Congenital and acquired bleeding problems in elderly patients
Identifieur interne : 002C95 ( Istex/Corpus ); précédent : 002C94; suivant : 002C96Congenital and acquired bleeding problems in elderly patients
Auteurs : Al Nicolle ; Kl Talks ; Jp HanleySource :
- Reviews in Clinical Gerontology [ 0959-2598 ] ; 2005-02.
Abstract
Bleeding in elderly patients is most commonly due to an underlying structural problem or an acquired coagulopathy. Occasionally, previously asymptomatic congenital bleeding disorders may present at an advanced age. When considering the possible causes of a clinical bleeding problem, the coagulation cascade is still a good starting-point. However, it is important to realize that the traditional model of the coagulation cascade has been superceded by the concept of a ‘coagulation network’. This updated model recognizes the importance of tissue factor in the initiation of coagulation. Despite the complexity of this model, the basic coagulation tests can still be interpreted in relation to the ‘intrinsic’, ‘extrinsic’ and ‘final common pathway’ components of the old-fashioned cascade (Figure 1).
Url:
DOI: 10.1017/S0959259805001735
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Occasionally, previously asymptomatic congenital bleeding disorders may present at an advanced age. When considering the possible causes of a clinical bleeding problem, the coagulation cascade is still a good starting-point. However, it is important to realize that the traditional model of the coagulation cascade has been superceded by the concept of a ‘coagulation network’. This updated model recognizes the importance of tissue factor in the initiation of coagulation. 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Gerontol.</abbrev-journal-title></journal-title-group><issn pub-type="epub">1469-9036</issn><issn pub-type="ppub">0959-2598</issn><publisher><publisher-name>Cambridge University Press</publisher-name><publisher-loc>Cambridge, UK</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pii">S0959259805001735</article-id><article-id pub-id-type="doi">10.1017/S0959259805001735</article-id><article-categories><subj-group subj-group-type="heading"><subject>Clinical geriatrics</subject></subj-group></article-categories><title-group><article-title>Congenital and acquired bleeding problems in elderly patients</article-title></title-group><contrib-group><contrib><name><surname>Nicolle</surname><given-names>AL</given-names></name><aff>Department of Haematology, <institution>Sunderland Royal Infirmary</institution>, Sunderland, <country>UK</country></aff></contrib><contrib><name><surname>Talks</surname><given-names>KL</given-names></name><aff>Newcastle Hospitals NHS Trust, <institution>Royal Victoria Infirmary</institution>, Newcastle-upon-Tyne, <country>UK</country></aff></contrib><contrib><name><surname>Hanley</surname><given-names>JP</given-names></name><aff>Newcastle Hospitals NHS Trust, <institution>Royal Victoria Infirmary</institution>, Newcastle-upon-Tyne, <country>UK</country></aff></contrib></contrib-group><pub-date pub-type="epub"><day>16</day><month>3</month><year>2006</year></pub-date><pub-date pub-type="ppub"><month>2</month><year>2005</year></pub-date><volume>15</volume><issue>1</issue><fpage>9</fpage><lpage>26</lpage><permissions><copyright-statement>© 2006 Cambridge University Press</copyright-statement></permissions><abstract abstract-type="text-abstract"><p>Bleeding in elderly patients is most commonly due to an underlying structural problem or an acquired coagulopathy. Occasionally, previously asymptomatic congenital bleeding disorders may present at an advanced age. When considering the possible causes of a clinical bleeding problem, the coagulation cascade is still a good starting-point. However, it is important to realize that the traditional model of the coagulation cascade has been superceded by the concept of a ‘coagulation network’. This updated model recognizes the importance of tissue factor in the initiation of coagulation. 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Occasionally, previously asymptomatic congenital bleeding disorders may present at an advanced age. When considering the possible causes of a clinical bleeding problem, the coagulation cascade is still a good starting-point. However, it is important to realize that the traditional model of the coagulation cascade has been superceded by the concept of a ‘coagulation network’. This updated model recognizes the importance of tissue factor in the initiation of coagulation. 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