Multicentric reticulohistiocytosis with elevated cytokine serum levels
Identifieur interne : 002A56 ( Istex/Corpus ); précédent : 002A55; suivant : 002A57Multicentric reticulohistiocytosis with elevated cytokine serum levels
Auteurs : Antoni Bennàssar ; Antoni Mas ; Antonio Guilabert ; Marc Julià ; José Manuel Mascar Aly ; Carmen HerreroSource :
- The Journal of Dermatology [ 0385-2407 ] ; 2011-09.
English descriptors
- Teeft :
- Acad dermatol, Arch dermatol, Arthritis mutilans, Arthritis rheum, Association multicentric reticulohistiocytosis, Autoimmune disorders, Bennassar, Case report, Clin, Clin dermatol, Clinical features, Cutaneous, Cytokine, Cytokine serum levels, Dermatol, Dermatology, Dermatomyositis, Destructive polyarthritis, Diabetes mellitus, Extensor surfaces, Factor xiiia, Histiocyte, Immunohistochemical, Immunohistochemical analysis, Interleukin, Internal malignancies, Macrophage, Malignancy, Methotrexate, Monocyte, Multicentric, Multicentric reticulohistiocytosis, Multinucleated, Multinucleated giant cells, Ndings, Papule, Positive tuberculin test, Remission, Reticulohistiocytosis, Rheumatol, Serum levels, Skin biopsy, Skin involvement, Skin lesions, Successful treatment, Synovium, Tumor necrosis, Uncommon cell histiocytosis, Unknown etiology, Upper chest, Weight loss.
Abstract
Multicentric reticulohistiocytosis (MRH) is an uncommon non‐Langerhans cell histiocytosis of unknown etiology. It is a multisystem disorder characterised by a papulonodular skin eruption, mainly in the extensor surfaces, and destructive polyarthritis. Histologically, either cutaneous lesions or the synovium show a dense dermal infiltrate of histiocytes and multinucleated giant cells with an eosinophilic granular material in the cytoplasm. In the immunohistochemical analysis these cells stain positively with monocyte/macrophage markers (CD68 and CD45), as well as with certain cytokines (tumor necrosis factor‐α, interleukin 1β and interleukin 6). Moreover, recent reports suggest an osteoclastic nature of the infiltrating cells, as they stain strongly with osteoclast tissue lytic markers including tartrate‐resistant acid phosphatase and cathepsin K. We report a case of MRH presenting with clinical features of dermatomyositis. Furthermore, the patient showed elevated cytokine serum levels that lowered after therapy.
Url:
DOI: 10.1111/j.1346-8138.2010.01146.x
Links to Exploration step
ISTEX:EA64E6774E66C9BAD1920C408ECDF2F36B9FE098Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Multicentric reticulohistiocytosis with elevated cytokine serum levels</title><author><name sortKey="Bennassar, Antoni" sort="Bennassar, Antoni" uniqKey="Bennassar A" first="Antoni" last="Bennàssar">Antoni Bennàssar</name><affiliation><mods:affiliation>Department of Dermatology, Hospital Clinic, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Mas, Antoni" sort="Mas, Antoni" uniqKey="Mas A" first="Antoni" last="Mas">Antoni Mas</name><affiliation><mods:affiliation>Department of Dermatology, Hospital Clinic, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Guilabert, Antonio" sort="Guilabert, Antonio" uniqKey="Guilabert A" first="Antonio" last="Guilabert">Antonio Guilabert</name><affiliation><mods:affiliation>Department of Dermatology, Hospital Clinic, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Julia, Marc" sort="Julia, Marc" uniqKey="Julia M" first="Marc" last="Julià">Marc Julià</name><affiliation><mods:affiliation>Department of Dermatology, Hospital Clinic, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Mascar Aly, Jose Manuel" sort="Mascar Aly, Jose Manuel" uniqKey="Mascar Aly J" first="José Manuel" last="Mascar Aly">José Manuel Mascar Aly</name><affiliation><mods:affiliation>Department of Dermatology, Hospital Clinic, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Herrero, Carmen" sort="Herrero, Carmen" uniqKey="Herrero C" first="Carmen" last="Herrero">Carmen Herrero</name><affiliation><mods:affiliation>Department of Dermatology, Hospital Clinic, Barcelona, Spain</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:EA64E6774E66C9BAD1920C408ECDF2F36B9FE098</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1111/j.1346-8138.2010.01146.x</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-6CHFZN36-9/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">002A56</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002A56</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Multicentric reticulohistiocytosis with elevated cytokine serum levels</title><author><name sortKey="Bennassar, Antoni" sort="Bennassar, Antoni" uniqKey="Bennassar A" first="Antoni" last="Bennàssar">Antoni Bennàssar</name><affiliation><mods:affiliation>Department of Dermatology, Hospital Clinic, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Mas, Antoni" sort="Mas, Antoni" uniqKey="Mas A" first="Antoni" last="Mas">Antoni Mas</name><affiliation><mods:affiliation>Department of Dermatology, Hospital Clinic, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Guilabert, Antonio" sort="Guilabert, Antonio" uniqKey="Guilabert A" first="Antonio" last="Guilabert">Antonio Guilabert</name><affiliation><mods:affiliation>Department of Dermatology, Hospital Clinic, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Julia, Marc" sort="Julia, Marc" uniqKey="Julia M" first="Marc" last="Julià">Marc Julià</name><affiliation><mods:affiliation>Department of Dermatology, Hospital Clinic, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Mascar Aly, Jose Manuel" sort="Mascar Aly, Jose Manuel" uniqKey="Mascar Aly J" first="José Manuel" last="Mascar Aly">José Manuel Mascar Aly</name><affiliation><mods:affiliation>Department of Dermatology, Hospital Clinic, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Herrero, Carmen" sort="Herrero, Carmen" uniqKey="Herrero C" first="Carmen" last="Herrero">Carmen Herrero</name><affiliation><mods:affiliation>Department of Dermatology, Hospital Clinic, Barcelona, Spain</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">The Journal of Dermatology</title><title level="j" type="alt">JOURNAL OF DERMATOLOGY</title><idno type="ISSN">0385-2407</idno><idno type="eISSN">1346-8138</idno><imprint><biblScope unit="vol">38</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="905">905</biblScope><biblScope unit="page" to="910">910</biblScope><biblScope unit="page-count">6</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2011-09">2011-09</date></imprint><idno type="ISSN">0385-2407</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0385-2407</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acad dermatol</term><term>Arch dermatol</term><term>Arthritis mutilans</term><term>Arthritis rheum</term><term>Association multicentric reticulohistiocytosis</term><term>Autoimmune disorders</term><term>Bennassar</term><term>Case report</term><term>Clin</term><term>Clin dermatol</term><term>Clinical features</term><term>Cutaneous</term><term>Cytokine</term><term>Cytokine serum levels</term><term>Dermatol</term><term>Dermatology</term><term>Dermatomyositis</term><term>Destructive polyarthritis</term><term>Diabetes mellitus</term><term>Extensor surfaces</term><term>Factor xiiia</term><term>Histiocyte</term><term>Immunohistochemical</term><term>Immunohistochemical analysis</term><term>Interleukin</term><term>Internal malignancies</term><term>Macrophage</term><term>Malignancy</term><term>Methotrexate</term><term>Monocyte</term><term>Multicentric</term><term>Multicentric reticulohistiocytosis</term><term>Multinucleated</term><term>Multinucleated giant cells</term><term>Ndings</term><term>Papule</term><term>Positive tuberculin test</term><term>Remission</term><term>Reticulohistiocytosis</term><term>Rheumatol</term><term>Serum levels</term><term>Skin biopsy</term><term>Skin involvement</term><term>Skin lesions</term><term>Successful treatment</term><term>Synovium</term><term>Tumor necrosis</term><term>Uncommon cell histiocytosis</term><term>Unknown etiology</term><term>Upper chest</term><term>Weight loss</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Multicentric reticulohistiocytosis (MRH) is an uncommon non‐Langerhans cell histiocytosis of unknown etiology. It is a multisystem disorder characterised by a papulonodular skin eruption, mainly in the extensor surfaces, and destructive polyarthritis. Histologically, either cutaneous lesions or the synovium show a dense dermal infiltrate of histiocytes and multinucleated giant cells with an eosinophilic granular material in the cytoplasm. In the immunohistochemical analysis these cells stain positively with monocyte/macrophage markers (CD68 and CD45), as well as with certain cytokines (tumor necrosis factor‐α, interleukin 1β and interleukin 6). Moreover, recent reports suggest an osteoclastic nature of the infiltrating cells, as they stain strongly with osteoclast tissue lytic markers including tartrate‐resistant acid phosphatase and cathepsin K. We report a case of MRH presenting with clinical features of dermatomyositis. Furthermore, the patient showed elevated cytokine serum levels that lowered after therapy.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>multicentric</json:string><json:string>reticulohistiocytosis</json:string><json:string>multicentric reticulohistiocytosis</json:string><json:string>cytokine</json:string><json:string>papule</json:string><json:string>dermatol</json:string><json:string>macrophage</json:string><json:string>dermatomyositis</json:string><json:string>cutaneous</json:string><json:string>histiocyte</json:string><json:string>methotrexate</json:string><json:string>monocyte</json:string><json:string>multinucleated</json:string><json:string>synovium</json:string><json:string>bennassar</json:string><json:string>dermatology</json:string><json:string>rheumatol</json:string><json:string>case report</json:string><json:string>clin</json:string><json:string>interleukin</json:string><json:string>internal malignancies</json:string><json:string>ndings</json:string><json:string>remission</json:string><json:string>arthritis rheum</json:string><json:string>immunohistochemical</json:string><json:string>malignancy</json:string><json:string>skin lesions</json:string><json:string>clinical features</json:string><json:string>factor xiiia</json:string><json:string>skin involvement</json:string><json:string>acad dermatol</json:string><json:string>extensor surfaces</json:string><json:string>cytokine serum levels</json:string><json:string>upper chest</json:string><json:string>serum levels</json:string><json:string>weight loss</json:string><json:string>tumor necrosis</json:string><json:string>association multicentric reticulohistiocytosis</json:string><json:string>arthritis mutilans</json:string><json:string>immunohistochemical analysis</json:string><json:string>autoimmune disorders</json:string><json:string>positive tuberculin test</json:string><json:string>multinucleated giant cells</json:string><json:string>destructive polyarthritis</json:string><json:string>diabetes mellitus</json:string><json:string>arch dermatol</json:string><json:string>clin dermatol</json:string><json:string>unknown etiology</json:string><json:string>uncommon cell histiocytosis</json:string><json:string>successful treatment</json:string><json:string>skin biopsy</json:string></teeft></keywords><author><json:item><name>Antoni BENNÀSSAR</name><affiliations><json:string>Department of Dermatology, Hospital Clinic, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Antoni MAS</name><affiliations><json:string>Department of Dermatology, Hospital Clinic, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Antonio GUILABERT</name><affiliations><json:string>Department of Dermatology, Hospital Clinic, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Marc JULIÀ</name><affiliations><json:string>Department of Dermatology, Hospital Clinic, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>José Manuel MASCARÓ‐GALY</name><affiliations><json:string>Department of Dermatology, Hospital Clinic, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Carmen HERRERO</name><affiliations><json:string>Department of Dermatology, Hospital Clinic, Barcelona, Spain</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>arthritis mutilans</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cytokines</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>multicentric reticulohistiocytosis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>osteoclast</value></json:item></subject><articleId><json:string>JDE1146</json:string></articleId><arkIstex>ark:/67375/WNG-6CHFZN36-9</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>caseStudy</json:string></originalGenre><abstract>Multicentric reticulohistiocytosis (MRH) is an uncommon non‐Langerhans cell histiocytosis of unknown etiology. It is a multisystem disorder characterised by a papulonodular skin eruption, mainly in the extensor surfaces, and destructive polyarthritis. Histologically, either cutaneous lesions or the synovium show a dense dermal infiltrate of histiocytes and multinucleated giant cells with an eosinophilic granular material in the cytoplasm. In the immunohistochemical analysis these cells stain positively with monocyte/macrophage markers (CD68 and CD45), as well as with certain cytokines (tumor necrosis factor‐α, interleukin 1β and interleukin 6). Moreover, recent reports suggest an osteoclastic nature of the infiltrating cells, as they stain strongly with osteoclast tissue lytic markers including tartrate‐resistant acid phosphatase and cathepsin K. We report a case of MRH presenting with clinical features of dermatomyositis. Furthermore, the patient showed elevated cytokine serum levels that lowered after therapy.</abstract><qualityIndicators><score>5.772</score><pdfWordCount>2140</pdfWordCount><pdfCharCount>14920</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>6</pdfPageCount><pdfPageSize>595.276 x 793.701 pts</pdfPageSize><pdfWordsPerPage>357</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>true</refBibsNative><abstractWordCount>136</abstractWordCount><abstractCharCount>1027</abstractCharCount><keywordCount>4</keywordCount></qualityIndicators><title>Multicentric reticulohistiocytosis with elevated cytokine serum levels</title><pmid><json:string>21658110</json:string></pmid><genre><json:string>case-report</json:string></genre><host><title>The Journal of Dermatology</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1346-8138</json:string></doi><issn><json:string>0385-2407</json:string></issn><eissn><json:string>1346-8138</json:string></eissn><publisherId><json:string>JDE</json:string></publisherId><volume>38</volume><issue>9</issue><pages><first>905</first><last>910</last><total>6</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Case Reports</value></json:item><json:item><value>CASE REPORT</value></json:item></subject></host><namedEntities><unitex><date><json:string>2011</json:string><json:string>1954</json:string></date><geogName></geogName><orgName><json:string>Department of Dermatology, Hospital Cl</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Antoni Bennassar</json:string></persName><placeName><json:string>Spain</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Codriansky et al.</json:string><json:string>Gorman et al.</json:string><json:string>A. Bennassar et al.</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-6CHFZN36-9</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - dermatology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - dermatology & venereal diseases</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Dermatology</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - General Medicine</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>2011</publicationDate><copyrightDate>2011</copyrightDate><doi><json:string>10.1111/j.1346-8138.2010.01146.x</json:string></doi><id>EA64E6774E66C9BAD1920C408ECDF2F36B9FE098</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-6CHFZN36-9/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-6CHFZN36-9/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/WNG-6CHFZN36-9/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Multicentric reticulohistiocytosis with elevated cytokine serum levels</title><title level="a" type="short">Multicentric reticulohistiocytosis</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><licence>© 2011 Japanese Dermatological Association</licence></availability><date type="published" when="2011-09"></date></publicationStmt><notesStmt><note type="content-type" subtype="case-report" source="caseStudy" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-29919SZJ-6">case-report</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="case-report"><analytic><title level="a" type="main">Multicentric reticulohistiocytosis with elevated cytokine serum levels</title><title level="a" type="short">Multicentric reticulohistiocytosis</title><author xml:id="author-0000"><persName><forename type="first">Antoni</forename><surname>BENNÀSSAR</surname></persName><affiliation><orgName type="department">Department of Dermatology</orgName><orgName type="institution">Hospital Clinic</orgName><address><addrLine>Barcelona</addrLine><addrLine>Spain</addrLine><country key="ES" xml:lang="en">SPAIN</country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Antoni</forename><surname>MAS</surname></persName><affiliation><orgName type="department">Department of Dermatology</orgName><orgName type="institution">Hospital Clinic</orgName><address><addrLine>Barcelona</addrLine><addrLine>Spain</addrLine><country key="ES" xml:lang="en">SPAIN</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Antonio</forename><surname>GUILABERT</surname></persName><affiliation><orgName type="department">Department of Dermatology</orgName><orgName type="institution">Hospital Clinic</orgName><address><addrLine>Barcelona</addrLine><addrLine>Spain</addrLine><country key="ES" xml:lang="en">SPAIN</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Marc</forename><surname>JULIÀ</surname></persName><affiliation><orgName type="department">Department of Dermatology</orgName><orgName type="institution">Hospital Clinic</orgName><address><addrLine>Barcelona</addrLine><addrLine>Spain</addrLine><country key="ES" xml:lang="en">SPAIN</country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">José Manuel</forename><surname>MASCARÓ‐GALY</surname></persName><affiliation><orgName type="department">Department of Dermatology</orgName><orgName type="institution">Hospital Clinic</orgName><address><addrLine>Barcelona</addrLine><addrLine>Spain</addrLine><country key="ES" xml:lang="en">SPAIN</country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Carmen</forename><surname>HERRERO</surname></persName><affiliation><orgName type="department">Department of Dermatology</orgName><orgName type="institution">Hospital Clinic</orgName><address><addrLine>Barcelona</addrLine><addrLine>Spain</addrLine><country key="ES" xml:lang="en">SPAIN</country></address></affiliation></author><idno type="istex">EA64E6774E66C9BAD1920C408ECDF2F36B9FE098</idno><idno type="ark">ark:/67375/WNG-6CHFZN36-9</idno><idno type="DOI">10.1111/j.1346-8138.2010.01146.x</idno><idno type="unit">JDE1146</idno><idno type="toTypesetVersion">file:JDE.JDE1146.pdf</idno></analytic><monogr><title level="j" type="main">The Journal of Dermatology</title><title level="j" type="alt">JOURNAL OF DERMATOLOGY</title><idno type="pISSN">0385-2407</idno><idno type="eISSN">1346-8138</idno><idno type="book-DOI">10.1111/(ISSN)1346-8138</idno><idno type="book-part-DOI">10.1111/jde.2011.38.issue-9</idno><idno type="product">JDE</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">38</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="905">905</biblScope><biblScope unit="page" to="910">910</biblScope><biblScope unit="page-count">6</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2011-09"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><encodingDesc><schemaRef type="ODD" url="https://xml-schema.delivery.istex.fr/tei-istex.odd"></schemaRef><appInfo><application ident="pub2tei" version="1.0.10" when="2019-12-20"><label>pub2TEI-ISTEX</label><desc>A set of style sheets for converting XML documents encoded in various scientific publisher formats into a common TEI format.
<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract xml:lang="en" style="main"><head>Abstract</head><p>Multicentric reticulohistiocytosis (MRH) is an uncommon non‐Langerhans cell histiocytosis of unknown etiology. It is a multisystem disorder characterised by a papulonodular skin eruption, mainly in the extensor surfaces, and destructive polyarthritis. Histologically, either cutaneous lesions or the synovium show a dense dermal infiltrate of histiocytes and multinucleated giant cells with an eosinophilic granular material in the cytoplasm. In the immunohistochemical analysis these cells stain positively with monocyte/macrophage markers (CD68 and CD45), as well as with certain cytokines (tumor necrosis factor‐α, interleukin 1β and interleukin 6). Moreover, recent reports suggest an osteoclastic nature of the infiltrating cells, as they stain strongly with osteoclast tissue lytic markers including tartrate‐resistant acid phosphatase and cathepsin K. We report a case of MRH presenting with clinical features of dermatomyositis. Furthermore, the patient showed elevated cytokine serum levels that lowered after therapy.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">arthritis <hi rend="italic">mutilans</hi></term><term xml:id="k2">cytokines</term><term xml:id="k3">multicentric reticulohistiocytosis</term><term xml:id="k4">osteoclast</term></keywords><keywords rend="tocHeading1"><term>Case Reports</term></keywords><keywords rend="articleCategory"><term>CASE REPORT</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-6CHFZN36-9/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1346-8138</doi><issn type="print">0385-2407</issn><issn type="electronic">1346-8138</issn><idGroup><id type="product" value="JDE"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="JOURNAL OF DERMATOLOGY">The Journal of Dermatology</title></titleGroup></publicationMeta><publicationMeta level="part" position="09109"><doi origin="wiley">10.1111/jde.2011.38.issue-9</doi><numberingGroup><numbering type="journalVolume" number="38">38</numbering><numbering type="journalIssue" number="9">9</numbering></numberingGroup><coverDate startDate="2011-09">September 2011</coverDate></publicationMeta><publicationMeta level="unit" type="caseStudy" position="10" status="forIssue"><doi origin="wiley">10.1111/j.1346-8138.2010.01146.x</doi><idGroup><id type="unit" value="JDE1146"></id></idGroup><countGroup><count type="pageTotal" number="6"></count></countGroup><titleGroup><title type="tocHeading1">Case Reports</title><title type="articleCategory">CASE REPORT</title></titleGroup><copyright>© 2011 Japanese Dermatological Association</copyright><eventGroup><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.9.1 mode:FullText" date="2011-08-22"></event><event type="publishedOnlineEarlyUnpaginated" date="2011-06-09"></event><event type="firstOnline" date="2011-06-09"></event><event type="publishedOnlineFinalForm" date="2011-08-22"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-30"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-11-04"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="905">905</numbering><numbering type="pageLast" number="910">910</numbering></numberingGroup><correspondenceTo>Antoni Bennàssar, M.D., Department of Dermatology, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain. Email: <email>tbennassar@hotmail.com</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JDE.JDE1146.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received 29 June 2010; accepted 21 September 2010.</unparsedEditorialHistory><countGroup><count type="figureTotal" number="3"></count><count type="tableTotal" number="0"></count></countGroup><titleGroup><title type="main">Multicentric reticulohistiocytosis with elevated cytokine serum levels</title><title type="shortAuthors">A. Bennàssar <i>et al.</i></title><title type="short">Multicentric reticulohistiocytosis</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#aff-1-1"><personName><givenNames>Antoni</givenNames><familyName>BENNÀSSAR</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#aff-1-1"><personName><givenNames>Antoni</givenNames><familyName>MAS</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#aff-1-1"><personName><givenNames>Antonio</givenNames><familyName>GUILABERT</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#aff-1-1"><personName><givenNames>Marc</givenNames><familyName>JULIÀ</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#aff-1-1"><personName><givenNames>José Manuel</givenNames><familyName>MASCARÓ‐GALY</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#aff-1-1"><personName><givenNames>Carmen</givenNames><familyName>HERRERO</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="aff-1-1" countryCode="ES"><unparsedAffiliation>Department of Dermatology, Hospital Clinic, Barcelona, Spain</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">arthritis <i>mutilans</i></keyword><keyword xml:id="k2">cytokines</keyword><keyword xml:id="k3">multicentric reticulohistiocytosis</keyword><keyword xml:id="k4">osteoclast</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Multicentric reticulohistiocytosis (MRH) is an uncommon non‐Langerhans cell histiocytosis of unknown etiology. It is a multisystem disorder characterised by a papulonodular skin eruption, mainly in the extensor surfaces, and destructive polyarthritis. Histologically, either cutaneous lesions or the synovium show a dense dermal infiltrate of histiocytes and multinucleated giant cells with an eosinophilic granular material in the cytoplasm. In the immunohistochemical analysis these cells stain positively with monocyte/macrophage markers (CD68 and CD45), as well as with certain cytokines (tumor necrosis factor‐α, interleukin 1β and interleukin 6). Moreover, recent reports suggest an osteoclastic nature of the infiltrating cells, as they stain strongly with osteoclast tissue lytic markers including tartrate‐resistant acid phosphatase and cathepsin K. We report a case of MRH presenting with clinical features of dermatomyositis. Furthermore, the patient showed elevated cytokine serum levels that lowered after therapy.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Multicentric reticulohistiocytosis with elevated cytokine serum levels</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Multicentric reticulohistiocytosis</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Multicentric reticulohistiocytosis with elevated cytokine serum levels</title></titleInfo><name type="personal"><namePart type="given">Antoni</namePart><namePart type="family">BENNÀSSAR</namePart><affiliation>Department of Dermatology, Hospital Clinic, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Antoni</namePart><namePart type="family">MAS</namePart><affiliation>Department of Dermatology, Hospital Clinic, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Antonio</namePart><namePart type="family">GUILABERT</namePart><affiliation>Department of Dermatology, Hospital Clinic, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marc</namePart><namePart type="family">JULIÀ</namePart><affiliation>Department of Dermatology, Hospital Clinic, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">José Manuel</namePart><namePart type="family">MASCARÓ‐GALY</namePart><affiliation>Department of Dermatology, Hospital Clinic, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Carmen</namePart><namePart type="family">HERRERO</namePart><affiliation>Department of Dermatology, Hospital Clinic, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="case-report" displayLabel="caseStudy" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-29919SZJ-6">case-report</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2011-09</dateIssued><edition>Received 29 June 2010; accepted 21 September 2010.</edition><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">3</extent><extent unit="tables">0</extent></physicalDescription><abstract lang="en">Multicentric reticulohistiocytosis (MRH) is an uncommon non‐Langerhans cell histiocytosis of unknown etiology. It is a multisystem disorder characterised by a papulonodular skin eruption, mainly in the extensor surfaces, and destructive polyarthritis. Histologically, either cutaneous lesions or the synovium show a dense dermal infiltrate of histiocytes and multinucleated giant cells with an eosinophilic granular material in the cytoplasm. In the immunohistochemical analysis these cells stain positively with monocyte/macrophage markers (CD68 and CD45), as well as with certain cytokines (tumor necrosis factor‐α, interleukin 1β and interleukin 6). Moreover, recent reports suggest an osteoclastic nature of the infiltrating cells, as they stain strongly with osteoclast tissue lytic markers including tartrate‐resistant acid phosphatase and cathepsin K. We report a case of MRH presenting with clinical features of dermatomyositis. Furthermore, the patient showed elevated cytokine serum levels that lowered after therapy.</abstract><subject lang="en"><genre>keywords</genre><topic>arthritis mutilans</topic><topic>cytokines</topic><topic>multicentric reticulohistiocytosis</topic><topic>osteoclast</topic></subject><relatedItem type="host"><titleInfo><title>The Journal of Dermatology</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Case Reports</topic><topic>CASE REPORT</topic></subject><identifier type="ISSN">0385-2407</identifier><identifier type="eISSN">1346-8138</identifier><identifier type="DOI">10.1111/(ISSN)1346-8138</identifier><identifier type="PublisherID">JDE</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>38</number></detail><detail type="issue"><caption>no.</caption><number>9</number></detail><extent unit="pages"><start>905</start><end>910</end><total>6</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cit1"><titleInfo><title>Multicentric reticulohistiocytosis of the skin and synovia; reticulohistiocytoma or ganglioneuroma</title></titleInfo><name type="personal"><namePart type="given">LW</namePart><namePart type="family">Goltz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CW</namePart><namePart type="family">Laymon</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Goltz LW, Laymon CW. Multicentric reticulohistiocytosis of the skin and synovia; reticulohistiocytoma or ganglioneuroma. AMA Arch Derm Syphilol 1954; 69(6): 717–731.</note><part><date>1954</date><detail type="volume"><caption>vol.</caption><number>69</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>717</start><end>731</end></extent></part><relatedItem type="host"><titleInfo><title>AMA Arch Derm Syphilol</title></titleInfo><part><date>1954</date><detail type="volume"><caption>vol.</caption><number>69</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>717</start><end>731</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit2"><titleInfo><title>Multicentric reticulohistiocytosis. A review of 33 patients</title></titleInfo><name type="personal"><namePart type="given">MV</namePart><namePart type="family">Barrow</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Holubar</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Barrow MV, Holubar K. Multicentric reticulohistiocytosis. A review of 33 patients. Medicine (Baltimore) 1969; 48(4): 287–305.</note><part><date>1969</date><detail type="volume"><caption>vol.</caption><number>48</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>287</start><end>305</end></extent></part><relatedItem type="host"><titleInfo><title>Medicine (Baltimore)</title></titleInfo><part><date>1969</date><detail type="volume"><caption>vol.</caption><number>48</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>287</start><end>305</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit3"><titleInfo><title>Multicentric reticulohistiocytosis (lipoid dermatoarthritis). A multisystem disorder</title></titleInfo><name type="personal"><namePart type="given">GE</namePart><namePart type="family">Ehrlich</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Young</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SZ</namePart><namePart type="family">Nosheny</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WA</namePart><namePart type="family">Katz</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ehrlich GE, Young I, Nosheny SZ, Katz WA. Multicentric reticulohistiocytosis (lipoid dermatoarthritis). A multisystem disorder. Am J Med 1972; 52(6): 830–840.</note><part><date>1972</date><detail type="volume"><caption>vol.</caption><number>52</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>830</start><end>840</end></extent></part><relatedItem type="host"><titleInfo><title>Am J Med</title></titleInfo><part><date>1972</date><detail type="volume"><caption>vol.</caption><number>52</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>830</start><end>840</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit4"><titleInfo><title>Multicentric reticulohistiocytosis: a lesson in screening for malignancy</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Millar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">O’Kane</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Taggart</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Millar A, O’Kane D, Taggart A. Multicentric reticulohistiocytosis: a lesson in screening for malignancy. Rheumatology (Oxford) 2008; 47(7):1102–1103. Epub 2008 Apr 29.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>47</number></detail><detail type="issue"><caption>no.</caption><number>7</number></detail><extent unit="pages"><start>1102</start><end>1103</end></extent></part><relatedItem type="host"><titleInfo><title>Rheumatology (Oxford)</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>47</number></detail><detail type="issue"><caption>no.</caption><number>7</number></detail><extent unit="pages"><start>1102</start><end>1103</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit5"><titleInfo><title>Multicentric reticulohistiocytosis: a systemic osteoclastic disease?</title></titleInfo><name type="personal"><namePart type="given">KA</namePart><namePart type="family">Codriansky</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TM</namePart><namePart type="family">Rünger</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Bhawan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Kantarci</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EY</namePart><namePart type="family">Kissin</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Codriansky KA, Rünger TM, Bhawan J, Kantarci A, Kissin EY. Multicentric reticulohistiocytosis: a systemic osteoclastic disease? Arthritis Rheum 2008; 59(3): 444–448.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>59</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>444</start><end>448</end></extent></part><relatedItem type="host"><titleInfo><title>Arthritis Rheum</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>59</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>444</start><end>448</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit6"><titleInfo><title>Multicentric reticulohistiocytosis</title></titleInfo><name type="personal"><namePart type="given">JL</namePart><namePart type="family">Lesher Jr</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BS</namePart><namePart type="family">Allen</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Lesher JL Jr, Allen BS. Multicentric reticulohistiocytosis. J Am Acad Dermatol 1984; 11(4 Pt 2):713–723.</note><part><date>1984</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><detail type="issue"><caption>no.</caption><number>4 Pt 2</number></detail><extent unit="pages"><start>713</start><end>723</end></extent></part><relatedItem type="host"><titleInfo><title>J Am Acad Dermatol</title></titleInfo><part><date>1984</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><detail type="issue"><caption>no.</caption><number>4 Pt 2</number></detail><extent unit="pages"><start>713</start><end>723</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit7"><titleInfo><title>Multicentric reticulohistiocytosis</title></titleInfo><name type="personal"><namePart type="given">AL</namePart><namePart type="family">Tajirian</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MK</namePart><namePart type="family">Malik</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Robinson‐Bostom</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EV</namePart><namePart type="family">Lally</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Tajirian AL, Malik MK, Robinson‐Bostom L, Lally EV. Multicentric reticulohistiocytosis. Clin Dermatol 2006; 24(6): 486–492.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>486</start><end>492</end></extent></part><relatedItem type="host"><titleInfo><title>Clin Dermatol</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>486</start><end>492</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit8"><titleInfo><title>Multicentric reticulohistiocytosis</title></titleInfo><name type="personal"><namePart type="given">R</namePart><namePart type="family">Katz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Anderson</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Katz R, Anderson K. Multicentric reticulohistiocytosis. Oral Surg Oral Med Oral Pathol 1988; 65: 721–725.</note><part><date>1988</date><detail type="volume"><caption>vol.</caption><number>65</number></detail><extent unit="pages"><start>721</start><end>725</end></extent></part><relatedItem type="host"><titleInfo><title>Oral Surg Oral Med Oral Pathol</title></titleInfo><part><date>1988</date><detail type="volume"><caption>vol.</caption><number>65</number></detail><extent unit="pages"><start>721</start><end>725</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit9"><titleInfo><title>Multicentric reticulohistiocytosis‐mimicking dermatomyositis. Case report and review of the literature</title></titleInfo><name type="personal"><namePart type="given">C</namePart><namePart type="family">Muñoz‐Santos</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Sàbat</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Sáez</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Gratacós</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Luelmo</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Muñoz‐Santos C, Sàbat M, Sáez A, Gratacós J, Luelmo J. Multicentric reticulohistiocytosis‐mimicking dermatomyositis. Case report and review of the literature. Dermatology 2007; 214(3): 268–271.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>214</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>268</start><end>271</end></extent></part><relatedItem type="host"><titleInfo><title>Dermatology</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>214</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>268</start><end>271</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit10"><titleInfo><title>Multicentric reticulohistiocytosis presenting with clinical features of dermatomyositis</title></titleInfo><name type="personal"><namePart type="given">SH</namePart><namePart type="family">Hsiung</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EF</namePart><namePart type="family">Chan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Elenitsas</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SL</namePart><namePart type="family">Kolasinski</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HR</namePart><namePart type="family">Schumacher</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">VP</namePart><namePart type="family">Werth</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Hsiung SH, Chan EF, Elenitsas R, Kolasinski SL, Schumacher HR, Werth VP. Multicentric reticulohistiocytosis presenting with clinical features of dermatomyositis. J Am Acad Dermatol 2003; 48 (Suppl 2): S11–S14.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>48</number></detail><detail type="issue"><caption>no.</caption><number>Suppl 2</number></detail><extent unit="pages"><start>S11</start><end>S14</end></extent></part><relatedItem type="host"><titleInfo><title>J Am Acad Dermatol</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>48</number></detail><detail type="issue"><caption>no.</caption><number>Suppl 2</number></detail><extent unit="pages"><start>S11</start><end>S14</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit11"><titleInfo><title>Multicentric reticulohistiocytosis with prominent cutaneous lesions and proximal muscle weakness masquerading as dermatomyositis</title></titleInfo><name type="personal"><namePart type="given">KL</namePart><namePart type="family">McIlwain</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JB</namePart><namePart type="family">DiCarlo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SB</namePart><namePart type="family">Miller</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Lim</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">McIlwain KL, DiCarlo JB, Miller SB, Lim S. Multicentric reticulohistiocytosis with prominent cutaneous lesions and proximal muscle weakness masquerading as dermatomyositis. J Rheumatol 2005; 32(1): 193–194.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>193</start><end>194</end></extent></part><relatedItem type="host"><titleInfo><title>J Rheumatol</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>193</start><end>194</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit12"><titleInfo><title>Multicentric reticulohistiocytosis: presentation with the cutaneous features of dermatomyositis</title></titleInfo><name type="personal"><namePart type="given">TJ</namePart><namePart type="family">Tait</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HA</namePart><namePart type="family">Bird</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GP</namePart><namePart type="family">Ford</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Tait TJ, Bird HA, Ford GP. Multicentric reticulohistiocytosis: presentation with the cutaneous features of dermatomyositis. Br J Rheumatol 1994; 33(1): 100–101.</note><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>33</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>100</start><end>101</end></extent></part><relatedItem type="host"><titleInfo><title>Br J Rheumatol</title></titleInfo><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>33</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>100</start><end>101</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit13"><titleInfo><title>Aggressive histiocytic disorders that can involve the skin</title></titleInfo><name type="personal"><namePart type="given">B</namePart><namePart type="family">Newman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Hu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Nigro</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AC</namePart><namePart type="family">Gilliam</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Newman B, Hu W, Nigro K, Gilliam AC. Aggressive histiocytic disorders that can involve the skin. J Am Acad Dermatol 2007; 56(2):302–316. Epub 2006 Oct 9.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>56</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>302</start><end>316</end></extent></part><relatedItem type="host"><titleInfo><title>J Am Acad Dermatol</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>56</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>302</start><end>316</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit14"><titleInfo><title>Multicentric reticulohistiocytosis: case report with immunohistochemical analysis and literature review</title></titleInfo><name type="personal"><namePart type="given">JD</namePart><namePart type="family">Gorman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Danning</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HR</namePart><namePart type="family">Schumacher</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JH</namePart><namePart type="family">Klippel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JC</namePart><namePart type="family">Davis Jr</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Gorman JD, Danning C, Schumacher HR, Klippel JH, Davis JC Jr. Multicentric reticulohistiocytosis: case report with immunohistochemical analysis and literature review. Arthritis Rheum 2000; 43(4): 930–938.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>43</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>930</start><end>938</end></extent></part><relatedItem type="host"><titleInfo><title>Arthritis Rheum</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>43</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>930</start><end>938</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit15"><titleInfo><title>Multicentric reticulohistiocytosis and cancer: a case report and review of the literature</title></titleInfo><name type="personal"><namePart type="given">J</namePart><namePart type="family">Nunnink</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Krusinski</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Yates</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Nunnink J, Krusinski P, Yates J. Multicentric reticulohistiocytosis and cancer: a case report and review of the literature. Med Pediatr Oncol 1985; 13(5): 273–279.</note><part><date>1985</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>273</start><end>279</end></extent></part><relatedItem type="host"><titleInfo><title>Med Pediatr Oncol</title></titleInfo><part><date>1985</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>273</start><end>279</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit16"><titleInfo><title>Multicentric reticulohistiocytosis</title></titleInfo><name type="personal"><namePart type="given">RP</namePart><namePart type="family">Rapini</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Rapini RP. Multicentric reticulohistiocytosis. Clin Dermatol 1993; 11(1): 107–111.</note><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>107</start><end>111</end></extent></part><relatedItem type="host"><titleInfo><title>Clin Dermatol</title></titleInfo><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>107</start><end>111</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit17"><titleInfo><title>Multicentric reticulohistiocytosis: systemic macrophage disorder</title></titleInfo><name type="personal"><namePart type="given">D</namePart><namePart type="family">Campbell</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Edwards</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Campbell D, Edwards N. Multicentric reticulohistiocytosis: systemic macrophage disorder. Baillieres Clin Rheumatol 1991; 5: 301–319.</note><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>301</start><end>319</end></extent></part><relatedItem type="host"><titleInfo><title>Baillieres Clin Rheumatol</title></titleInfo><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>301</start><end>319</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit18"><titleInfo><title>Complete remission of multicentric reticulohistiocytosis with combination therapy of steroid, cyclophosphamide, and low‐dose pulse methotrexate. Case report, review of the literature, and proposal for treatment</title></titleInfo><name type="personal"><namePart type="given">GC</namePart><namePart type="family">Liang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AS</namePart><namePart type="family">Granston</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Liang GC, Granston AS. Complete remission of multicentric reticulohistiocytosis with combination therapy of steroid, cyclophosphamide, and low‐dose pulse methotrexate. Case report, review of the literature, and proposal for treatment. Arthritis Rheum 1996; 39: 171–174.</note><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>39</number></detail><extent unit="pages"><start>171</start><end>174</end></extent></part><relatedItem type="host"><titleInfo><title>Arthritis Rheum</title></titleInfo><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>39</number></detail><extent unit="pages"><start>171</start><end>174</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit19"><titleInfo><title>Treatment trial of multicentric reticulohistiocytosis with a combination of predonisolone, methotrexate and alendronate</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Satoh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Oyama</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Yamada</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Nakamura</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Kaneko</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Satoh M, Oyama N, Yamada H, Nakamura K, Kaneko F. Treatment trial of multicentric reticulohistiocytosis with a combination of predonisolone, methotrexate and alendronate. J Dermatol 2008; 35(3): 168–171.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>35</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>168</start><end>171</end></extent></part><relatedItem type="host"><titleInfo><title>J Dermatol</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>35</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>168</start><end>171</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit20"><titleInfo><title>Multicentric reticulohistiocytosis: response to alkylating agents in six patients</title></titleInfo><name type="personal"><namePart type="given">WW</namePart><namePart type="family">Ginsburg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JD</namePart><namePart type="family">O’Duffy</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JL</namePart><namePart type="family">Morris</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KA</namePart><namePart type="family">Huston</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ginsburg WW, O’Duffy JD, Morris JL, Huston KA. Multicentric reticulohistiocytosis: response to alkylating agents in six patients. Ann Intern Med 1989; 111: 384–388.</note><part><date>1989</date><detail type="volume"><caption>vol.</caption><number>111</number></detail><extent unit="pages"><start>384</start><end>388</end></extent></part><relatedItem type="host"><titleInfo><title>Ann Intern Med</title></titleInfo><part><date>1989</date><detail type="volume"><caption>vol.</caption><number>111</number></detail><extent unit="pages"><start>384</start><end>388</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit21"><titleInfo><title>Multicentric reticulohistiocytosis with generalized systemic involvement</title></titleInfo><name type="personal"><namePart type="given">YH</namePart><namePart type="family">Liu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Fang</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Liu YH, Fang K. Multicentric reticulohistiocytosis with generalized systemic involvement. Clin Exp Dermatol 2004; 29(4): 373–376.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>29</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>373</start><end>376</end></extent></part><relatedItem type="host"><titleInfo><title>Clin Exp Dermatol</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>29</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>373</start><end>376</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit22"><titleInfo><title>Successful treatment of multicentric reticulohistiocytosis with a combination of infliximab, prednisolone and methotrexate</title></titleInfo><name type="personal"><namePart type="given">MW</namePart><namePart type="family">Lee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EY</namePart><namePart type="family">Lee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">YI</namePart><namePart type="family">Jeong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JH</namePart><namePart type="family">Choi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KC</namePart><namePart type="family">Moon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JK</namePart><namePart type="family">Koh</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Lee MW, Lee EY, Jeong YI, Choi JH, Moon KC, Koh JK. Successful treatment of multicentric reticulohistiocytosis with a combination of infliximab, prednisolone and methotrexate. Acta Derm Venereol 2004; 84(6): 478–479.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>84</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>478</start><end>479</end></extent></part><relatedItem type="host"><titleInfo><title>Acta Derm Venereol</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>84</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>478</start><end>479</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit23"><titleInfo><title>Multicentric reticulohistiocytosis successfully treated with infliximab</title></titleInfo><name type="personal"><namePart type="given">AH</namePart><namePart type="family">Halajian</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JP</namePart><namePart type="family">Callen</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Halajian AH, Callen JP. Multicentric reticulohistiocytosis successfully treated with infliximab. Arch Dermatol 2008; 144(10): 1360–1366.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>144</number></detail><detail type="issue"><caption>no.</caption><number>10</number></detail><extent unit="pages"><start>1360</start><end>1366</end></extent></part><relatedItem type="host"><titleInfo><title>Arch Dermatol</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>144</number></detail><detail type="issue"><caption>no.</caption><number>10</number></detail><extent unit="pages"><start>1360</start><end>1366</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit24"><titleInfo><title>Treatment of multicentric reticulohistiocytosis with etanercept</title></titleInfo><name type="personal"><namePart type="given">BT</namePart><namePart type="family">Kovach</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KT</namePart><namePart type="family">Calamia</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JS</namePart><namePart type="family">Walsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WW</namePart><namePart type="family">Ginsburg</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kovach BT, Calamia KT, Walsh JS, Ginsburg WW. Treatment of multicentric reticulohistiocytosis with etanercept. Arch Dermatol 2004; 140(8): 919–921.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>140</number></detail><detail type="issue"><caption>no.</caption><number>8</number></detail><extent unit="pages"><start>919</start><end>921</end></extent></part><relatedItem type="host"><titleInfo><title>Arch Dermatol</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>140</number></detail><detail type="issue"><caption>no.</caption><number>8</number></detail><extent unit="pages"><start>919</start><end>921</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit25"><titleInfo><title>Multicentric reticulohistiocytosis responding to tumor necrosis factor‐α inhibition in a renal transplant patient</title></titleInfo><name type="personal"><namePart type="given">SE</namePart><namePart type="family">Shannon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Schumacher</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Self</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Shannon SE, Schumacher R, Self S. Multicentric reticulohistiocytosis responding to tumor necrosis factor‐α inhibition in a renal transplant patient. J Rheumatol 2005; 32(3): 565–567.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>565</start><end>567</end></extent></part><relatedItem type="host"><titleInfo><title>J Rheumatol</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>565</start><end>567</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit26"><titleInfo><title>Successful treatment of multicentric reticulohistiocytosis with alendronate: evidence for a direct effect of bisphosphonate on histiocytes</title></titleInfo><name type="personal"><namePart type="given">H</namePart><namePart type="family">Goto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Inaba</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Kobayashi</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Goto H, Inaba M, Kobayashi K et al. Successful treatment of multicentric reticulohistiocytosis with alendronate: evidence for a direct effect of bisphosphonate on histiocytes. Arthritis Rheum 2003; 48(12): 3538–3541.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>48</number></detail><detail type="issue"><caption>no.</caption><number>12</number></detail><extent unit="pages"><start>3538</start><end>3541</end></extent></part><relatedItem type="host"><titleInfo><title>Arthritis Rheum</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>48</number></detail><detail type="issue"><caption>no.</caption><number>12</number></detail><extent unit="pages"><start>3538</start><end>3541</end></extent></part></relatedItem></relatedItem><identifier type="istex">EA64E6774E66C9BAD1920C408ECDF2F36B9FE098</identifier><identifier type="ark">ark:/67375/WNG-6CHFZN36-9</identifier><identifier type="DOI">10.1111/j.1346-8138.2010.01146.x</identifier><identifier type="ArticleID">JDE1146</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2011 Japanese Dermatological Association</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Converted from (version ) to MODS version 3.6.</recordOrigin><recordCreationDate encoding="w3cdtf">2019-11-15</recordCreationDate></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-6CHFZN36-9/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002A56 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 002A56 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:EA64E6774E66C9BAD1920C408ECDF2F36B9FE098
|texte= Multicentric reticulohistiocytosis with elevated cytokine serum levels
}}
| This area was generated with Dilib version V0.6.33. |  |