Tumor‐ and Drug‐Induced Cutaneous Neuro‐Phospholipidosis
Identifieur interne : 000590 ( Istex/Curation ); précédent : 000589; suivant : 000591Tumor‐ and Drug‐Induced Cutaneous Neuro‐Phospholipidosis
Auteurs : C. E. Orfanos [Allemagne] ; U. Runne [Allemagne]Source :
- Journal of Cutaneous Pathology [ 0303-6987 ] ; 1975-10.
English descriptors
- Teeft :
- Abraham hendy, Axon, Axonal, Barbituric acid, Brain gangliosides, Bronchogenic carcinoma, Carcinoma, Carcinomatous, Carcinomatous neuropathy, Chloroquine, Chronic abuse, Cutaneous, Cutaneous axons, Drug history, Electron microscope, Hereditary disorders, Jottrnal, Lipid, Lipid storage, Neuromyopathy, Neuropathy, Orfanos, Peripheral neuromyopathy, Runne, Schwann cells.
Abstract
Drugs and metastatic malignant tumors may induce severe alterations in cutaneous axons. The most prominent ultrastructural feature of axonal dystrophy of this type was the presence of multiple lamellated osmiophilic bodies (LOB), similar to those occurring in hereditary disorders with increase of brain gangliosides and lipid storage. Chloroquine, ergotamine, ethaverine and chronic abuse of non‐narcotic analgesic drugs seem to be responsible for the drug‐induced cutaneous neuro‐phospholipidosis, whereas the same condition was found in two patients with metastatic bronchogenic carcinoma and malignant melanoma.
Url:
DOI: 10.1111/j.1600-0560.1975.tb00171.x
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<affiliation wicri:level="1"><mods:affiliation>Department of Dermatology, University of Cologne, W. Germany</mods:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Dermatology, University of Cologne</wicri:regionArea>
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<affiliation wicri:level="1"><mods:affiliation>Correspondence address: Professor Dr. C. E. Orfanos, Dr. U. Runne, University Skin Hospital, 5 Cologne, Joseph‐Steltzmann‐Str. 9, West Germany</mods:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Correspondence address: Professor Dr. C. E. Orfanos, Dr. U. Runne, University Skin Hospital, 5 Cologne, Joseph‐Steltzmann‐Str. 9</wicri:regionArea>
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<author><name sortKey="Runne, U" sort="Runne, U" uniqKey="Runne U" first="U." last="Runne">U. Runne</name>
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<affiliation wicri:level="1"><mods:affiliation>Correspondence address: Professor Dr. C. E. Orfanos, Dr. U. Runne, University Skin Hospital, 5 Cologne, Joseph‐Steltzmann‐Str. 9, West Germany</mods:affiliation>
<country xml:lang="fr">Allemagne</country>
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<author><name sortKey="Runne, U" sort="Runne, U" uniqKey="Runne U" first="U." last="Runne">U. Runne</name>
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<series><title level="j" type="main">Journal of Cutaneous Pathology</title>
<title level="j" type="alt">JOURNAL OF CUTANEOUS PATHOLOGY</title>
<idno type="ISSN">0303-6987</idno>
<idno type="eISSN">1600-0560</idno>
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<publisher>Blackwell Publishing Ltd</publisher>
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<profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Abraham hendy</term>
<term>Axon</term>
<term>Axonal</term>
<term>Barbituric acid</term>
<term>Brain gangliosides</term>
<term>Bronchogenic carcinoma</term>
<term>Carcinoma</term>
<term>Carcinomatous</term>
<term>Carcinomatous neuropathy</term>
<term>Chloroquine</term>
<term>Chronic abuse</term>
<term>Cutaneous</term>
<term>Cutaneous axons</term>
<term>Drug history</term>
<term>Electron microscope</term>
<term>Hereditary disorders</term>
<term>Jottrnal</term>
<term>Lipid</term>
<term>Lipid storage</term>
<term>Neuromyopathy</term>
<term>Neuropathy</term>
<term>Orfanos</term>
<term>Peripheral neuromyopathy</term>
<term>Runne</term>
<term>Schwann cells</term>
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<front><div type="abstract" xml:lang="en">Drugs and metastatic malignant tumors may induce severe alterations in cutaneous axons. The most prominent ultrastructural feature of axonal dystrophy of this type was the presence of multiple lamellated osmiophilic bodies (LOB), similar to those occurring in hereditary disorders with increase of brain gangliosides and lipid storage. Chloroquine, ergotamine, ethaverine and chronic abuse of non‐narcotic analgesic drugs seem to be responsible for the drug‐induced cutaneous neuro‐phospholipidosis, whereas the same condition was found in two patients with metastatic bronchogenic carcinoma and malignant melanoma.</div>
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