</term>
<term>Johns hopkins university</term>
<term>Laboratory animals</term>
<term>Liver microsomes</term>
<term>Lucanthone</term>
<term>Mammalian cells</term>
<term>Metabolic activation</term>
<term>Mouse lymphoma cells</term>
<term>Mutagen</term>
<term>Mutagenic</term>
<term>Mutagenic activity</term>
<term>Mutagenicity</term>
<term>Mutagenicity studies</term>
<term>Mutagenicity tests</term>
<term>Mutat</term>
<term>Mutation</term>
<term>National institutes</term>
<term>Negative results</term>
<term>Niridazole</term>
<term>Oltipraz</term>
<term>Oxaminiquine</term>
<term>Personal communication</term>
<term>Pharmaceutical agents</term>
<term>Positive results</term>
<term>Praziquantel</term>
<term>Primaquine</term>
<term>Qualitative results</term>
<term>Quantitative data</term>
<term>Rodent cells</term>
<term>Salmonella</term>
<term>Salmonella strains</term>
<term>Salmonella typhimurium</term>
<term>Schistosoma mansoni</term>
<term>Schistosomiasis treatment</term>
<term>Shubber</term>
<term>Sister chromatid exchange</term>
<term>Sister chromatid exchanges</term>
<term>Sodium azide</term>
<term>Test system</term>
<term>Test systems</term>
<term>Tester</term>
<term>Tester strains</term>
<term>Toxicity</term>
<term>Toxicology</term>
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<front><div type="abstract" xml:lang="en">: Seven antischistosomal drugs, two antimalarial drugs, and one antiamoebic drug were tested in all five Ames strains for induction of mutation, as well as for induction of cytotoxicity, inhibition of cellular progression, and the induction of sister chromatid exchanges in two cultured mammalian cell lines. We found that two agents shown to be negative in the Ames test were positive for sister chromatid exchange induction. Based on qualitative and quantitative evaluation, we find that all but three of the pharmaceuticals should be considered to be potential human carcinogens.</div>
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